Longevity Papers

Current Week (July 21 - July 23, 2025)
and Previous Week (July 16 - July 20, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), 2025-07-18 episode:
Tuesday, July 22, 2025
Zhao, K., Xie, H., Fonzo, G. A. ... · neuroscience · Stanford University · biorxiv
As populations age, identifying the neurobiological basis of cognitive resilience is critical for delaying or preventing Alzheimers disease (AD). While most older adults experience memory decline, a subset known as superagers (SA) maintains youthful memory into late life, offerin...
Sophie Dürauer, Hyun-Seo Kang, Christian Wiebeler ... · Ubiquitin · Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany. · pubmed
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslinks (DPCs). To understand how SPRTN's promiscuous protease activity is confined to cleavage of crosslinked proteins, we reconstitute the repair of DPCs including their modification w...
Bozack, A. K., Khodasevich, D., Nwanaji-Enwerem, J. C. ... · nutrition · Stanford University · medrxiv
Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999-2002), we tested for associations of total, saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and subtypes of dietary fatty acids with DNA...
Elder, M. A., Ellmore, T. M. · neuroscience · The City College of New York · biorxiv
Age-related differences in white matter structure are increasingly understood as nonlinear, regionally specific, and behaviorally relevant. Using whole-brain fixel-based analysis (FBA), we examined how recognition memory speed relates to micro- and macrostructural white matter pr...
Yidan Pang, Siyuan Zhu, Peng Ding ... · MedComm · Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China. · pubmed
Obesity and aging are major risk factors for diseases such as Type 2 diabetes mellitus, dementia, and osteoporosis. High-fat diet (HFD) consumption is one of the most important factors contributing to obesity. To elucidate and provide resources on how long-term HFD to aging (LHA)...
Chenke Jiang, Yihong Gan, Shengyu Chen ... · Aging clinical and experimental research · School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China. · pubmed
Observational studies have shown that physical activity and sedentary behavior are associated with aging. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationships between genetic...
Critchlow, A. J., Hiam, D., O'Bryan, S. ... · endocrinology · Deakin University · medrxiv
Whether and how ovarian hormone fluctuations mediate the skeletal muscle response to ageing in females remains to be elucidated. We examined a tightly controlled, cross-sectional cohort of 96 females between 18-80 years of age to map the functional and molecular trajectory of mus...
Monday, July 21, 2025
STOLZ, A., XUAN, C., FREITAS, C. ... · cell biology · INSERM UMR1287, Universite Paris Saclay, Gustave Roussy Cancer Center, 94805 Villejuif, France · biorxiv
Chronic inflammation that accompanies aging impairs the function of hematopoietic stem cells (HSCs) and promotes expansion of TET2-mutated cells, leading to clonal hematopoiesis of indeterminate potential (CHIP). The molecular mechanisms underlying these processes are still uncle...
Nguyen, T. D., Khan, Y. Z., Hossen, F. ... · cell biology · University of Illinois Chicago · biorxiv
As the innermost lining of blood vessels, endothelial cells (ECs) regulate blood flow, maintain vascular tone, and limit inflammation for vessel health. EC-derived nitric oxide (NO), synthesized by endothelial nitric oxide synthase (eNOS), is a vasodilator essential for improving...
Fernandez Molina, C., Chatre, L., Montagne, B. ... · cell biology · Institut Pasteur · biorxiv
The maintenance of mitochondrial proteins homeostasis, which is essential for proper cell function, is affected in pathophysiological ageing, yet several underlying mechanisms remain unexplored. We show that in normal and accelerated ageing cells, POLG1, the enzyme responsible fo...
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S Hanner ... · Aging cell · Craniofacial Anomalies and Regeneration Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA. · pubmed
Large-scale bone defects require complex surgical procedures to repair, but full restoration of the bone is not guaranteed due to the significant tissue loss involved. In contrast, fractures can frequently be treated with conservative techniques. Particularly, ribs have a remarka...
Sunday, July 20, 2025
Douglas M Ruden · Epigenomics · C. S. Mott Center for Human Growth and Development, Institute for Environmental Health Sciences, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. · pubmed
Aging is a complex biological process involving coordinated changes across multiple molecular systems. Traditional reductionist approaches, while valuable, are insufficient to capture the full scope of aging's systemic nature. Multiomics - integrating data from genomics, transcri...
Saturday, July 19, 2025
Korcari, A., Tauc, H., Duggan, J. ... · immunology · Genentech · biorxiv
Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake ...
Nusrat Jan, Shazia Sofi, Aijaz Ahmad Mir ... · Molecular and cellular biochemistry · Cancer Biology Laboratory, Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, 190006, India. · pubmed
Aging and cancer are interconnected processes resulting from irreversible dysfunctions, primarily caused by stress-induced DNA and cellular damage. While aging is characterized by the accumulation of senescent cells (SnCs), cancer development is linked to a progressive decline in...
Dieu-Huong Hoang, Jessica Bouvière, Johanna Galvis ... · EMBO reports · Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, Université Claude Bernard Lyon 1, Inserm U1315, CNRS 5261, Lyon, France. · pubmed
Muscle regeneration is impaired with aging, due to both intrinsic defects of muscle stem cells (MuSCs) and alterations of their niche. Here, we monitor the cells constituting the MuSC niche over time in young and old regenerating mouse muscle. Aging alters the expansion of all ni...
Lihuan Guan, Lei Feng, Anderson Li Yang Khoo ... · European journal of epidemiology · Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · pubmed
The global population is ageing rapidly. While genetics, lifestyle, and environment are known contributors to healthspan, most insights are drawn from Western cohorts, leaving Asian populations underrepresented despite unique biological, lifestyle, and cultural factors. The SG90 ...
Friday, July 18, 2025
Li, M., Song, Z., Reed, E. ... · molecular biology · Boston University · biorxiv
Background. Age is one of the major risk factors for a wide range of diseases. Nevertheless, some individuals can better cope with these changes and become centenarians. We hypothesize that their blood transcriptome may provide insights into the mechanisms contributing to healthy...
Sadoughi, B., Petersen, R., Patterson, S. K. ... · genomics · Vanderbilt University · biorxiv
Age and early life adversity (ELA) are both key determinants of health, but whether they target similar physiological mechanisms across the body is unknown due to limited multi-tissue datasets from well-characterized cohorts. We generated DNA methylation (DNAm) profiles across 14...
Jantrapirom, S., Sangphukieo, A., U-on, N. ... · neuroscience · Faculty of Medicine, ChiangMai University · biorxiv
Targeting Endoplasmic Reticulum Oxidoreductase 1 Alpha (ERO1A) offers therapeutic potential for ER stress-related conditions, including motor neurone diseases and congenital muscle disorders. However, selective ERO1A inhibitors remain unavailable. Here, we developed a multi-modal...
Wanting Jiang, Xing Wang, Lijuan Mao · Journal of Alzheimer's disease : JAD · School of Athletic Performance, Shanghai University of Sport, Shanghai, China. · pubmed
Cognitive decline is age-specific or related to dementia and Alzheimer's disease (AD), which poses great concern to older adults. Exercise contributes to cognitive gains, with aerobic exercise (AE) being the most commonly studied type. However, other types, such as resistance exe...
Bahr, L., Amrit, F. R., Silvia, P. E. ... · genetics · University of Pittsburgh School of Medicine · biorxiv
Reproduction and immunity are fundamental, energy intensive processes that often compete for resources, leading to trade-offs observed across diverse species. Lipid metabolism plays a crucial role in integrating these processes, particularly during stressful conditions such as pa...
Guoqing Pan, Yi Zhang, Ju-Jiao Kang ... · npj aging · Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. · pubmed
Given the growing global elderly population and the accelerating decrease in grey matter volume (GMV) with age, understanding healthy brain aging is increasingly important. This study investigates whether variations in modifiable traits can account for differences in GMV and whet...
Pei Lin Li, Jie Tang, Xiao Tong Li ... · Osteoarthritis · Department of Stem Cells and Regenerative Medicine, Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing 100850, P.R. China. · pubmed
Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenit...
Huang, Q., Wang, Y., Farias, K. ... · pharmacology and toxicology · Weill Cornell Medicine · biorxiv
Cardiomyocyte senescence, characterized by elevated cell cycle inhibitor expression, persistent DNA damage response, and mitochondrial dysfunction, contributes to myocardial stiffness and the progression of heart failure with preserved ejection fraction (HFpEF), the most common f...
Pablo-Reina Gonzalez, Muhammet Ay, Monica Langley ... · Toxicological sciences : an official journal of the Society of Toxicology · Dept of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA. · pubmed
Astrocytes, the most abundant glial cells in the central nervous system, play essential roles in maintaining neuronal homeostasis, synaptic regulation, and blood-brain barrier integrity. However, these cells can undergo senescence, a cellular state characterized by irreversible g...
Gopal, S., Chaturbedi, A., Ramachandrula, T. V. ... · developmental biology · Cornell University · biorxiv
The nuclear hormone receptor NHR-49, a homolog of mammalian PPAR and HNF4, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here we uncovered a new function of NHR-49 in reproduction - controlling oocyte activation and o...
Gotz, M., Hayman, D. J., Adams, G. ... · physiology · University of Sheffield · biorxiv
Stress response pathways are emerging as conserved modulators of lifespan. The prevailing hypothesis is that activation of stress responsive pathways, including the amino acid deprivation arm of the integrated stress response (ISR; the GCN2-ATF4 pathway) is pro-longevity. Activat...
Thursday, July 17, 2025
Onder Albayram, Natalia Oleinik, Besim Ogretmen · Aging cell · Department of Pathology and Laboratory Medicine, ER-AL Neurovascular Protection Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA. · pubmed
The misclassification of functional genomic loci as pseudogenes has long obscured critical regulators of cellular homeostasis, particularly in aging-related pathways. One such locus, originally annotated as RPL29P31, encodes a 17-kDa protein now redefined as PERMIT (Protein that ...
Shchukina, I., Rodriguez-Hernandez, C., Ruiz, H. S. ... · immunology · Washington University in St. Louis · biorxiv
Aging profoundly reshapes the immune cell landscape, with particularly strong effects on CD8+ T cells, including a marked decline in naive cells and the emergence of age-associated GZMK+ CD8+ T cells (TAA cells). Although TAA cells make up a significant fraction of the aged CD8+ ...
Mekulu, K., Aqlan, F., Yang, H. · health informatics · Pennsylvania State University · medrxiv
Early detection of cognitive impairment in assisted living is hindered by time intensive tools like MMSE and MoCA. We present a 60-second voice based screening model that analyzes picture descriptions to estimate dementia risk. Using transcripts from the DementiaBank corpus, our ...
Bravo, J. I., Tewelde, E., King, C. D. ... · genomics · University of Southern California · biorxiv
During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though Alu elements are often studied for thei...
Alan Kavšek, Jérôme Salignon, Lluís Millan-Ariño ... · Caenorhabditis elegans · Integrated Cardio Metabolic Centre (ICMC) and Division of Biosciences and Nutrition, Department of Medicine, Karolinska Institute, Huddinge, Sweden. · pubmed
The nuclear chromatin landscape changes with age. Here, we investigate whether chromatin alterations distinguish also animals with unusual aging rates, focusing on Caenorhabditis elegans with reduced insulin/IGF-like signaling (IIS), i.e., daf-2 mutants. In these animals, enhance...
Brittany Intzandt, Safa Sanami, Julia Huck ... · The journals of gerontology. Series A, Biological sciences and medical sciences · BrainLab, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto Canada. · pubmed
Cerebral blood flow (CBF) declines consistently in aging and this decline is a critical component of several late life diseases. Understanding why this occurs in normal aging, prior to pathological changes, is crucial. Physical activity (PA) is a powerful preventative tool to imp...
Shoma Ishikawa, Björn Schumacher · Annual review of genetics · 1Institute for Genome Stability in Aging and Disease and Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne and University Hospital of Cologne, Cologne, Germany; email: [email protected], [email protected]. · pubmed
The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current understanding of heredity; it proposed that genetic inheritance is exclusively ...
Wednesday, July 16, 2025
Yidan Liu, Xiuxing Liu, Jianjie Lv ... · Receptors, Adiponectin · State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510060, China. · pubmed
Aging induces substantial structural and functional decline in the retina, yet the molecular drivers of this process remain elusive. In this study, we used heterochronic parabiosis (HP) combined with single-cell RNA sequencing to generate comprehensive transcriptomic profiles of ...
Valentin J A Barthet, Scott W Lowe · Genes & development · Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. · pubmed
Cellular senescence plays a dual role in tissue biology by promoting tumor suppression and wound healing when transient but driving inflammation, fibrosis, and age-related disease when persistent. The growing recognition that senescent cell clearance can reverse these pathologies...
Enzo Scifo, Sarah Morsy, Ting Liu ... · The EMBO journal · Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany. · pubmed
Aging is associated with the accumulation of molecular damage, functional decline, increasing disease prevalence, and ultimately mortality. Although our system-wide understanding of aging has significantly progressed at the genomic and transcriptomic levels, the availability of l...
Ryan G Walker, Tomohiro Kato, Laura Ben Driss ... · Growth Differentiation Factors · Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. · pubmed
Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 after prodomain activation. In 11,609 pat...
Ki Yun Park, Abraham Z Snyder, Manu S Goyal ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, 63110, USA. · pubmed
Cerebral glucose metabolism (CMRGlc) systematically decreases with advancing age. We sought to identify correlates of decreased CMRGlc in the spectral properties of fMRI signals imaged in the task-free state. Lifespan resting-state fMRI data acquired in 455 healthy adults (ages 1...
Amelia Farinas, Jarod Rutledge, Veronica Augustina Bot ... · Nature medicine · Graduate Program in Neuroscience, Stanford University, Stanford, CA, USA. · pubmed
The brain barrier system, including the choroid plexus, meninges and brain vasculature, regulates substrate transport and maintains differential protein concentrations between blood and cerebrospinal fluid (CSF). Aging and neurodegeneration disrupt brain barrier function, but pro...
Willian R Gomes, Shan Hama, Giorgio Napolitani ... · Blood advances · University of Sao Paulo, Brazil. · pubmed
Pathogenic germline variants causing excessive telomere shortening may result in bone marrow failure, hematopoietic malignancy, and extramedullary complications, such as pulmonary fibrosis, liver cirrhosis, and solid tumors. Patients with short telomeres also develop immunodefici...
Tan Ma, Lulin Tan, Chenghao Shen ... · Environmental science & technology · Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China. · pubmed
Dibutyl phthalate (DBP), a common plastic additive, is employed extensively to enhance the flexibility of various polymeric materials despite its known toxicity to multiple organ systems. Our previous study found that maternal DBP exposure caused early puberty in male offspring, ...
Jose Alberto Santiago-de-la-Cruz, Nadia Alejandra Rivero-Segura, Juan Carlos Gomez-Verjan · Journal of cheminformatics · Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City, 10200, México. · pubmed
Age-related diseases and syndromes result in poor quality of life and adverse outcomes, representing a challenge to healthcare systems worldwide. Several pharmacological interventions have been proposed to target the aging process to slow its adverse effects. The so-called geropr...
Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga ... · Cellular Senescence · Department of Orthopaedics, Emory University School of Medicine, Atlanta, United States. · pubmed
Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. While previous studies have highlighted that platelet-derived growth factor (PDGF) mitigated IVD degeneration through a...