Longevity Papers

Current Week (June 09 - June 11, 2025)
and Previous Week (June 04 - June 08, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 05 episode:
Wednesday, June 11, 2025
Zhen Yu, Ruiye Chen, Peng Gui ... · NPJ digital medicine · The AIM for Health Lab, Monash University, Melbourne, VIC, Australia. · pubmed
Retinal age has emerged as a promising biomarker of aging, offering a non-invasive and accessible assessment tool. We developed a deep learning model to estimate retinal age with enhanced accuracy, leveraging retinal images from diverse populations. Our approach integrates self-s...
Balun Li, Yanheng Ding, Miao Han ... · Aging · College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, China. · pubmed
Dogs serve as ideal research subjects for aging studies. In this study, 9 aging-related cell populations are identified through single-cell RNA sequencing of dogs of different ages. Additionally, 9 CD8+ T cell senescence-specific markers conserved across species are identified. F...
Cassandra J McGill, Amy Christensen, Wenjie Qian ... · Communications medicine · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed
The apolipoprotein ε4 allele (APOE4) is associated with decreased longevity and increased vulnerability to age-related declines and disorders across multiple systems. Interventions that promote healthspan and lifespan represent a promising strategy to attenuate the development of...
Gwladys Revêchon, Anna Witasp, Nikenza Viceconte ... · Nature aging · Department of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden. [email protected]. · pubmed
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we found progerin, the prote...
Young Du Choi, Young Un Kim, HyunJoon Gi ... · BMB reports · Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22212; Program in Biomedical Science & Engineering, Inha University, Incheon 22212; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Korea. · pubmed
Skin aging is a complex biological process driven by intrinsic and extrinsic factors, leading to a progressive structural and functional decline. The balance between extracellular matrix (ECM) degradation and synthesis is critical for maintaining skin homeostasis, with collagen l...
Fangxi Xu, Yuqi Guo, Scott C Thomas ... · Dysbiosis · Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA. · pubmed
Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation. This study examines the role of succinate...
Tuesday, June 10, 2025
Naz Şerifoğlu, Giulia Allavena, Bruno Lopes-Bastos ... · The EMBO journal · Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR7284, INSERM U1081, Université Cote d'Azur, 06107, Nice, France. · pubmed
Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA-damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro, cells with short telomeres activate the cGAS-STING innate im...
Lauren Monroe, Samantha Kaonis, Natalie Calahan ... · Advanced biology · School of Biomedical Engineering, Colorado State University, 800 Meridian Ave, Fort Collins, CO, 80523, USA. · pubmed
In eukaryotic cell nuclei, chromatin exhibits a high degree of structural and functional dynamics. Recent findings suggest that chromatin has the ability to reorganize in response to changes within the cellular microenvironment. Such changes include oxidative stress found in hype...
M N Núñez-Lisboa, A H Dewolf · npj aging · Laboratory of biomechanics and Physiology of Locomotion, Institute of NeuroScience, Université catholique de Louvain, Louvain-la-Neuve, Belgium. · pubmed
Exercise induces neural and muscular adaptations, improving muscle mass and function in older adults. We investigated its impact on gait neuromuscular control in young and older adults, classified as more active (young: n = 15, 5185 ± 1471 MET-min/week; old: n = 14, 6481 ± 4846 M...
Gilbert B Ampomah, Eldon R Hard, Matthew Robert Pratt · Chembiochem : a European journal of chemical biology · University of Southern California, Chemistry, UNITED STATES OF AMERICA. · pubmed
The overall process of protein aggregation from soluble species to amyloid fibrils is toxic to neurons and can propagate along neuronal connections in ways that potentially explain the pathological progression in most neurodegenerative diseases. One of these aggregation-prone pro...
Monday, June 09, 2025
Schleh, M., Cambraia, A., Cutler, M. ... · physiology · Vanderbilt University · biorxiv
Aging is a major risk factor for insulin resistance and type 2 diabetes, driven in part by declining pancreatic beta cell function. While calorie restriction (CR) initiated early in life improves metabolic health and preserves beta cell function, its impact when initiated later i...
Arjun Jain, Yuuki Hosokawa, Kevin Joseph · Cellular reprogramming · Retro Biosciences, San Francisco, California, USA. · pubmed
Sahu et al. (2024) demonstrate that targeted partial reprogramming with Oct4, Sox2, and Klf4 (OSK) delivered via adeno-associated virus (AAV) to Cdkn2a-positive cells rejuvenates senescent cells while maintaining cellular identity. In a progeroid and naturally aged mouse model, a...
Fullerton, M. O., Phillips, L. C., Redgrave, R. E. ... · genetics · Newcastle University · biorxiv
Abstract Background and Aims The sodium-dependent multivitamin transporter, encoded by SLC5A6, mediates cellular uptake of the vitamins, biotin and pantothenic acid, both of which are essential cofactors for energy metabolism. Here, we report two families with SLC5A6 mutations pr...
Masahiro Tamura, Wakana Yamashita, Takahide Hibi ... · Schizosaccharomyces · Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan. · pubmed
Inhibition of the activity of Pma1, a widely conserved P-type proton exporting ATPase, has been shown to extend the chronological lifespan (CLS) in fission yeast Schizosaccharomyces pombe. To develop a specific inhibitor for Pma1 of S. pombe, we focused on Si01, a candidate inhib...
Shvedova, M., Thanapaul, R. J. R. S., Wang, Q. ... · cell biology · Boston University School of Medicine · biorxiv
The transient upregulation of cellular senescence within wound tissues has been demonstrated to be an important biological process facilitating efficient tissue repair. Dysregulation of this transient wound-induced senescence-like response can result in impaired healing outcomes....
Samuel D Anderson, Maria Razzoli, Brian Chen ... · GeroScience · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed
A strong association exists between exposure to life stressors and accelerated aging in humans and animal models. However, the molecular mechanisms that underlie the adverse effect of stress on aging remain poorly characterized, and there is a paucity of prognostic predictors of ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar ... · Aging cell · Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary. · pubmed
Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorl...
Zhang, W., Lukacsovich, D., Young, J. ... · genetic and genomic medicine · University of Miami · medrxiv
Aging is the strongest risk factor for Alzheimer's disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. In this study, we performed a meta-analysis of blood DNAm samples from 475 dementia-free su...
Sunday, June 08, 2025
Rehman, A., Duffy, M., Gresova, K. ... · genomics · National Institute on Aging, NIH · biorxiv
Aging is associated with increases in risk of multiple chronic diseases and at the cellular level, with disruptions in RNA homeostasis. Single-cell transcriptomic studies have revealed RNA abundance heterogeneity across brain cell types but the more complex changes in RNA process...
Xiao, L., Sharma, P., Yang, X. ... · neuroscience · NICHD,NIH · biorxiv
Background The global aging population is increasingly inflicted with Alzheimer\'s disease (AD), but a cure is still unavailable. Neurotrophic Factor-1/carboxypeptidase E (NF-1/CPE) gene therapy has been shown to prevent and reverse memory loss and pathology AD mouse models Howev...
Kim, M., Berger, C., Wolf, A. ... · bioengineering · Institute of Biological and Medical Imaging, Bioengineering Center, Helmholtz Zentrum Muenchen · biorxiv
Adipose tissue plasticity and functional heterogeneity play a central role in maintaining energy homeostasis, and their malfunction leads to metabolic disorders such as obesity, diabetes, and cardiometabolic disease. Rapid, single-cell metabolic imaging of intact fat tissue not o...
Saturday, June 07, 2025
Otto, D. J., Arriaga-Gomez, E., Thieme, E. ... · bioinformatics · Fred Hutchinson Cancer Center · biorxiv
Kompot is a statistical framework for holistic comparison of multi-condition single-cell datasets, supporting both differential abundance and differential expression. Differential abundance captures changes in how cells populate the phenotypic manifold across conditions, while di...
Emily, M. F., Guillaud, L., De la Fuente Ruiz, S. ... · neuroscience · Okinawa Institute of Science and Technology · biorxiv
Mitochondria are trafficked along axons and provide the energy required for several intracellular mechanisms including molecular transport and local translation, which is believed to contribute to the homeostasis of the axonal compartment. Decline in mitochondria activity is one ...
Antonio Marino, Domenico Di Fraia, Diana Panfilova ... · Ubiquitination · Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany. · pubmed
Post-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse aging brain. We show that...
Dmitrii Usoltsev, Ekaterina Moguchaya, Maria Boyarinova ... · Cardiovascular Diseases · Almazov National Medical Research Centre, St. Petersburg, Russia. · pubmed
Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular ris...
Yuan Zhang, Huayu Wang, Fang Li ... · Cellular Senescence · Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · pubmed
MRG15, a chromatin remodeling protein, plays a pivotal role in cellular senescence and proliferation. However, the precise roles and mechanisms of MRG15 in aging regulation remain unclear. Our research elucidates the distinct functions of MRG15's splice variants in aging. We find...
Xing-Yi Chen, Dong-Mei Wang, Ya Zhou ... · Mitophagy · Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, 611137, Sichuan, China. · pubmed
Pulmonary fibrosis is often associated with aging, marked notably by the senescence of lung epithelial cells and the development of interstitial fibrosis. Mitophagy plays a crucial role in aging by degrading damaged mitochondria, thereby maintaining mitochondrial quality and cell...
Watowich, M., Brassington, L., Longtin, A. ... · epidemiology · Vanderbilt University · medrxiv
Declines in cardiometabolic health among older individuals are so ubiquitous in Western, high-income countries that non-communicable diseases (NCDs) like type 2 diabetes, hypertension, and cardiovascular disease have been termed "diseases of aging". In contrast, research from non...
Friday, June 06, 2025
Chia-Ling Kuo, Peiran Liu, Gabin Drouard ... · Proteomics · Department of Public Health Sciences, University of Connecticut Health Center, Farmington, CT 06032. · pubmed
The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-ba...
de Lima Camillo, L. P., Gam, R., Maskalenka, K. ... · cell biology · Shift Bioscience Ltd · biorxiv
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the Yamanaka factors (OCT4, SOX2, KLF4, with or without c-MYC: \"OSK(M)\") have been...
Sadoughi, B., Hernandez-Rojas, R., Hamou, H. ... · genomics · Arizona State University · biorxiv
Elucidating the socio-ecological factors that shape patterns of epigenetic modification in long-lived vertebrates is of broad interest to evolutionary biologists, geroscientists, and ecologists. However, aging research in wild populations is limited due to inability to measure ce...
Shemtov, S. J., McGann, E., Carrillo, L. ... · molecular biology · University of Southern California · biorxiv
Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian lifespan and protects against a range of age-related diseases. Surprisingly though, we found that reduced IGF-1 signaling fails to extend the lifespan of mitochondrial mutator mice. Accordingly, most ...
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu ... · Aging cell · Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. · pubmed
Multiple studies in mice with genetically disrupted growth hormone (GH) signaling have demonstrated that such disruption results in reduced body size, robustly increased longevity (> 50% in some cases), and improvements across multiple health parameters. However, it remains uncle...
Sturmlechner, I., Jain, A., Jiang, J. ... · immunology · Mayo Clinic · biorxiv
Older adults are susceptible to infections, in part due to waning of immune memory. To determine mechanisms that determine long-lasting versus short-term immunity, we examined varicella zoster virus (VZV) vaccination as a model system. We contrasted VZV antigen-specific T cells s...
Ming Ann Sim, Jorming Goh, Jasinda Lee ... · Sirolimus · Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [email protected]. · pubmed
The geroprotective effects of rapamycin in mitigating frailty and cognitive complications in the perioperative period remains unknown. Of 39 C57BL/6 mice tested, 19 were young (16 weeks), and 20 were old (80 weeks). The interventional group (10 old, 10 young) received daily oral ...
Jia Xie, Ze-Guang Han · BioEssays : news and reviews in molecular, cellular and developmental biology · Key Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Heterochromatin, a crucial constituent of the eukaryotic nucleus with highly conserved and transcriptionally silenced characteristics, plays a pivotal role in safeguarding genome stability, regulating nuclear morphology, and mediating cell fate. Recent convincing evidence indicat...
Rychlicka-Buniowska, E., Sarkisyan, D., Horbacz, M. ... · genetic and genomic medicine · Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; 3P-Medicine Laboratory, Medical Universit · medrxiv
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events associated with multiple adverse outcomes in the elderly. While LOY has been associated with higher risk of Alzheimer disease (AD), CHIP has been suggested to perfo...
McQuade, A., Castillo, V. C., Hagan, V. ... · neuroscience · University of California, San Francisco · biorxiv
Microglia dynamically support brain homeostasis through the induction of specialized activation programs or states. One such program is the Interferon-Responsive Microglia state (IRM), which has been identified in developmental windows, aging, and disease. While the functional im...
Palomares, D., Vanparys, A., Jorgji, J. ... · neuroscience · Aging and Dementia group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium · biorxiv
Background: Although the connection between aging and neurodegenerative pathologies like Alzheimer\'s disease (AD) has long been recognized, the underlying pathological mechanisms remain largely unknown. Senescent brain cells build up in the brains of AD patients and a causal lin...
Hiroshi Kobayashi, Shogo Imanaka · DNA, Mitochondrial · Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Nara 634‑0813, Japan. · pubmed
Mitochondria and mitochondrial DNA (mtDNA) are crucial for cellular energy metabolism and the adaptive response to environmental changes. mtDNA collaborates with the nuclear genome to regulate mitochondrial function. Dysfunctional mitochondria and mutations in mtDNA are implicate...
Thursday, June 05, 2025
Matías Fuentealba, Laure Rouch, Sophie Guyonnet ... · Nature aging · Buck AI Platform, Buck Institute for Research on Aging, Novato, CA, USA. · pubmed
Age-related decline in intrinsic capacity (IC), defined as the sum of an individual's physical and mental capacities, is a cornerstone for promoting healthy aging by prioritizing maintenance of function over disease treatment. However, assessing IC is resource-intensive, and the ...
Mareike Peters, Patric Teodorescu, Sergiu Pasca ... · Haematologica · Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD. · pubmed
Not available.
Xiao-Wei Liu, Hao-Wei Xu, Shu-Bao Zhang ... · Cell death discovery · Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China. · pubmed
Intervertebral disc degeneration (IVDD) is a common pathology involving various degenerative diseases of the spine, with nucleus pulposus cell (NPC) senescence playing an important role in its pathogenesis. Transcriptional and epigenetic processes have been increasingly implicate...
Rooban Sivakumar, K A Arul Senghor, V M Vinodhini ... · Drugs & aging · Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Kanchipuram, Chennai, Tamil Nadu, 603203, India. [email protected]. · pubmed
Metformin, traditionally promoted for its efficacy in diabetes, is increasingly appreciated for its geroprotective potential in the development of vascular aging, a key contributor to cardiovascular morbidity. This review aims at understanding the spectrum of mechanisms that gove...
Jackson Nuss, Matt Kaeberlein, Alessandro Bitto ... · GeroScience · Department of Laboratory Medicine & Pathology, School of Medicine, University of Washington, Seattle, WA, USA. · pubmed
Mice missing the complex I subunit Ndufs4 of the electron transport chain are widely used as a leading animal model of Leigh syndrome, a pediatric neurodegenerative disorder that leads to premature death. More broadly, this animal model has enabled a better understanding of the p...
Jing, Y., Li, L., Guo, W. ... · cell biology · Department of Urology, Shanghai General 32 Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 33 200080, China · biorxiv
Benign prostatic hyperplasia (BPH) is a common age-associated urological condition characterized by stromal expansion, but its cellular origins and regulatory mechanisms remain unclear. In this study, we identified endothelial-to-mesenchymal transition (EndMT) as a contributor to...
Wednesday, June 04, 2025
Salignon, J., Tsiokou, M., Marques, P. ... · bioinformatics · Karolinska Institute · biorxiv
As the prevalence of age-related diseases rises, understanding and modulating the aging process is becoming a priority. Transcriptomic aging clocks (TACs) hold great promise for this endeavor, yet most are hampered by platform or tissue specificity and limited accessibility. Here...
Bradley Olinger, Reema Banarjee, Amit Dey ... · Nature aging · Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA. · pubmed
Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence and related them to clinical traits in humans to facilitate future noninvasive assessment of individual senescence burden, and effica...
Keyu Kong, Li Liu, Renfang Zhang ... · Lopinavir · Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · pubmed
Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained contentious, with conjectures pointing towards its correlation with distinct antiviral regimes. Protease inhibitors (PIs) stand as a prominent class of antivira...
Julian M Carosi, Alexis Martin, Leanne K Hein ... · Autophagy · Lysosomal Health in Ageing, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia. · pubmed
Autophagy is a 'waste-disposal' pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during aging remain unknown. Here, we present the most comprehensive in vivo study of a...
Oliver Polzer, E Kinloch, P J Lucassen ... · Aging cell · Brain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands. · pubmed
Hippocampal adult neural stem cells (NSCs) contribute to neurogenesis and astrogliogenesis throughout life. They play multifaceted roles in hippocampal function, including memory processing, stress regulation, and cognitive flexibility. Located in unique neurogenic niches like th...
Aileen H Lee, Lucie Orliaguet, Yun-Hee Youm ... · Nature metabolism · Department of Pathology, Yale School of Medicine, New Haven, CT, USA. · pubmed
Caloric restriction and methionine restriction-driven enhanced lifespan and healthspan induces 'browning' of white adipose tissue, a metabolic response that increases heat production to defend core body temperature. However, how specific dietary amino acids control adipose thermo...
Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu ... · The EMBO journal · Stem Cell Biology and Medicine, Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. · pubmed
Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling and transcriptional regulation that compromises hippocampal NSC activity during th...
Xu Jiang, Jing Ke, Yiting Liu ... · Biogerontology · Department of Otorhinolaryngology-Head and Neck Surgery, Chongqing General Hospital, Chongqing University, No .118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, China. · pubmed
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA sequencing of C57BL/6J mice were...
Tej D Azad, Marvin W Li, Chiu Ping-Yeh ... · Spine deformity · Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA. [email protected]. · pubmed
The incidence of spine-related pathologies is expected to increase in developed countries due to ongoing fundamental demographic shifts toward an older population. These changes present significant challenges to public health, as healthcare systems worldwide must confront the bur...
NyamErdene, A., Thao Ngoc Le, N., Nebie, O. ... · neuroscience · International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei ,Taiwan,Graduate Institute of Biomed · biorxiv
Platelet-derived materials are emerging as promising, cell-free biotherapies for regenerative medicine. While platelet lysates have shown neuroprotective activity in preclinical models, the neurogenic potential of platelet concentrate-derived extracellular vesicles (pEVs) remains...
Jonalyn DeCastro, Ami Mehta-Doshi, Chao Liu ... · Rejuvenation research · Riggs School of Applied Life Sciences, Keck Graduate Institute, Claremont, California, USA. · pubmed
Age-associated neurodegenerative diseases (NDDs), including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, are marked by progressive degeneration of the nervous system. Current diagnostic approaches, such as neuroimaging and cerebrospinal fluid bioma...
Fengli Xu, Haipeng Huang, Kun Peng ... · Aging · State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China. · pubmed
Reactive thiols of proteinaceous cysteines are vital to cell biology by serving as sensor, effector and buffer of environmental redox fluctuations. Being the major source, as well as the prime target, of reactive oxygen species (ROS), mitochondria confront great challenges in pre...
Kenna Brown, Ghazal Vahidi, Brady D Hislop ... · Diet, High-Fat · Department of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, USA. · pubmed
The elderly are at increased risk of bone fracture and more often consume poor quality diets, such as high-fat diet (HFD). We hypothesized that HFD exacerbates the loss of bone fracture resistance in aging. Female and male 5-month and 22-month C57BL/6JN mice were fed moderate HFD...
Jinhua Zhou, Xin Meng, Fan Wang ... · Aging · Department of Critical Care Medicine, The Third People's Hospital of Chengdu, Chengdu, 610031, China. · pubmed
Biological Age Acceleration (BAA), as quantified by epigenetic clocks, is a well-established biomarker for mortality and age-related morbidity. This study aimed to investigate the independent and combined associations of sleep duration, sedentary behavior, and physical activity w...