Longevity Papers

Week of July 07 - July 13, 2025


Weekly AI-generated podcast (YT) (Apple) (feed), June 26 episode:
Saturday, July 12, 2025
Tsotras, M., Charbonneau, J. A., Lepage, C. ... · neuroscience · Center of Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, New York, NY · biorxiv
Large-scale brain networks are vulnerable to change with aging and become dysregulated. How these networks are altered at the cellular level remains unclear owing to challenges of bridging data across scales. Here, we integrate in vivo cortical similarity networks with whole brai...
Mohankumar Chandrakanth, Nishant Kumar, Chand Sura ... · Journal of evolutionary biology · Integrated Genetics and Evolution Laboratory (IGEL), Department of Biology, Ashoka University, Sonipat, Haryana, India, 131029. · pubmed
Life-history traits such as body size, reproduction, survival, and stress resistance are fundamental to an organism's fitness and are highly influenced by nutritional environments across life stages. In this study, we employed a full factorial experimental design to investigate t...
Kawasaki, H., Sato, T., Ishida, N. · physiology · Institute for Foundation for Advancement of International Science · biorxiv
Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects of dietary CBD to the circadian clock of Drosophila melanogaster as a model animal and its many physiological effect to flies...
Shang, Y., Wu, H., Pan, D. · cancer biology · Yi Shang Bio · biorxiv
Aging is a major risk factor for the development of many cancers, yet the mechanisms underlying this increased susceptibility remain incompletely understood. Traditionally, the accumulation of genetic mutations over time has been considered a primary driver of age-related tumorig...
Ali Al-Samydai, Farah Al-Mamoori, Amal Mayyas ... · Molecular diversity · Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan. · pubmed
Sirtuin-6 (SIRT6) is a NAD+-dependent deacetylase that maintains genome stability, metabolic regulation, and cellular stress responses, making it an attractive target for therapeutic intervention in metabolic and age-related diseases. Despite its biological importance, the identi...
Fulvio Lauretani, Marcello Maggio, Andrea M Pilotto ... · Journal of the American Geriatrics Society · Geriatric Clinic Unit, Medical Geriatric Rehabilitative Department, University Hospital of Parma, Parma, Italy. · pubmed
To examine the structural, metabolic, and functional trajectories of neuromuscular decline in aging and identify key mechanisms and early biomarkers to guide interventions preserving function and independence.
Friday, July 11, 2025
Hao Nie, Tianyi Ji, Zixin Wan ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Department of Geriatrics, Key Laboratory of Vascular ageing, Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. · pubmed
Vascular smooth muscle cell (VSMC) senescence is a pivotal driver of atherosclerosis (AS), but molecular links to ageing-related dysfunction are unclear. It is aimed to identify regulators of VSMC senescence and develop clinical interventions for ageing-related AS. Using single-c...
The MULTI Consortium, , Cao, H., Song, Z. ... · health informatics · Columbia University · medrxiv
Leveraging clinical phenotypes, neuroimaging, proteomics, metabolomics, and epigenetics, biological aging clocks across organ systems and tissues have advanced our understanding of human aging and disease. In this study, we expand this biological aging clock framework to multi-or...
Ines Sturmlechner, Abhinav Jain, Bin Hu ... · CD8-Positive T-Lymphocytes · Department of Immunology, Mayo Clinic, Rochester, MN, USA. [email protected]. · pubmed
Memory T cells are a highly heterogeneous collection of antigen-experienced cells that undergo dynamic adaptations upon antigen re-encounter and environmental signals. This heterogeneity hinders studies on memory T cell durability and age-related dysfunction. Using chronic Epstei...
Brian O Diekman, Ming-Feng Hsueh · Connective tissue research · Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA. · pubmed
Aging is the largest risk factor for the development of osteoarthritis (OA), a major contributor to increased years lived with disability. This review reflects on how age-related changes relevant to OA have been measured at various length scales. Key discoveries include increased...
Kang, P. J., Mazak, H., Lee, S. S. ... · cell biology · The Ohio State University · biorxiv
The small GTPase Cdc42 is a central regulator of cell polarity, but it is often hyperactivated in aged cells, contributing to senescence and aging in both yeast and animal cells. Yet, the mechanisms underlying its age-related upregulation remain poorly understood. Here, we examin...
Yuko Sogabe, Hirofumi Shibata, Mio Kabata ... · Nature aging · Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. · pubmed
There is robust evidence that senescence can be propagated in vitro through mechanisms including the senescence-associated secretory phenotype, resulting in the non-cell-autonomous induction of secondary senescence. However, the induction, regulation and physiological role of sec...
Xiaoyu Guo, Chan Wei, Rui Liu ... · Journal of agricultural and food chemistry · Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. · pubmed
The aging process is often accompanied by hepatic metabolic dysregulation and related complications, including lipid accumulation and fibrosis. Nutritional interventions are crucial for maintaining metabolic health. This study explored the effects of exogenous nucleotides (NTs) o...
Naor Sagy, Chieh Chang, Maayan Gal ... · GeroScience · Department of Oral Biology, Goldschleger School of Dental Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, 69978, Tel Aviv, Israel. · pubmed
Aging is a major risk factor for a plethora of diseases. The information theory of aging posits that epigenetic information loss is a principal driver of the aging process. Despite this, the connection between epigenetic information loss and disease has not been thoroughly invest...
Shoko Mizutani, Kanji Furuya, Ayumi Mure ... · EMBO reports · Graduate School of Biostudies, Kyoto University, Kyoto, Japan. · pubmed
The nutritional environment in early life, referred to as the nutrition history, exerts far-reaching health effects beyond the developmental stage. Here, with Drosophila melanogaster as a model, we fed larvae on diets consisting of a variety of yeast mutants and explored the resu...
Tangchang Xu, Xiaoyun Wu, Yifei Zhang ... · Aging cell · School of Life Sciences, Nanchang University, Nanchang, China. · pubmed
Gut microbiota delays aging by regulating the immune, metabolic, and neurological functions of the host. However, current research on novel probiotics with antiaging properties significantly lags, impacting their application in clinical treatments. In this study, metagenomics, cu...
Pengfei Xu, Xiuli Zhang, Donghe Li ... · Blood · Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. · pubmed
Hematopoietic stem cells (HSCs) are responsible for sustaining hematopoietic system throughout life, and their functional decline contributes to hematological disorders and organismal aging. Understanding the molecular mechanisms that govern HSC function is critical for developin...
G R Scott Budinger, Navdeep S Chandel · Genes & development · Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [email protected] [email protected]. · pubmed
Mitochondria are no longer viewed solely as ATP- or metabolite-generating organelles but as key regulators of cellular signaling that shape physiologic aging. Contrary to earlier theories linking aging to mitochondrial DNA mutations and oxidative damage, current evidence shows th...
Fan-Qian Yin, Xia-Yan Wang, Yong-Xuan Li ... · Aging · State Key Laboratory of Genetic Evolution and Animal Models, State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China. · pubmed
Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs o...
Xueling Ma, Yonghe Ding, David Mondaca-Ruff ... · npj aging · Department of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. · pubmed
African turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be bred in captivity, making it an ideal model organism for aging studies. However, whether the animal can be used for studying cardiac aging and whether cellular senescence contribute ...
Elisabetta Di Fede, Esi Taci, Silvia Castiglioni ... · npj aging · Department of Health Sciences, Università degli Studi di Milano, Milan, Italy. · pubmed
Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p300 inhibition could rescue the stress-ind...
Minwen Jie, Tong Feng, Fengjuan Hu ... · Frailty · Department of Gastroenterology and Hepatology and Laboratory of Aging and Cancer, National Clinical Research Center for Geriatrics and State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Transplant Engineering and Immunology, NHFPC, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. · pubmed
Frailty, a geriatric syndrome, is characterized by the age-related deterioration of physical capabilities and multiple organ systems. However, its age-associated and age-independent mechanisms remain vague, impeding prevention and clinical intervention. Here, the physical frailty...
Bérénice A Benayoun, Alison Kochersberger, Jennifer L Garrison · Genes & development · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA; [email protected] [email protected]. · pubmed
Ovarian aging is a critical yet understudied driver of systemic aging in female bodies, with profound implications for female health and longevity. Despite its significance, we still know little about ovarian aging and its systemic effects on aging trajectories. With new efforts ...
Samuel I Bloom, Jan Karlseder · Genes & development · The Salk Institute for Biological Studies, La Jolla, California 92037, USA. · pubmed
Aging is the greatest risk factor for most diseases. We propose that aging manifests as disease as a function of tumor-suppressive capabilities. Adequate tumor suppression results in cell death or an accumulation of damaged cells leading to inflammation and tissue dysfunction tha...
Jesús Gil · Genes & development · MRC Laboratory of Medical Sciences (LMS), London W12 0NN, United Kingdom; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom [email protected]. · pubmed
The past 40 years have witnessed significant progress in aging research. Although aging was once considered a stochastic process, it is now understood to be regulated by pathways and processes that can be dissected with modern cellular and molecular biology approaches. The aberra...
Ioannis Oikonomakos, Richard Siow, Stefan R Bornstein ... · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. · pubmed
Aging is marked by a gradual decline in multiple physiological functions, increasing the risk of age-related disorders. Multiple factors have been identified as contributors to aging, many of which are regulated by the hypothalamus. Growth hormone-releasing hormone (GHRH) produce...
Zhi-Peng Yang, Shui-Hong Lu, Yan-Hong Pan ... · MicroRNAs · Dongguan Key Laboratory of Aging and Anti-Aging, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China. · pubmed
Senescence of vascular endothelial cells leads to endothelial dysfunction and exacerbates atherosclerosis. In this study, we presented evidence that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-Exos) could delay endothelial cell senescence, promote en...
Fontana, G. A., Singh, N. K., Rotankova, N. ... · genomics · ETHZ · biorxiv
Ultraviolet (UV) radiation from the sun causes adverse skin changes such as premature aging. UVA radiation is the primary factor for photoaging due to its deep penetration into the dermis, and UV-induced mitochondrial DNA (mtDNA) alterations, including deletions, contribute to ph...
Thursday, July 10, 2025
Sebastian Balch, Zala Sekne, Elsa Franco-Echevarría ... · Telomerase · MRC Laboratory of Molecular Biology, Cambridge, UK. · pubmed
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showed that human telomerase is typically monomeric, containing a single copy of TERT...
Hamilton Se-Hwee Oh, Yann Le Guen, Nimrod Rappoport ... · Nature medicine · Graduate Program in Stem Cell and Regenerative Medicine, Stanford University, Stanford, CA, USA. [email protected]. · pubmed
Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 or...
Ziyu Meng, Yuhao Ma, Wenqi Zhang ... · Cerebrovascular Circulation · National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Cerebral blood flow (CBF) is a crucial biological marker providing valuable insights into the developmental and aging processes of the central nervous system. A comprehensive understanding of the age- and sex-specific distribution of CBF in healthy populations is essential for di...
Fan Wang, Lei Zhou, Yun Zhong ... · MedComm · Department of Dermatology, Xiangya Hospital Central South University Changsha China. · pubmed
N6-methyladenosine (m6A), as the most common RNA modification at the post-transcriptional level, plays a role in various pathophysiological processes. However, its underlying mechanism in skin aging remains enigmatic. Here, we identified that fat mass and obesity-associated prote...
Monteiro-Black, B., Corbally, M.-K., Aleksandrowicz, J. ... · immunology · University of Edinburgh · biorxiv
It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, we do not all age in the same way, and increased susceptibility may not be solely...
Zhang, P., Zheng, L., Qiao, J. ... · respiratory medicine · Southern University of Science and Technology · medrxiv
Background: Leukocyte telomere length (LTL) has been implicated in aging and age-related diseases, including chronic respiratory diseases (CRDs). However, the extent and mechanisms of shared genetic architecture between LTL and respiratory health indicators (such as CRDs and lung...
Mengya Feng, Min Li, Jing Lou ... · Longevity · Center for Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. · pubmed
It is well-known that physical activity exerts health benefits, yet the potential impacts of early-life regular exercise on later-life health and lifespan remains poorly understood. Here, we demonstrate that 3 months of early-life exercise in mice results in lasting health benefi...
Amir Ajoolabady, Domenico Pratico, Suhad Bahijri ... · Experimental & molecular medicine · National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China. · pubmed
Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, telomere shortening and oxidative stress, can trigger cellular senescence. Physiologic...
Reyhan Westbrook, Vinal Menon, Joy Cagmat ... · GeroScience · Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected]. · pubmed
Chronic inflammatory pathway activation increases with age and is epidemiologically linked to multiple aging-related pathophysiological processes, phenotypes such as physical frailty and sarcopenia and early healthspan declines in aging organisms. Despite this, molecular mechanis...
Pei Wei, Xiaoyan Zhang, Chi Yan ... · Aging · Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. · pubmed
Aging is an inherent phenomenon that is highly important in the pathological development of numerous diseases. Aging is a multidimensional phenomenon characterized by the progressive impairment of various cellular structures and organelle functions. The basis of human organ senes...
Joon Hyuk Park, Ki Woong Kim · Psychiatry investigation · Department of Psychiatry, Jeju National University Hospital, Jeju, Republic of Korea. · pubmed
Haenyeo, Korea's traditional female breath-hold divers, represent a unique model for studying brain adaptation to extreme environmental stressors. Diving daily without breathing equipment, they endure hypoxia, hydrostatic pressure, and cold exposure, often well into their senior ...
Wednesday, July 09, 2025
Jacinta Correia, Promit Sinha Roy, Kaitlyn G Holden ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA. · pubmed
Emerging evidence highlights the critical role of cellular metabolism in immune cell activation, development, and function. Peroxisomes, key metabolic organelles, maintain metabolic homeostasis, yet their role in immune cells remains underexplored. While animal studies show age-r...
Perdikis, D., Sleimen-Malkoun, R., Müller, V. ... · neuroscience · Charite University Hospital Berlin: Charite Universitatsmedizin Berlin · biorxiv
Adaptive behavior depends on the brains capacity to vary its activity across multiple spatial and temporal scales. Yet, how distinct facets of this variability evolve from childhood to older adulthood remains poorly understood, limiting mechanistic models of neurocognitive aging....
Valeria Cordone, Teresa Vergara, Stefano Falone ... · Biology of reproduction · Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. · pubmed
Recent findings highlight NAD+ as a central regulator of various cellular processes, including energy metabolism, stress response, and aging. The growing evidence of the benefits associated with dietary NAD+ precursors has elevated NAD+ to a promising therapeutic target for addre...
Guo, D., Chen, Y., Wu, Y. ... · microbiology · Tsinghua University Shenzhen International Graduate School · biorxiv
Shifts in the skin microbiome have shown a close link to chronological age. However, the contribution of skin microbiome in skin aging phenotypes remains unclear. To explore this, we performed phenotypic, metabolomic, metagenomic, and functional analyses on a cohort with divergen...
Gurcharan Kaur, Tamas Fulop, Arpita Konar ... · Longevity · Department of Biotechnology, Guru Nanak Dev University, Amritsar, India. [email protected]. · pubmed
Ageing is associated with neuroimmune shifts from a resting to a hyperactive and inflammatory state, termed 'Neuroinflammageing', attributed to microglial priming, hyperactive astrocytes, cytokine and chemokine release, blood brain barrier leakage, and infiltration of peripheral ...
Jinchai Qi, Xuhua Gao, Wanting Ye ... · Naunyn-Schmiedeberg's archives of pharmacology · School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China. · pubmed
Aging is a degenerative process, and while Rosa roxburghii Tratt has demonstrated notable anti-aging and antioxidant properties, the precise anti-aging effects of its seeds are not yet fully understood. The aim of this study was to employ a blend of in "dry" and "wet" approaches ...
Yumeng Lin, Mengjun Yan, Lili Shen ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Health Management Center, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China. · pubmed
As human lifespan extends, the impact of aging on health has become a significant research area, with increasing focus on pulmonary health. The lung, as a complex organ, undergoes various microenvironmental changes during aging, which are crucial for lung function and the develop...
Can Liu, Dongbin Zheng, Rui Zhang ... · Aging cell · State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China. · pubmed
Aging leads to a gradual decline in muscle function, yet the mechanisms by which different skeletal muscles respond to aging remain unclear. Here, we constructed transcriptional maps of 11 skeletal muscles with extensive transcriptional diversity from young and old mice. Age-rela...