Longevity Papers

Current Week (June 16 - June 21, 2025)
and Previous Week (June 14 - June 15, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 20 episode:
Saturday, June 21, 2025
Guoqiang Sun, Xiaolong Fu, Yandong Zheng ... · Nature aging · State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. · pubmed
Cochlear aging causes substantial hearing impairment in older adults, yet primate-specific mechanisms remain poorly characterized. Our comprehensive analysis combining single-cell and histopathological profiling in aging Macaca fascicularis demonstrates progressive cochlear degen...
Alicia Toto Nienguesso, Juliane-Susanne Jung, Marie Alfes ... · Scientific reports · Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, Halle (Saale), Germany. · pubmed
Adipose tissue is continuously regenerated by stromal mesenchymal stem cells throughout life. This study hypothesises that early age-related changes in the proteome and metabolic properties of subcutaneous (s) and visceral (v) adipose tissue-derived stromal/stem cells (ASCs) from...
Ying Liu, Ting Hong, Mingxuan Lv ... · Alzheimer's research & therapy · Department of Neurology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. · pubmed
Emerging evidence suggests that senescent microglia play a role in β-amyloid (Aβ) pathology and neuroinflammation in Alzheimer's disease (AD). Targeting senescent cells with naturally derived compounds exhibiting minimal cytotoxicity represents a promising therapeutic strategy.
Antero Salminen, Kai Kaarniranta, Anu Kauppinen · Biogerontology · Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. [email protected]. · pubmed
Excessive exposure of the skin to UV radiaton (UVR) accelerates the aging process and leads to a photoaging state which involves similar pathological alterations to those occurring in chronological aging. UVR exposure, containing both UVA and UVB radiation, triggers cellular sene...
Larissa Lipskaia, Lou Delval, Valentin Sencio ... · Aging cell · Institut Mondor de Recherche Biomédicale (IMRB), FHU SENEC, Univ. Paris-Est Créteil, INSERM U955, Créteil, France. · pubmed
Influenza A virus (IAV) infection causes acute and long-term lung damage. Here, we used immunostaining, genetic, and pharmacological approaches to determine whether IAV-induced cellular senescence causes prolonged alterations in lungs. Mice infected with a sublethal dose of H1N1p...
Friday, June 20, 2025
Alberto J Espay, Andrea Sturchio, Alberto Imarisio ... · BioEssays : news and reviews in molecular, cellular and developmental biology · James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA. · pubmed
Protein aggregation is a normal response to age-related exposures. According to the thermodynamic hypothesis of protein folding, soluble proteins precipitate into amyloids (pathology) under supersaturated conditions through a process similar to crystallization. This soluble-to-in...
Miaomiao Du, Yujia Wang, Xinyuan Wang ... · Aging cell · Department of Laboratory Animal Sciences, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China. · pubmed
Aging is the greatest risk factor for learning and memory disorders; dementia prevalence significantly increases with age due to numerous molecular changes in the body. Although research has consistently shown that aging leads to learning and memory impairments, the molecular mec...
Vazquez Ramos, G. J. A. · neuroscience · Morehouse School of Medicine · biorxiv
Background: The pineal gland secretes melatonin but paradoxically calcifies more than any other intracranial structure, forming hydroxyapatite "brain-sand" (corpora arenacea) that correlates with reduced melatonin output, sleep disruption and heightened neuro-degenerative risk. W...
Juan Liu, Qingru Song, Chen Li ... · Cell proliferation · Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China. · pubmed
Aging is characterised by progressive structural and functional changes in the liver, with the extracellular matrix (ECM) playing a key role in modulating these changes. Our study presents a comprehensive proteomic analysis of the liver ECM across different age stages, uncovering...
Jing Lu, Hongyan Wang, Haiyu Zhang ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China. · pubmed
Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic inflammation. This study investiga...
Nicolas P Tessier, Lise M Hardy, Florence Mauger ... · Aging cell · Laboratory for Genomics, Foundation Jean Dausset-CEPH, Paris, France. · pubmed
Plasma circulating cell-free nucleic acids (ccfNAs) provide an exceptional source of information about an individual's health, yet their biology in healthy individuals during aging remains poorly understood. Here, we present the first integrative multiparametric analysis of the m...
Hong Guo-Parke, Oisin Cappa, Dermot A Linden ... · American journal of respiratory cell and molecular biology · Queen's University Belfast, Wellcome Wolfson Institute for Experimental Medicine, Belfast, United Kingdom of Great Britain and Northern Ireland. · pubmed
Cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). The mechanisms of senescence in the bronchial epithelium, however, remain largely unknown. This study aimed to elucidate whether cellular senescence in COPD epithelial cel...
Minsol Jeon, Da-Eun Kim, So Young Choi ... · Cell communication and signaling : CCS · Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea. · pubmed
The autophagy-lysosomal pathway is a cellular degradation mechanism that regulates protein quality by eliminating aggregates and maintaining normal protein function. It has been reported that aging itself reduces lysosomal proteolytic activity in age-related neurodegenerative dis...
Mutz, J., Gilchrist, L., Allegrini, A. G. ... · epidemiology · King\'s College London · medrxiv
Background: Individuals with mental and behavioural disorders face increased risk of age-related diseases and premature mortality. Accelerated biological ageing may contribute to this disparity. We investigated differences in metabolomic ageing between individuals with and withou...
Xianhong Zhang, Yue Gao, Siyu Zhang ... · Cell communication and signaling : CCS · State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, 010070, China. · pubmed
Aging is an irreversible physiological process that progresses with age, leading to structural disorders and dysfunctions of organs, thereby increasing the risk of chronic diseases such as neurodegenerative diseases, diabetes, hypertension, and cancer. Both organismal and cellula...
Birong Jiang, Hongwei Zhang, Qixia Xu ... · Aging cell · School of Pharmacy, Institute of Aging Medicine, Binzhou Medical University, Yantai, Shandong, China. · pubmed
Cellular senescence is an aging-related mechanism characterized by cell cycle arrest, macromolecular alterations, and a senescence-associated secretory phenotype (SASP). Recent preclinical trials established that senolytic drugs, which target survival mechanisms of senescent cell...
Chenghui Yu, Xingxing Qiu, Si Tao ... · Biogerontology · Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China. · pubmed
This study investigates the impact of dietary restriction (DR) on gene expression in hematopoietic stem cells (HSCs) derived from aged mice. RNA sequencing (RNA-seq) data were obtained from sorted HSCs, followed by weighted gene co-expression network analysis (WGCNA) to identify ...
Danai Koftori, Charandeep Kaur, Laura Mora Bitria ... · PLoS biology · Department of Infectious Disease, Imperial College London, London, United Kingdom. · pubmed
T stem cell-like memory cells (TSCM cells) are considered to be essential for the maintenance of immune memory. The TSCM population has been shown to have the key properties of a stem cell population: multipotency, self-renewal and clonal longevity. Here we show that no single po...
Brigos-Barril, E., Vasallo, C., Farre, X. ... · genetic and genomic medicine · Hospital Universitari Institut Pere Mata (HUIPM), Institut d\'Investigacio Sanitaria Pere Virgili (IISPV-CERCA), Universitat Rovira i Virgili (URV), Reus, Catal · medrxiv
The persistence of genetic variants that increase susceptibility to complex diseases poses an evolutionary paradox: despite their detrimental health effects, these variants are not eliminated by natural selection. Life-history theory proposes that trade-offs and pleiotropic effec...
Thursday, June 19, 2025
Edward R Ivimey-Cook, Zahida Sultanova, Alexei A Maklakov · Aging cell · School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK. · pubmed
Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension fro...
Cansell, C., Goepp, V., Bain, F. ... · physiology · CNRS · biorxiv
Living animals reach their end-of-life through a stereotypic set of fascinating but poorly understood processes. The discovery, first in flies and later in nematodes and zebrafish, of the "Smurf phenotype" is a central tool for picking this complex "lock of biology", that one of ...
Wuzhe Fan, Tao Zheng, Mingsong Mao ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, China. · pubmed
Traditional biomaterial design often prioritizes empirical knowledge over disease mechanisms and pathological dynamics, resulting in imprecise solutions in complex clinical conditions. Age-related osteoporosis (A-OP) is a disease associated with aging, characterized by a dysfunct...
Garrod-Ketchely, C., Callender, L. A., Schroth, J. ... · immunology · QMUL · biorxiv
Ageing is associated with significant immune changes, with unhealthy ageing characterised by chronic inflammation and immune dysregulation. Here we identify a population of CD8 TEMRA cells during unhealthy ageing, which exhibit features of premature senescence and are regulated i...
Eleanor L S Conole, Josephine A Robertson, Hannah M Smith ... · Nature reviews. Neurology · Department of Biochemistry, University of Oxford, Oxford, UK. · pubmed
Ageing has profound effects on the human brain across the lifespan. Cognitive testing and brain imaging are currently used to monitor healthy and pathological brain ageing. However, peripheral markers of cognitive function, cognitive ageing and neurological disease could provide ...
Adiv A Johnson, Maxim N Shokhirev · Aging · Tally Health, New York, NY, USA. [email protected]. · pubmed
Aging biomarkers that predict age given methylomic data are referred to as epigenetic aging clocks. While the earliest, first-generation clocks were exclusively trained to predict chronological age, more recent next-generation models have been explicitly trained to associate with...
Jieyu Wu, Victoria R Yarmey, Olivia Jiaming Yang ... · Nature neuroscience · Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. · pubmed
The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in regulating the development and function of the brain. Neuron-glia signal transduction is known to be mediated by secreted signals through ligand-receptor interac...
Lei Zhang, Kai Xiang, Jinlong Li ... · ACS nano · School of Pharmacy, Wannan Medical College, Wuhu 241002, China. · pubmed
Osteoarthritis (OA) is a classic age-related disorder, and its progression is positively associated with the number of senescent cells in the synovium of the joint. Senolytics have been used to slow or reverse the aging process, which is currently limited by off-target toxicity. ...
Yuan Liu, Shiyang He, Kawon Pyo ... · Cell Proliferation · Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA, USA. · pubmed
Cellular quiescence is a state of reversible proliferative arrest that plays essential roles in development, resistance to stress, aging, and longevity of organisms. Here we report that rapid depletion of RNase MRP, a deeply conserved RNA-based enzyme required for rRNA biosynthes...
Caihong Gu, Ting Guo, Xiaobing Chen ... · Mitochondria · Department of Critical Care Medicine, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, 222000, Jiangsu, PR China. · pubmed
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in global cerebral ischemic (GCI) brain injury remain unexplored. In current study, we aim to investigate the effects of combined senolytics Dasatinib plus Quercetin...
Karina A Cicali, Angie K Torres, Cheril Tapia-Rojas · Neural regeneration research · Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile. · pubmed
Aging is a physiological and complex process produced by accumulative age-dependent cellular damage, which significantly impacts brain regions like the hippocampus, an essential region involved in memory and learning. A crucial factor contributing to this decline is the dysfuncti...
Wednesday, June 18, 2025
Jiajin Chen, Sicheng Li, Shichen Bu ... · GeroScience · Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. [email protected]. · pubmed
Older adults with established cardiovascular diseases (CVD) are at elevated risk of heart failure (HF). Frailty, a hallmark of multi-system aging, may contribute to HF development through inflammation. However, population-based evidence remains scarce. Leveraging data from 49,530...
Payet, A., Guillou, E., Bernat-Fabre, S. ... · cell biology · RESTORE Research Center · biorxiv
Aging involves a progressive decline in physiological functions, often marked by the onset of a \"frailty point\" just before survival rates decrease rapidly. Here, we investigate how the Mediator subunit Med19 modulates this transition in Drosophila. We find that upregulating Me...
Kristian E Markon, Frank D Mann, Colin D Freilich ... · Aging · University of Minnesota, Minneapolis, Minnesota, United States of America. · pubmed
Measurement of aging is critical to understanding its causes and developing interventions, but little consensus exists on what components such measurements should include or how they perform in predicting mortality. The aim of this study was to identify factors of aging among a c...
Lukacsovich, D., Young, J., Gomez, L. ... · genetic and genomic medicine · University of Miami · medrxiv
Aging is the strongest risk factor for Alzheimer's disease (AD), yet the molecular mechanisms linking aging to AD remain poorly understood. DNA methylation (DNAm) is an epigenetic modification that plays a critical role in gene regulation and has been implicated in both aging and...
Ayala-Hernandez, M. G., Torales, A. B., Tan, H. C. ... · biochemistry · University of California Davis · biorxiv
Mutations in mitochondrial complex I can cause severe metabolic disease. Although no treatments are available for complex I deficiencies, chronic hypoxia improves lifespan and function in a mouse model of the severe mitochondrial disease Leigh syndrome caused by mutation of compl...
Rimsha Abaidullah, Shaukat Ali, Muhammad Summer ... · Cell biochemistry and biophysics · Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan. · pubmed
Aging as a complex process is marked by physiological and functional deterioration, making the individual vulnerable to age-related diseases. Different organs experience unique aging processes that lead to conditions such as cardiovascular, cancer, metabolic, and musculoskeletal ...
Hansknecht, A., Mankarious, M., Baranda, M. V. ... · cell biology · Helmholtz Institute For Biomedical Engineering, Uniklinik Aachen · biorxiv
Epigenetic regulatory mechanisms, which include histone modifications and DNA methylation, play a central role in development and aging. Dimethylation of H3K36, deposited mainly by the histone methyltransferase NSD1, occurs predominantly in intergenic regions and recruits the DNA...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan ... · Aging cell · Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, Connecticut, USA. · pubmed
The relationship between in vitro senescence cell induction and intracellular biomolecular dysregulation is still poorly understood. In this study, we have found that a range of metabolic subphenotypes exists and is dependent on the induction method that is used. To develop under...
David Furman, Johan Auwerx, Anne-Laure Bulteau ... · Nature aging · Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. [email protected]. · pubmed
Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on system...
Qianglan Lu, Chengwei Ye, Wei Mao ... · ACS nano · Department of Gastric and Hernia Surgery, Nanjing Drum Tower Hospital, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China. · pubmed
Idiopathic pulmonary fibrosis (IPF) remains an age-related, fatal, incurable, epithelial-driven fibrotic lung disease despite the availability of approved antifibrotic drugs. The medical need for effective antipulmonary fibrotic therapies is thus very high. A promising therapeuti...
Abel Anwar, Tianchen Li, Yi Shen · ACS applied materials & interfaces · School of Chemical and Biomolecular Engineering, The University of Sydney, PNR Building, Darlington, NSW 2008, Australia. · pubmed
The ability of biomolecular condensates to reversibly dissolve and reform is crucial for maintaining cellular stability and functions. In the context of cell physiology and disease, they can serve as a metastable phase mediating the liquid-to-solid transition of disease proteins ...
Lewis, C., Levis, H., Holbrook, J. ... · bioengineering · University of Utah Department of Biomedical Engineering, Salt Lake City, UT · biorxiv
Senescence has been shown to contribute to the progression of aging related diseases including degenerative disc disease (DDD). However, the mechanisms regulating senescence in the intervertebral disc (IVD) and other tissues/diseases remain poorly understood. Recently, in a CRISP...
Tuesday, June 17, 2025
Dalgarno, A., Evans, S. A., Kelsey, M. M. G. ... · genomics · Brown University · biorxiv
Cellular senescence is a stable form of cell cycle arrest that contributes to aging and age-associated diseases through the secretion of inflammatory factors collectively known as the senescence-associated secretory phenotype (SASP). While senescence is driven by transcriptional ...
Hanpei Miao, Sian Liu, Zehua Wang ... · NPJ digital medicine · The Tenth Affiliated Hospital, The First School of Clinical Medicine, Southern Medical University, Dongguan, 523059, China. · pubmed
Reproductive aging impacts women's health through fertility decline, disease susceptibility, and systemic aging. This study explores the retinal age gap-the difference between predicted retinal age and chronological age-as a novel biomarker for reproductive aging. By developing a...
McGovern, S. E., Meng, G., Marlin, M. N. ... · molecular biology · Purdue University · biorxiv
Alterations in biological rhythms are a common feature of aging, and disruption of circadian rhythms can exacerbate age-associated pathologies. The retina is critical for detecting light for both vision and for transmitting time-of-day information to the brain, synchronizing rhyt...
Bean, L. A., Thomas, C., Villa, J. F. ... · physiology · Indiana University School of Medicine · biorxiv
Muscle wasting and weakness are important clinical problems that impact quality of life and health span by restricting mobility and independence, and by increasing the risk for physical disability. The molecular basis for this has not been fully determined. Klotho expression is d...
Carrilho, B. d. S., Silva, A. D., Sant Anna, A. M. K. ... · neuroscience · D\'Or Institute for Research and Education · biorxiv
Aging is modulated by nutrient-sensing pathways that integrate metabolic and hormonal cues to regulate growth, stress resilience, and lifespan. Caloric restriction (CR), a well-established intervention, extends longevity in diverse species primarily through inhibition of the TOR ...
Marinelli, S., Rossi, C., Pieroni, L. ... · neuroscience · Consiglio Nazionale delle Ricerche · biorxiv
Biological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience, the ability to flexibly switch fuel sources and maintain energy homeostasis, rules successful recovery from ner...
Lu, R. J., Chen, S., Kim, M. ... · immunology · USC · biorxiv
Aging is a complex process characterized by a progressive decline in physiological functions driven by both biological and environmental factors, with notable differences between sexes. Immune function is strongly influenced by biological sex, affecting both innate and adaptive i...
Goldman-Pham, R., Alter, M. P., Bao, R. ... · epidemiology · Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec Canada · medrxiv
Background: Early-life growth adversity is important to later-life health, but precision assess-ment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height ("height-GaP") would associate with prospectively ascertained...
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin ... · Aging cell · Charles Perkins Centre, The University of Sydney, Sydney, Australia. · pubmed
Prediabetes, characterized by impaired fasting glucose and/or glucose tolerance, is associated with organ damage, increased mortality, and accelerated aging, even before diabetes onset. Severe short-term energy restriction while maintaining essential nutrient intake is among the ...
Li, J., Wang, T., Lu, W. ... · cell biology · University of Pennsylvania · biorxiv
Lysosomal pH is frequently elevated in age-dependent neurodegenerations like Age-related Macular Degeneration (AMD), Alzheimer\'s Disease (AD), and Parkinson\'s Disease (PD). Tools that restore lysosomal pH to an optimal acidic range could enhance enzymatic degradation and reduce...
Rathore, D. · molecular biology · Indian Institute of Sciences · biorxiv
Genomic instability is a hallmark of ageing, driven by the accumulation of DNA lesions and the decline of high-fidelity repair pathways such as homologous recombination (HR) and classical nonhomologous end joining (c-NHEJ). We hypothesised that ageing cells increasingly rely on m...
Monday, June 16, 2025
Chengchi Huang, Hong Tian, Wei Li · GeroScience · Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, 77030, USA. · pubmed
Recent studies reported that anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) alleviate choroidal neovascularization (CNV) in young but not aged animals. We recently developed a disease-targeted anti-angiogenic therapy against secretogranin III (Scg3), wh...
Marc Tatar, Wenjing Zheng, Shweta Yadav ... · PLoS genetics · Department of Ecology, Evolution and Organismal Biology, The Center for the Biology of Aging, Brown University, Providence, Rhode Island, United States of America. · pubmed
Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. Multiple mechanisms are proposed for how this altered signaling slows aging. To elaborate these causes, we recently developed a series of Drosophila insulin-like receptor (...
Zhai, T., Mazzucato, P., Ricciardi, C. ... · epidemiology · Harvard T.H. Chan School of Public Health · medrxiv
Rare genetic DNA repair deficiency syndromes can lead to immunodeficiency, neurological disorders, and cancer. In the general population, inter-individual variation in DNA repair capacity (DRC) influences susceptibility to cancer and several age-related diseases. Genome wide asso...
Chenyu Zhu, Tingting Huang, Jiaqi Fu ... · mSystems · Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China. · pubmed
Hydrogen peroxide (H
Sophie Guyonnet, Claudie Hooper, Heike A Bischoff-Ferrari ... · GeroScience · IHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France. · pubmed
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the "INStitute for Prevention" "healthy aging" and "m...
Zink, M. E., Zhen, L., McHaney, J. R. ... · neuroscience · University of Pittsburgh · biorxiv
Middle age represents a critical period of accelerated brain changes and provides a window for early detection and intervention in age-related neurological decline. Hearing loss is a key early marker of such decline and is linked to numerous comorbidities in older adults. Yet, ~1...
Xicong Tang, Hongyu Qiu · Mitochondria · Cardiovascular Translational Research Center, College of Medicine-Phoenix, University of Arizona, Phoenix, United States. · pubmed
The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
Zhihai Huang, Yulan Zhang, Peibin Zou ... · Myelin Sheath · Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA. · pubmed
Myelin is a multilamellar membrane that surrounds axons in the vertebrate nervous system. Properly functioning myelin is essential for the rapid conduction of nerve impulses, and it metabolically supports axonal integrity. Emerging evidence indicates that myelin is also involved ...
Gupta, N., Sinks, M., Hubbard, E. J. A. · cell biology · NYU Grossman School of Medicine · biorxiv
A decline in tissue renewal and repair due to changes in tissue stem cells is a hallmark of aging. Many stem cell pools are maintained by interaction with morphologically complex local niches. Using the C. elegans hermaphrodite germline stem cell system, we analyzed age-related c...
Susan F Cheng, Wan Lin Yue, Kwun Kei Ng ... · Brain · Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore. · pubmed
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. Furthermore, most brain age models are tr...
Sonam Fathima Mehak, Apoorva Bettagere Shivakumar, Feyba Jijimon ... · Aging cell · Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. · pubmed
Remembering familiar versus novel stimuli is fundamental to survival, but it is compromised in several neurodegenerative disorders where aging is a key factor. Although the components of the extracellular matrix (ECM) have been suggested to be implicated in memory maintenance, th...
Sunday, June 15, 2025
Dhanekula, A. S., Harrison, B., Pharaoh, G. ... · cell biology · University of Washington · biorxiv
This study investigated the role of mitochondrial function in aortic aging. As the aorta ages, it becomes stiffer and less compliant, increasing the risk of aneurysmal disease, hypertension, and diastolic dysfunction. Given the role of mitochondrial dysfunction in non-age related...
Jayarathne, H. S., Manchanayake, D. H., Chimienti, N. ... · neuroscience · Wayne State University · biorxiv
Aging is the strongest risk factor for cognitive decline and Alzheimer\'s disease (AD), yet the mechanisms underlying brain aging and their modulation by pharmacological interventions remain poorly defined. The hippocampus, essential for learning and memory, is particularly vulne...
De Man, R., Cai, Z., Doddaballapur, P. ... · physiology · Yale · biorxiv
The geroscience hypothesis suggests that understanding underlying ageing mechanisms will enable us to delay aging and lessen age-related disability and diseases. While hallmarks of ageing list multiple contributing factors, role of mechanics has only been recently recognized and ...
Chen, X., Wang, S., Torres, M. ... · cell biology · University of Virginia School of Medicine · biorxiv
Mitochondrial quality control is essential for maintaining cellular energy homeostasis, particularly in brown adipocytes where dynamic mitochondrial remodeling supports thermogenesis. Although the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) pathway and aut...
Saturday, June 14, 2025
Alexandru, A. C., Hormazabal, G. V., Matsui, H. ... · immunology · Buck Institute for Research on Aging · biorxiv
Aging is associated with a decline in immune function termed immunosenescence, characterized by accumulation of senescent-like immune cells and chronic inflammation, known as inflammaging. While senescence-associated {beta}-galactosidase (SA-{beta}Gal) activity is a well establis...
Liu, Z., Jia, X., Gao, W. ... · epidemiology · Zhejiang University School of Medicine · medrxiv
Proteomics enables systematic elucidation of the biological mechanisms underlying health states including frailty. Here, through a large-scale proteome-wide association study (PWAS) encompassing 2,911 plasma proteins in 50,506 UK Biobank participants, we identified 1,339 proteins...
Hyeonuk Jeon, Siyeon Lee, Yumin Kim ... · npj aging · Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea. · pubmed
Senescence is the gradual process of aging in tissues and cells, and a primary cause of aging-associated diseases. Among them, intestinal stem cells (ISCs) experience exhaustion during aging, leading to reduced regenerative capacity in the intestinal crypt, which impairs intestin...