Longevity Papers

Current Week (June 02 - June 07, 2025)
and Previous Week (May 31 - June 01, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 05 episode:
Friday, June 06, 2025
Chia-Ling Kuo, Peiran Liu, Gabin Drouard ... · Proteomics · Department of Public Health Sciences, University of Connecticut Health Center, Farmington, CT 06032. · pubmed
The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-ba...
de Lima Camillo, L. P., Gam, R., Maskalenka, K. ... · cell biology · Shift Bioscience Ltd · biorxiv
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the Yamanaka factors (OCT4, SOX2, KLF4, with or without c-MYC: \"OSK(M)\") have been...
Sadoughi, B., Hernandez-Rojas, R., Hamou, H. ... · genomics · Arizona State University · biorxiv
Elucidating the socio-ecological factors that shape patterns of epigenetic modification in long-lived vertebrates is of broad interest to evolutionary biologists, geroscientists, and ecologists. However, aging research in wild populations is limited due to inability to measure ce...
Shemtov, S. J., McGann, E., Carrillo, L. ... · molecular biology · University of Southern California · biorxiv
Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian lifespan and protects against a range of age-related diseases. Surprisingly though, we found that reduced IGF-1 signaling fails to extend the lifespan of mitochondrial mutator mice. Accordingly, most ...
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu ... · Aging cell · Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. · pubmed
Multiple studies in mice with genetically disrupted growth hormone (GH) signaling have demonstrated that such disruption results in reduced body size, robustly increased longevity (> 50% in some cases), and improvements across multiple health parameters. However, it remains uncle...
Sturmlechner, I., Jain, A., Jiang, J. ... · immunology · Mayo Clinic · biorxiv
Older adults are susceptible to infections, in part due to waning of immune memory. To determine mechanisms that determine long-lasting versus short-term immunity, we examined varicella zoster virus (VZV) vaccination as a model system. We contrasted VZV antigen-specific T cells s...
Ming Ann Sim, Jorming Goh, Jasinda Lee ... · Sirolimus · Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [email protected]. · pubmed
The geroprotective effects of rapamycin in mitigating frailty and cognitive complications in the perioperative period remains unknown. Of 39 C57BL/6 mice tested, 19 were young (16 weeks), and 20 were old (80 weeks). The interventional group (10 old, 10 young) received daily oral ...
Jia Xie, Ze-Guang Han · BioEssays : news and reviews in molecular, cellular and developmental biology · Key Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Heterochromatin, a crucial constituent of the eukaryotic nucleus with highly conserved and transcriptionally silenced characteristics, plays a pivotal role in safeguarding genome stability, regulating nuclear morphology, and mediating cell fate. Recent convincing evidence indicat...
Rychlicka-Buniowska, E., Sarkisyan, D., Horbacz, M. ... · genetic and genomic medicine · Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; 3P-Medicine Laboratory, Medical Universit · medrxiv
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events associated with multiple adverse outcomes in the elderly. While LOY has been associated with higher risk of Alzheimer disease (AD), CHIP has been suggested to perfo...
McQuade, A., Castillo, V. C., Hagan, V. ... · neuroscience · University of California, San Francisco · biorxiv
Microglia dynamically support brain homeostasis through the induction of specialized activation programs or states. One such program is the Interferon-Responsive Microglia state (IRM), which has been identified in developmental windows, aging, and disease. While the functional im...
Palomares, D., Vanparys, A., Jorgji, J. ... · neuroscience · Aging and Dementia group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium · biorxiv
Background: Although the connection between aging and neurodegenerative pathologies like Alzheimer\'s disease (AD) has long been recognized, the underlying pathological mechanisms remain largely unknown. Senescent brain cells build up in the brains of AD patients and a causal lin...
Hiroshi Kobayashi, Shogo Imanaka · DNA, Mitochondrial · Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Nara 634‑0813, Japan. · pubmed
Mitochondria and mitochondrial DNA (mtDNA) are crucial for cellular energy metabolism and the adaptive response to environmental changes. mtDNA collaborates with the nuclear genome to regulate mitochondrial function. Dysfunctional mitochondria and mutations in mtDNA are implicate...
Thursday, June 05, 2025
Matías Fuentealba, Laure Rouch, Sophie Guyonnet ... · Nature aging · Buck AI Platform, Buck Institute for Research on Aging, Novato, CA, USA. · pubmed
Age-related decline in intrinsic capacity (IC), defined as the sum of an individual's physical and mental capacities, is a cornerstone for promoting healthy aging by prioritizing maintenance of function over disease treatment. However, assessing IC is resource-intensive, and the ...
Mareike Peters, Patric Teodorescu, Sergiu Pasca ... · Haematologica · Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD. · pubmed
Not available.
Xiao-Wei Liu, Hao-Wei Xu, Shu-Bao Zhang ... · Cell death discovery · Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China. · pubmed
Intervertebral disc degeneration (IVDD) is a common pathology involving various degenerative diseases of the spine, with nucleus pulposus cell (NPC) senescence playing an important role in its pathogenesis. Transcriptional and epigenetic processes have been increasingly implicate...
Rooban Sivakumar, K A Arul Senghor, V M Vinodhini ... · Drugs & aging · Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Kanchipuram, Chennai, Tamil Nadu, 603203, India. [email protected]. · pubmed
Metformin, traditionally promoted for its efficacy in diabetes, is increasingly appreciated for its geroprotective potential in the development of vascular aging, a key contributor to cardiovascular morbidity. This review aims at understanding the spectrum of mechanisms that gove...
Jackson Nuss, Matt Kaeberlein, Alessandro Bitto ... · GeroScience · Department of Laboratory Medicine & Pathology, School of Medicine, University of Washington, Seattle, WA, USA. · pubmed
Mice missing the complex I subunit Ndufs4 of the electron transport chain are widely used as a leading animal model of Leigh syndrome, a pediatric neurodegenerative disorder that leads to premature death. More broadly, this animal model has enabled a better understanding of the p...
Jing, Y., Li, L., Guo, W. ... · cell biology · Department of Urology, Shanghai General 32 Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 33 200080, China · biorxiv
Benign prostatic hyperplasia (BPH) is a common age-associated urological condition characterized by stromal expansion, but its cellular origins and regulatory mechanisms remain unclear. In this study, we identified endothelial-to-mesenchymal transition (EndMT) as a contributor to...
Wednesday, June 04, 2025
Salignon, J., Tsiokou, M., Marques, P. ... · bioinformatics · Karolinska Institute · biorxiv
As the prevalence of age-related diseases rises, understanding and modulating the aging process is becoming a priority. Transcriptomic aging clocks (TACs) hold great promise for this endeavor, yet most are hampered by platform or tissue specificity and limited accessibility. Here...
Bradley Olinger, Reema Banarjee, Amit Dey ... · Nature aging · Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA. · pubmed
Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence and related them to clinical traits in humans to facilitate future noninvasive assessment of individual senescence burden, and effica...
Keyu Kong, Li Liu, Renfang Zhang ... · Lopinavir · Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · pubmed
Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained contentious, with conjectures pointing towards its correlation with distinct antiviral regimes. Protease inhibitors (PIs) stand as a prominent class of antivira...
Julian M Carosi, Alexis Martin, Leanne K Hein ... · Autophagy · Lysosomal Health in Ageing, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia. · pubmed
Autophagy is a 'waste-disposal' pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during aging remain unknown. Here, we present the most comprehensive in vivo study of a...
Oliver Polzer, E Kinloch, P J Lucassen ... · Aging cell · Brain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands. · pubmed
Hippocampal adult neural stem cells (NSCs) contribute to neurogenesis and astrogliogenesis throughout life. They play multifaceted roles in hippocampal function, including memory processing, stress regulation, and cognitive flexibility. Located in unique neurogenic niches like th...
Aileen H Lee, Lucie Orliaguet, Yun-Hee Youm ... · Nature metabolism · Department of Pathology, Yale School of Medicine, New Haven, CT, USA. · pubmed
Caloric restriction and methionine restriction-driven enhanced lifespan and healthspan induces 'browning' of white adipose tissue, a metabolic response that increases heat production to defend core body temperature. However, how specific dietary amino acids control adipose thermo...
Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu ... · The EMBO journal · Stem Cell Biology and Medicine, Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. · pubmed
Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling and transcriptional regulation that compromises hippocampal NSC activity during th...
Xu Jiang, Jing Ke, Yiting Liu ... · Biogerontology · Department of Otorhinolaryngology-Head and Neck Surgery, Chongqing General Hospital, Chongqing University, No .118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, China. · pubmed
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA sequencing of C57BL/6J mice were...
Tej D Azad, Marvin W Li, Chiu Ping-Yeh ... · Spine deformity · Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA. [email protected]. · pubmed
The incidence of spine-related pathologies is expected to increase in developed countries due to ongoing fundamental demographic shifts toward an older population. These changes present significant challenges to public health, as healthcare systems worldwide must confront the bur...
NyamErdene, A., Thao Ngoc Le, N., Nebie, O. ... · neuroscience · International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei ,Taiwan,Graduate Institute of Biomed · biorxiv
Platelet-derived materials are emerging as promising, cell-free biotherapies for regenerative medicine. While platelet lysates have shown neuroprotective activity in preclinical models, the neurogenic potential of platelet concentrate-derived extracellular vesicles (pEVs) remains...
Jonalyn DeCastro, Ami Mehta-Doshi, Chao Liu ... · Rejuvenation research · Riggs School of Applied Life Sciences, Keck Graduate Institute, Claremont, California, USA. · pubmed
Age-associated neurodegenerative diseases (NDDs), including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, are marked by progressive degeneration of the nervous system. Current diagnostic approaches, such as neuroimaging and cerebrospinal fluid bioma...
Fengli Xu, Haipeng Huang, Kun Peng ... · Aging · State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China. · pubmed
Reactive thiols of proteinaceous cysteines are vital to cell biology by serving as sensor, effector and buffer of environmental redox fluctuations. Being the major source, as well as the prime target, of reactive oxygen species (ROS), mitochondria confront great challenges in pre...
Kenna Brown, Ghazal Vahidi, Brady D Hislop ... · Diet, High-Fat · Department of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, USA. · pubmed
The elderly are at increased risk of bone fracture and more often consume poor quality diets, such as high-fat diet (HFD). We hypothesized that HFD exacerbates the loss of bone fracture resistance in aging. Female and male 5-month and 22-month C57BL/6JN mice were fed moderate HFD...
Jinhua Zhou, Xin Meng, Fan Wang ... · Aging · Department of Critical Care Medicine, The Third People's Hospital of Chengdu, Chengdu, 610031, China. · pubmed
Biological Age Acceleration (BAA), as quantified by epigenetic clocks, is a well-established biomarker for mortality and age-related morbidity. This study aimed to investigate the independent and combined associations of sleep duration, sedentary behavior, and physical activity w...
Tuesday, June 03, 2025
Anna Konturek-Ciesla, Qinyu Zhang, Shabnam Kharazi ... · Lymphopoiesis · Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Medical Faculty, Lund University, Lund, Sweden. · pubmed
Hematopoietic stem cell (HSC) transplantation offers a cure for a variety of blood disorders, predominantly affecting the elderly; however, its application, especially in this demographic, is limited by treatment toxicity. In response, we employ a murine transplantation model bas...
Sabnam Sahin Rahman, Shreya Bhattacharjee, Simran Motwani ... · Caenorhabditis elegans · Molecular Aging Laboratory, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India. · pubmed
The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorph...
Shinde, P. L., Kumar, V., Singh, S. ... · pathology · Rajiv Gandhi Centre for Biotechnology · biorxiv
Biological aging and pressure overload-induced left ventricular cardiac hypertrophy (PO-CH) is marked by myocardial thickening, fibrosis, and functional decline, heightening the risk of heart failure. To advance therapeutic monitoring and intervention, we aimed to identify drug-r...
Bae, H., Song, Z., Ali, A. ... · genetics · Oregon State University · biorxiv
We constructed a polygenic protective score specific to Alzheimer\'s disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longevity in the US, Europe, and Asia. This AD PPS did not include variants on Apolip...
Ayke Haller, Judith Risse, Bernice Sepers ... · Molecular ecology resources · Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, the Netherlands. · pubmed
Information on individual age is a fundamental aspect in many ecological and evolutionary studies. However, accurate and non-lethal methods that can be applied to estimate the age of wild animals are often absent. Furthermore, since the process of ageing is accompanied by a physi...
Myung Suk Rho, Kwang Pum Lee · The Journal of experimental biology · Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. · pubmed
Macronutrients profoundly affect both lifespan and reproduction and also modulate the fundamental trade-off between these two components of fitness in many insects. Beetles represent the largest group of insects, but nutritional interventions in lifespan and reproduction have nev...
Kevin Rhine, Rachel Li, Hema M Kopalle ... · Nature neuroscience · Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, USA. · pubmed
Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts fro...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka ... · Aging cell · Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan. · pubmed
Werner syndrome (WS) is a rare hereditary progeroid syndrome caused by mutations in the WRN gene. Patients frequently develop various age-associated diseases prematurely, often leading to early mortality (≤ 60 years of age). Depletion of nicotinamide adenine dinucleotide (NAD)
Zorikova, E. O., Chourasia, S., Rosenhek-Goldian, I. ... · biophysics · Department of Immunology and Regenerative Biology, Weizmann Institute of Science · biorxiv
Mitochondria play a pivotal role in energy production, signaling, and apoptosis. Yet, probing their functional state at the single-organelle level without invasive labels remains a major challenge. Here, we introduce a novel, label-free approach that leverages Atomic Force Micros...
Jiaxin Wen, Lingxian Yi, Lei Chen ... · Stem cell research & therapy · Senior Department of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, P.R. China. · pubmed
Mesenchymal stem cells (MSCs) have potential for treating degenerative and immune diseases, but their clinical efficacy is limited by senescence, characterized by mitochondrial dysfunction, impaired mitophagy, and metabolic imbalance. The goal of this study was to investigate the...
Zijing Zhang, Lu Huang, Lynae Brayboy ... · Biology of reproduction · Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR. · pubmed
The aging of mammalian ovary is accompanied by an increase in tissue fibrosis and heightened inflammation. Myeloid cells, including macrophages, monocytes, dendritic cells, and neutrophils, play pivotal roles in shaping the ovarian tissue microenvironment and regulating inflammat...
Jose Miguel Ramirez, Rogério Ribeiro, Oleksandra Soldatkina ... · Genome medicine · Department of Life Sciences, Barcelona Supercomputing Center (BSC), C/Jordi Girona 31, Barcelona, 08034, Spain. · pubmed
Tobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular mechanisms driving smoking-related health decline and aging acceleration in most tissues re...
Monday, June 02, 2025
Pooja Raj Devrukhkar, Mark A Watson, Bikem Soygur ... · Aging cell · Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. · pubmed
A major aging hallmark is the accumulation of cellular senescence burden. Over time, senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis driven by the senescence-associated secretory phenotype (SASP). The human ovary is one of the first or...
Qiuyan Wang, Yi Liang, Qingjuan Zuo ... · Molecular and cellular biochemistry · Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People's Republic of China. · pubmed
Hypertension and its complications seriously affect human health, bringing about long-term medical burdens, functional impairments and even death. This study explored the impact of Canagliflozin (CANA) on the blood vessels of salt-sensitive hypertension. Male Dahl salt-sensitive ...
Seung Eun Cha, Jieun Song, Steve Cole ... · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · Department of Psychology, University of Wisconsin-Madison. · pubmed
Cellular epigenetic aging has become an important marker of healthy or unhealthy aging. The current study examined whether lifelong cumulative stressors across multiple domains were linked with epigenetic age acceleration (EAA; i.e., epigenetic age greater than chronological age)...
Connie J Mulligan · Epigenomics · Department of Anthropology, Genetics Institute, University of Florida, Gainesville, FL, USA. · pubmed
The impact of psychosocial stress on mental and physical health is well-documented. Adverse experiences that occur early in life are particularly impactful on later life health. Epigenetic modifications, such as DNA methylation, have been proposed as a possible mechanism to media...
Birgit Kastberger, Anupam Sah, Simone B Sartori ... · Journal of dietary supplements · EVER Neuro Pharma, Unterach am Attersee, Austria. · pubmed
This study investigates the effects of N‑PEP‑12, a neuroprotective dietary supplement, on cognitive function, neuroplasticity, and neurogenesis in aged 129S1/SvImJ (S1) mice, which are known for age‑associated cognitive impairments. The primary objective was to determine whether ...
Faranak Elmi, Fatemeh Soltanmohammadi, Tahura Fayeghi ... · Regenerative therapy · Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. · pubmed
The efficacy of mesenchymal stem cells (MSCs) mediated regenerative therapies has been hindered by the senescence of them during long period cultures. Aged MSCs exhibit altered morphology, decreased stemmas, changed intercellular communication, and poor differentiation ability. B...
Athanase Benetos, Coralie Fritsch, Emma Horton ... · Telomerase · Université de Lorraine, Inserm, DCAC, Nancy, F-54000, France. · pubmed
Telomeres are repetitive sequences of nucleotides at the end of chromosomes, whose evolution over time is intrinsically related to biological ageing. In most cells, with each cell division, telomeres shorten due to the so-called end replication problem, which can lead to replicat...
Jamie L Arnst, Uma D Alappan, Manjula Viggeswarapu ... · GeroScience · The Atlanta Department of Veterans Affairs Medical Center, Decatur, GA, 30033, USA. · pubmed
The loss of bone volume during aging is common in both men and women and can have substantial negative health impacts. Weakened bones can lead to fractures which in turn can result in hospitalization, decreased quality of life, and early death. The post-diagnosis treatment of ost...
Sunday, June 01, 2025
Kriz, A. J., Mao, S., Shao, D. D. ... · genomics · Boston Children\'s Hospital · biorxiv
Elucidating the role of somatic mutations in cancer, healthy tissues, and aging depends on methods that can accurately characterize somatic mosaicism across different cell types, as well as assay their impact on cellular function. Current technologies to study cell-type-specific ...
Bai, Y., Yuan, T., Ren, L. ... · genetics · Peking University · biorxiv
DNA methylation dynamics, including 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC), critically regulate brain function, yet conventional methods cannot distinguish these modifications, obscuring their distinct roles in gene regulation and aging. We present Joint-Cabern...
Yang, L., Lin, S., Tao, Y. ... · bioinformatics · University of Nottingham Ningbo China · biorxiv
Single-cell RNA sequencing (scRNA-seq) has significantly advanced our understanding of retinal aging, yet the specific molecular characteristics within cell populations remain incompletely defined. We profiled 223,612 single cells from 18 unfrozen human retinas obtained from 13 C...
Saturday, May 31, 2025
Wang, J., Cai, Z., Gu, J. ... · physiology · Hunan Normal University · biorxiv
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferentially regulates the translation of 5\'-terminal oligopyrimidine (TOP) motif-conta...
Hushpulian, D. M., Ammal Kaidery, N., Soni, P. ... · biochemistry · Department of Pediatrics, Darby Childrens Research Institute, Department of Neuroscience, Department of Drug Discovery, Medical University of South Carolina, Ch · biorxiv
Activating Nrf2 with small molecules is a promising strategy for countering aging, oxidative stress, inflammation, and various disorders, including neurodegeneration. The primary regulator of Nrf2 protein stability is Keap1, a redox sensor protein and an adapter in the Cullin III...
Guan, C., Ryu, S., Dong, M. ... · immunology · Yale School of Medicine · biorxiv
Taurine, the most abundant sulfonic amino acid in humans is largely obtained from diets rich in animal proteins. However, taurine is dietary non-essential because it can be synthesized from cysteine by activation of transsulfuration pathway (TSP) when food consumption is low or i...