Longevity Papers

Current Week (June 16 - June 19, 2025)
and Previous Week (June 12 - June 15, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 13 episode:
Thursday, June 19, 2025
Edward R Ivimey-Cook, Zahida Sultanova, Alexei A Maklakov · Aging cell · School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK. · pubmed
Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension fro...
Eleanor L S Conole, Josephine A Robertson, Hannah M Smith ... · Nature reviews. Neurology · Department of Biochemistry, University of Oxford, Oxford, UK. · pubmed
Ageing has profound effects on the human brain across the lifespan. Cognitive testing and brain imaging are currently used to monitor healthy and pathological brain ageing. However, peripheral markers of cognitive function, cognitive ageing and neurological disease could provide ...
Adiv A Johnson, Maxim N Shokhirev · Aging · Tally Health, New York, NY, USA. [email protected]. · pubmed
Aging biomarkers that predict age given methylomic data are referred to as epigenetic aging clocks. While the earliest, first-generation clocks were exclusively trained to predict chronological age, more recent next-generation models have been explicitly trained to associate with...
Jieyu Wu, Victoria R Yarmey, Olivia Jiaming Yang ... · Nature neuroscience · Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. · pubmed
The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in regulating the development and function of the brain. Neuron-glia signal transduction is known to be mediated by secreted signals through ligand-receptor interac...
Yuan Liu, Shiyang He, Kawon Pyo ... · Cell Proliferation · Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA, USA. · pubmed
Cellular quiescence is a state of reversible proliferative arrest that plays essential roles in development, resistance to stress, aging, and longevity of organisms. Here we report that rapid depletion of RNase MRP, a deeply conserved RNA-based enzyme required for rRNA biosynthes...
Caihong Gu, Ting Guo, Xiaobing Chen ... · Mitochondria · Department of Critical Care Medicine, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, 222000, Jiangsu, PR China. · pubmed
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in global cerebral ischemic (GCI) brain injury remain unexplored. In current study, we aim to investigate the effects of combined senolytics Dasatinib plus Quercetin...
Wednesday, June 18, 2025
Jiajin Chen, Sicheng Li, Shichen Bu ... · GeroScience · Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. [email protected]. · pubmed
Older adults with established cardiovascular diseases (CVD) are at elevated risk of heart failure (HF). Frailty, a hallmark of multi-system aging, may contribute to HF development through inflammation. However, population-based evidence remains scarce. Leveraging data from 49,530...
Payet, A., Guillou, E., Bernat-Fabre, S. ... · cell biology · RESTORE Research Center · biorxiv
Aging involves a progressive decline in physiological functions, often marked by the onset of a \"frailty point\" just before survival rates decrease rapidly. Here, we investigate how the Mediator subunit Med19 modulates this transition in Drosophila. We find that upregulating Me...
Kristian E Markon, Frank D Mann, Colin D Freilich ... · Aging · University of Minnesota, Minneapolis, Minnesota, United States of America. · pubmed
Measurement of aging is critical to understanding its causes and developing interventions, but little consensus exists on what components such measurements should include or how they perform in predicting mortality. The aim of this study was to identify factors of aging among a c...
Lukacsovich, D., Young, J., Gomez, L. ... · genetic and genomic medicine · University of Miami · medrxiv
Aging is the strongest risk factor for Alzheimer's disease (AD), yet the molecular mechanisms linking aging to AD remain poorly understood. DNA methylation (DNAm) is an epigenetic modification that plays a critical role in gene regulation and has been implicated in both aging and...
Ayala-Hernandez, M. G., Torales, A. B., Tan, H. C. ... · biochemistry · University of California Davis · biorxiv
Mutations in mitochondrial complex I can cause severe metabolic disease. Although no treatments are available for complex I deficiencies, chronic hypoxia improves lifespan and function in a mouse model of the severe mitochondrial disease Leigh syndrome caused by mutation of compl...
Rimsha Abaidullah, Shaukat Ali, Muhammad Summer ... · Cell biochemistry and biophysics · Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan. · pubmed
Aging as a complex process is marked by physiological and functional deterioration, making the individual vulnerable to age-related diseases. Different organs experience unique aging processes that lead to conditions such as cardiovascular, cancer, metabolic, and musculoskeletal ...
Hansknecht, A., Mankarious, M., Baranda, M. V. ... · cell biology · Helmholtz Institute For Biomedical Engineering, Uniklinik Aachen · biorxiv
Epigenetic regulatory mechanisms, which include histone modifications and DNA methylation, play a central role in development and aging. Dimethylation of H3K36, deposited mainly by the histone methyltransferase NSD1, occurs predominantly in intergenic regions and recruits the DNA...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan ... · Aging cell · Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, Connecticut, USA. · pubmed
The relationship between in vitro senescence cell induction and intracellular biomolecular dysregulation is still poorly understood. In this study, we have found that a range of metabolic subphenotypes exists and is dependent on the induction method that is used. To develop under...
David Furman, Johan Auwerx, Anne-Laure Bulteau ... · Nature aging · Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. [email protected]. · pubmed
Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on system...
Qianglan Lu, Chengwei Ye, Wei Mao ... · ACS nano · Department of Gastric and Hernia Surgery, Nanjing Drum Tower Hospital, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China. · pubmed
Idiopathic pulmonary fibrosis (IPF) remains an age-related, fatal, incurable, epithelial-driven fibrotic lung disease despite the availability of approved antifibrotic drugs. The medical need for effective antipulmonary fibrotic therapies is thus very high. A promising therapeuti...
Abel Anwar, Tianchen Li, Yi Shen · ACS applied materials & interfaces · School of Chemical and Biomolecular Engineering, The University of Sydney, PNR Building, Darlington, NSW 2008, Australia. · pubmed
The ability of biomolecular condensates to reversibly dissolve and reform is crucial for maintaining cellular stability and functions. In the context of cell physiology and disease, they can serve as a metastable phase mediating the liquid-to-solid transition of disease proteins ...
Lewis, C., Levis, H., Holbrook, J. ... · bioengineering · University of Utah Department of Biomedical Engineering, Salt Lake City, UT · biorxiv
Senescence has been shown to contribute to the progression of aging related diseases including degenerative disc disease (DDD). However, the mechanisms regulating senescence in the intervertebral disc (IVD) and other tissues/diseases remain poorly understood. Recently, in a CRISP...
Tuesday, June 17, 2025
Dalgarno, A., Evans, S. A., Kelsey, M. M. G. ... · genomics · Brown University · biorxiv
Cellular senescence is a stable form of cell cycle arrest that contributes to aging and age-associated diseases through the secretion of inflammatory factors collectively known as the senescence-associated secretory phenotype (SASP). While senescence is driven by transcriptional ...
Hanpei Miao, Sian Liu, Zehua Wang ... · NPJ digital medicine · The Tenth Affiliated Hospital, The First School of Clinical Medicine, Southern Medical University, Dongguan, 523059, China. · pubmed
Reproductive aging impacts women's health through fertility decline, disease susceptibility, and systemic aging. This study explores the retinal age gap-the difference between predicted retinal age and chronological age-as a novel biomarker for reproductive aging. By developing a...
McGovern, S. E., Meng, G., Marlin, M. N. ... · molecular biology · Purdue University · biorxiv
Alterations in biological rhythms are a common feature of aging, and disruption of circadian rhythms can exacerbate age-associated pathologies. The retina is critical for detecting light for both vision and for transmitting time-of-day information to the brain, synchronizing rhyt...
Bean, L. A., Thomas, C., Villa, J. F. ... · physiology · Indiana University School of Medicine · biorxiv
Muscle wasting and weakness are important clinical problems that impact quality of life and health span by restricting mobility and independence, and by increasing the risk for physical disability. The molecular basis for this has not been fully determined. Klotho expression is d...
Carrilho, B. d. S., Silva, A. D., Sant Anna, A. M. K. ... · neuroscience · D\'Or Institute for Research and Education · biorxiv
Aging is modulated by nutrient-sensing pathways that integrate metabolic and hormonal cues to regulate growth, stress resilience, and lifespan. Caloric restriction (CR), a well-established intervention, extends longevity in diverse species primarily through inhibition of the TOR ...
Marinelli, S., Rossi, C., Pieroni, L. ... · neuroscience · Consiglio Nazionale delle Ricerche · biorxiv
Biological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience, the ability to flexibly switch fuel sources and maintain energy homeostasis, rules successful recovery from ner...
Lu, R. J., Chen, S., Kim, M. ... · immunology · USC · biorxiv
Aging is a complex process characterized by a progressive decline in physiological functions driven by both biological and environmental factors, with notable differences between sexes. Immune function is strongly influenced by biological sex, affecting both innate and adaptive i...
Goldman-Pham, R., Alter, M. P., Bao, R. ... · epidemiology · Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec Canada · medrxiv
Background: Early-life growth adversity is important to later-life health, but precision assess-ment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height ("height-GaP") would associate with prospectively ascertained...
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin ... · Aging cell · Charles Perkins Centre, The University of Sydney, Sydney, Australia. · pubmed
Prediabetes, characterized by impaired fasting glucose and/or glucose tolerance, is associated with organ damage, increased mortality, and accelerated aging, even before diabetes onset. Severe short-term energy restriction while maintaining essential nutrient intake is among the ...
Li, J., Wang, T., Lu, W. ... · cell biology · University of Pennsylvania · biorxiv
Lysosomal pH is frequently elevated in age-dependent neurodegenerations like Age-related Macular Degeneration (AMD), Alzheimer\'s Disease (AD), and Parkinson\'s Disease (PD). Tools that restore lysosomal pH to an optimal acidic range could enhance enzymatic degradation and reduce...
Rathore, D. · molecular biology · Indian Institute of Sciences · biorxiv
Genomic instability is a hallmark of ageing, driven by the accumulation of DNA lesions and the decline of high-fidelity repair pathways such as homologous recombination (HR) and classical nonhomologous end joining (c-NHEJ). We hypothesised that ageing cells increasingly rely on m...
Monday, June 16, 2025
Chengchi Huang, Hong Tian, Wei Li · GeroScience · Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, 77030, USA. · pubmed
Recent studies reported that anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) alleviate choroidal neovascularization (CNV) in young but not aged animals. We recently developed a disease-targeted anti-angiogenic therapy against secretogranin III (Scg3), wh...
Marc Tatar, Wenjing Zheng, Shweta Yadav ... · PLoS genetics · Department of Ecology, Evolution and Organismal Biology, The Center for the Biology of Aging, Brown University, Providence, Rhode Island, United States of America. · pubmed
Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. Multiple mechanisms are proposed for how this altered signaling slows aging. To elaborate these causes, we recently developed a series of Drosophila insulin-like receptor (...
Zhai, T., Mazzucato, P., Ricciardi, C. ... · epidemiology · Harvard T.H. Chan School of Public Health · medrxiv
Rare genetic DNA repair deficiency syndromes can lead to immunodeficiency, neurological disorders, and cancer. In the general population, inter-individual variation in DNA repair capacity (DRC) influences susceptibility to cancer and several age-related diseases. Genome wide asso...
Chenyu Zhu, Tingting Huang, Jiaqi Fu ... · mSystems · Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China. · pubmed
Hydrogen peroxide (H
Sophie Guyonnet, Claudie Hooper, Heike A Bischoff-Ferrari ... · GeroScience · IHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France. · pubmed
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the "INStitute for Prevention" "healthy aging" and "m...
Zink, M. E., Zhen, L., McHaney, J. R. ... · neuroscience · University of Pittsburgh · biorxiv
Middle age represents a critical period of accelerated brain changes and provides a window for early detection and intervention in age-related neurological decline. Hearing loss is a key early marker of such decline and is linked to numerous comorbidities in older adults. Yet, ~1...
Xicong Tang, Hongyu Qiu · Mitochondria · Cardiovascular Translational Research Center, College of Medicine-Phoenix, University of Arizona, Phoenix, United States. · pubmed
The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
Zhihai Huang, Yulan Zhang, Peibin Zou ... · Myelin Sheath · Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA. · pubmed
Myelin is a multilamellar membrane that surrounds axons in the vertebrate nervous system. Properly functioning myelin is essential for the rapid conduction of nerve impulses, and it metabolically supports axonal integrity. Emerging evidence indicates that myelin is also involved ...
Gupta, N., Sinks, M., Hubbard, E. J. A. · cell biology · NYU Grossman School of Medicine · biorxiv
A decline in tissue renewal and repair due to changes in tissue stem cells is a hallmark of aging. Many stem cell pools are maintained by interaction with morphologically complex local niches. Using the C. elegans hermaphrodite germline stem cell system, we analyzed age-related c...
Susan F Cheng, Wan Lin Yue, Kwun Kei Ng ... · Brain · Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore. · pubmed
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. Furthermore, most brain age models are tr...
Sonam Fathima Mehak, Apoorva Bettagere Shivakumar, Feyba Jijimon ... · Aging cell · Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. · pubmed
Remembering familiar versus novel stimuli is fundamental to survival, but it is compromised in several neurodegenerative disorders where aging is a key factor. Although the components of the extracellular matrix (ECM) have been suggested to be implicated in memory maintenance, th...
Sunday, June 15, 2025
Dhanekula, A. S., Harrison, B., Pharaoh, G. ... · cell biology · University of Washington · biorxiv
This study investigated the role of mitochondrial function in aortic aging. As the aorta ages, it becomes stiffer and less compliant, increasing the risk of aneurysmal disease, hypertension, and diastolic dysfunction. Given the role of mitochondrial dysfunction in non-age related...
Jayarathne, H. S., Manchanayake, D. H., Chimienti, N. ... · neuroscience · Wayne State University · biorxiv
Aging is the strongest risk factor for cognitive decline and Alzheimer\'s disease (AD), yet the mechanisms underlying brain aging and their modulation by pharmacological interventions remain poorly defined. The hippocampus, essential for learning and memory, is particularly vulne...
De Man, R., Cai, Z., Doddaballapur, P. ... · physiology · Yale · biorxiv
The geroscience hypothesis suggests that understanding underlying ageing mechanisms will enable us to delay aging and lessen age-related disability and diseases. While hallmarks of ageing list multiple contributing factors, role of mechanics has only been recently recognized and ...
Chen, X., Wang, S., Torres, M. ... · cell biology · University of Virginia School of Medicine · biorxiv
Mitochondrial quality control is essential for maintaining cellular energy homeostasis, particularly in brown adipocytes where dynamic mitochondrial remodeling supports thermogenesis. Although the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) pathway and aut...
Saturday, June 14, 2025
Alexandru, A. C., Hormazabal, G. V., Matsui, H. ... · immunology · Buck Institute for Research on Aging · biorxiv
Aging is associated with a decline in immune function termed immunosenescence, characterized by accumulation of senescent-like immune cells and chronic inflammation, known as inflammaging. While senescence-associated {beta}-galactosidase (SA-{beta}Gal) activity is a well establis...
Liu, Z., Jia, X., Gao, W. ... · epidemiology · Zhejiang University School of Medicine · medrxiv
Proteomics enables systematic elucidation of the biological mechanisms underlying health states including frailty. Here, through a large-scale proteome-wide association study (PWAS) encompassing 2,911 plasma proteins in 50,506 UK Biobank participants, we identified 1,339 proteins...
Hyeonuk Jeon, Siyeon Lee, Yumin Kim ... · npj aging · Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea. · pubmed
Senescence is the gradual process of aging in tissues and cells, and a primary cause of aging-associated diseases. Among them, intestinal stem cells (ISCs) experience exhaustion during aging, leading to reduced regenerative capacity in the intestinal crypt, which impairs intestin...
Friday, June 13, 2025
Takahisa Anada, Michiharu Kawahara, Taisei Shimada ... · Journal of the American Chemical Society · Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. · pubmed
Mitochondrial dysfunction caused by aging leads to decreased energy metabolism, resulting in functional decline and increased frailty in multiple tissues. Strategies for protecting and activating mitochondria under stressful conditions are required to suppress aging and age-relat...
Jianda Kong, Yingao Xie, Rao Fan ... · Aging · College of Basic Medicine, Qilu Medical University, Zibo, China. · pubmed
Aging is a systemic process marked by progressive multi-organ dysfunction, metabolic dysregulation, and chronic low-grade inflammation ("inflammaging"), which collectively drive neurodegenerative diseases such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). Emerging evi...
Arturo Bujarrabal-Dueso, George A Garinis, Paul D Robbins ... · Nature reviews. Drug discovery · Institute for Genome Stability in Aging and Disease, University and University Hospital of Cologne, Cologne, Germany. · pubmed
Ageing is the most important risk factor for many common human diseases, including cancer, diabetes, neurodegeneration and cardiovascular disease. Consequently, combating ageing itself has emerged as a rational strategy for addressing age-related multimorbidity. Over the past thr...
Limor Zwi-Dantsis, Vignesh Jayarajan, George M Church ... · Advanced healthcare materials · Department of Mechanical Engineering, Roberts Building, University College London, London, WC1E 6BT, United Kingdom. · pubmed
Aging is a complex process and the main risk factor for many common human diseases. Traditional aging research using short-lived animal models and two-dimensional cell cultures has led to key discoveries, but their relevance to human aging remains debatable. Microfluidics, a rapi...
Zhangrong Cheng, Haiyang Gao, Pengzhi Shi ... · Intervertebral Disc Degeneration · Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. · pubmed
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been associated with inflammat...
Xichi Ma, Yun Ma, Xilin Ma ... · Food science & nutrition · Bayi Orthopaedic Hospital Chengdu China. · pubmed
Osteoporosis, characterized by reduced bone mineral density (BMD) and impaired bone microarchitecture, imposes a significant global health and economic burden, particularly on postmenopausal women. This study investigated the efficacy of a novel supplement that combines pilose an...
Avery Rui Sun, Md Faris H Ramli, Xingyu Shen ... · Nature materials · Mechanobiology Institute (MBI), National University of Singapore, Singapore, Singapore. · pubmed
Extracellular matrix remodelling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodelling is multifaceted including changes to the biochemical composition, architecture and mechanics, clouding our understanding of how and whic...
Kate M Van Pelt, Matthias C Truttmann · PLoS genetics · Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, United States of America. · pubmed
Targeted regulation of cellular proteostasis machinery represents a promising strategy for the attenuation of pathological protein aggregation. Recent work suggests that the unfolded protein response in the endoplasmic reticulum (UPRER) directly regulates the aggregation and toxi...
Ruomeng Qiu, Wei Ji, Zaida Álvarez ... · Journal of the American Chemical Society · Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States. · pubmed
The regeneration of human tissues is a great scientific challenge and a critical factor to achieve a long healthspan and prevent disabilities due to injury or disease. Materials chemistry can contribute to this goal with the development of bioactive supramolecular systems that ca...
Junbiao Tu · Molecular neurobiology · Physical Education College of Luoyang Normal University, Henan Province, Luoyang, 471934, China. [email protected]. · pubmed
Age-related central nervous system (CNS) disorders, including neurodegenerative diseases, represent a growing global health burden. Mitochondrial dysfunction is a recognized hallmark in the pathogenesis of these conditions, emphasizing the critical importance of maintaining neuro...
Xin Sun, Xiang Xu, Xue Zhao ... · ACS nano · Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China. · pubmed
Age-related bone defects cause disability and mortality in older individuals. During bone repair in older individuals, high oxidative stress and excessive inflammation in the senescent microenvironment (SME) lead to bone marrow mesenchymal stem cell (BMSC) senescence, thereby aff...
Thursday, June 12, 2025
Behnam Sabayan, Bernadette Boden-Albala, Natalia S Rost · Neurologists · Hennepin Healthcare Research Institute, Department of Neurology, Hennepin County Medical Center, Minneapolis, MN. · pubmed
The global burden of neurologic disorders is rising, driven by aging populations and improved survival following acute neurologic events. As a result, more individuals are living with long-term disabilities from conditions such as stroke, dementia, and other neurodegenerative dis...
Kalailingam, P., Ngan, S. C., Gallart-Palau, X. ... · pharmacology and toxicology · NTU · biorxiv
Background: Degenerative protein modifications (DPMs) accumulate with aging and can alter biomolecule structure and function, including via spontaneous conversion of Asn-Gly-Arg (NGR) to isoAsp-Gly-Arg (isoDGR) motifs that can bind integrins and drive chronic inflammation. Since ...
Anglas, U., Tamez Gonzalez, A. A., Promi, M. M. ... · genetics · McGill University · biorxiv
The reactive oxygen species superoxide is generated by mitochondria during the process of producing energy. While superoxide can cause oxidative damage to the cell, we and others have shown that a mild increase in mitochondrial superoxide extends longevity in multiple model organ...
Agus Surachman, Meera N Harhay, Rose Ann DiMaria-Ghalili ... · GeroScience · Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, 3215 Market St, Rm 552, Philadelphia, PA, 19104, USA. [email protected]. · pubmed
Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioeconomic status (SES) and decrements in kid...
Ping Wu, Lieselot Vandemeulebroucke, Kevin Rey A Guiritan ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium. · pubmed
Axenic dietary restriction (ADR) represents a powerful and unique DR regimen for C. elegans as it robustly extends lifespan independently of well-known key genes associated with DR, such as those of insulin/IGF-1 signaling, skn-1, and pha-4. Here, we analyze C. elegans survival i...
Xieyang Xu, Yan Pang, Xianqun Fan · Oxidative Stress · Department of Ophthalmology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces an imbalance between oxidation and anti...
Na Zhang, Yan You, Yanhua Zhao ... · Biology of reproduction · Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, P. R. China. · pubmed
The advanced maternal age is strongly correlated with a notable decline in oocyte quality, yet definitive and effective strategies to enhance it remain incompletely identified. In this study, we reported that near-infrared light, administered in vitro, efficaciously improves the ...
Haoxian Zhou, Shu Wu, Bin Li ... · Protein & cell · Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. · pubmed
Loss of protein homeostasis is a hallmark of cellular senescence, and ribosome pausing plays a crucial role in the collapse of proteostasis. However, our understanding of ribosome pausing in senescent cells remains limited. In this study, we utilized ribosome profiling and G-quad...
Wallis, R., Hughes, B. K., Moore, M. ... · cancer biology · Blizard Institute, Queen Mary University of London · biorxiv
Background Senescence identification is rendered challenging due to a lack of universally available biomarkers. This represents a bottleneck in efforts to develop pro-senescence therapeutics - agents designed to induce the arrest of cellular proliferation associated with a senesc...
Santana, R. A., McWhirt, J., Brewer, G. J. · neuroscience · University of California Irvine · biorxiv
Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged organelles and proteins. Age-related ATP depletion would impact cognition dependent on ionic homeostasis, but limits on proteostasis powered by GTP are less cl...
Shuying Chen, Qian Chen, Xinru You ... · Nature aging · Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · pubmed
Aging is characterized by a gradual decline of cellular and physiological functions over time and an increased risk of different diseases. RNA therapeutics constitute an emerging approach to target the molecular mechanisms of aging and age-related diseases via rational design and...