Longevity Papers

Week of July 21 - July 27, 2025


Weekly AI-generated podcast (YT) (Apple) (feed), 2025-07-18 episode:
Saturday, July 26, 2025
Rees-Baylis, E., Wang, D., Li Richter, X.-Y. ... · evolutionary biology · Institute of Ecology and Evolution, University of Bern, Bern, Switzerland · biorxiv
Sex differences in ageing and lifespan are widespread across taxa, yet their evolutionary causes remain debated. A leading hypothesis suggests these differences are adaptive and driven by sex-specific life-history trade-offs, but formal theoretical support is lacking. To address ...
Ong, R. C. S., Tang, A. · neuroscience · University of Western Australia · biorxiv
Repetitive transcranial magnetic stimulation (rTMS) is an attractive tool to promote healthy brain ageing in older adults and treat age-related neurological conditions. Despite its popularity, the neurological processes and plasticity mechanisms altered by rTMS in the aged brain,...
Ravindran, S., Corripio-Miyar, Y., Pick, J. L. ... · ecology · Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK · biorxiv
The hormone insulin-like growth factor 1 (IGF-1) is a key player in the insulin/IGF-1 signaling (IIS) pathway. Extensive biogerontological research demonstrates that this evolutionarily conserved nutrient-sensing pathway plays a causal role in the regulation of growth, reproducti...
Babygirija, R., Green, C. L., Sonsalla, M. M. ... · physiology · University of Wisconsin-Madison · biorxiv
Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumption of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and va...
Victoria-Chavez, R., Lamas, M. · molecular biology · Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional · biorxiv
The regenerative response of retinal cells to injury and aging depends on the epigenomic plasticity that enables the dedifferentiation and neuronal differentiation capacities of Muller glial cells (MG). In mammals, this regenerative ability is extremely limited, and disruptions i...
Friday, July 25, 2025
Jie Li, Qiyang Chen, Fuliang Xiao ... · Food science & nutrition · Chongqing Academy of Agricultural Sciences Chongqing China. · pubmed
Although tea polyphenols have antiaging potential, the molecular interplay between black tea components and cellular longevity remains unclear. This study has pioneered a dual approach combining
Yingqi Xu, Maohao Li, Congxue Hu ... · Genome medicine · College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. · pubmed
The decline in organ function due to aging significantly impacts the health and quality of life of the elderly. Assessing and delaying aging has become a major societal concern. Previous studies have largely focused on differences between young and old individuals, often overlook...
Junjie Cao, Xuan Wang, Keyi Huang ... · IEEE journal of biomedical and health informatics · Not available · pubmed
As the aging population continues to grow, falls among older adults have become a significant public health concern worldwide. Data-driven approaches for effective fall risk prediction, which integrate standard functional tests with 3D skeleton data from depth sensors, are gainin...
Zhaoqi Yan, Yifeng Xu, Ting Peng ... · Biogerontology · Department of Rehabilitation Medicine, The Third Hospital of Nanchang, Nanchang People's Hospital, 240 Zhanqian West Road, Xihu District, Nanchang City, 330009, Jiangxi Province, China. · pubmed
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA methylation age (Horvathage) ...
Hyejin Mun, Chang Hoon Shin, Mercy Kim ... · Aging · Department of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA. · pubmed
Signaling pathways and transcriptional regulation during cellular senescence have been investigated; however, energy metabolism is one of the understudied areas. Senescent cells secrete pro-inflammatory cytokines and release proteins and RNAs via exosomes that contribute to organ...
Yangxin Yu, Xinhang Lv, Zhuowei Chen ... · Journal of medicinal chemistry · Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, P. R. China. · pubmed
Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies. Recently, emerging evidence has revealed pathological accumulation of senescent c...
Emma M Tinney, Aaron E L Warren, Amanda O'Brien ... · Alzheimer's & dementia (New York, N. Y.) · Department of Psychology Northeastern University Boston Massachusetts USA. · pubmed
Age-related cognitive decline occurs, in part, due to diminishing white matter integrity. Higher cardiorespiratory fitness (CRF) is associated with better cognitive performance, but the neurobiological mechanisms underlying this association remain uncertain. Previous magnetic res...
Thursday, July 24, 2025
Yanjun Li, Qi Huang, Jin Jiang ... · Nature medicine · Vanke School of Public Health, Tsinghua University, Beijing, China. · pubmed
Accurate and convenient assessment of individual aging is crucial for identifying health risks and preventing aging-related diseases. Nonetheless, current aging proxies often face challenges such as methodological limitations, weak associations with adverse outcomes and limited g...
Jacques, M., Seale, K., Voisin, S. ... · bioinformatics · Monash University · biorxiv
Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserved and tissue-specific aging signatures. ...
Ruonan Liu, Zheng Zhu, Yuanyue Zhu ... · GeroScience · Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Geriatric Medical Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. · pubmed
Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected processes of lifespan extension and aging remains poorly understood. This study employed genetic approaches to identify GM taxa exerting causal effects on longevity...
Zhuoyan Lyu, Anatoly B Kolomeisky · The journal of physical chemistry letters · Department of Chemistry, Rice University, Houston, Texas 77005, United States. · pubmed
Although understanding the biology of ovarian aging and the timing of menopause is critical for supporting women's reproductive health, many aspects of these processes remain unclear. Stimulated by observations of transitions between different stages of functional units of ovaria...
Zachary Miller, Laura-Marie Twardowski, Brenda F Reader ... · Lung · Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, Davis Heart Lung Research Institute, The Ohio State University, Columbus, OH, USA. · pubmed
Ageing significantly impacts lung function and increases susceptibility to chronic lung diseases. The lung is a complex organ with multiple cell types that undergo cellular age-related perturbations or hallmarks. As knowledge of ageing mechanisms has progressed, we have a better ...
Alper Cevirgel, Marieke van der Heiden, Sudarshan A Shetty ... · Aging cell · Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. · pubmed
Immune aging is associated with decreased vaccine responses, but biomarkers for vaccine responsiveness remain unidentified. We analyzed immunotypes describing pre-vaccination immune cell profiles and their associations with triple vaccine responsiveness to influenza, pneumococcal...
Lenart, P., Psalmon, S., Towbin, B. D. · evolutionary biology · University of Bern · biorxiv
For most animals, intrinsic senescence-induced mortality increases with age, while deaths from extrinsic threats, such as predation or accidents, decline during development as individuals grow and mature. Age-dependent modulation of extrinsic mortality is known to influence the e...
Wednesday, July 23, 2025
Okamura, Y. T., Wang, T.-W., Kawakami, S. ... · cell biology · The Institute of Medical Science, The University of Tokyo · biorxiv
A plethora of senolytic compounds and technologies have been identified. However, the efficacy of these treatments in eliminating senescent cells and the suppression of chronic inflammation remains to be substantiated in vivo. Here, we employ single-cell RNA sequencing and find t...
Pouneh K Fazeli, Matthew L Steinhauser · Endocrine reviews · Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. · pubmed
The adaptive starvation response allows us to survive periods of starvation - a characteristic of the environment in which humans evolved. We are now in an evolutionary transition from a global environment which was characterized by periods of famine to a world where obesity and ...
Hongyu Lin, Kazunori Sasaki, Farhana Ferdousi ... · GeroScience · Tsukuba Life Science Innovation (T-LSI) Program, University of Tsukuba, 305-8577, Tsukuba, Japan. · pubmed
This study is the first to investigate the anti-aging effects of the newly synthesized compound, 3,4,5-tri-feruloylquinic acid (TFQA), in vivo using the senescence-accelerated mouse prone 8 (SAMP8) model, through integrated whole-transcriptomic and biochemical analyses. Oral admi...
Peizhong Qin, Qi Wang, You Wu ... · Aging · Department of Medical Genetics, School of Basic Medicine, Institute for Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · pubmed
Improving gut health by altering the activity of intestinal stem cells is thought to have the potential to reverse aging. The aged Drosophila midgut undergoes hyperplasia and barrier dysfunction. However, it is still unclear how to limit hyperplasia to extend lifespan. Here, we s...
Chuanle Wang, Wei Chen, Ruofei Li ... · Cell & bioscience · MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangzhou Key Laboratory of Healthy Aging Research, School of Lifesciences, Sun Yat-Sen University, Guangzhou, 510275, China. · pubmed
Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 85% of tumor cells, telomerase formed by TERT and TERC RNA complex is re...
Zihan Zhou, Zhenhua Zhou, Chunying Ye ... · Molecular human reproduction · Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. · pubmed
Thin endometrium (TE) is generally recognized as a contributing factor to reduced pregnancy rates and adverse perinatal outcomes, yet the pathogenesis of the disease remains elusive. We conducted an analysis and validation of the single-cell RNA sequencing (scRNA-seq) data pertai...
Qiaofeng Ye, Aaliya Ahamed, Idan Shalev ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA. · pubmed
Evolutionary theories of aging indicate trade-offs between reproduction and longevity. Epigenetic clocks, such as PhenoAge, GrimAge, and DunedinPoAm, were designed to reflect biological age and be used as surrogates for mortality and healthspan. The current study investigated the...
Maggie E Zink, Leslie Zhen, Jacie R McHaney ... · Noise · Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, United States. · pubmed
Middle age represents a critical period of accelerated brain changes and provides a window for early detection and intervention in age-related neurological decline. Hearing loss is a key early marker of such decline and is linked to numerous comorbidities in older adults. Yet, ~1...
Farnaz Karimani, Mehdi Eivani, Afsaneh Asgari Taei ... · Melatonin · Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. · pubmed
Aging is commonly associated with cognitive decline, particularly in memory, and is linked to neuronal hyperexcitability and disrupted sleep-related oscillations in key brain regions such as the hippocampus and prefrontal cortex. Melatonin has been proposed as a potential therape...
Jing Wang, Xiang Ren, Huan Lu ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei, 430030, China. · pubmed
Aging increases the vulnerability of kidneys to injury and impairs their regenerative capacity. SIRT3 expression declines with aging and is associated with multiple age-related pathologies. The expression profile and functional role of SIRT3 in renal aging remain unclear. Here, S...
Bradley A Ruple, Nicholas A Carlini, Jason S Kofoed ... · American journal of physiology. Endocrinology and metabolism · Geriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah. · pubmed
Aging is associated with alterations in immune cell function, contributing to age-related diseases and frailty. As peripheral blood mononuclear cells (PBMCs) are key drivers of the immune response, we investigated their transcriptome using RNA-sequencing before and immediately af...
Tyler D Robinson, Yutong L Sun, Paul T H Chang ... · GeroScience · Rotman Research Institute, 3560 Bathurst Street Baycrest, Toronto, Ontario, M6A 2E1, Canada. [email protected]. · pubmed
One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, ...
Tuesday, July 22, 2025
Zhao, K., Xie, H., Fonzo, G. A. ... · neuroscience · Stanford University · biorxiv
As populations age, identifying the neurobiological basis of cognitive resilience is critical for delaying or preventing Alzheimers disease (AD). While most older adults experience memory decline, a subset known as superagers (SA) maintains youthful memory into late life, offerin...
Sophie Dürauer, Hyun-Seo Kang, Christian Wiebeler ... · Ubiquitin · Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany. · pubmed
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslinks (DPCs). To understand how SPRTN's promiscuous protease activity is confined to cleavage of crosslinked proteins, we reconstitute the repair of DPCs including their modification w...
Bozack, A. K., Khodasevich, D., Nwanaji-Enwerem, J. C. ... · nutrition · Stanford University · medrxiv
Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999-2002), we tested for associations of total, saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and subtypes of dietary fatty acids with DNA...
Yi, Y.-J., Johansson, J., Garcia-Garcia, B. ... · neuroscience · Institute for Cognitive Neurology and Dementia Research · biorxiv
Cognitive ageing is marked by progressive decline in episodic memory and dopaminergic function, yet the extent to which individual differences in dopaminergic system integrity influence memory under motivational contexts remains unclear. In this study, we investigated how baselin...
Elder, M. A., Ellmore, T. M. · neuroscience · The City College of New York · biorxiv
Age-related differences in white matter structure are increasingly understood as nonlinear, regionally specific, and behaviorally relevant. Using whole-brain fixel-based analysis (FBA), we examined how recognition memory speed relates to micro- and macrostructural white matter pr...
Yidan Pang, Siyuan Zhu, Peng Ding ... · MedComm · Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China. · pubmed
Obesity and aging are major risk factors for diseases such as Type 2 diabetes mellitus, dementia, and osteoporosis. High-fat diet (HFD) consumption is one of the most important factors contributing to obesity. To elucidate and provide resources on how long-term HFD to aging (LHA)...
Chenke Jiang, Yihong Gan, Shengyu Chen ... · Aging clinical and experimental research · School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China. · pubmed
Observational studies have shown that physical activity and sedentary behavior are associated with aging. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationships between genetic...
Critchlow, A. J., Hiam, D., O'Bryan, S. ... · endocrinology · Deakin University · medrxiv
Whether and how ovarian hormone fluctuations mediate the skeletal muscle response to ageing in females remains to be elucidated. We examined a tightly controlled, cross-sectional cohort of 96 females between 18-80 years of age to map the functional and molecular trajectory of mus...
Monday, July 21, 2025
STOLZ, A., XUAN, C., FREITAS, C. ... · cell biology · INSERM UMR1287, Universite Paris Saclay, Gustave Roussy Cancer Center, 94805 Villejuif, France · biorxiv
Chronic inflammation that accompanies aging impairs the function of hematopoietic stem cells (HSCs) and promotes expansion of TET2-mutated cells, leading to clonal hematopoiesis of indeterminate potential (CHIP). The molecular mechanisms underlying these processes are still uncle...
Nguyen, T. D., Khan, Y. Z., Hossen, F. ... · cell biology · University of Illinois Chicago · biorxiv
As the innermost lining of blood vessels, endothelial cells (ECs) regulate blood flow, maintain vascular tone, and limit inflammation for vessel health. EC-derived nitric oxide (NO), synthesized by endothelial nitric oxide synthase (eNOS), is a vasodilator essential for improving...
Fernandez Molina, C., Chatre, L., Montagne, B. ... · cell biology · Institut Pasteur · biorxiv
The maintenance of mitochondrial proteins homeostasis, which is essential for proper cell function, is affected in pathophysiological ageing, yet several underlying mechanisms remain unexplored. We show that in normal and accelerated ageing cells, POLG1, the enzyme responsible fo...
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S Hanner ... · Aging cell · Craniofacial Anomalies and Regeneration Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA. · pubmed
Large-scale bone defects require complex surgical procedures to repair, but full restoration of the bone is not guaranteed due to the significant tissue loss involved. In contrast, fractures can frequently be treated with conservative techniques. Particularly, ribs have a remarka...
Sunday, July 20, 2025
Douglas M Ruden · Epigenomics · C. S. Mott Center for Human Growth and Development, Institute for Environmental Health Sciences, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. · pubmed
Aging is a complex biological process involving coordinated changes across multiple molecular systems. Traditional reductionist approaches, while valuable, are insufficient to capture the full scope of aging's systemic nature. Multiomics - integrating data from genomics, transcri...