Longevity Papers

Current Week (July 28 - July 30, 2025)
and Previous Week (July 23 - July 27, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), July 28 episode:
Wednesday, July 30, 2025
Anne Kirstine Eriksen, Kathrine Grell, Peter Fjeldstad Hendriksen ... · Scientific reports · Diet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark. [email protected]. · pubmed
Health behaviors affect life expectancy, but whether disease is present can greatly impact both the individual and society. How health behavior is reflected in the utilization of health care services is yet to be investigated to support the impact of prevention efforts. Based on ...
Raoul Orvieto, Omri Nayshool, Louisa Cohen ... · Reproductive biology and endocrinology : RB&E · Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel. [email protected]. · pubmed
Aging affects gene expression in pathways essential for energy metabolism, DNA repair, cell cycle regulation, and antioxidant defenses, directly affecting oocyte quality and viability. Single-cell RNA deep sequencing studies of aged versus young human MII oocytes revealed many di...
Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu ... · npj aging · Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan. · pubmed
Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate cancer patients at Juntendo University Hospi...
Tze Mun Loo, Xiangyu Zhou, Yoko Tanaka ... · Nature communications · Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. · pubmed
Senescent cells, characterized by irreversible cell cycle arrest and inflammatory factor secretion, promote various age-related pathologies. Senescent cells exhibit resistance to ferroptosis, a form of iron-dependent cell death; however, the underlying mechanisms remain unclear. ...
Surendra Kumar, Kangping Song, Jiekang Wang ... · Nature aging · Department of Orthopaedic Surgery, the Johns Hopkins University School of Medicine, Baltimore, MD, USA. · pubmed
The accumulation of amyloid fibrils has been identified in tissues outside the brain, yet little is understood about the formation of extracerebral amyloidosis and its impact on organ aging. Here, we demonstrate that both transgenic Alzheimer's disease (AD) mice and naturally agi...
Priyanka Mallick, Sebabrata Maity, Rupsha Mondal ... · Cell death & disease · Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, IICB TRUE Campus, CN-6, Sector 5, Kolkata, 700091, India. · pubmed
ER and mitochondrial stress are often interconnected and considered major contributors to aging as well as neurodegeneration. Coordinated induction of ER
Wei Kang, Zhiyue Wu, Xinzhi Huang ... · Nature communications · MOE Key Laboratory of Bio-Intelligent Manufacturing, State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, School of Bioengineering, Dalian University of Technology, Dalian, China. [email protected]. · pubmed
Biomolecular condensates are dynamic cellular compartments that concentrate proteins and enzymes to regulate biochemical reactions in time and space. While these condensates can enhance enzyme activity, how this function changes as condensates age remains poorly understood. Here,...
Tuesday, July 29, 2025
Trofimova, O., Böttger, L., Bors, S. ... · radiology and imaging · University of Lausanne · medrxiv
Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tuned a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The resulting ...
Andrei O Zheltukhin, Peter M Chumakov, Andrei V Budanov · Aging · Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. · pubmed
Sestrins, evolutionarily conserved stress-responsive proteins, are increasingly recognized for their potential role in lifespan regulation. This study aimed to elucidate the influence of the
Natalia Hernández-Bellido, Adrián Hernández-Vicente, Laura García-Mendívil ... · GeroScience · Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza, Zaragoza, Spain. [email protected]. · pubmed
The need to monitor the aging process as a risk factor for disease and mortality beyond chronological age (CA) has led to numerous investigations into the estimation of the biological age (BA) of individuals. However, the accuracy of BA estimation tools is often judged by their a...
Guillermo Luxán, Timm Winkelmeier, Colin Bodemer ... · Cardiovascular research · Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany. · pubmed
Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function. Here, we have combined single-nucleus-RNA-sequencing, imaging, and molecular an...
Mina Yamane, Hiroki Umeda, Moe Toyobe ... · Journal of the American Chemical Society · Graduate School of Pharmaceutical Sciences, Synthetic Organic Chemistry Lab, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. · pubmed
The escalating global trend of aging populations has brought attention to the rising prevalence of late-onset amyloid disorders. Among them, amyloid transthyretin (ATTR) amyloidosis presents a growing area of unmet medical needs. While current treatment modalities have demonstrat...
Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim ... · Aging · Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea. · pubmed
Aging is associated with a decline in liver function, which increases the risk of age-related metabolic disorders. Calorie restriction (CR) counteracts age-related changes in the liver; however, the underlying molecular mechanism remains elusive. In this study, we integrated tran...
Spyropoulos, D., Ziemens, D., Curley, G. A. ... · neuroscience · Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Luebeck, Luebeck, Germany · biorxiv
Cognitive impairment is a major medical problem in the aging population. The risk of developing cognitive impairment is higher in several systemic conditions like hypertension, diabetes, and obesity. While a vascular contribution to cognitive impairment in these pathologies is we...
David G Le Couteur, Meng C Ngu, Nicholas J Hunt ... · Nature reviews. Gastroenterology & hepatology · ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia. [email protected]. · pubmed
As the global population ages, research on the biology of ageing and its role in chronic disease is expanding, alongside a growing clinical focus on the unique needs of older adults. In the past, the liver was not thought to undergo substantial age-related changes, nor was there ...
Asa Farahani, Zhen-Qi Liu, Eric G Ceballos ... · PLoS biology · Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. · pubmed
Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood perfusion maps onto micro-, meso- and macro-scale brain structure and function is therefore a key question in neuroscience. Here we analyze pseudo...
Hunter L Porter, Victor A Ansere, Ram Babu Undi ... · GeroScience · Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104-5005, USA. · pubmed
DNA methylation data has been used to make "epigenetic clocks" which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methyla...
Kai Wang, Mailin Gan, Yuhang Lei ... · Cellular & molecular biology letters · Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China. · pubmed
As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases is increasing. With advancing age, skeletal muscle undergoes progressive oxidative stress infiltration, coupled with detrimental factors such as impaired prote...
Sixu Zhang, Sixian Zhang, Wenwen Fan ... · Journal of materials chemistry. B · Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China. [email protected]. · pubmed
Senile osteoporosis (SOP) features reduced bone density and degraded trabecular structure, primarily mediated through senescent impairment of osteoblasts that disrupts coupled bone remodeling homeostasis. This pathological process induces systemic bone resorption and localized bo...
John D Elsworth, Albert Neutzner, Julien Roux ... · Aging cell · Virscio Inc, New Haven, Connecticut, USA. · pubmed
Strategies to slow the aging process or mitigate its consequences on health rely on the validation of minimally-invasive biomarkers of aging that can be used to track aging and test the effectiveness of antiaging interventions. Study of aging in a nonhuman primate species offers ...
Peiyong Zhai, Eun-Ah Sung, Koichiro Takayama ... · Cardiovascular research · Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103. · pubmed
We have previously shown that prevention of GSK-3β inactivation with GSK-3β (S9A), stimulates autophagy through phosphorylation of Ulk1 at Ser913. In the current study, we investigated whether cardiac aging is accelerated in Ulk1S913A knock in mice and whether cardiomyocyte senes...
M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad ... · Nature communications · Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA. · pubmed
Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining ...
Mariah F Calubag, Ismail Ademi, Isaac D Grunow ... · Aging cell · Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. · pubmed
Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels of the branched-chain amino acids (BCAAs) recapitulates many of the benefits of a low protein diet; BCAA-restricted diets extend lifespan, reduce frailty, and improve met...
Monday, July 28, 2025
Havas, A., Rajesh, A., Lei, X. ... · cell biology · Sanford Burnham Prebys Medical Discovery Institute · biorxiv
Aging is associated with increased susceptibility to metabolic stress and chronic liver disease, yet the interactions between age and metabolic stressors and the potential for ameliorating interventions remain incompletely understood. Here, we examined the hepatic response of you...
Abigail Morales-Sánchez, Marieke Lavaert, Melanie S Vacchio ... · PLoS biology · National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. · pubmed
Age-related thymic involution leads to diminished output of naïve T-cells. While this process is suggested to increase the risk of disease severity in the elderly following infection, direct evidence is lacking. We developed two mouse models that allow us to experimentally preven...
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. · pubmed
The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major ...
Gote-Schniering, J., Melo-Narvaez, M. C., Boosarpu, G. ... · cell biology · Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC) with CPC-M bioArchive, Member of the German Center for Lung · biorxiv
Aging impairs the regenerative capacity of mammalian organs and is a major risk factor for organ fibrosis. The causalities for persistent fibrosis after lung injury in old individuals have been unclear. We used longitudinal single-cell RNA-seq after lung injury and dissected agin...
Sunday, July 27, 2025
Gaal, Z. A., Kojouharova, P., Nagy, B. ... · neuroscience · Department of Psychology, University of Calgary, Calgary, Alberta, Canada · biorxiv
Given the well-established structural and functional changes in the aging brain, it is widely assumed that cognitive aging is primarily driven by robust group-level differences between young and older adults. However, our individual-level EEG functional connectivity analysis chal...
Saturday, July 26, 2025
Rees-Baylis, E., Wang, D., Li Richter, X.-Y. ... · evolutionary biology · Institute of Ecology and Evolution, University of Bern, Bern, Switzerland · biorxiv
Sex differences in ageing and lifespan are widespread across taxa, yet their evolutionary causes remain debated. A leading hypothesis suggests these differences are adaptive and driven by sex-specific life-history trade-offs, but formal theoretical support is lacking. To address ...
Ong, R. C. S., Tang, A. · neuroscience · University of Western Australia · biorxiv
Repetitive transcranial magnetic stimulation (rTMS) is an attractive tool to promote healthy brain ageing in older adults and treat age-related neurological conditions. Despite its popularity, the neurological processes and plasticity mechanisms altered by rTMS in the aged brain,...
Ravindran, S., Corripio-Miyar, Y., Pick, J. L. ... · ecology · Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK · biorxiv
The hormone insulin-like growth factor 1 (IGF-1) is a key player in the insulin/IGF-1 signaling (IIS) pathway. Extensive biogerontological research demonstrates that this evolutionarily conserved nutrient-sensing pathway plays a causal role in the regulation of growth, reproducti...
Babygirija, R., Green, C. L., Sonsalla, M. M. ... · physiology · University of Wisconsin-Madison · biorxiv
Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumption of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and va...
Victoria-Chavez, R., Lamas, M. · molecular biology · Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional · biorxiv
The regenerative response of retinal cells to injury and aging depends on the epigenomic plasticity that enables the dedifferentiation and neuronal differentiation capacities of Muller glial cells (MG). In mammals, this regenerative ability is extremely limited, and disruptions i...
Friday, July 25, 2025
Jie Li, Qiyang Chen, Fuliang Xiao ... · Food science & nutrition · Chongqing Academy of Agricultural Sciences Chongqing China. · pubmed
Although tea polyphenols have antiaging potential, the molecular interplay between black tea components and cellular longevity remains unclear. This study has pioneered a dual approach combining
Yingqi Xu, Maohao Li, Congxue Hu ... · Genome medicine · College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. · pubmed
The decline in organ function due to aging significantly impacts the health and quality of life of the elderly. Assessing and delaying aging has become a major societal concern. Previous studies have largely focused on differences between young and old individuals, often overlook...
Junjie Cao, Xuan Wang, Keyi Huang ... · IEEE journal of biomedical and health informatics · Not available · pubmed
As the aging population continues to grow, falls among older adults have become a significant public health concern worldwide. Data-driven approaches for effective fall risk prediction, which integrate standard functional tests with 3D skeleton data from depth sensors, are gainin...
Zhaoqi Yan, Yifeng Xu, Ting Peng ... · Biogerontology · Department of Rehabilitation Medicine, The Third Hospital of Nanchang, Nanchang People's Hospital, 240 Zhanqian West Road, Xihu District, Nanchang City, 330009, Jiangxi Province, China. · pubmed
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA methylation age (Horvathage) ...
Hyejin Mun, Chang Hoon Shin, Mercy Kim ... · Aging · Department of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA. · pubmed
Signaling pathways and transcriptional regulation during cellular senescence have been investigated; however, energy metabolism is one of the understudied areas. Senescent cells secrete pro-inflammatory cytokines and release proteins and RNAs via exosomes that contribute to organ...
Yangxin Yu, Xinhang Lv, Zhuowei Chen ... · Journal of medicinal chemistry · Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, P. R. China. · pubmed
Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies. Recently, emerging evidence has revealed pathological accumulation of senescent c...
Emma M Tinney, Aaron E L Warren, Amanda O'Brien ... · Alzheimer's & dementia (New York, N. Y.) · Department of Psychology Northeastern University Boston Massachusetts USA. · pubmed
Age-related cognitive decline occurs, in part, due to diminishing white matter integrity. Higher cardiorespiratory fitness (CRF) is associated with better cognitive performance, but the neurobiological mechanisms underlying this association remain uncertain. Previous magnetic res...
Thursday, July 24, 2025
Yanjun Li, Qi Huang, Jin Jiang ... · Nature medicine · Vanke School of Public Health, Tsinghua University, Beijing, China. · pubmed
Accurate and convenient assessment of individual aging is crucial for identifying health risks and preventing aging-related diseases. Nonetheless, current aging proxies often face challenges such as methodological limitations, weak associations with adverse outcomes and limited g...
Jacques, M., Seale, K., Voisin, S. ... · bioinformatics · Monash University · biorxiv
Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserved and tissue-specific aging signatures. ...
Ruonan Liu, Zheng Zhu, Yuanyue Zhu ... · GeroScience · Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Geriatric Medical Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. · pubmed
Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected processes of lifespan extension and aging remains poorly understood. This study employed genetic approaches to identify GM taxa exerting causal effects on longevity...
Zhuoyan Lyu, Anatoly B Kolomeisky · The journal of physical chemistry letters · Department of Chemistry, Rice University, Houston, Texas 77005, United States. · pubmed
Although understanding the biology of ovarian aging and the timing of menopause is critical for supporting women's reproductive health, many aspects of these processes remain unclear. Stimulated by observations of transitions between different stages of functional units of ovaria...
Zachary Miller, Laura-Marie Twardowski, Brenda F Reader ... · Lung · Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, Davis Heart Lung Research Institute, The Ohio State University, Columbus, OH, USA. · pubmed
Ageing significantly impacts lung function and increases susceptibility to chronic lung diseases. The lung is a complex organ with multiple cell types that undergo cellular age-related perturbations or hallmarks. As knowledge of ageing mechanisms has progressed, we have a better ...
Alper Cevirgel, Marieke van der Heiden, Sudarshan A Shetty ... · Aging cell · Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. · pubmed
Immune aging is associated with decreased vaccine responses, but biomarkers for vaccine responsiveness remain unidentified. We analyzed immunotypes describing pre-vaccination immune cell profiles and their associations with triple vaccine responsiveness to influenza, pneumococcal...
Lenart, P., Psalmon, S., Towbin, B. D. · evolutionary biology · University of Bern · biorxiv
For most animals, intrinsic senescence-induced mortality increases with age, while deaths from extrinsic threats, such as predation or accidents, decline during development as individuals grow and mature. Age-dependent modulation of extrinsic mortality is known to influence the e...
Wednesday, July 23, 2025
Okamura, Y. T., Wang, T.-W., Kawakami, S. ... · cell biology · The Institute of Medical Science, The University of Tokyo · biorxiv
A plethora of senolytic compounds and technologies have been identified. However, the efficacy of these treatments in eliminating senescent cells and the suppression of chronic inflammation remains to be substantiated in vivo. Here, we employ single-cell RNA sequencing and find t...
Pouneh K Fazeli, Matthew L Steinhauser · Endocrine reviews · Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. · pubmed
The adaptive starvation response allows us to survive periods of starvation - a characteristic of the environment in which humans evolved. We are now in an evolutionary transition from a global environment which was characterized by periods of famine to a world where obesity and ...
Hongyu Lin, Kazunori Sasaki, Farhana Ferdousi ... · GeroScience · Tsukuba Life Science Innovation (T-LSI) Program, University of Tsukuba, 305-8577, Tsukuba, Japan. · pubmed
This study is the first to investigate the anti-aging effects of the newly synthesized compound, 3,4,5-tri-feruloylquinic acid (TFQA), in vivo using the senescence-accelerated mouse prone 8 (SAMP8) model, through integrated whole-transcriptomic and biochemical analyses. Oral admi...
Peizhong Qin, Qi Wang, You Wu ... · Aging · Department of Medical Genetics, School of Basic Medicine, Institute for Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · pubmed
Improving gut health by altering the activity of intestinal stem cells is thought to have the potential to reverse aging. The aged Drosophila midgut undergoes hyperplasia and barrier dysfunction. However, it is still unclear how to limit hyperplasia to extend lifespan. Here, we s...
Chuanle Wang, Wei Chen, Ruofei Li ... · Cell & bioscience · MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangzhou Key Laboratory of Healthy Aging Research, School of Lifesciences, Sun Yat-Sen University, Guangzhou, 510275, China. · pubmed
Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 85% of tumor cells, telomerase formed by TERT and TERC RNA complex is re...
Zihan Zhou, Zhenhua Zhou, Chunying Ye ... · Molecular human reproduction · Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. · pubmed
Thin endometrium (TE) is generally recognized as a contributing factor to reduced pregnancy rates and adverse perinatal outcomes, yet the pathogenesis of the disease remains elusive. We conducted an analysis and validation of the single-cell RNA sequencing (scRNA-seq) data pertai...
Qiaofeng Ye, Aaliya Ahamed, Idan Shalev ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA. · pubmed
Evolutionary theories of aging indicate trade-offs between reproduction and longevity. Epigenetic clocks, such as PhenoAge, GrimAge, and DunedinPoAm, were designed to reflect biological age and be used as surrogates for mortality and healthspan. The current study investigated the...
Maggie E Zink, Leslie Zhen, Jacie R McHaney ... · Noise · Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, United States. · pubmed
Middle age represents a critical period of accelerated brain changes and provides a window for early detection and intervention in age-related neurological decline. Hearing loss is a key early marker of such decline and is linked to numerous comorbidities in older adults. Yet, ~1...
Farnaz Karimani, Mehdi Eivani, Afsaneh Asgari Taei ... · Melatonin · Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. · pubmed
Aging is commonly associated with cognitive decline, particularly in memory, and is linked to neuronal hyperexcitability and disrupted sleep-related oscillations in key brain regions such as the hippocampus and prefrontal cortex. Melatonin has been proposed as a potential therape...
Jing Wang, Xiang Ren, Huan Lu ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei, 430030, China. · pubmed
Aging increases the vulnerability of kidneys to injury and impairs their regenerative capacity. SIRT3 expression declines with aging and is associated with multiple age-related pathologies. The expression profile and functional role of SIRT3 in renal aging remain unclear. Here, S...
Bradley A Ruple, Nicholas A Carlini, Jason S Kofoed ... · American journal of physiology. Endocrinology and metabolism · Geriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah. · pubmed
Aging is associated with alterations in immune cell function, contributing to age-related diseases and frailty. As peripheral blood mononuclear cells (PBMCs) are key drivers of the immune response, we investigated their transcriptome using RNA-sequencing before and immediately af...
Tyler D Robinson, Yutong L Sun, Paul T H Chang ... · GeroScience · Rotman Research Institute, 3560 Bathurst Street Baycrest, Toronto, Ontario, M6A 2E1, Canada. [email protected]. · pubmed
One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, ...