Longevity Papers

Current Week (July 28 - August 01, 2025)
and Previous Week (July 25 - July 27, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), July 28 episode:
Friday, August 01, 2025
Ting Dong, Nianyu Li, Huirui Wang ... · Nature aging · Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, China. [email protected]. · pubmed
Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified deleterious mutations and decreased expres...
Wenbo Wu, Genshiro A Sunagawa, Hong Chen · Nature metabolism · Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. · pubmed
Torpor is a naturally occurring state of metabolic suppression that enables animals to adapt and survive extreme environmental conditions. Inspired by this adaptation, researchers have pursued synthetic torpor-an artificially induced, reversible hypometabolic state with transform...
Abbas Mohammadi, Daniel Thomas Jones, Somayeh Mohammadi ... · Cardiology in review · From the Department of Medicine, Valley Health System, Las Vegas, NV. · pubmed
Telomere attrition stands as a fundamental hallmark of cardiovascular aging, driving cellular senescence and dysfunction across endothelial, cardiomyocyte, and vascular smooth muscle compartments. This review systematically examines: (1) molecular mechanisms linking telomere shor...
Jodi Protasiewicz, Sarah Snider, Mousumee Khan ... · Longevity · Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. · pubmed
Prolonged inactivity due to medical conditions can cause chronic muscle disuse and lead to physical incapacity and poor quality of life. Here, we developed a Drosophila model of confinement inactivity (CI) to observe its effects on lifespan and muscle function. We found that, sim...
Pitaksin Chitta, Timothy M Barrow, Busadee Pratumvinit ... · Scientific reports · Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. · pubmed
Epigenetic age provides a reliable biomarker for biological aging, reflecting the cumulative impact on health over time. Frailty is common among elderly individuals and is further compounded by hypertension, which increases the risk associated with aging. Therefore, we examined t...
Yu Wu, Yuru Deng, Borislav Angelov ... · FASEB bioAdvances · Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay Orsay France. · pubmed
Plasmalogens are natural glycerophospholipids that account for approximately 15%-20% (mol%) of human tissues' cellular membrane phospholipid composition. They play an important role in lipid membrane organization and function, including acting as endogenous antioxidants. Plasmalo...
Thursday, July 31, 2025
Domenico Di Fraia, Antonio Marino, Jae Ho Lee ... · Aging · Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany. · pubmed
Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the transcriptome, translatome, and proteome in the brain of short-lived killifish....
Yaqing Wang, Pengyu Sun, Fuqiang Yang ... · Aging cell · State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. · pubmed
cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER-to-Golgi trafficking, and secretion. However, whether cTAGE5/MEA6 is involved in other cellular functions remains unclear. Here, we show that conditional cTAGE5 knockout results in embryonic lethality during developme...
Zhou, Z., Lamanna, A., Halder, R. ... · microbiology · Luxembourg Centre for Systems Biomedicine, University of Luxembourg · biorxiv
The gut microbiota both adapts to, and shapes, the metabolic state of individuals. This bidirectional relationship is mediated via circulating metabolites and gene regulatory networks and interacts with many organs, including by the gut-brain axis. Here, we have processed the cec...
Sugai, A., Moridono, H., Bilgic, M. ... · neuroscience · Institute for Quantitative Biosciences, The University of Tokyo · biorxiv
Microglial senescence contributes to inflammation and various neurodegenerative diseases. Recent single-cell transcriptome data have revealed age-associated microglial substates (AAMs) and their potential roles in the development of neurodegenerative diseases. However, the charac...
Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang ... · Aging cell · Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas, USA. · pubmed
Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens d...
Matlack, J. K., Miner, R. E., Lokhandwala, J. ... · biochemistry · Moffitt Cancer Center · biorxiv
Protein glycation is a detrimental byproduct of living cells\' reliance on carbohydrate metabolism, and nearly all organisms encode kinases that facilitate the removal of early glycation products. In humans, these repair functions are performed by Fructosamine-3 kinase (FN3K) and...
Jacob-Dolan, J. W., Sterling, A. C., Brutus, M. E. ... · biochemistry · Tufts University · biorxiv
Glycation crosslinks account for more than 40% of all known advanced glycation end products (AGEs) and are correlated with many age-related diseases. Despite much interest, crosslinking AGEs (xl-AGEs) remain poorly understood, as they have been challenging to discover, prepare, a...
Jin, X., Tang, W., Zheng, Z. ... · neuroscience · Institute of Psychology, Chinese Academy of Sciences · biorxiv
Non-pharmacological interventions (NPIs) in aging neuroscience have largely focused on intervention-specific regional effects, with limited understanding of generalizable network-level mechanisms. Here, adopting a previously unexplored gradient-based perspective of functional bra...
Cong Chen, Tong-Yao Gao, Hua-Wei Yi ... · Proteasome Endopeptidase Complex · Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China. · pubmed
Ubiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson's disease, but the mechanistic lin...
Ebenebe, O. V., Kabir, R., Booher, A. ... · physiology · Johns Hopkins University · biorxiv
S-nitrosoglutathione reductase (GSNOR), a regulator of protein S-nitrosylation (SNO), has been proposed as a longevity protein. GSNOR signaling has been implicated in both the alleviation and exacerbation of aging. In the context of ischemia reperfusion injury, we previously show...
Cécile Marcourt, Claudio Rivera, Jürgen Tuvikene ... · GeroScience · Aix Marseille Univ, INSERM, INMED, Marseille, France. · pubmed
Aging is associated with metabolic decline in the brain, increasing susceptibility to neurodegenerative diseases. While exercise is a well-established strategy to counteract these changes, no study has directly compared the effects of moderate-intensity continuous training (MICT)...
Battaglia, M. C., Bhalla, M., Marzullo, B. ... · immunology · Department of Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo NY · biorxiv
Aging drives increased susceptibility to respiratory infections by Streptococcus pneumoniae (pneumococci). Polymorphonuclear leukocytes (PMNs) are among the first responders in the lung following pneumococcal infection and are required for bacterial clearance. However, PMN antimi...
Sturgis, J., Jiang, K., Hagstrom, S. ... · cell biology · Cleveland Clinic Foundation · biorxiv
Retinal degenerative diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, and glaucoma, have been linked to mitochondrial dysfunction. However, the impact of mitochondrial DNA (mtDNA) mutation accumulation in the context of these retinopathies has yet t...
Xiao Lu, Jiao Wu, Ewud Agborbesong ... · Cell death discovery · Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA. · pubmed
Diabetic kidney disease (DKD) is characterized by kidney damage and abnormal renal energy metabolism, but the molecular mechanism of DKD is still unclear. In this study, we show that p16- positive senescent cells are an important regulator in the progression of DKD. The expressio...
Donghoon Kang, Yeji Lim, Dabin Ahn ... · Journal of medicinal chemistry · Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. · pubmed
Cellular senescence, marked by irreversible cell cycle arrest and senescence-associated secretory phenotype, contributes to aging and cancer recurrence. While chemotherapy can induce senescence in cancer cells, these therapy-induced senescent cells often resist apoptosis and prom...
Joruiz, S. M., Lissa, D., von Muhlinen, N. ... · cell biology · Center for Cancer Research, National Cancer Institute, National Institutes of Health · biorxiv
Background: Patients with Hutchinson-Gilford progeria syndrome (HGPS) show accelerated aging phenotypes and have shortened lifespan, with implications in physiological aging processes as well. While therapeutic approaches targeting the disease-causing abnormal protein, progerin, ...
Shigeru Chiba · International journal of hematology · Division of Stem Cell Therapy, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. [email protected]. · pubmed
Clonal hematopoiesis (CH) has emerged as a common age-related phenomenon and a central concept linking somatic mutations in hematopoietic stem cells to both malignant and non-malignant diseases. While initially recognized in the context of hematologic neoplasms, CH is now known t...
Nehar-Belaid, D., Thibodeau, A., Eroglu, A. ... · immunology · The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA · biorxiv
The human immune system undergoes continuous remodeling from infancy through old age, yet the timing and trajectory of these changes across the lifespan remain poorly defined. To address this, we profiled peripheral blood mononuclear cells from 95 healthy individuals (ages 2 mont...
Ali, M., Li, F., Katari, M. S. · bioinformatics · New York University · biorxiv
Identifying the set of genes that regulate baseline healthy aging - aging that is not confounded by illness - is critical to understating aging biology. Machine learning-based age-estimators (such as epigenetic clocks) offer a robust method for capturing biomarkers that strongly ...
Olivier Dionne, Benoit Laurent · Aging · Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. · pubmed
Ribosome stalling drives aging in the killifish brain.
Wednesday, July 30, 2025
Saw, W.-Y., Kim, K., Huang, Y. ... · genetic and genomic medicine · Brigham and Women\'s Hospital · medrxiv
Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene Study and 7,235 from six additional cohort...
Thura Tun Oo, Anjhana Hariharasubramanian, Sruthy Pallikonda Chakravarthy ... · Journal of immunology (Baltimore, Md. : 1950) · Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL 61107, United States. · pubmed
As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet, older mice develop insulin resistance more easily than young mice. But how aging renders both humans and mice more vulnerable to the ...
Laura Cianfruglia, Carlo Fortunato, Gretta Veronica Badillo Pazmay ... · Oxidative Stress · Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, Ancona, Italy. · pubmed
Cytomegalovirus (CMV) drives immunosenescence, while its reactivation is associated with inflammation and oxidative stress. This study investigates the interplay between CMV, oxidative stress and inflammation in a cohort of 2065 age-stratified individuals randomly recruited from ...
Clarice A Myers, Wuyang Zhang, Niranjani Nagarajan ... · Journal of Alzheimer's disease : JAD · Department of Epidemiology, Cochlear Center for Hearing and Public Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. · pubmed
BackgroundHearing loss (HL) and vision loss (VL) occur frequently among older adults and are independent risk factors for dementia, including in low- and middle-income countries (LMICs), where incident dementia is common. There is little research on the prevalence of dual sensory...
Anne Kirstine Eriksen, Kathrine Grell, Peter Fjeldstad Hendriksen ... · Scientific reports · Diet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark. [email protected]. · pubmed
Health behaviors affect life expectancy, but whether disease is present can greatly impact both the individual and society. How health behavior is reflected in the utilization of health care services is yet to be investigated to support the impact of prevention efforts. Based on ...
Raoul Orvieto, Omri Nayshool, Louisa Cohen ... · Reproductive biology and endocrinology : RB&E · Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel. [email protected]. · pubmed
Aging affects gene expression in pathways essential for energy metabolism, DNA repair, cell cycle regulation, and antioxidant defenses, directly affecting oocyte quality and viability. Single-cell RNA deep sequencing studies of aged versus young human MII oocytes revealed many di...
Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu ... · npj aging · Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan. · pubmed
Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate cancer patients at Juntendo University Hospi...
Eduardo H Moretti, Ally L Y Lin, Luca Peruzzotti-Jametti ... · Extracellular Vesicles · Department of Clinical Neurosciences, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Cambridge, UK. · pubmed
The limited regenerative capacity of the central nervous system (CNS) severely hinders treatment of neurodegenerative and neuroinflammatory diseases. These conditions, frequently exacerbated by aging, share common hallmarks such as neuroinflammation, demyelination, and neuronal l...
Tze Mun Loo, Xiangyu Zhou, Yoko Tanaka ... · Nature communications · Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. · pubmed
Senescent cells, characterized by irreversible cell cycle arrest and inflammatory factor secretion, promote various age-related pathologies. Senescent cells exhibit resistance to ferroptosis, a form of iron-dependent cell death; however, the underlying mechanisms remain unclear. ...
Surendra Kumar, Kangping Song, Jiekang Wang ... · Nature aging · Department of Orthopaedic Surgery, the Johns Hopkins University School of Medicine, Baltimore, MD, USA. · pubmed
The accumulation of amyloid fibrils has been identified in tissues outside the brain, yet little is understood about the formation of extracerebral amyloidosis and its impact on organ aging. Here, we demonstrate that both transgenic Alzheimer's disease (AD) mice and naturally agi...
Priyanka Mallick, Sebabrata Maity, Rupsha Mondal ... · Cell death & disease · Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, IICB TRUE Campus, CN-6, Sector 5, Kolkata, 700091, India. · pubmed
ER and mitochondrial stress are often interconnected and considered major contributors to aging as well as neurodegeneration. Coordinated induction of ER
Wei Kang, Zhiyue Wu, Xinzhi Huang ... · Nature communications · MOE Key Laboratory of Bio-Intelligent Manufacturing, State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, School of Bioengineering, Dalian University of Technology, Dalian, China. [email protected]. · pubmed
Biomolecular condensates are dynamic cellular compartments that concentrate proteins and enzymes to regulate biochemical reactions in time and space. While these condensates can enhance enzyme activity, how this function changes as condensates age remains poorly understood. Here,...
Tuesday, July 29, 2025
Trofimova, O., Böttger, L., Bors, S. ... · radiology and imaging · University of Lausanne · medrxiv
Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tuned a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The resulting ...
Andrei O Zheltukhin, Peter M Chumakov, Andrei V Budanov · Aging · Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. · pubmed
Sestrins, evolutionarily conserved stress-responsive proteins, are increasingly recognized for their potential role in lifespan regulation. This study aimed to elucidate the influence of the
Natalia Hernández-Bellido, Adrián Hernández-Vicente, Laura García-Mendívil ... · GeroScience · Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza, Zaragoza, Spain. [email protected]. · pubmed
The need to monitor the aging process as a risk factor for disease and mortality beyond chronological age (CA) has led to numerous investigations into the estimation of the biological age (BA) of individuals. However, the accuracy of BA estimation tools is often judged by their a...
Guillermo Luxán, Timm Winkelmeier, Colin Bodemer ... · Cardiovascular research · Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany. · pubmed
Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function. Here, we have combined single-nucleus-RNA-sequencing, imaging, and molecular an...
Mina Yamane, Hiroki Umeda, Moe Toyobe ... · Journal of the American Chemical Society · Graduate School of Pharmaceutical Sciences, Synthetic Organic Chemistry Lab, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. · pubmed
The escalating global trend of aging populations has brought attention to the rising prevalence of late-onset amyloid disorders. Among them, amyloid transthyretin (ATTR) amyloidosis presents a growing area of unmet medical needs. While current treatment modalities have demonstrat...
Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim ... · Aging · Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea. · pubmed
Aging is associated with a decline in liver function, which increases the risk of age-related metabolic disorders. Calorie restriction (CR) counteracts age-related changes in the liver; however, the underlying molecular mechanism remains elusive. In this study, we integrated tran...
Spyropoulos, D., Ziemens, D., Curley, G. A. ... · neuroscience · Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Luebeck, Luebeck, Germany · biorxiv
Cognitive impairment is a major medical problem in the aging population. The risk of developing cognitive impairment is higher in several systemic conditions like hypertension, diabetes, and obesity. While a vascular contribution to cognitive impairment in these pathologies is we...
David G Le Couteur, Meng C Ngu, Nicholas J Hunt ... · Nature reviews. Gastroenterology & hepatology · ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia. [email protected]. · pubmed
As the global population ages, research on the biology of ageing and its role in chronic disease is expanding, alongside a growing clinical focus on the unique needs of older adults. In the past, the liver was not thought to undergo substantial age-related changes, nor was there ...
Asa Farahani, Zhen-Qi Liu, Eric G Ceballos ... · PLoS biology · Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. · pubmed
Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood perfusion maps onto micro-, meso- and macro-scale brain structure and function is therefore a key question in neuroscience. Here we analyze pseudo...
Hunter L Porter, Victor A Ansere, Ram Babu Undi ... · GeroScience · Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104-5005, USA. · pubmed
DNA methylation data has been used to make "epigenetic clocks" which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methyla...
M A Frick, J L Woodruff, Y M Caudillo ... · Orexins · Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA. · pubmed
Neuroinflammation has emerged as a contributing mechanism in age-related cognitive decline (ARCD), Parkinson's disease (PD), obesity, sleep disorders, and autoimmune disorders. Orexin/hypocretin, a neuropeptide expressed in the lateral hypothalamus (LH), has well-established role...
Kai Wang, Mailin Gan, Yuhang Lei ... · Cellular & molecular biology letters · Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China. · pubmed
As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases is increasing. With advancing age, skeletal muscle undergoes progressive oxidative stress infiltration, coupled with detrimental factors such as impaired prote...
Sixu Zhang, Sixian Zhang, Wenwen Fan ... · Journal of materials chemistry. B · Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China. [email protected]. · pubmed
Senile osteoporosis (SOP) features reduced bone density and degraded trabecular structure, primarily mediated through senescent impairment of osteoblasts that disrupts coupled bone remodeling homeostasis. This pathological process induces systemic bone resorption and localized bo...
John D Elsworth, Albert Neutzner, Julien Roux ... · Aging cell · Virscio Inc, New Haven, Connecticut, USA. · pubmed
Strategies to slow the aging process or mitigate its consequences on health rely on the validation of minimally-invasive biomarkers of aging that can be used to track aging and test the effectiveness of antiaging interventions. Study of aging in a nonhuman primate species offers ...
Peiyong Zhai, Eun-Ah Sung, Koichiro Takayama ... · Cardiovascular research · Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103. · pubmed
We have previously shown that prevention of GSK-3β inactivation with GSK-3β (S9A), stimulates autophagy through phosphorylation of Ulk1 at Ser913. In the current study, we investigated whether cardiac aging is accelerated in Ulk1S913A knock in mice and whether cardiomyocyte senes...
M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad ... · Nature communications · Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA. · pubmed
Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining ...
Mehmet Kanbay, Sama Mahmoud Abdel-Rahman, Mustafa Guldan ... · Sarcopenia · Department of Medicine, Section of Nephrology, Koc University School of Medicine, Istanbul, Turkey. · pubmed
Ultra-processed foods (UPFs), foods with high levels of artificial additives and preservatives, often low in protein and essential nutrients despite being calorie-dense, have been associated with a range of adverse health outcomes, including cardiovascular and kidney diseases, ob...
Mariah F Calubag, Ismail Ademi, Isaac D Grunow ... · Aging cell · Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. · pubmed
Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels of the branched-chain amino acids (BCAAs) recapitulates many of the benefits of a low protein diet; BCAA-restricted diets extend lifespan, reduce frailty, and improve met...
Monday, July 28, 2025
Havas, A., Rajesh, A., Lei, X. ... · cell biology · Sanford Burnham Prebys Medical Discovery Institute · biorxiv
Aging is associated with increased susceptibility to metabolic stress and chronic liver disease, yet the interactions between age and metabolic stressors and the potential for ameliorating interventions remain incompletely understood. Here, we examined the hepatic response of you...
Abigail Morales-Sánchez, Marieke Lavaert, Melanie S Vacchio ... · PLoS biology · National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. · pubmed
Age-related thymic involution leads to diminished output of naïve T-cells. While this process is suggested to increase the risk of disease severity in the elderly following infection, direct evidence is lacking. We developed two mouse models that allow us to experimentally preven...
Mengyuan Peng, Niannian Li, Hongbo Wang ... · MedComm · School of Anesthesiology Shandong Second Medical University Weifang China. · pubmed
Macrophages are heterogeneous immune cells with diverse subtypes and tissue-specific distributions, displaying dynamic polarization states that critically govern their immunomodulatory functions and responses to environmental cues. As key regulators of innate and adaptive immunit...
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. · pubmed
The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major ...
Gote-Schniering, J., Melo-Narvaez, M. C., Boosarpu, G. ... · cell biology · Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC) with CPC-M bioArchive, Member of the German Center for Lung · biorxiv
Aging impairs the regenerative capacity of mammalian organs and is a major risk factor for organ fibrosis. The causalities for persistent fibrosis after lung injury in old individuals have been unclear. We used longitudinal single-cell RNA-seq after lung injury and dissected agin...
Sunday, July 27, 2025
Gaal, Z. A., Kojouharova, P., Nagy, B. ... · neuroscience · Department of Psychology, University of Calgary, Calgary, Alberta, Canada · biorxiv
Given the well-established structural and functional changes in the aging brain, it is widely assumed that cognitive aging is primarily driven by robust group-level differences between young and older adults. However, our individual-level EEG functional connectivity analysis chal...
Saturday, July 26, 2025
Rees-Baylis, E., Wang, D., Li Richter, X.-Y. ... · evolutionary biology · Institute of Ecology and Evolution, University of Bern, Bern, Switzerland · biorxiv
Sex differences in ageing and lifespan are widespread across taxa, yet their evolutionary causes remain debated. A leading hypothesis suggests these differences are adaptive and driven by sex-specific life-history trade-offs, but formal theoretical support is lacking. To address ...
Ong, R. C. S., Tang, A. · neuroscience · University of Western Australia · biorxiv
Repetitive transcranial magnetic stimulation (rTMS) is an attractive tool to promote healthy brain ageing in older adults and treat age-related neurological conditions. Despite its popularity, the neurological processes and plasticity mechanisms altered by rTMS in the aged brain,...
Ravindran, S., Corripio-Miyar, Y., Pick, J. L. ... · ecology · Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK · biorxiv
The hormone insulin-like growth factor 1 (IGF-1) is a key player in the insulin/IGF-1 signaling (IIS) pathway. Extensive biogerontological research demonstrates that this evolutionarily conserved nutrient-sensing pathway plays a causal role in the regulation of growth, reproducti...
Babygirija, R., Green, C. L., Sonsalla, M. M. ... · physiology · University of Wisconsin-Madison · biorxiv
Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumption of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and va...
Victoria-Chavez, R., Lamas, M. · molecular biology · Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional · biorxiv
The regenerative response of retinal cells to injury and aging depends on the epigenomic plasticity that enables the dedifferentiation and neuronal differentiation capacities of Muller glial cells (MG). In mammals, this regenerative ability is extremely limited, and disruptions i...
Friday, July 25, 2025
Jie Li, Qiyang Chen, Fuliang Xiao ... · Food science & nutrition · Chongqing Academy of Agricultural Sciences Chongqing China. · pubmed
Although tea polyphenols have antiaging potential, the molecular interplay between black tea components and cellular longevity remains unclear. This study has pioneered a dual approach combining
Yingqi Xu, Maohao Li, Congxue Hu ... · Genome medicine · College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. · pubmed
The decline in organ function due to aging significantly impacts the health and quality of life of the elderly. Assessing and delaying aging has become a major societal concern. Previous studies have largely focused on differences between young and old individuals, often overlook...
Junjie Cao, Xuan Wang, Keyi Huang ... · IEEE journal of biomedical and health informatics · Not available · pubmed
As the aging population continues to grow, falls among older adults have become a significant public health concern worldwide. Data-driven approaches for effective fall risk prediction, which integrate standard functional tests with 3D skeleton data from depth sensors, are gainin...
Zhaoqi Yan, Yifeng Xu, Ting Peng ... · Biogerontology · Department of Rehabilitation Medicine, The Third Hospital of Nanchang, Nanchang People's Hospital, 240 Zhanqian West Road, Xihu District, Nanchang City, 330009, Jiangxi Province, China. · pubmed
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA methylation age (Horvathage) ...
Hyejin Mun, Chang Hoon Shin, Mercy Kim ... · Aging · Department of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA. · pubmed
Signaling pathways and transcriptional regulation during cellular senescence have been investigated; however, energy metabolism is one of the understudied areas. Senescent cells secrete pro-inflammatory cytokines and release proteins and RNAs via exosomes that contribute to organ...
Yangxin Yu, Xinhang Lv, Zhuowei Chen ... · Journal of medicinal chemistry · Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, P. R. China. · pubmed
Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies. Recently, emerging evidence has revealed pathological accumulation of senescent c...
Emma M Tinney, Aaron E L Warren, Amanda O'Brien ... · Alzheimer's & dementia (New York, N. Y.) · Department of Psychology Northeastern University Boston Massachusetts USA. · pubmed
Age-related cognitive decline occurs, in part, due to diminishing white matter integrity. Higher cardiorespiratory fitness (CRF) is associated with better cognitive performance, but the neurobiological mechanisms underlying this association remain uncertain. Previous magnetic res...