Longevity Papers

Current Week (August 11 - August 16, 2025)
and Previous Week (August 09 - August 10, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), August 12 episode:
Saturday, August 16, 2025
Liqian Chen, Zixin Chen, Jiahui Mo ... · Cell death and differentiation · Guangdong Cardiovascular Institute, Medical Research Institute, School of Basic Medical Science, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. · pubmed
Cellular senescence is the major hallmark and therapeutic target of aging and age-related diseases. The role of ALKBH5, one of the main m6A demethylases, in cellular senescence emerges however remains contentious. Herein, we show the reversible ALKBH5 aggregation in cytoplasm pro...
Xuyun Peng, Panlong Li, Ying Zhang ... · Genome medicine · Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China. · pubmed
The epidemiological observational studies unveiled that aging is one of the risk factors for liver fibrosis, and the hepatic tissues in the elderly harbor more fibrotic lesions when compared to those in young people. Previous investigations found that TGFβ1 was elevated with agin...
Christian Gaser, Marta Garo-Pascual, Bryan A Strange · GeroScience · Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany. [email protected]. · pubmed
Episodic memory, the ability to recall past events, is particularly vulnerable to ageing. A decline in episodic memory performance is generally considered part of ageing. However, the episodic memory performance of superagers -defined as individuals aged 80+ years old with episod...
Botong Shen, Nicole Noren Hooten, Nicolle A Mode ... · GeroScience · Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA. · pubmed
A new DNA methylation biomarker, Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE), is associated with healthy lifespan in several European ancestry cohorts. Few studies have examined the relation between dietary quality and DunedinPACE in African American and Whi...
Friday, August 15, 2025
Seung-Chul J Lee, Gee-Yoon Lee, Sieun S Kim ... · Aging cell · Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. · pubmed
Transcriptome analysis has become increasingly utilized in aging research. However, the identification of the key molecular changes underlying aging processes and longevity-promoting regimens from transcriptome data remains challenging. Here, we present Transcriptomic CLassificat...
Kawamura, Y. K., Khalil, V., Kitazawa, T. · genomics · DANDRITE Nordic EMBL, Aarhus University · biorxiv
Advances in single-cell sequencing have deepened our understanding of cellular identities. However, because they inherently capture only static snapshots, after which no further observations are possible, we cannot compare past and present profiles within the same cell. Thus, mul...
Luengo-Mateos, M., Gonzalez-Vila, A., Silveira-Loureiro, M. ... · neuroscience · USC · biorxiv
Circadian clocks coordinate behaviour and physiology with daily cycles of light and nutrient availability, yet how metabolic signals tune brain timing remains unclear. Astrocytes integrate metabolic and hormonal cues and sustain cell-autonomous rhythms, implicating them as candid...
Xiaojie Wang, Yujia Li, Qingqing Chu ... · Chinese medical journal · Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China. · pubmed
Cellular senescence, stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stressors, has been highlighted as one of the most important mechanisms involved in kidney diseases. It not only serves as a fundamental biological p...
Alcaraz, J., Keyse, C., Hall, C. ... · physiology · Durham University · biorxiv
Inflammaging is considered a driver of age-associated pathology across tissues. Similarly, intestinal permeability is a feature of ageing and underlies a range of inflammatory and age-related diseases. Increased intestinal permeability has been described as both a cause and a con...
Michael Stern · Journal of cell science · Department of BioSciences Program in Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA. · pubmed
In youth, energy deprivation primarily results from fasting. Because inconsistent nutrient availability is common for most organisms, natural selection has provided mechanisms that detect nutrient-deprived states, followed by adaptive responses that increase the likelihood of sur...
Runliu Li, Bastian Draphoen, Mika Lindén ... · Nanoscale horizons · Institute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. [email protected]. · pubmed
Nowadays, aptamers have transitioned into valuable antibody alternatives. We present the first anti-glucosepane aptamer targeting a key glycation product linked to aging and diabetes. Glu3, with high specificity and affinity, enabled the first-ever direct, fluorescence-based hist...
Jiaqi Xiao, Xuan Qin, WenTao Chen ... · Journal of translational medicine · Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and Technology, Xianning, 437000, China. · pubmed
Aging is an intrinsic biological decline marked by multidimensional alterations spanning molecular, cellular, tissue, and organ levels. One hallmark of aging is the progressive deterioration of immune function, a condition referred to as immunosenescence. This process often invol...
Shiqi Deng, Xinglei Yin, Ruigong Zhu · Journal of cardiovascular pharmacology · School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City 210023, China. · pubmed
Cardiovascular diseases (CVDs) are life-threatening conditions with multifactorial causes. As the most abundant cells in the vascular wall, vascular smooth muscle cells (VSMCs) play a crucial role in regulating vascular tone. Under physiological conditions, VSMCs predominantly de...
Michael Gao, Toren Finkel · Current cardiology reports · Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive Bridgeside Point 1; Room 555, Pittsburgh, PA, 15219, USA. · pubmed
Metabolic changes can play a critical role in the structural and functional decline of the aging cardiovascular system. In this review, we examine how key metabolic pathways and regulatory mechanisms influence cardiovascular aging, highlighting recent studies into metabolic flexi...
B L McNeish, I Miljkovic, T Liu-Ambrose ... · GeroScience · Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA. [email protected]. · pubmed
Cognitive impairment and dementia in older adults represent significant global health challenges. Although the bidirectional relationship between physical function and brain health is well established, the mechanistic drivers of this link remain poorly understood. Muscle function...
Olivier Bruyère, David Scott, Alexandra Papaioannou ... · Calcified tissue international · Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium. [email protected]. · pubmed
Physical activity (PA) and sedentary behavior (SB) are two key lifestyle factors with profound implications for bone health across the lifespan. While PA is recognized for its positive effects on bone mineral density (BMD) and fracture prevention, emerging evidence highlights the...
Thursday, August 14, 2025
Patrick Lacolley, Stéphane Avril, Tamás Gáll ... · Cardiovascular research · Université de Lorraine, Inserm, DCAC, Nancy, France. · pubmed
Vascular aging is considered now to be the first factor of multiorgan aging in what is called "the vascular theory of aging". Clinical understanding of vascular aging has long been limited to arterial hypertension and arterial stiffness. The effects of age on arterial mechanical ...
Tianhao Wu, Yingqian You, Yuhan Zhou ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. · pubmed
Both mosaic loss of the Y chromosome (mLOY) and frailty are related to human aging. However, their relationship and the potential mediating effect of mLOY on the association between frailty and mortality risk remain understudied. A total of 8947 middle-aged and older male adults ...
Steven B Wells, Daniel B Rainbow, Michal Mark ... · Nature immunology · Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. · pubmed
The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from...
Shun-Ming Ting, Xiurong Zhao, Guanghua Sun ... · The Journal of neuroscience : the official journal of the Society for Neuroscience · Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA. · pubmed
After stroke, microglia and hematogenous macrophages, together referred to as MΦ, clear dead cells and cellular debris in the infarcted brain through phagocytosis as an essential part of the recovery process. However, the phagocytic capability of MΦ declines with age. Furthermore...
Xiaoyue Luo, Jiong Zhang, Johan Tolö ... · Neural regeneration research · Department of Neurology, University Medical Center Go.ttingen, Go.ttingen, Germany. · pubmed
Aging is characterized by a decreased autophagic activity contributing to the intracellular deposition of damaged organelles and macromolecules. Autophagy is particularly challenging in neurons since autophagic vesicles are formed at the axonal tip and must be transported to the ...
Lyu, L., Sideris, D., Lee, H. ... · cell biology · Astellas Pharma · biorxiv
The mitochondrial transcription factor A (TFAM) is essential for mitochondrial genome maintenance. It binds to mitochondrial DNA (mtDNA) and determines the abundance, packaging and stability of the mitochondrial genome. Because its function is tightly associated with mtDNA, TFAM ...
Minwoo Baek, Wijeong Jang, Changsoo Kim · PloS one · School of Biological Sciences and Technology, Chonnam National University, Gwangju, South Korea. · pubmed
Mild distress of mitochondria extends animal lifespan, yet the underlying mechanisms are not completely understood. Here we screened mitochondrial proteins for effects on longevity and found that flies mutant in Uncoupling protein 4a (Ucp4a), which encodes a mitochondrial asparta...
Boyang Zheng, Weijie Zhang, Gongwang Yu ... · Nature communications · Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. · pubmed
Aging is a series of adverse changes over time that increases mortality risk. Several hypotheses have been proposed to explain aging, including Leslie Orgel's Error-Catastrophe Theory, which asserts that translation errors erode the translational machinery, become self-amplifying...
Wednesday, August 13, 2025
Ciarchi, M., Simons, B. D., Rulands, S. · cell biology · Ludwig-Maximilian-Universitity Munich · biorxiv
Aging involves processes spanning orders of magnitude in time, from fast events that occur at the molecular scale to the slow decrease of physiological function. Whether and how fast molecular events lead to the slow progression of aging, and what ultimately sets the timescale of...
Torsak Tippairote, Pruettithada Hoonkaew, Aunchisa Suksawang ... · Biogerontology · School of Health Sciences, Sukhothai Thammathirat Open University, Pak Kret District, Nonthaburi, 11120, Thailand. [email protected]. · pubmed
Aging is increasingly understood not as the passive accumulation of molecular damage, but as the cumulative cost of unresolved physiological adaptation under bioenergetic constraint. This review introduces Exposure-Related Malnutrition (ERM) as a mechanistically grounded and clin...
Yishu Wang, Jianmei Huang, Sixiong Lin ... · Bone research · Department of Biochemistry, Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen, China. · pubmed
The focal adhesion (FA) is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function. Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-relate...
Oghogho P Ebeigbe, Volha Mezhnina, Artem Astafev ... · Cell reports · Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, OH 44115, USA; Department of Biological Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA. · pubmed
Calorie restriction (CR) improves health and longevity. CR induces a periodic fasting cycle in mammals; our study compares CR with unanticipated fasting (F), when the food is unexpectedly withheld. F induces hepatic steatosis, whereas CR reduces it; surprisingly, the difference i...
Peijie Luo, Miao Yu, Shuncong Zhang ... · Biogerontology · Spinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China. · pubmed
Cytoskeleton-Associated Protein 4 (CKAP4) is a multifunctional protein implicated in diverse cellular processes, including cytoskeletal organization, signal transduction, and extracellular matrix remodeling. Recent studies have highlighted the dual role of CKAP4 in regulating cel...
Haruhisa Kawasaki, Toshihiko Sato, Norio Ishida · Biogerontology · Institute for Chronobiology, Foundation for Advancement of International Science (FAIS), 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0812, Japan. · pubmed
Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects of dietary CBD to the circadian clock of Drosophila melanogaster as a model animal and its many physiological effect to flies...
Emily R Lowry, Tulsi Patel, Jonathon A Costa ... · Nature neuroscience · Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. [email protected]. · pubmed
Aging is a major risk factor in amyotrophic lateral sclerosis (ALS) and other adult-onset neurodegenerative disorders. Whereas young neurons are capable of buffering disease-causing stresses, mature neurons lose this ability and degenerate over time. We hypothesized that the resi...
Stefan Stamenkovic, Franca Schmid, Gokce Gurler ... · Nature neuroscience · Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA. · pubmed
The progressive loss of cerebral white matter during aging contributes to cognitive decline, but whether reduced blood flow is a cause or a consequence remains debatable. Using deep multi-photon imaging in mice, we examined microvascular networks perfusing myelinated tissues in c...
Kim, C., Ofria, L. D., Kshirsagar, A. ... · bioengineering · The University of Texas at Austin · biorxiv
Aging is increasingly recognized as a systemic process, yet the mechanisms by which senescent cells signal from peripheral tissues accelerate brain aging remain poorly defined. Here, we used chronic exposure of human cerebral organoids to the secretome of senescent osteocytes to ...
Barny, L. A., Garcia, S. K., Houcek, A. J. ... · biochemistry · Vanderbilt University · biorxiv
Proteostasis, or protein homeostasis, is a tightly regulated network of cellular pathways essential for maintaining proper protein folding, trafficking, and degradation. Neurons are particularly vulnerable to proteostasis collapse due to their post-mitotic and long-lived nature a...
Robert G Leija, José Pablo Vázquez-Medina, George A Brooks · American journal of physiology. Endocrinology and metabolism · Exercise Physiology, Department of Integrative Biology, University of California, Berkeley, CA 94720-3140. · pubmed
Resting and maximal exercise respiratory rates (V̇O
Tuesday, August 12, 2025
Watrous, J. D., Tiwari, S., Long, T. ... · biochemistry · Sapient Bioanalytics, LLC · biorxiv
Mass spectrometry (MS)-based metabolomics is a key technology for the interrogation of exogenous and endogenous small molecule mediators that influence human health and disease. To date, however, low throughput of MS systems have largely precluded large-scale metabolomics studies...
Ogg, M., Coon, W. G. · neurology · Johns Hopkins University Applied Physics Laboratory · medrxiv
Biological age estimation, derived from physiological signatures such as brain activity, is emerging as a valuable biomarker for health and well-being. Discrepancies between biological and chronological age have been linked to multiple physical, mental, and cognitive health outco...
Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim ... · B-Lymphocytes · Center for Virus Research Resource, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea. · pubmed
Aging significantly influences host immune responses to viral infections, including Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), which is associated with high mortality in elderly patients. Despite its high fatality rate and pandemic potential, effective therapies r...
Kirsten C Sadler, Mekayla A Storer, N Sumru Bayin · The FEBS journal · Program in Biology and Center for Genomics and Systems Biology, NYU Abu Dhabi, UAE. · pubmed
A strong regenerative capacity is a hallmark of youth. From the tadpole's tail to the mammalian brain, young animals of many species can repair or regrow damaged tissues more effectively than older animals. Here, we take a broad perspective on ageing, inclusive of the transition ...
Ryo Murayama, Kenichi Horisawa, Shizuka Miura ... · Aging cell · Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. · pubmed
Aging causes significant changes in gene expression and metabolic function of cells in various organs. Although it is known that liver regeneration is delayed by aging, the effects of aging on changes in gene expression and metabolic functions in liver regeneration need further i...
Yifan Xiang, Vineeta Tanwar, Parminder Singh ... · Menarche · The Buck Institute for Research on Aging, Novato, United States. · pubmed
Aging can be understood as a consequence of the declining force of natural selection with age. Consistent with this, the antagonistic pleiotropy theory of aging proposes that aging arises from trade-offs that favor early growth and reproduction. However, evidence supporting antag...
Evgeniia Bakaleinikova · Aging · Western Governors University, Millcreek, UT, USA. [email protected]. · pubmed
Aging is increasingly understood as a multifactorial process involving mitochondrial dysfunction, epigenetic drift, and chronic inflammation. While many age-related pathologies have been linked to impaired mitophagy and transcriptional deregulation, the upstream mechanisms drivin...
Boyang Li, Shaowei Wang, Bilal Kerman ... · Aging cell · Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. · pubmed
Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD), but much less is known about the key cell types and pathways driving senescence mechanisms in the brain. We hypothesized that dysregulated cholesterol metabolism...
Anyu Zeng, Hailong Liu, Shuling He ... · DNA Methylation · Department of Bone and Soft Tissue Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510080, P. R. China. · pubmed
Skeletal muscle stem cells (MuSCs) have strong regenerative abilities, but as we age, their ability to regenerate decreases, leading to a decline in muscle function. Although the methylation reprogramming of super-enhancers (SEs) plays a pivotal role in regulating gene expression...
Monday, August 11, 2025
Athanasios Siametis, George A Garinis · BioEssays : news and reviews in molecular, cellular and developmental biology · Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece. · pubmed
Persistent genomic instability compromises cellular viability while also triggers non-cell-autonomous responses that drive dysfunction across tissues, contributing to aging. Recent evidence suggests that DNA damage activates secretory programs, including the release of inflammato...
Miras Moreno, S., Torres, A., Ruiz, J. ... · epidemiology · University of Almeria · medrxiv
Cardiorespiratory fitness (CRF) is a strong predictor of mortality and non-communicable disease risk, but its underlying molecular mechanisms are poorly understood. In this study, we identified CRF associated metabolomics (n=30,010) and proteomics (n=4,235) signatures in UK Bioba...
Leite, J. A., Ergun, Z., Stylianakis, E. ... · immunology · University Medical Center Mainz · biorxiv
Aging is associated with a chronic, low-grade inflammatory state referred to as inflammaging, which contributes to impaired immune regulation and increased susceptibility to disease. While regulatory T (Treg) cells are key mediators of immune homeostasis, their role in the contex...
Maxim N Shokhirev, Adiv A Johnson · GeroScience · Tally Health, New York, NY, USA. [email protected]. · pubmed
Using 100 technical replicate samples from two adult buccal cohorts, we compared technical methylation variability and signal strength between the Infinium MethylationEPIC v2.0 array and the Twist Human Methylome Panel across 753,648 shared CpGs. Twist methylation sequencing show...
Wan-Hsuan Lu, Sophie Guyonnet, Jérémy Raffin ... · Aging cell · IHU HealthAge, Toulouse, France. · pubmed
Evidence connecting skin aging to functional decline and systemic aging biomarkers is lacking. This study investigated how skin-aging biomechanics were associated with changes in intrinsic capacity (IC), a marker of healthy aging. We also explored their links with biological agin...
Andrea Castegnaro, Alexander Dior, Neil Burgess ... · Psychology and aging · Institute of Cognitive Neuroscience, University College London. · pubmed
Navigational skills are essential for interacting with our environment, supported by multiple types of spatial representations. We investigated age-related differences in spatial memory using a virtual reality task that manipulated viewpoints between the encoding and retrieval of...
Raymond Laboy, Marjana Ndoci, Shamsh Tabrez Syed ... · Hexokinase · Department of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany. · pubmed
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in
Yuko Maejima, Shoko Yokota, Megumi Yamachi ... · Aging cell · Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan. · pubmed
While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms remain elusive. This study aimed to elucidate the physiological mechanisms contributing to this age-related decrease in plasma OXT and the possible use of OXT supplementation...
The MULTI Study, , O'Toole, C. K., Song, Z. ... · health informatics · Columbia University · medrxiv
Optimal sleep plays a vital role in promoting healthy aging and enhancing longevity. This study proposes a Sleep Chart to assess the relationship between sleep duration and 23 biological aging clocks across 17 organ systems or tissues and 3 omics data types (imaging, proteomics, ...
Ying Huang, Zhenxing Zhou, Mengjia Huan ... · Aging cell · The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, P. R. China. · pubmed
Antioxidant decline is crucial to driving age-related macular degeneration (AMD). Ferroptosis, a regulated cell death mediated by iron-dependent hydroxyl radical-catalyzed phospholipid peroxidation through the Fenton reaction, is implicated in various chronic degenerative disease...
Saturday, August 09, 2025
A G Newman, J Sharif, P Bessa ... · Heterochromatin · Institute of Cell and Neurobiology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. [email protected]. · pubmed
In aging cells and animal models of premature aging, heterochromatin loss coincides with transcriptional disruption including the activation of normally silenced endogenous retroviruses (ERVs). Here we show that loss of heterochromatin maintenance and de-repression of ERVs result...
Saptashwa Datta, Jen-Chieh Yu, Yi-Hsiang Lin ... · Machine Learning · Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. · pubmed
Aging is a natural phenomenon characterized by the loss of normal morphology and physiological functioning of the body, causing wrinkles on the skin, loss of hair, and compromised immune systems. Peptide therapies have emerged as a promising approach in aging studies because of t...
Jing-Yu Chang, Kuei-Ru Chou, Yu-Ling Chang ... · Journal of physical activity & health · Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan. · pubmed
Cognitive frailty, defined by the coexistence of physical frailty and mild cognitive impairment, can be reversed through targeted interventions. This meta-analysis evaluated the efficacy of physical activity interventions on cognitive function and well-being in older adults with ...
Bo Ma, Yuanxin Miao, Yan Xu ... · NPJ science of food · School of Food and Biology, Jingchu University of Technology, Jingmen, PR China. · pubmed
This study evaluated the in vitro and in vivo antioxidant activities of puerarin (PUE) and β-lactoglobulin (β-lg). The results of the in vitro antioxidant assay revealed that the DPPH and ABTS radical scavenging rates of the PUE/β-lg complex were generally superior to those of fr...
Saha, S., Chakraborty, P., Roy, D. ... · neuroscience · Indian Institute of Technology Jodhpur · biorxiv
Aging brain undergoes a structural decline over lifespan accompanied by changes in neurotransmitter levels, leading to altered functional markers. Past studies have reported human resting state brain display a remarkable preservation of coordination among neural assemblies stemmi...
Jihwan Myung, Hélène Vitet, Sheena Yin Xin Tiong · Aging · Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University, Taipei, Taiwan. [email protected]. · pubmed
Circadian freerunning periods change across the lifespan, yet most computational models do not reproduce these shifts without assuming additional mechanisms. Although the maturation and later deterioration of the suprachiasmatic nucleus (SCN) shape behavioral and humoral rhythms,...