Longevity Papers

Current Week (September 08 - September 11, 2025)
and Previous Week (September 04 - September 07, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), September 02 episode:
Thursday, September 11, 2025
Yan Bai, Tengfei Ma, Shan Zhao ... · Nature aging · State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan and Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China. · pubmed
Membraneless organelles assembled by liquid-liquid phase separation interact with diverse membranous organelles to regulate distinct cellular processes. It remains unknown how membraneless organelles are engaged in mitochondrial homeostasis. Here we demonstrate that mitochondria-...
Amador Gallardo, Efres Belmonte-Reche, María Marti-Marimon ... · Nature communications · Centre for Genomics and Oncological Research (GENYO), Avenue de la Ilustración 114, 18016, Granada, Spain. · pubmed
Circadian oscillations of gene transcripts rely on a negative feedback loop executed by the activating BMAL1-CLOCK heterodimer and its negative regulators PER and CRY. Although circadian rhythms and CLOCK protein are mostly absent during embryogenesis, the lack of BMAL1 during pr...
Mengyan Hu, Xinmei Kang, Zhiruo Liu ... · Nature aging · Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. · pubmed
Aging is a major risk factor for various neurological disorders, including Alzheimer's disease, and is associated with the accumulation of senescent cells, which can themselves propagate the senescence process through paracrine signaling. Migrasomes are organelles that form durin...
Paula Benny, Xi Yuan, Qian Yang ... · GeroScience · NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · pubmed
In the past century, the human Lifespan has doubled. However, this is not equivalent to Healthspan which refers to the number of years spent healthy and free from disease. Women have an additional level of complexity on the path to optimal healthspan where health resilience drama...
Wednesday, September 10, 2025
Jianying Zhang, He-Ling Wang, Sofie Lautrup ... · Nature aging · Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. · pubmed
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic re...
Oya Sayin, Rabia Ilgin, Erhan Caner Akkaya ... · Diet, Ketogenic · College of Vocational School of Health Services, School of Medicine, Dokuz Eylul University, Izmir, Turkey. · pubmed
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various neurological models. This study explored how KD-alone or combined with antibiotic-induced gut microbiota depletion-affects cognition and neuroinflammation in ...
Symeonidou, V., Bond, L., Giannelou, E. ... · cell biology · University of Cambridge · biorxiv
The global rise in ageing populations is driving an increase in age-associated diseases, including haematological malignancies such as myelodysplastic syndromes and acute myeloid leukaemia. A major challenge in addressing this burden is the lack of experimental systems that enabl...
Jiaming Li, Mengmeng Jiang, Qiaoran Wang ... · Nature aging · Aging Biomarker Consortium (ABC), Beijing, China. · pubmed
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehen...
Tuesday, September 09, 2025
Rui Feng, Sarah F Rosen, Irshad Ansari ... · Aging · Department of Neuroscience, Washington University School of Medicine, St Louis, United States. · pubmed
Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many disea...
Yonghe Ding, Xueling Ma, Feixiang Yan ... · Aging cell · Department of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. · pubmed
While BAG3 has been identified as a causative gene for dilated cardiomyopathy, the major pathological events in BAG3-related cardiomyopathy that could be targeted for therapeutic benefit remain to be discovered. Here, we aim to uncover novel pathological events through genetic st...
Jiang, W. I., Vale, G. D. d., Pearce, Q. ... · physiology · UCSF · biorxiv
The Arctic ground squirrel (AGS, Urocitellus parryii), an extreme hibernator, exhibits remarkable resilience to stressors like hypoxia and hypothermia, making it an ideal model for studying cellular metabolic adaptation. The underlying mechanisms of AGS resilience are largely unk...
Habib Joukhdar, Sunny Shinchen Lee, Thomas R Cox ... · Advanced materials (Deerfield Beach, Fla.) · School of Medical Sciences, University of Sydney, Sydney, NSW, 2006, Australia. · pubmed
The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging. Although this current tools for studying aging outside of the human body-such as animal models and ce...
Maanya Vittal, Manlio Vinciguerra · Withania · School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK. [email protected]. · pubmed
Ashwagandha (Withania somnifera), a revered herb in Ayurvedic medicine, has gained significant scientific recognition for its potential to promote healthy aging. Traditionally used as a Rasayana or rejuvenator, this potent adaptogen helps the body manage stress and enhance vitali...
Zachary J Fennel, Negar Kosari, Paul-Emile Bourrant ... · JCI insight · Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, United States of America. · pubmed
Impaired muscle regrowth in aging is underpinned by reduced pro-inflammatory macrophage function and subsequently impaired muscle cellular remodeling. Macrophage phenotype is metabolically controlled through TCA intermediate accumulation and activation of HIF1A. We hypothesized t...
Yina Lan, Xiaole Liang, Guotao Kuang ... · Aging cell · Department of Pediatrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. · pubmed
The CST (CTC1-STN1-TEN1) complex, a single-stranded DNA (ssDNA) binding complex, is essential for telomere maintenance and genome stability. Depletion of either CTC1 or STN1 results in cellular senescence, while mutations in these components are associated with severe hereditary ...
Angela D Mazza · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · Endocrinology, Metabolic Center for Wellness, Oviedo, United States. · pubmed
Thyroid hormones (TH), primarily triiodothyronine (T3) and thyroxine (T4), are critical regulators of metabolic rate, mitochondrial function, and cellular repair mechanisms. Emerging evidence suggests that thyroid status may significantly influence aging trajectories and longevit...
Hariharan Easwaran, Ashani T Weeraratna · Nature reviews. Cancer · The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA. [email protected]. · pubmed
Somatic mutations in several genes, including key oncogenes and tumour suppressor genes, are present from early life and can accumulate as an individual ages, indicating that the potential for cancer is present and growing throughout life. However, the risk of developing cancer r...
Monday, September 08, 2025
Groves, J. W., Bot, V. A., Ding, D. Y. ... · epidemiology · Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK · medrxiv
The pace of organ ageing varies substantially between individuals, yet drivers of variability remain poorly understood. This gap is critical, given only 20-30% of longevity is genetically inherited and age-related diseases are leading causes of morbidity and mortality. Proteomic ...
Meneses-Plascencia, J., Moreno-Mendez, E., Ascencio, D. ... · cell biology · Cinvestav, Centro de Investigacion sobre el Envejecimiento, 14330 Tlalpan, Cd.Mx., Mexico · biorxiv
The widely used antidiabetic drug metformin extends lifespan across diverse model organisms, from yeast to primates. However, the cellular mechanisms underlying its anti-aging effects remain only partially understood. Here, we combined large-scale genetic screening and high-resol...
Sen Zhang, Charles E Ayemoba, Anna M Di Staulo ... · Blood · University of Illinois at Chicago, Chicago, Illinois, United States. · pubmed
Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the me...
Sruthi Sivakumar, Ryan William LeFebre, Giulia Menichetti ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Physical Medicine and Rehabilitation, University of Pittsburgh (U. Pitt.); Pittsburgh, USA. · pubmed
Maintenance of organismal function requires tightly regulated biomolecular communication. However, with aging, communication deteriorates, thereby disrupting effective information flow. Using information theory applied to skeletal muscle single cell RNA-seq data from young, middl...
Gebremeskel, S., Embile, I. B., Bazhanov, N. ... · immunology · Fibrobiologics Inc · biorxiv
Thymic function can decline due to age-related involution, congenital disorders, acute infections or chemo/radiation therapy. Decline in thymic function leads to decreased T cell production and weakened immunity. To address these thymic insufficiencies, we sought to develop a tra...
Bari, K. A., Librais, G. N., Duennwald, M. L. ... · cell biology · The University of Western Ontario · biorxiv
Impaired proteostasis is a hallmark of aging and is associated with several neurodegenerative diseases, including Huntington\'s Disease (HD) where the polyglutamine (polyQ) expanded Huntingtin aggregates to form insoluble inclusions bodies (IBs) associated with neurotoxicity. Chr...
Watts, T., Johnston, H. E., Al-Mufti, Y. ... · cell biology · Signalling Programme, The Babraham Institute, Cambridge, UK · biorxiv
Healthy protein homeostasis (\'proteostasis\') relies on tightly-regulated protein quality-control (PQC) circuits that co-ordinate sequestration and clearance of potentially toxic aggregation-prone proteins, arising from various internal or external stress throughout an organism\...
Eun-Sun Yang, Se-Yun Cheon, Ji Yeong Park ... · BMB reports · Research Institute for Korean Medicine, Pusan National University, Yangsan 50612, Korea. · pubmed
Lipid metabolism plays an important role in aging and longevity, and lipophagy-a specialized form of autophagy that targets lipid vesicles-regulates lipid homeostasis and alleviates metabolic diseases such as metabolic dysfunctionassociated steatotic liver disease (MASLD). Ilimaq...
Kehan Zhang, Xiangyao Wang, Yuxiao Zhang ... · Journal of clinical periodontology · Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · pubmed
To investigate the functional significance of mitophagy in age-related osteogenic decline and the underlying mechanisms using in vivo and in vitro models.
Cassandra Malecki, Giovanni Guglielmi, Benjamin Hunter ... · Aging cell · School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. · pubmed
Ageing is one of the most significant risk factors for heart disease; however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed omics analyses (transcriptomics, prote...
Sunday, September 07, 2025
Gizowski, C., Popova, G., Shin, H. ... · neuroscience · Calico Life Sciences · biorxiv
Aging, the key risk factor for cognitive decline, impacts the brain in a region-specific manner, with microglia among the most affected cell types. However, it remains unclear whether this is intrinsically mediated or driven by age-related changes in neighboring cells. Here, we d...
Catlin, J. P., Fraher, S., Alexander, J. J. ... · neuroscience · State University of New York at Buffalo · biorxiv
It is widely thought that age-related damage is the single biggest contributing factor to neurodegenerative diseases. However, recent studies are beginning to indicate that many of these diseases may have developmental origins that become unmasked overtime. It has been difficult ...
Fernandez Ugidos, I., Calvo Iglesias, J., Milanes, S. ... · neuroscience · Tulane University · biorxiv
Healthy aging is accompanied by a gradual decline in higher-order cognitive functions, including working memory, attention, and cognitive flexibility, processes that critically rely on intact frontal cortical circuits. While neuronal loss is minimal during aging, whether there ar...
Rathod, B., Samvelyan, J., Gustafsson, N. ... · developmental biology · KAROLINSKA INSTITUTET · biorxiv
Tartrate-resistant acid phosphatase (TRAP/ACP5), primarily known as an osteoclast marker, has emerged as a critical regulator of skeletal integrity, regulating sex-specific bone growth, and bones response to mechanical load in young adult male mice. In this study, we investigated...
Saturday, September 06, 2025
Daisy Sproviero, César Payán-Gómez, Chiara Milanese ... · Nature aging · IFOM-ETS, The AIRC Institute of Molecular Oncology, Milan, Italy. · pubmed
Aging is the main risk factor for Parkinson's disease (PD), yet our understanding of how age-related mechanisms contribute to PD pathophysiology remains limited. We conducted a longitudinal analysis of blood samples from the Parkinson's Progression Markers Initiative cohort to in...
Ibrahim, R., Froschauer, C., Broschk, S. ... · genetics · University of Glasgow · biorxiv
The changing demography of human populations has motivated a search for interventions that promote healthy ageing, and especially for evolutionarily-conserved mechanisms that can be studied in lab systems to generate hypotheses about function in humans. Reduced Insulin/IGF signal...
Holthusen, H., Trinkaus, V. A., Fernandez Gonzalez, C. ... · cell biology · Max Planck Institute for Biochemistry · biorxiv
Protein aggregation in various cellular compartments is a hallmark of proteostasis impairment linked to aging and numerous pathologies. Mitochondrial function depends on a balanced interplay of proteins imported from the cytosol as well as those synthesized on mitochondrial ribos...
A O Esemezie, D J Lizotte, G Tsakos ... · Journal of dental research · Dentistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. · pubmed
The fundamental cause theory posits social factors as causes of disease as they encompass access to important resources such as knowledge, wealth, and social networks. While these social factors have been consistently associated with oral and systemic diseases, causality remains ...
Friday, September 05, 2025
Itai, S., Usami, R., Korekata, M. ... · bioengineering · Tohoku University · biorxiv
Vascular aging contributes to multisystem diseases and limits health span. Although various animal models have contributed to aging research, their vasculatures poorly recapitulate human physiology. Even existing tissue-engineered blood vessels fail to mimic human vascular functi...
Gao-Hong Zhu, Rui He, Zhi-Yu Yang ... · Brain : a journal of neurology · Department of Nuclear Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China. · pubmed
The hippocampus (HC), a central hub for memory and cognition, exhibits unique metabolic resilience during aging despite widespread brain glucose hypometabolism. Here, we report that aged humans and macaques paradoxically display elevated HC glucose uptake (18F-FDG PET SUVR) along...
Jian Liu, Mingjie Rong, Chen Liu ... · ACS nano · State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. · pubmed
Cellular senescence is a critical factor in organismal aging and age-related diseases. Nicotinamide adenine dinucleotide (NAD
Sarah Al-Dulaimi, Ross Thomas, Sheila Matta ... · Telomerase · Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK. · pubmed
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related di...
Xin Shen, Xianzhi Gao, Lie Wang · Acta biochimica et biophysica Sinica · Co-Facility Center, Zhejiang University School of Medicine, Hangzhou 310058, China. · pubmed
Intestinal immunosenescence, a hallmark of organismal aging, has emerged as a critical biological process impacting the health of elderly individuals. This review systematically examines the core mechanisms underlying intestinal immunosenescence, including immune cell dysfunction...
Sarah M Chang, Latisha P Franklin, Sampurna Sattar ... · Genetics · Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. · pubmed
Mitochondrial sirtuins regulate metabolism and are emerging drug targets for metabolic and age-related diseases such as cancer, diabetes, and neurodegeneration. Yet, the extent of their functions remain unclear. Here, we uncover a physiological role for the C. elegans mitochondri...
Anam Naseer, Pranoy Toppo, Mahmood Akbar ... · Disease models & mechanisms · Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. · pubmed
Mitochondria are the regulators of energy production and play a vital role in modulating ageing and age-associated diseases. We investigated the role of sirtuins, a well-studied class of longevity-associated proteins (NAD+-dependent histone deacetylases), in mitochondrial biology...
Yunqi Xing, Junfeng Zhu · International journal of molecular medicine · Department of Hepatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China. · pubmed
Cellular senescence, a hallmark of aging, is characterized by irreversible, permanent cell cycle arrest accompanied by halted proliferation triggered by endogenous or exogenous stimuli. The accumulation of senescent cells in tissues or organs elicits detrimental effects on adjace...
Antoine M Dujon, Klara Asselin, Jean François Lemaître ... · Aging cell · CREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD, Montpellier, France. · pubmed
Aging, and by extension age-related diseases, has traditionally been understood through classical evolutionary genetic models, such as the mutation accumulation and antagonistic pleiotropy theories. However, these frameworks primarily focus on the declining efficacy of organismal...
Thursday, September 04, 2025
Zhihua Huang, Xinxin Liu, Xiaojia Zhou ... · Aging cell · Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Beijing, China. · pubmed
The accumulation of senescent cells (SNCs) contributes to tissue dysfunction and age-related diseases, creating an urgent need for effective senolytic strategies. We identified a metabolic vulnerability in SNCs characterized by marked downregulation of asparagine synthetase (ASNS...
Zhou, Y., Ahsan, F., Li, S. ... · molecular biology · Massachusetts General Hospital and Harvard Medical School · biorxiv
Exposure to low levels of environmental challenges, known as hormetic stress, such as nutrient deprivation and heat shock, fosters subsequent stress resistance and promotes healthy aging in later life. However, specific mechanisms governing transcriptional reprogramming upon horm...
Herzog, C. M. S., Vavourakis, C. D., Theeuwes, B. ... · systems biology · Universitaet Innsbruck · biorxiv
Smoking is one of the single most important preventable risk factors for cancer and other adverse health outcomes [1,2]. Smoking cessation represents a key public health intervention with the potential to reduce its negative health outcomes [2-4]. While epidemiological, cross-sec...
Herzog, C. M. S., Vavourakis, C. D., Theeuwes, B. ... · systems biology · Universitaet Innsbruck · biorxiv
While intermittent fasting (IF) promotes longevity in animal models, its systemic effects in humans remain poorly understood. Here, we present a six-month longitudinal IF intervention in 114 women (BMI 25-35) with deep clinical, molecular, and microbiome profiling across >3,400 b...
Seda Koyuncu, Yaiza Dominguez-Canterla, Rafael Alis ... · Nature aging · Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. [email protected]. · pubmed
Aging is a major risk factor for neurodegenerative diseases associated with protein aggregation, including Huntington's disease and amyotrophic lateral sclerosis (ALS). Although these diseases involve different aggregation-prone proteins, their common late onset suggests a link t...
Bridge, J. E., Xia, C., Zheng, C. ... · genomics · University of Minnesota · biorxiv
Accurate detection of somatic mutations in noncancerous cells is critical for studying somatic mosaicism, a process implicated in aging and multiple chronic diseases. However, single-cell and single-molecule DNA sequencing platforms differ in their error profiles, coverage biases...
Stefan M M Goetz, Todd Lucas, Eric Finegood ... · Psychoneuroendocrinology · Wayne State University, USA. · pubmed
Age related diseases present disproportionately among African Americans and have been tied to broad social inequalities and accompanying stress. Yet, there is considerable variability among African Americans in susceptibility, highlighting potential connections to both intersecti...
Safina, K. R., Kotliar, D. A., Curtis, M. ... · cell biology · Brigham and Women\'s Hospital · biorxiv
Aging of the blood system impacts systemic health and can be traced to hematopoietic stem cells (HSCs). Despite multiple reports on human HSC aging, a unified map detailing their molecular age-related changes is lacking. We developed a consensus map of gene expression in HSCs by ...
Ya Zhao, Jia-Yu Qiu, Fang Wu ... · Aging cell · Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China. · pubmed
Vascular aging increases the susceptibility to cardio-cerebrovascular conditions, such as atherosclerotic diseases and hypertension, the leading causes of global disability and mortality. Dietary citrate extends the lifespan of Drosophila melanogaster and Caenorhabditis elegans a...
Qifeng Song, Shi Sun, Yuxiu Song ... · Neural regeneration research · Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. · pubmed
Ferroptosis is a newly recognized form of programmed cell death characterized by iron overload-dependent lipid peroxidation. These pathological phenomena are often observed in neurodegenerative diseases. Aging is an irreversible process characterized by the deterioration of tissu...
Brandon T Tran, Vidthiya Jeyanathan, Ruoqiong Cao ... · Hematopoietic Stem Cells · Department of Pediatrics, Division of Infectious Diseases, and Stem Cells and Regenerative Medicine Center, Baylor College of Medicine and Texas Children's Hospital, Houston, United States. · pubmed
Human and murine studies reveal that innate immune cells are able to mount enhanced responses to pathogens after primary inflammatory exposure. Innate immune memory has been shown to last for months to years, longer than the lifespan of most innate immune cells. Indeed, long-live...
Feng, G., Ruark, E. M., Mulligan, A. G. ... · physiology · Vanderbilt University · biorxiv
While certain forms of mitochondrial impairment confer longevity, disease-associated mutations trigger dysfunction and severe pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex...
Calubag, M. F., Ademi, I., Green, C. L. ... · physiology · University of Wisconsin-Madison · biorxiv
Dietary protein is a key regulator of metabolic health in humans and rodents. Many of the benefits of protein restriction are mediated by reduced consumption of dietary branched-chain amino acids (BCAAs; leucine, valine and isoleucine), and restriction of the BCAAs is sufficient ...
A Ibáñez de Opakua, R Conde, A de Diego ... · npj metabolic health and disease · ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain. · pubmed
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-th...
Ailsa M Jeffries, Tianxiong Yu, Jennifer S Ziegenfuss ... · Nature · Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA. · pubmed
Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process
Lars Thielecke, Kalpana Nattamai, Aishlin Hassan ... · Stem cells (Dayton, Ohio) · Institute for Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany. · pubmed
The sustained production of blood and immune cells is driven by a pool of hematopoietic stem cells (HSCs) and their offspring. Due to the intrinsic heterogeneity of HSCs, the composition of emergent clones changes over time, leading to a reduced clonality in aging mice and humans...
Jiaxin Shi, Jason M Fletcher · Population studies · The Hong Kong University of Science and Technology. · pubmed
Research indicates a significant slowdown in life expectancy growth in the United States (US) post 2010, marking a departure from the consistent progress in longevity throughout the twentieth century. We extend this understanding, tracing the deceleration of US life expectancy ba...
Wednesday, September 03, 2025
Bnaya Gross, Joseph Ehlert, Vadim N. Gladyshev ... · q-bio.MN · Not available · arxiv
Despite the thousands of genes implicated in age-related phenotypes, effective interventions for aging remain elusive, a lack of advance rooted in the multifactorial nature of longevity and the functional interconnectedness of the molecular components implicated in aging. Here, w...