Longevity Papers

Current Week (August 18 - August 19, 2025)
and Previous Week (August 12 - August 17, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), August 12 episode:
Tuesday, August 19, 2025
Haozheng Li, Yuanming Zheng, Chunlei Yuan ... · Cell discovery · State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai, China. · pubmed
A hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP). How the SASP is initiated to accelerate tissue inflammation and aging is an outstanding question in agin...
Xiufei Chen, Jingfei Cheng, Linzhen Kong ... · Genome biology · Department of Central Laboratory, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China. · pubmed
We present direct sequencing methodologies, scTAPS for 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) and scCAPS + specifically for 5hmC, enabling quantitative detection of 5mC and 5hmC at single-base resolution and single-cell level. Achieving approximately 90% mappin...
Yang Pan, Zhijie Huang, Xiao Sun ... · npj aging · Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, IL, USA. · pubmed
The relationship between epigenetic age acceleration (EAA) and midlife cognitive function remains unclear, with limited causal evidence. We investigated this association in 1252 Black and White middle-aged adults from the Bogalusa Heart Study (BHS) and conducted a two-sample Mend...
Liuwei Huang, Yanting Shen, Xiaoling Pan ... · Nature communications · Division of Nephrology, National Key Laboratory for Prevention and Treatment of Multi-organ Injury, Nanfang Hospital, Southern Medical University, Guangzhou, China. · pubmed
Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), a transition driven by cellular senescence, a state of irreversible cell-cycle arrest. However, the molecular mechanisms promoting this pathological process remain unclear. Here we show that the channel protein P...
Monday, August 18, 2025
Kondusamy Vignesh, Ayyakannu Arumugam Napoleon, Krishnaswamy Balamurugan ... · Chemistry (Weinheim an der Bergstrasse, Germany) · Nano and Bioelectrochemistry Research Laboratory, CO2 Research and Green Technologies Centre, and Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632 014, India. · pubmed
The search for drugs that extend lifespan in human-like biological models is a frontier area in biomedical research. In this study, we report a novel electrochemical approach using flufenamic acid (FFA), a widely known nonsteroidal anti-inflammatory drug (NSAID), to generate and ...
Han Gao, Kangkang Ma, Zhiqiang Cao ... · ACS nano · State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, China. · pubmed
Human telomeres exhibit progressive shortening with each replication cycle. This phenomenon plays a critical role in the onset of senescence and the development of cancers. The measurement of absolute telomere length (TL) is not only serving as a marker of aging, but also holds s...
Scott J Mongold, Christian Georgiev, Thomas Legrand ... · Scientific reports · Laboratory of Functional Anatomy, Université libre de Bruxelles (ULB), 1070, Brussels, Belgium. [email protected]. · pubmed
Altered neuromuscular strategies are suggested to contribute to age-related decreases in postural stability. Current approaches tend to overlook global (whole body) neuromuscular postural control strategies, potentially due to methodological constraints or residual influence from...
Batalha, C. M. P. F., Yu, L., Zammit, A. R. ... · neuroscience · Instituto de Assistencia Medica ao Servidor Publico Estadual · biorxiv
Here, we define cognitive resilience as slower or faster cognitive decline after we regress out the effects of common brain neuropathologies. Its understanding could provide important insights into the biology underlying cognitive health, enabling the development of more effectiv...
Yijun He, Xuanbei Lu, Sisi Pang ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Division of Geriatric Endocrinology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China. · pubmed
Senescent cardiac fibroblasts (CFs), which are activated and acquire a pro-fibrotic phenotype, exacerbate age-related interstitial fibrosis and cardiac dysfunction by unclear mechanisms. Traditionally regarded as a central organ involved in regulating aging, the small intestine (...
Kobayashi, H., Maeda, K., Wakui, T. ... · neuroscience · Fujifilm Corporation · biorxiv
Astrocytes play a critical role in neuroinflammation and the pathogenesis of neurodegenerative diseases. Here we found that human induced pluripotent stem cell (iPSC)-derived astrocytes responded differently to inflammatory triggers compared to rodent astrocytes, showing increase...
Tanner J Anderson, Marina M Watowich, Kenneth L Chiou ... · GeroScience · Department of Anthropology, University of Oregon, Eugene, OR, USA. · pubmed
Patterns of brain aging are generally conserved among primates; however, there is marked variation in the observed rate among individuals, species, and brain regions. The hippocampus is a region particularly susceptible to the aging process. To better understand how the hippocamp...
Shiyun Xiao, Seung Woo Kang, Kimberly E Oliva ... · Journal of immunology (Baltimore, Md. : 1950) · Department of Genetics, University of Georgia, Athens, GA, United States. · pubmed
The thymus is a primary lymphoid organ generating self-restricted and self-tolerant naïve T cells. Early in life the thymus starts to involute, resulting in decreased naïve T cell output which may be more self-reactive, leading to an increased prevalence of autoimmunity. A decrea...
Mahoney, S. A., Mazan-Mamczarz, K., Tsitsipatis, D. ... · physiology · National Institute on Aging Intramural Research Program · biorxiv
Background: Advancing age is the strongest risk factor for cardiovascular diseases (CVDs), primarily due to progressive vascular endothelial dysfunction. Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related endothelial dysfunction...
Sunday, August 17, 2025
Sahu, A. K., Minetti, A., Di Fraia, D. ... · biochemistry · Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany · biorxiv
The ubiquitin-proteasome system is essential for neuronal proteostasis, and its activity declines with age. How deubiquitylating enzymes (DUBs) are affected by aging in the vertebrate brain remains unclear. Here, we profiled cysteine protease DUBs using activity-based proteomics ...
Ye, B., Shang, L., Yuan, X. ... · molecular biology · University of Texas Health Science Center at San Antonio · biorxiv
Background: Telomere homeostasis is critical for normal cellular and organ function, and its dysregulation is implicated in aging and chronic diseases. Although telomere length (TL) is critical for normal telomere function, its functional status can also be altered by many other ...
Saturday, August 16, 2025
Liqian Chen, Zixin Chen, Jiahui Mo ... · Cell death and differentiation · Guangdong Cardiovascular Institute, Medical Research Institute, School of Basic Medical Science, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. · pubmed
Cellular senescence is the major hallmark and therapeutic target of aging and age-related diseases. The role of ALKBH5, one of the main m6A demethylases, in cellular senescence emerges however remains contentious. Herein, we show the reversible ALKBH5 aggregation in cytoplasm pro...
Xuyun Peng, Panlong Li, Ying Zhang ... · Genome medicine · Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China. · pubmed
The epidemiological observational studies unveiled that aging is one of the risk factors for liver fibrosis, and the hepatic tissues in the elderly harbor more fibrotic lesions when compared to those in young people. Previous investigations found that TGFβ1 was elevated with agin...
Christian Gaser, Marta Garo-Pascual, Bryan A Strange · GeroScience · Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany. [email protected]. · pubmed
Episodic memory, the ability to recall past events, is particularly vulnerable to ageing. A decline in episodic memory performance is generally considered part of ageing. However, the episodic memory performance of superagers -defined as individuals aged 80+ years old with episod...
Shimura, A., Yamanishi, K., Ishii, T. ... · genomics · Stanford University · biorxiv
Background: Human DNA is known to exhibit an overall tendency toward demethylation with aging. However, assuming a simple linear relationship between DNA methylation and age does not align with the phenotype of human development and the aging process. This study aimed to investig...
Botong Shen, Nicole Noren Hooten, Nicolle A Mode ... · GeroScience · Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA. · pubmed
A new DNA methylation biomarker, Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE), is associated with healthy lifespan in several European ancestry cohorts. Few studies have examined the relation between dietary quality and DunedinPACE in African American and Whi...
Zhao, J., Zhang, L.-S., Liu, Y. ... · biochemistry · Wuhan University · biorxiv
Accurately quantifying oxidative DNA damage at the single-cell level remains a major challenge due to the limitations of conventional ensemble-based assays, which obscure cell to cell variability and lack molecular specificity. To address this, we developed a super-resolution ima...
Friday, August 15, 2025
Seung-Chul J Lee, Gee-Yoon Lee, Sieun S Kim ... · Aging cell · Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. · pubmed
Transcriptome analysis has become increasingly utilized in aging research. However, the identification of the key molecular changes underlying aging processes and longevity-promoting regimens from transcriptome data remains challenging. Here, we present Transcriptomic CLassificat...
Kawamura, Y. K., Khalil, V., Kitazawa, T. · genomics · DANDRITE Nordic EMBL, Aarhus University · biorxiv
Advances in single-cell sequencing have deepened our understanding of cellular identities. However, because they inherently capture only static snapshots, after which no further observations are possible, we cannot compare past and present profiles within the same cell. Thus, mul...
Luengo-Mateos, M., Gonzalez-Vila, A., Silveira-Loureiro, M. ... · neuroscience · USC · biorxiv
Circadian clocks coordinate behaviour and physiology with daily cycles of light and nutrient availability, yet how metabolic signals tune brain timing remains unclear. Astrocytes integrate metabolic and hormonal cues and sustain cell-autonomous rhythms, implicating them as candid...
Xiaojie Wang, Yujia Li, Qingqing Chu ... · Chinese medical journal · Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China. · pubmed
Cellular senescence, stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stressors, has been highlighted as one of the most important mechanisms involved in kidney diseases. It not only serves as a fundamental biological p...
Alcaraz, J., Keyse, C., Hall, C. ... · physiology · Durham University · biorxiv
Inflammaging is considered a driver of age-associated pathology across tissues. Similarly, intestinal permeability is a feature of ageing and underlies a range of inflammatory and age-related diseases. Increased intestinal permeability has been described as both a cause and a con...
Michael Stern · Journal of cell science · Department of BioSciences Program in Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA. · pubmed
In youth, energy deprivation primarily results from fasting. Because inconsistent nutrient availability is common for most organisms, natural selection has provided mechanisms that detect nutrient-deprived states, followed by adaptive responses that increase the likelihood of sur...
Runliu Li, Bastian Draphoen, Mika Lindén ... · Nanoscale horizons · Institute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. [email protected]. · pubmed
Nowadays, aptamers have transitioned into valuable antibody alternatives. We present the first anti-glucosepane aptamer targeting a key glycation product linked to aging and diabetes. Glu3, with high specificity and affinity, enabled the first-ever direct, fluorescence-based hist...
Jiaqi Xiao, Xuan Qin, WenTao Chen ... · Journal of translational medicine · Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and Technology, Xianning, 437000, China. · pubmed
Aging is an intrinsic biological decline marked by multidimensional alterations spanning molecular, cellular, tissue, and organ levels. One hallmark of aging is the progressive deterioration of immune function, a condition referred to as immunosenescence. This process often invol...
Shiqi Deng, Xinglei Yin, Ruigong Zhu · Journal of cardiovascular pharmacology · School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City 210023, China. · pubmed
Cardiovascular diseases (CVDs) are life-threatening conditions with multifactorial causes. As the most abundant cells in the vascular wall, vascular smooth muscle cells (VSMCs) play a crucial role in regulating vascular tone. Under physiological conditions, VSMCs predominantly de...
Michael Gao, Toren Finkel · Current cardiology reports · Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive Bridgeside Point 1; Room 555, Pittsburgh, PA, 15219, USA. · pubmed
Metabolic changes can play a critical role in the structural and functional decline of the aging cardiovascular system. In this review, we examine how key metabolic pathways and regulatory mechanisms influence cardiovascular aging, highlighting recent studies into metabolic flexi...
B L McNeish, I Miljkovic, T Liu-Ambrose ... · GeroScience · Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA. [email protected]. · pubmed
Cognitive impairment and dementia in older adults represent significant global health challenges. Although the bidirectional relationship between physical function and brain health is well established, the mechanistic drivers of this link remain poorly understood. Muscle function...
Olivier Bruyère, David Scott, Alexandra Papaioannou ... · Calcified tissue international · Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium. [email protected]. · pubmed
Physical activity (PA) and sedentary behavior (SB) are two key lifestyle factors with profound implications for bone health across the lifespan. While PA is recognized for its positive effects on bone mineral density (BMD) and fracture prevention, emerging evidence highlights the...
Thursday, August 14, 2025
Patrick Lacolley, Stéphane Avril, Tamás Gáll ... · Cardiovascular research · Université de Lorraine, Inserm, DCAC, Nancy, France. · pubmed
Vascular aging is considered now to be the first factor of multiorgan aging in what is called "the vascular theory of aging". Clinical understanding of vascular aging has long been limited to arterial hypertension and arterial stiffness. The effects of age on arterial mechanical ...
Tianhao Wu, Yingqian You, Yuhan Zhou ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. · pubmed
Both mosaic loss of the Y chromosome (mLOY) and frailty are related to human aging. However, their relationship and the potential mediating effect of mLOY on the association between frailty and mortality risk remain understudied. A total of 8947 middle-aged and older male adults ...
Steven B Wells, Daniel B Rainbow, Michal Mark ... · Nature immunology · Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. · pubmed
The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from...
Shun-Ming Ting, Xiurong Zhao, Guanghua Sun ... · The Journal of neuroscience : the official journal of the Society for Neuroscience · Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA. · pubmed
After stroke, microglia and hematogenous macrophages, together referred to as MΦ, clear dead cells and cellular debris in the infarcted brain through phagocytosis as an essential part of the recovery process. However, the phagocytic capability of MΦ declines with age. Furthermore...
Xiaoyue Luo, Jiong Zhang, Johan Tolö ... · Neural regeneration research · Department of Neurology, University Medical Center Go.ttingen, Go.ttingen, Germany. · pubmed
Aging is characterized by a decreased autophagic activity contributing to the intracellular deposition of damaged organelles and macromolecules. Autophagy is particularly challenging in neurons since autophagic vesicles are formed at the axonal tip and must be transported to the ...
Lyu, L., Sideris, D., Lee, H. ... · cell biology · Astellas Pharma · biorxiv
The mitochondrial transcription factor A (TFAM) is essential for mitochondrial genome maintenance. It binds to mitochondrial DNA (mtDNA) and determines the abundance, packaging and stability of the mitochondrial genome. Because its function is tightly associated with mtDNA, TFAM ...
Minwoo Baek, Wijeong Jang, Changsoo Kim · PloS one · School of Biological Sciences and Technology, Chonnam National University, Gwangju, South Korea. · pubmed
Mild distress of mitochondria extends animal lifespan, yet the underlying mechanisms are not completely understood. Here we screened mitochondrial proteins for effects on longevity and found that flies mutant in Uncoupling protein 4a (Ucp4a), which encodes a mitochondrial asparta...
Boyang Zheng, Weijie Zhang, Gongwang Yu ... · Nature communications · Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. · pubmed
Aging is a series of adverse changes over time that increases mortality risk. Several hypotheses have been proposed to explain aging, including Leslie Orgel's Error-Catastrophe Theory, which asserts that translation errors erode the translational machinery, become self-amplifying...
Wednesday, August 13, 2025
Ciarchi, M., Simons, B. D., Rulands, S. · cell biology · Ludwig-Maximilian-Universitity Munich · biorxiv
Aging involves processes spanning orders of magnitude in time, from fast events that occur at the molecular scale to the slow decrease of physiological function. Whether and how fast molecular events lead to the slow progression of aging, and what ultimately sets the timescale of...
Torsak Tippairote, Pruettithada Hoonkaew, Aunchisa Suksawang ... · Biogerontology · School of Health Sciences, Sukhothai Thammathirat Open University, Pak Kret District, Nonthaburi, 11120, Thailand. [email protected]. · pubmed
Aging is increasingly understood not as the passive accumulation of molecular damage, but as the cumulative cost of unresolved physiological adaptation under bioenergetic constraint. This review introduces Exposure-Related Malnutrition (ERM) as a mechanistically grounded and clin...
Yishu Wang, Jianmei Huang, Sixiong Lin ... · Bone research · Department of Biochemistry, Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen, China. · pubmed
The focal adhesion (FA) is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function. Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-relate...
Oghogho P Ebeigbe, Volha Mezhnina, Artem Astafev ... · Cell reports · Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, OH 44115, USA; Department of Biological Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA. · pubmed
Calorie restriction (CR) improves health and longevity. CR induces a periodic fasting cycle in mammals; our study compares CR with unanticipated fasting (F), when the food is unexpectedly withheld. F induces hepatic steatosis, whereas CR reduces it; surprisingly, the difference i...
Peijie Luo, Miao Yu, Shuncong Zhang ... · Biogerontology · Spinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China. · pubmed
Cytoskeleton-Associated Protein 4 (CKAP4) is a multifunctional protein implicated in diverse cellular processes, including cytoskeletal organization, signal transduction, and extracellular matrix remodeling. Recent studies have highlighted the dual role of CKAP4 in regulating cel...
Haruhisa Kawasaki, Toshihiko Sato, Norio Ishida · Biogerontology · Institute for Chronobiology, Foundation for Advancement of International Science (FAIS), 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0812, Japan. · pubmed
Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects of dietary CBD to the circadian clock of Drosophila melanogaster as a model animal and its many physiological effect to flies...
Emily R Lowry, Tulsi Patel, Jonathon A Costa ... · Nature neuroscience · Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. [email protected]. · pubmed
Aging is a major risk factor in amyotrophic lateral sclerosis (ALS) and other adult-onset neurodegenerative disorders. Whereas young neurons are capable of buffering disease-causing stresses, mature neurons lose this ability and degenerate over time. We hypothesized that the resi...
Stefan Stamenkovic, Franca Schmid, Gokce Gurler ... · Nature neuroscience · Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA. · pubmed
The progressive loss of cerebral white matter during aging contributes to cognitive decline, but whether reduced blood flow is a cause or a consequence remains debatable. Using deep multi-photon imaging in mice, we examined microvascular networks perfusing myelinated tissues in c...
Kim, C., Ofria, L. D., Kshirsagar, A. ... · bioengineering · The University of Texas at Austin · biorxiv
Aging is increasingly recognized as a systemic process, yet the mechanisms by which senescent cells signal from peripheral tissues accelerate brain aging remain poorly defined. Here, we used chronic exposure of human cerebral organoids to the secretome of senescent osteocytes to ...
Barny, L. A., Garcia, S. K., Houcek, A. J. ... · biochemistry · Vanderbilt University · biorxiv
Proteostasis, or protein homeostasis, is a tightly regulated network of cellular pathways essential for maintaining proper protein folding, trafficking, and degradation. Neurons are particularly vulnerable to proteostasis collapse due to their post-mitotic and long-lived nature a...
Robert G Leija, José Pablo Vázquez-Medina, George A Brooks · American journal of physiology. Endocrinology and metabolism · Exercise Physiology, Department of Integrative Biology, University of California, Berkeley, CA 94720-3140. · pubmed
Resting and maximal exercise respiratory rates (V̇O
Tuesday, August 12, 2025
Watrous, J. D., Tiwari, S., Long, T. ... · biochemistry · Sapient Bioanalytics, LLC · biorxiv
Mass spectrometry (MS)-based metabolomics is a key technology for the interrogation of exogenous and endogenous small molecule mediators that influence human health and disease. To date, however, low throughput of MS systems have largely precluded large-scale metabolomics studies...
Ogg, M., Coon, W. G. · neurology · Johns Hopkins University Applied Physics Laboratory · medrxiv
Biological age estimation, derived from physiological signatures such as brain activity, is emerging as a valuable biomarker for health and well-being. Discrepancies between biological and chronological age have been linked to multiple physical, mental, and cognitive health outco...
Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim ... · B-Lymphocytes · Center for Virus Research Resource, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea. · pubmed
Aging significantly influences host immune responses to viral infections, including Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), which is associated with high mortality in elderly patients. Despite its high fatality rate and pandemic potential, effective therapies r...
Kirsten C Sadler, Mekayla A Storer, N Sumru Bayin · The FEBS journal · Program in Biology and Center for Genomics and Systems Biology, NYU Abu Dhabi, UAE. · pubmed
A strong regenerative capacity is a hallmark of youth. From the tadpole's tail to the mammalian brain, young animals of many species can repair or regrow damaged tissues more effectively than older animals. Here, we take a broad perspective on ageing, inclusive of the transition ...
Ryo Murayama, Kenichi Horisawa, Shizuka Miura ... · Aging cell · Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. · pubmed
Aging causes significant changes in gene expression and metabolic function of cells in various organs. Although it is known that liver regeneration is delayed by aging, the effects of aging on changes in gene expression and metabolic functions in liver regeneration need further i...
Yifan Xiang, Vineeta Tanwar, Parminder Singh ... · Menarche · The Buck Institute for Research on Aging, Novato, United States. · pubmed
Aging can be understood as a consequence of the declining force of natural selection with age. Consistent with this, the antagonistic pleiotropy theory of aging proposes that aging arises from trade-offs that favor early growth and reproduction. However, evidence supporting antag...
Evgeniia Bakaleinikova · Aging · Western Governors University, Millcreek, UT, USA. [email protected]. · pubmed
Aging is increasingly understood as a multifactorial process involving mitochondrial dysfunction, epigenetic drift, and chronic inflammation. While many age-related pathologies have been linked to impaired mitophagy and transcriptional deregulation, the upstream mechanisms drivin...
Boyang Li, Shaowei Wang, Bilal Kerman ... · Aging cell · Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. · pubmed
Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD), but much less is known about the key cell types and pathways driving senescence mechanisms in the brain. We hypothesized that dysregulated cholesterol metabolism...
Anyu Zeng, Hailong Liu, Shuling He ... · DNA Methylation · Department of Bone and Soft Tissue Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510080, P. R. China. · pubmed
Skeletal muscle stem cells (MuSCs) have strong regenerative abilities, but as we age, their ability to regenerate decreases, leading to a decline in muscle function. Although the methylation reprogramming of super-enhancers (SEs) plays a pivotal role in regulating gene expression...