Longevity Papers

Current Week (June 23 - June 25, 2025)
and Previous Week (June 18 - June 22, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 20 episode:
Wednesday, June 25, 2025
Tae Jun Lee, Andrea Santeford, Kristen M Pitts ... · Lysophospholipids · John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. · pubmed
Age-related macular degeneration (AMD) is a leading cause of blindness in people over 50. AMD and cardiovascular disease share risk factors including age, impaired lipid metabolism, and extracellular lipid deposition. Because of its importance in age-related diseases, we hypothes...
Tuesday, June 24, 2025
Guan Wang, Anying Song, Qiong A Wang · Nature reviews. Endocrinology · Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Medical Center, Duarte, CA, USA. · pubmed
Adipose tissue, a pivotal player in whole-body energy homeostasis and insulin sensitivity, undergoes considerable remodelling throughout the ageing process, a facet that has garnered little attention until the past decade. This Review comprehensively summarizes the dynamic metabo...
Enhui Wang, Yuting Wang, Zhaofeng Zhang ... · Biogerontology · Beijing Qingyan Boshi Health Management Co., Ltd, Beijing, China. · pubmed
The increasing global population aging has made the prevention and control of aging-related diseases a major public health challenge in the twenty-first century. Nicotinamide mononucleotide (NMN), as a precursor of nicotinamide adenine dinucleotide (NAD
Sakshi Chaudhary, Mani Raj Chaudhary, Manoj Kumar Jena ... · Biogerontology · Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, India. · pubmed
Geroprotectors, a class of compounds that ameliorate molecular, cellular, or physiological aging-related alterations, have garnered significant attention in the quest to promote healthy aging and extend the human health span. Among these, Calorie Restriction Mimetics (CRMs) have ...
Indi P Joore, Sawsan Shehata, Irena Muffels ... · DNA, Mitochondrial · Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. · pubmed
Mutations in the mitochondrial genome can cause maternally inherited diseases, cancer, and aging-related conditions. Recent technological progress now enables the creation and correction of mutations in the mitochondrial genome, but it remains relatively unknown how patients with...
Rui Zhao, Taili Zhao, Tingting Shi ... · Biogerontology · School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. · pubmed
Jingfang Granule (JFG), a traditional Chinese medicine preparation, is widely used in clinical practice. It has been shown to extend both lifespan and healthspan in the Caenorhabditis elegans model. However, the molecular mechanisms of its main constituents and their targets rema...
Alyssa C Rodriguez, Emiko A Kramár, Agatha S Augustynski ... · The Journal of neuroscience : the official journal of the Society for Neuroscience · Department of Neurobiology and Behavior, University of California, Irvine; Irvine, California; 92697, USA. · pubmed
Long-term memory formation is negatively regulated by histone deacetylase 3 (HDAC3), a transcriptional repressor. Emerging evidence suggests that post-translational phosphorylation of HDAC3 at its serine 424 (S424) residue is critical for its deacetylase activity in transcription...
Smith, S. A., Pease, J. B., Carruthers, T. ... · evolutionary biology · Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA · biorxiv
Many long-lived plant species exhibit notable patterns in phylogenies, such as short molecular branch lengths and high gene-tree conflict. However, it is not clear what biological properties of long-lived plant species or concomitant processes acting within these lineages generat...
Tong Chen, Yan-Lan Liu, Hui-Na Qiu ... · Diabetology & metabolic syndrome · School of Medicine, Nankai University, Tianjin, China. · pubmed
Metformin is a widely used antidiabetic agent for obesity-related type 2 diabetes mellitus, providing significant health benefits such as reduced blood glucose levels and body weight. Emerging evidence suggests that metformin may play a beneficial role in delaying aging. However,...
Joost Verduijn, Kelly Coutant, Mitchell E Fane ... · Cell death and differentiation · Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA. · pubmed
Along with organismal aging, multiple compartments of the immune system undergo a progressive functional degeneration that may contribute to - or at least allow for - disease, a scenario that is commonly known as "immunosenescence". While not all immune cell populations suffer fr...
Aubrey Converse, Madeline J Perry, Shweta S Dipali ... · PLoS biology · Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. · pubmed
The ovary is one of the first organs to exhibit signs of aging, characterized by reduced tissue function, chronic inflammation, and fibrosis. Multinucleated giant cells (MNGCs), formed by macrophage fusion, typically occur in chronic immune pathologies, including infectious and n...
Irish, S. D., Kimberley, A., Immler, S. ... · evolutionary biology · University of East Anglia · biorxiv
Dietary restriction (DR) extends lifespan in animals and plants, but its evolutionary causes are elusive. Adaptive hypotheses posit that DR extends lifespan because organisms reallocate resources from reproduction to survival (\"disposable soma\") or recycle cellular waste to max...
Chenji Li, Sadegh Dabiri, Arezoo M Ardekani · Fluids and barriers of the CNS · School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47906, USA. · pubmed
The glymphatic theory suggests a convective transport mechanism through brain tissue, which has significant implications for both brain waste clearance and drug delivery. However, the existence and driving mechanisms of directional convection from periarterial to perivenous space...
Yu Liu, Meiling Ge, Xina Xiao ... · Nature aging · National Clinical Research Center for Geriatrics and Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. · pubmed
Age-related changes in circulating metabolites influence systemic physiology and may contribute to diseases such as sarcopenia. Although metabolic dysregulation is closely linked to sarcopenia, the roles of specific metabolites remain unclear. In this study, we performed comprehe...
Monday, June 23, 2025
Gabriel Meca-Laguna, Michael Qiu, Yafei Hou ... · Aging cell · Lifespan Research Institute, Mountain View, California, USA. · pubmed
The accumulation of senescent cells (SEN) with aging produces a chronic inflammatory state that accelerates age-related diseases. Eliminating SEN has been shown to delay, prevent, and in some cases reverse aging in animal disease models and extend lifespan. There is thus an unmet...
Jones, S. W., Shigdar, S., Tollitt, B. R. ... · bioengineering · University of Liverpool · biorxiv
Microgravity provides a unique model for understanding accelerated skeletal muscle loss, and potentially a model of muscle ageing, offering insights into the molecular mechanisms underlying reductions in muscle mass and function. During spaceflight, astronauts experience pronounc...
Basma Abdelkader, Xiang Qun Shi, Wen Bo Sam Zhou ... · Pain · The Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, Canada. · pubmed
As individuals age, they often experience persistent, unresolved pain, impacting their quality of life. Aging as a process is accompanied by "inflammaging," a state of chronic, low-grade systemic inflammation contributing to various diseases. Understanding the functional link bet...
Parast, S., Wang, S., Iwanaszko, M. ... · molecular biology · Simpson Querrey Institute for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine; Chicago, IL 6 · biorxiv
Transcription elongation factors control post-initiation steps of gene expression by RNA polymerase II (RNAPII). We have established distinct mechanistic roles for the essential elongation factors PAF1, NELF, SPT5, SPT6, and the Super Elongaiton Complex (SEC) via acute depletion ...
Sunday, June 22, 2025
Zhu, K., Cheng, G., Ren, Y. ... · cell biology · Tohoku University · biorxiv
Aneuploid cells are known to increase with age. Previously, we demonstrated that aneuploid cells increase in fibroblasts from aged mice due to chromosomal instability (CIN), which is caused by oxidative stress. It is unclear whether this phenomenon also occurs in human cells, whi...
Cazzolla, G., Toppe, D., Krause, G. ... · neuroscience · Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics and SupraFAB, Freie Universitaet Berlin, 14195, Berlin, Germany · biorxiv
Macroautophagy/autophagy, a critical cellular degradation pathway essential for maintaining neuronal proteostasis, declines with age and has been increasingly implicated in the regulation of synaptic integrity and circuit resilience. Neuropeptide Y (NPY), the most abundantly expr...
Saturday, June 21, 2025
Guoqiang Sun, Xiaolong Fu, Yandong Zheng ... · Nature aging · State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. · pubmed
Cochlear aging causes substantial hearing impairment in older adults, yet primate-specific mechanisms remain poorly characterized. Our comprehensive analysis combining single-cell and histopathological profiling in aging Macaca fascicularis demonstrates progressive cochlear degen...
Alicia Toto Nienguesso, Juliane-Susanne Jung, Marie Alfes ... · Scientific reports · Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, Halle (Saale), Germany. · pubmed
Adipose tissue is continuously regenerated by stromal mesenchymal stem cells throughout life. This study hypothesises that early age-related changes in the proteome and metabolic properties of subcutaneous (s) and visceral (v) adipose tissue-derived stromal/stem cells (ASCs) from...
Ying Liu, Ting Hong, Mingxuan Lv ... · Alzheimer's research & therapy · Department of Neurology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. · pubmed
Emerging evidence suggests that senescent microglia play a role in β-amyloid (Aβ) pathology and neuroinflammation in Alzheimer's disease (AD). Targeting senescent cells with naturally derived compounds exhibiting minimal cytotoxicity represents a promising therapeutic strategy.
Antero Salminen, Kai Kaarniranta, Anu Kauppinen · Biogerontology · Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. [email protected]. · pubmed
Excessive exposure of the skin to UV radiaton (UVR) accelerates the aging process and leads to a photoaging state which involves similar pathological alterations to those occurring in chronological aging. UVR exposure, containing both UVA and UVB radiation, triggers cellular sene...
Larissa Lipskaia, Lou Delval, Valentin Sencio ... · Aging cell · Institut Mondor de Recherche Biomédicale (IMRB), FHU SENEC, Univ. Paris-Est Créteil, INSERM U955, Créteil, France. · pubmed
Influenza A virus (IAV) infection causes acute and long-term lung damage. Here, we used immunostaining, genetic, and pharmacological approaches to determine whether IAV-induced cellular senescence causes prolonged alterations in lungs. Mice infected with a sublethal dose of H1N1p...
Friday, June 20, 2025
Alberto J Espay, Andrea Sturchio, Alberto Imarisio ... · BioEssays : news and reviews in molecular, cellular and developmental biology · James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA. · pubmed
Protein aggregation is a normal response to age-related exposures. According to the thermodynamic hypothesis of protein folding, soluble proteins precipitate into amyloids (pathology) under supersaturated conditions through a process similar to crystallization. This soluble-to-in...
Miaomiao Du, Yujia Wang, Xinyuan Wang ... · Aging cell · Department of Laboratory Animal Sciences, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China. · pubmed
Aging is the greatest risk factor for learning and memory disorders; dementia prevalence significantly increases with age due to numerous molecular changes in the body. Although research has consistently shown that aging leads to learning and memory impairments, the molecular mec...
Vazquez Ramos, G. J. A. · neuroscience · Morehouse School of Medicine · biorxiv
Background: The pineal gland secretes melatonin but paradoxically calcifies more than any other intracranial structure, forming hydroxyapatite "brain-sand" (corpora arenacea) that correlates with reduced melatonin output, sleep disruption and heightened neuro-degenerative risk. W...
Juan Liu, Qingru Song, Chen Li ... · Cell proliferation · Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China. · pubmed
Aging is characterised by progressive structural and functional changes in the liver, with the extracellular matrix (ECM) playing a key role in modulating these changes. Our study presents a comprehensive proteomic analysis of the liver ECM across different age stages, uncovering...
Jing Lu, Hongyan Wang, Haiyu Zhang ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China. · pubmed
Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic inflammation. This study investiga...
Nicolas P Tessier, Lise M Hardy, Florence Mauger ... · Aging cell · Laboratory for Genomics, Foundation Jean Dausset-CEPH, Paris, France. · pubmed
Plasma circulating cell-free nucleic acids (ccfNAs) provide an exceptional source of information about an individual's health, yet their biology in healthy individuals during aging remains poorly understood. Here, we present the first integrative multiparametric analysis of the m...
Hong Guo-Parke, Oisin Cappa, Dermot A Linden ... · American journal of respiratory cell and molecular biology · Queen's University Belfast, Wellcome Wolfson Institute for Experimental Medicine, Belfast, United Kingdom of Great Britain and Northern Ireland. · pubmed
Cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). The mechanisms of senescence in the bronchial epithelium, however, remain largely unknown. This study aimed to elucidate whether cellular senescence in COPD epithelial cel...
Minsol Jeon, Da-Eun Kim, So Young Choi ... · Cell communication and signaling : CCS · Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea. · pubmed
The autophagy-lysosomal pathway is a cellular degradation mechanism that regulates protein quality by eliminating aggregates and maintaining normal protein function. It has been reported that aging itself reduces lysosomal proteolytic activity in age-related neurodegenerative dis...
Mutz, J., Gilchrist, L., Allegrini, A. G. ... · epidemiology · King\'s College London · medrxiv
Background: Individuals with mental and behavioural disorders face increased risk of age-related diseases and premature mortality. Accelerated biological ageing may contribute to this disparity. We investigated differences in metabolomic ageing between individuals with and withou...
Xianhong Zhang, Yue Gao, Siyu Zhang ... · Cell communication and signaling : CCS · State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, 010070, China. · pubmed
Aging is an irreversible physiological process that progresses with age, leading to structural disorders and dysfunctions of organs, thereby increasing the risk of chronic diseases such as neurodegenerative diseases, diabetes, hypertension, and cancer. Both organismal and cellula...
Birong Jiang, Hongwei Zhang, Qixia Xu ... · Aging cell · School of Pharmacy, Institute of Aging Medicine, Binzhou Medical University, Yantai, Shandong, China. · pubmed
Cellular senescence is an aging-related mechanism characterized by cell cycle arrest, macromolecular alterations, and a senescence-associated secretory phenotype (SASP). Recent preclinical trials established that senolytic drugs, which target survival mechanisms of senescent cell...
Chenghui Yu, Xingxing Qiu, Si Tao ... · Biogerontology · Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China. · pubmed
This study investigates the impact of dietary restriction (DR) on gene expression in hematopoietic stem cells (HSCs) derived from aged mice. RNA sequencing (RNA-seq) data were obtained from sorted HSCs, followed by weighted gene co-expression network analysis (WGCNA) to identify ...
Danai Koftori, Charandeep Kaur, Laura Mora Bitria ... · PLoS biology · Department of Infectious Disease, Imperial College London, London, United Kingdom. · pubmed
T stem cell-like memory cells (TSCM cells) are considered to be essential for the maintenance of immune memory. The TSCM population has been shown to have the key properties of a stem cell population: multipotency, self-renewal and clonal longevity. Here we show that no single po...
Brigos-Barril, E., Vasallo, C., Farre, X. ... · genetic and genomic medicine · Hospital Universitari Institut Pere Mata (HUIPM), Institut d\'Investigacio Sanitaria Pere Virgili (IISPV-CERCA), Universitat Rovira i Virgili (URV), Reus, Catal · medrxiv
The persistence of genetic variants that increase susceptibility to complex diseases poses an evolutionary paradox: despite their detrimental health effects, these variants are not eliminated by natural selection. Life-history theory proposes that trade-offs and pleiotropic effec...
Thursday, June 19, 2025
Edward R Ivimey-Cook, Zahida Sultanova, Alexei A Maklakov · Aging cell · School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK. · pubmed
Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension fro...
Cansell, C., Goepp, V., Bain, F. ... · physiology · CNRS · biorxiv
Living animals reach their end-of-life through a stereotypic set of fascinating but poorly understood processes. The discovery, first in flies and later in nematodes and zebrafish, of the "Smurf phenotype" is a central tool for picking this complex "lock of biology", that one of ...
Wuzhe Fan, Tao Zheng, Mingsong Mao ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, China. · pubmed
Traditional biomaterial design often prioritizes empirical knowledge over disease mechanisms and pathological dynamics, resulting in imprecise solutions in complex clinical conditions. Age-related osteoporosis (A-OP) is a disease associated with aging, characterized by a dysfunct...
Garrod-Ketchely, C., Callender, L. A., Schroth, J. ... · immunology · QMUL · biorxiv
Ageing is associated with significant immune changes, with unhealthy ageing characterised by chronic inflammation and immune dysregulation. Here we identify a population of CD8 TEMRA cells during unhealthy ageing, which exhibit features of premature senescence and are regulated i...
Eleanor L S Conole, Josephine A Robertson, Hannah M Smith ... · Nature reviews. Neurology · Department of Biochemistry, University of Oxford, Oxford, UK. · pubmed
Ageing has profound effects on the human brain across the lifespan. Cognitive testing and brain imaging are currently used to monitor healthy and pathological brain ageing. However, peripheral markers of cognitive function, cognitive ageing and neurological disease could provide ...
Adiv A Johnson, Maxim N Shokhirev · Aging · Tally Health, New York, NY, USA. [email protected]. · pubmed
Aging biomarkers that predict age given methylomic data are referred to as epigenetic aging clocks. While the earliest, first-generation clocks were exclusively trained to predict chronological age, more recent next-generation models have been explicitly trained to associate with...
Jieyu Wu, Victoria R Yarmey, Olivia Jiaming Yang ... · Nature neuroscience · Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. · pubmed
The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in regulating the development and function of the brain. Neuron-glia signal transduction is known to be mediated by secreted signals through ligand-receptor interac...
Lei Zhang, Kai Xiang, Jinlong Li ... · ACS nano · School of Pharmacy, Wannan Medical College, Wuhu 241002, China. · pubmed
Osteoarthritis (OA) is a classic age-related disorder, and its progression is positively associated with the number of senescent cells in the synovium of the joint. Senolytics have been used to slow or reverse the aging process, which is currently limited by off-target toxicity. ...
Yuan Liu, Shiyang He, Kawon Pyo ... · Cell Proliferation · Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA, USA. · pubmed
Cellular quiescence is a state of reversible proliferative arrest that plays essential roles in development, resistance to stress, aging, and longevity of organisms. Here we report that rapid depletion of RNase MRP, a deeply conserved RNA-based enzyme required for rRNA biosynthes...
Caihong Gu, Ting Guo, Xiaobing Chen ... · Mitochondria · Department of Critical Care Medicine, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, 222000, Jiangsu, PR China. · pubmed
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in global cerebral ischemic (GCI) brain injury remain unexplored. In current study, we aim to investigate the effects of combined senolytics Dasatinib plus Quercetin...
Karina A Cicali, Angie K Torres, Cheril Tapia-Rojas · Neural regeneration research · Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile. · pubmed
Aging is a physiological and complex process produced by accumulative age-dependent cellular damage, which significantly impacts brain regions like the hippocampus, an essential region involved in memory and learning. A crucial factor contributing to this decline is the dysfuncti...
Wednesday, June 18, 2025
Jiajin Chen, Sicheng Li, Shichen Bu ... · GeroScience · Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. [email protected]. · pubmed
Older adults with established cardiovascular diseases (CVD) are at elevated risk of heart failure (HF). Frailty, a hallmark of multi-system aging, may contribute to HF development through inflammation. However, population-based evidence remains scarce. Leveraging data from 49,530...
Payet, A., Guillou, E., Bernat-Fabre, S. ... · cell biology · RESTORE Research Center · biorxiv
Aging involves a progressive decline in physiological functions, often marked by the onset of a \"frailty point\" just before survival rates decrease rapidly. Here, we investigate how the Mediator subunit Med19 modulates this transition in Drosophila. We find that upregulating Me...
Kristian E Markon, Frank D Mann, Colin D Freilich ... · Aging · University of Minnesota, Minneapolis, Minnesota, United States of America. · pubmed
Measurement of aging is critical to understanding its causes and developing interventions, but little consensus exists on what components such measurements should include or how they perform in predicting mortality. The aim of this study was to identify factors of aging among a c...
Lukacsovich, D., Young, J., Gomez, L. ... · genetic and genomic medicine · University of Miami · medrxiv
Aging is the strongest risk factor for Alzheimer's disease (AD), yet the molecular mechanisms linking aging to AD remain poorly understood. DNA methylation (DNAm) is an epigenetic modification that plays a critical role in gene regulation and has been implicated in both aging and...
Ayala-Hernandez, M. G., Torales, A. B., Tan, H. C. ... · biochemistry · University of California Davis · biorxiv
Mutations in mitochondrial complex I can cause severe metabolic disease. Although no treatments are available for complex I deficiencies, chronic hypoxia improves lifespan and function in a mouse model of the severe mitochondrial disease Leigh syndrome caused by mutation of compl...
Rimsha Abaidullah, Shaukat Ali, Muhammad Summer ... · Cell biochemistry and biophysics · Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan. · pubmed
Aging as a complex process is marked by physiological and functional deterioration, making the individual vulnerable to age-related diseases. Different organs experience unique aging processes that lead to conditions such as cardiovascular, cancer, metabolic, and musculoskeletal ...
Hansknecht, A., Mankarious, M., Baranda, M. V. ... · cell biology · Helmholtz Institute For Biomedical Engineering, Uniklinik Aachen · biorxiv
Epigenetic regulatory mechanisms, which include histone modifications and DNA methylation, play a central role in development and aging. Dimethylation of H3K36, deposited mainly by the histone methyltransferase NSD1, occurs predominantly in intergenic regions and recruits the DNA...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan ... · Aging cell · Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, Connecticut, USA. · pubmed
The relationship between in vitro senescence cell induction and intracellular biomolecular dysregulation is still poorly understood. In this study, we have found that a range of metabolic subphenotypes exists and is dependent on the induction method that is used. To develop under...
David Furman, Johan Auwerx, Anne-Laure Bulteau ... · Nature aging · Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. [email protected]. · pubmed
Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on system...
Qianglan Lu, Chengwei Ye, Wei Mao ... · ACS nano · Department of Gastric and Hernia Surgery, Nanjing Drum Tower Hospital, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China. · pubmed
Idiopathic pulmonary fibrosis (IPF) remains an age-related, fatal, incurable, epithelial-driven fibrotic lung disease despite the availability of approved antifibrotic drugs. The medical need for effective antipulmonary fibrotic therapies is thus very high. A promising therapeuti...
Abel Anwar, Tianchen Li, Yi Shen · ACS applied materials & interfaces · School of Chemical and Biomolecular Engineering, The University of Sydney, PNR Building, Darlington, NSW 2008, Australia. · pubmed
The ability of biomolecular condensates to reversibly dissolve and reform is crucial for maintaining cellular stability and functions. In the context of cell physiology and disease, they can serve as a metastable phase mediating the liquid-to-solid transition of disease proteins ...
Lewis, C., Levis, H., Holbrook, J. ... · bioengineering · University of Utah Department of Biomedical Engineering, Salt Lake City, UT · biorxiv
Senescence has been shown to contribute to the progression of aging related diseases including degenerative disc disease (DDD). However, the mechanisms regulating senescence in the intervertebral disc (IVD) and other tissues/diseases remain poorly understood. Recently, in a CRISP...