Longevity Papers

Current Week (May 26 - May 31, 2025)
and Previous Week (May 24 - May 25, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), May 29 episode:
Saturday, May 31, 2025
Wang, J., Cai, Z., Gu, J. ... · physiology · Hunan Normal University · biorxiv
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferentially regulates the translation of 5\'-terminal oligopyrimidine (TOP) motif-conta...
Friday, May 30, 2025
Jiayu Guo, Yan Wang, Qiudi Liu ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150081, China. · pubmed
Idiopathic pulmonary fibrosis (IPF) is a prototype of chronic, progressive, and fibrotic lung disease. While advancing age is recognized as the most significant risk factor for both the development and mortality associated with pulmonary fibrosis, precise mechanisms underlying th...
Ye, Y., Ming, D. · bioinformatics · Nanjing Tech University · biorxiv
Senolytics, a category of drugs targeting aging processes, have garnered significant attention since their emergence in 2015. Unlike traditional drug development approaches that rely on randomized screening, research on aging-related pharmaceuticals has employed mechanism-based s...
Jiaojiao Xie, Taewan Kim, Zhongmao Liu ... · mSystems · The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. · pubmed
The gut microbiota evolves over a lifetime and significantly impacts the aging process. Targeting the gut microbiota represents a novel avenue to delay aging and aging-related physical and mental decline. However, the underlying mechanism by which the microbiota modulates the agi...
Masaya Hane, Ayane Naramura, Kaito Hayakawa ... · Sialic Acids · Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan. · pubmed
Polysialic acid (polySia), a glycoepitope critical for neural development and plasticity, remains difficult to quantify owing to its structural complexity. Here, we present a highly sensitive sandwich enzyme-linked immunosorbent assay (ELISA) utilizing novel probes to measure pol...
Jing Wang, Xiaolan Zhou, Peng Yu ... · Nature aging · State Key Laboratory of Genetics and Development of Complex Phenotypes, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, China. · pubmed
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited markers or homogeneous samples, which might ...
Zhiming Liu, Gang Du, Yi Chen ... · PLoS genetics · West China Centre of Excellence for Pancreatitis, and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. · pubmed
The decline in adult stem cell performance is closely linked to tissue malfunction and the rising incidence of age-related diseases. To investigate the molecular basis of these impairments, our screening strategy identified reduced activity in the pantothenate/coenzyme A (CoA) pa...
Simmons, S. R., Rivera, A., Ghanem, E. N. B. · immunology · University at Buffalo · biorxiv
The decline in neutrophil antimicrobial function renders vaccinated aged hosts less protected against Streptococcus pneumoniae infection. In vaccinated hosts, activation of neutrophils via phagocytic receptors, like complement and Fc{gamma} receptors, mediates bacterial uptake an...
Yejin Cho, Woo Jin Lee, Hee Soo Kim ... · GeroScience · Aging Research Group, Korea Food Research Institute, Wanju-gun, South Korea. · pubmed
Sarcopenia, a condition characterized by the loss of muscle mass and function with aging, is linked to various health issues including diabetes and increased risk of falls and fractures. Currently, there is no FDA-approved treatment exists for sarcopenia. Citrinin, a natural comp...
Priyankaa Bhatia, Judith Tafur, Ruchi Amin ... · Oocytes · Department of Cell Biology, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA. · pubmed
Animals store oocytes in a dormant state for weeks to decades before ovulation. The homeostatic programs that oocytes use to endure long-term storage are poorly understood. Using female nematodes as a short-lived model, we found that oocyte formation and storage required IFET-1, ...
Maarouf Baghdadi, Helena Hinterding, Thies Gehrmann ... · GeroScience · Max Planck Institute for Biology of Ageing, Cologne, Germany. · pubmed
Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequ...
Mega Obukohwo Oyovwi, Ejime A Chijiokwu, Arientare Rume Rotu ... · Journal of assisted reproduction and genetics · Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun, Nigeria. [email protected]. · pubmed
The intersection of aging and reproductive decline presents a significant challenge in human health, with fertility rates decreasing sharply in later life for both sexes. This review delves into the intricate relationship between germ cells, the fundamental units of reproduction,...
Fan, W., Ishikawa, M., Raja, E. ... · developmental biology · Kyushu University · biorxiv
The extracellular matrix (ECM) is crucial in building the extracellular environment and translating extracellular information into biochemical signals that sustain organ functions. Fibulin-5 (Fbln5) is a multifunctional ECM protein essential for forming elastic fibers and regulat...
Martin, M. S., Bayaraa, N., Fox, B. ... · biochemistry · Tufts University · biorxiv
Glycation is a non-enzymatic post-translational modification associated with aging and disease. Because it occurs spontaneously, it is extremely difficult to control the extent of glycation at distinct sites within target proteins, especially in cellular systems. Here we report a...
Xinfeng Bai, Pu Shi, Weihua Chu · Probiotics · Shandong Provincial Third Hospital, Shandong University, Jinan, China. · pubmed
Γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system, has been shown to alleviate various physiological disorders including insomnia, hypertension, depression, and memory loss. Lactic acid bacteria (LAB), recognized as safe GABA producers,...
Samuel Ruiz-Pérez, Nicolás Alcaraz, Karla Torres-Arciga ... · Advanced biology · Laboratorio de Regulación de la Cromatina y Genómica, Instituto Nacional de Cancerología, Av. San Fernando 22, Belisario Domínguez Sección XVI, Tlalpan, Ciudad de México, 14080, Mexico. · pubmed
The axolotl (Ambystoma mexicanum) has a great capacity to regenerate its tissues; however, the fidelity and success of its regenerative process diminish with age. Retrotransposons make up the largest portion of the axolotl genome, and their expression may be involved in this age-...
Ruin Moaddel, Chad Sanehira, Gregory Keyes ... · npj aging · Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD, USA. [email protected]. · pubmed
Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very f...
Yuanxin Miao, Yan Xu, Jia Gao ... · NPJ science of food · Functional Exploration and Comprehensive Utilization Team for Specialty Foods, Jingchu University of Technology, Jingmen, China. · pubmed
Chinese olive (Canarium album L.) contains various phytochemical compositions, exhibiting multiple health-promoting bioactivities. In this study, we used Caenorhabditis elegans (C. elegans) as model organisms to investigate the anti-aging functions of Chinese olive fruit extract ...
Prajakta Tiwari, Shreesh Kumar Shukla, Smita Rastogi Verma · Neoplasms · Department of Biotechnology, Delhi Technological University, Delhi, 110042, India. · pubmed
Senescence is a pivotal cellular process, which also plays a major role in development, immune regulation, tissue repair, and aging, triggered by stressors such as telomere shortening, oncogene activation, and DNA damage. Characterized by distinct morphological and molecular feat...
Thursday, May 29, 2025
Kevin O Murray, Sophia A Mahoney, Katelyn R Ludwig ... · Aging cell · Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA. · pubmed
Excess cellular senescence contributes to age-related increases in frailty and reductions in skeletal muscle strength. In the present study, we determined the efficacy of oral intermittent treatment (1 week on-2 weeks off-1 week on) with the natural flavonoid senolytic fisetin to...
Mingtong, G., Alfatah, M. · genetics · Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117544, Singapore · biorxiv
Aging involves cellular decline and reduced stress resilience. We investigated geroprotective interventions using the yeast chronological aging model and identified methyl nicotinate (MN) as a potent lifespan-extending compound. MN enhanced cellular lifespan and stress resistance...
Lisonia Gkioni, Tobias Nespital, Maarouf Baghdadi ... · Nature aging · Department Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany. · pubmed
Suppression of the insulin-IGF-mTORC1-Ras network ameliorates aging in animals. Many drugs have targets in the network because of its roles in cancer and metabolic disease and are candidates for repurposing as geroprotectors. Rapamycin, an established geroprotective drug, blocks ...
Panek, J., Sun, C., Kataura, T. ... · cell biology · Newcastle University · biorxiv
Autophagy is a critical mechanism of cellular quality control, orchestrated by selective autophagy receptor (SAR) proteins. Pharmacologically enhancing the cargo-targeting capacity of SARs presents an attractive but underexplored strategy for the precise therapeutic activation of...
Inés Fernández Maestre, Alexander S Harris, Corina Amor · Genes & development · Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. · pubmed
The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involve...
Xu Wang, Dan Guo, Chengmei He ... · Mesenchymal Stem Cells · Clinical Biobank, Department Medical Research Central, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. · pubmed
Aging leads to a gradual decline in immune function, termed immunosenescence, which significantly elevates the susceptibility to infections, cancers, and other aging-related diseases. Recent advancements have shed light on the molecular underpinnings of immune aging and pioneered...
Xu, P., Zhang, H., Zhu, S. ... · genomics · Center of Clinical Laboratory Medicine, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Southeast University · biorxiv
Cellular senescence represents a stable cell cycle arrest state that plays critical roles in tissue aging and age-related pathologies. While single-cell RNA sequencing (scRNA-seq) has enabled comprehensive profiling of millions of cells in aged tissues, reliable identification of...
Flora, Y., Shastri, D., Bohnert, K. A. · cell biology · Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana USA 70803 · biorxiv
Peroxisomes execute essential functions in cells, including detoxification and lipid oxidation. Despite their centrality to cell biology, the relevance of peroxisomes to aging remains understudied. We recently reported that peroxisomes are degraded en masse via pexophagy during e...
Carina Kern, Joseph V Bonventre, Alexander W Justin ... · Oncogene · LinkGevity, Babraham Research Campus, Cambridge, UK. [email protected]. · pubmed
Necrosis is uncontrolled cell death that marks the irreversible threshold of biological degeneration. Rooted in the Greek nekros (death), it is a pivotal mechanism underlying numerous diseases, including cancer, as well as renal, cardiac, neuronal, and hepatic disorders, and more...
Marc Daniel Opfermann, Maria Bøgelund Søndergård, Louise Vase Bech ... · Nature chemical biology · Department of Forensic Medicine, Aarhus University, Aarhus, Denmark. · pubmed
Methylglyoxal (MG) is a reactive metabolite involved in diabetes and aging through the formation of protein adducts. Less is known about the extent that MG and its metabolic product S-D-lactoylglutathione (LGSH) form adducts with cell metabolites. Using a 'symmetric' isotope-labe...
Mingyu Xia, Feng Zhang, Jiaoyao Ma ... · Cell reports · ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China. · pubmed
Degeneration of the auditory and vestibular hair cells (HCs) leads to dysfunction of two essential senses: hearing loss and decompensated balance perception. However, the cellular and molecular mechanisms governing inner ear aging and its link to dysfunctions of sensory HCs remai...
Chen, F., Nam, Q., Wang, L. D. ... · molecular biology · Nanyang Technological University · biorxiv
Lipofuscin, a protein-lipid complex that progressively accumulates in senescent cells, was commonly observed in the liver biopsies from patients with liver fibrosis or cirrhosis regardless of the etiological insults. However, whether and how lipofuscin contributes to the developm...
Wednesday, May 28, 2025
Gupta, R., Durham, T. J., Chau, G. ... · genetics · Harvard Medical School · biorxiv
One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, abundance, and heteroplasmic variation in human blood using whole genome sequences...
Zhenguo Wang, Zhe Li, Hongyu Liu ... · Nature aging · CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. · pubmed
Mitochondria rapidly accumulate mutations throughout a lifetime, potentially acting as a molecular clock for aging and disease. We profiled mitochondrial RNA across 47 human tissues from 838 individuals, revealing rapid development of clonal mosaicism with two distinct tissue-spe...
Shiyi Zhou, Katherine E Novak, Rachel Kaletsky ... · Nature aging · Department of Molecular Biology, Princeton University, Princeton, NJ, USA. · pubmed
While memory regulation is predominantly understood as autonomous to neurons, factors outside the brain can also affect neuronal function. In Caenorhabditis elegans, the insulin/IGF-1-like signaling (IIS) pathway regulates longevity, metabolism and memory: long-lived daf-2 insuli...
Dandan Zong, Baihui Sun, Qiting Ye ... · Aging cell · Department of Endocrinology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. · pubmed
As global aging accelerates, the incidence of thyroid diseases, particularly hypothyroidism, is rising in the elderly. The thyroid-stimulating hormone (TSH) levels increase in healthy elderly populations. However, whether the thyroid undergoes cellular senescence and how this rel...
Pushkal Sharma, Colin Y Kim, Heather R Keys ... · Polyamines · Whitehead Institute for Biomedical Research, Cambridge, MA, USA. · pubmed
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutical...
Anna Calabrò, Anna Aiello, Paula Silva ... · GeroScience · Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90134, Palermo, Italy. · pubmed
Geroprotectors are compounds that target the underlying mechanisms of ageing to delay the onset of age-related diseases and extend both lifespan and health span. As ageing is driven by the accumulation of cellular damage, DNA instability, epigenetic changes, mitochondrial dysfunc...
Xinying Wang, Limin Song, Jingwen Zhao ... · Journal of materials chemistry. B · National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, P. R. China. [email protected]. · pubmed
During tissue repair, stress-induced cellular senescence represents a critical factor that impedes the regenerative potential of tissues. While the regulatory effects of matrix viscoelasticity on cellular behavior have been documented, their role and correlated mechanisms underly...
Graham, Z. A., Bubak, M. P., Raymond-Pope, C. J. ... · geriatric medicine · Florida Institute for Human and Machine Cognition · medrxiv
Age-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments compromising intrinsic capacity, healthspan and quality-of-life. Exercise is a multipotent treatment with promise to mitigate mos...
Koitz, F. A., Miller, C. P., Gordon, K. L. · developmental biology · The University of North Carolina at Chapel Hill · biorxiv
Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improve. We discovered dramatic differences in gonad size and germ cell number among d...
Yao Zhang, Peng Ma, Saifei Wang ... · Autophagy · Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 20092, China. · pubmed
Breakdown of calcium network is closely associated with cellular aging. Previously, we found that cytosolic calcium (CytoCa
Klara Kohoutova, Pavel Srb, Veronika Obsilova ... · Tumor Suppressor Protein p53 · Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic. · pubmed
The transcription factors FOXO4 and p53 regulate aging, and their deregulation has been linked to several diseases, including cancer. Under stress conditions, cellular senescence is promoted by p53 sequestration and senescence-associated protein p21 transcriptional upregulation i...
Tuesday, May 27, 2025
Matias Fuentealba, Dobri Kiprov, Kevin Schneider ... · Aging cell · Buck Institute for Research on Aging, Novato, California, USA. · pubmed
We conducted a randomized, placebo-controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE) regimens in healthy adults over 50. Participants received bi-weekly TPE with or without intravenous immunoglobulin (IVIG), monthly...
Allavena, G., Rossiello, F., Idilli, A. I. ... · pathology · Institute for Research on Cancer and Aging of Nice (IRCAN) · biorxiv
Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and cellular senescence or apoptosis. We previously reported that telomere dysfunction...
Vivas, O., Baudot, M., Choi, S. ... · biophysics · University of Washington · biorxiv
Every heartbeat is initiated by a spontaneous electrical signal generated inside the cardiac pacemaker. The generation of this electrical signal depends on the coordinated opening and closing of different ion channels, where voltage-gated L-type calcium channels play a central ro...
Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin ... · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. · pubmed
Human aging is intrinsically associated with the onset and the progression of several disease states causing significant disability and poor quality of life. Although such association was traditionally considered immutable, recent advances have led to a better understanding of se...
Woldhuis, R. R., Bekker, N. J., Nijnatten, J. L. L. ... · pathology · Department of Pathology and Medical Biology, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Gronin · biorxiv
Rationale: Higher levels of senescence have been demonstrated in COPD patients, including severe early onset (SEO)-COPD. Recently we demonstrated a link between senescence and extracellular matrix (ECM) dysregulation in lung fibroblasts. Whether this in vitro observation also tra...
Jung Min Hwang, Soo Hyun Lee, Eun Jae Baek ... · Skin Aging · Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. · pubmed
Skin ageing is a complex and multifaceted biological process that involves the accumulation of senescent dermal fibroblasts. While fractional microneedle radiofrequency (MNRF) is widely used for skin rejuvenation, the underlying molecular mechanisms are unknown. This study aimed ...
Shu, J., Guo, Y., Chirinos, J. ... · genetic and genomic medicine · University of Pennsylvania · medrxiv
Organ-specific aging clocks have shown promise as predictors of disease risk and aging trajectories; however, the underlying biological mechanisms they reflect remain largely unexplored. Here, we use large-scale proteomic and imaging data to investigate the relationships among or...
Yan Pan, Hongxia Cai, Fang Ye ... · Aging cell · Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
Despite the growing interest in developing anti-aging drugs, high costs and low success rates of traditional drug discovery methods pose significant challenges. Aging is a complex biological process associated with numerous diseases, making the identification of compounds that ca...
Sibin Nambidi, Sneha Pallatt, Antara Banerjee ... · Neoplasms · Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, India. · pubmed
Klotho, named after the youngest of the three Fates in Greek mythology daughters of Zeus and Nyx, who together spin the thread of life, allot destiny, and determine the time of passing for both mortals and immortals, is an important regulatory factor in aging and cancer dynamics....
Noureen, N., Kang, M. H. · bioinformatics · Texas Tech University Health Sciences Center · biorxiv
Telomerase activity plays a critical role in tumor growth and is quantified based on its level of expression. However, how these levels are associated with different pathways across various cancer types remains elusive due to the lack of a classification schema. Here, we defined ...
Yu Zhang, Xiaojie Liu, Hairong Lian ... · Aging cell · College of Marine Science and Engineering, Nanjing Normal University, Nanjing, Jiangsu, People's Republic of China. · pubmed
Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties. Although the metabolic and cellular pathways behind its longevity effects have been widely studied, few studies have explored the epigenetic regulatory effects ...
Filippos Anagnostakis, Sarah Ko, Mehrshad Saadatinia ... · Metabolome · Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. · pubmed
Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 pl...
Abhishek Vats, Yibo Xi, Amanda S Wolf-Johnston ... · Guanine · Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. · pubmed
Vision decline in the elderly, often due to retinal aging, predisposes individuals to pathologies like age-related macular degeneration. Currently, there are few effective oral treatments for this condition. Our study introduces an oral agent, 8-aminoguanine (8-AG), which targets...
Arun Balachandran, Heming Pei, Yifan Shi ... · Nature aging · Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. · pubmed
As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy do not distinguish differences caused by early-life factors, like prenatal care and nut...
Monday, May 26, 2025
Nicholas Riccardi, Alex Teghipco, Sarah Newman-Norlund ... · Aging · Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA. [email protected]. · pubmed
'Brain age' is a biological clock typically used to describe brain health with one number, but its relationship with established gradients of cortical organization remains unclear. We address this gap by leveraging a data-driven, region-specific brain age approach in 335 neurolog...
Schurman, C. A., Bons, J., Kumaar, P. V. ... · cell biology · Buck Institute for Research on Aging · biorxiv
Mass spectrometry imaging (MSI) is a rapidly advancing technology that provides mapping of the spatial molecular landscape of tissues for a variety of analytes. Matrix-assisted laser desorption/ionization (MALDI)-MSI is commonly employed, however, confident in situ identification...
Aitor Picos, Nuria Seoane, Manuel Campos-Toimil ... · Aging · Physiology and Pharmacology of Chronic Diseases (FIFAEC), Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. [email protected]. · pubmed
The aging vasculature is characterized by endothelial dysfunction, arterial stiffness, and increased susceptibility to vascular pathologies. Central to these changes is the process of cellular senescence, where endothelial and vascular smooth muscle cells lose their replicative a...
Saswat Kumar Mohanty, Vikas Kumar Sahu, Bhanu Pratap Singh ... · Renal Insufficiency, Chronic · Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India. [email protected]. · pubmed
Chronic kidney disease (CKD) is a global health challenge marked by progressive renal decline and increased mortality. The interplay between CKD and hypothyroidism, particularly nonthyroidal low-triiodothyronine (T3) syndrome, exacerbates disease progression, driven by HPT axis d...
Ghazal Darfarin, Janice Pluth · Environmental and molecular mutagenesis · Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, Nevada, USA. · pubmed
The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress-rel...
Sunday, May 25, 2025
Lee, B., Ciciurkaite, G., Peng, S. ... · epidemiology · New York University · medrxiv
Negative social ties, or "difficult ties," are pervasive yet understudied components of social networks that may accelerate biological aging and morbidity. Using ego-centric network data and DNA methylation-based biological aging clocks from a state representative probability sam...
Toga, K., Oka, K., Tanaka, H. ... · genomics · Hiroshima University · biorxiv
The naked mole rat (NMR, Heterocephalus glaber) is a eusocial rodent that is native to northeastern Africa. NMRs exhibit extraordinary traits such as longevity, resistance to age-related decline, and remarkable hypoxia tolerance. Although the reference genome of this species has ...
Saturday, May 24, 2025
Daozheng Yang, Natalia Skinder, Yun-Ruei Kao ... · Nature aging · European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. · pubmed
During aging, hematopoietic stem cell (HSC) function progressively declines which can lead to reduced blood cell production and regeneration. This work uncovered that cell surface presentation of P-selectin (CD62P, encoded by Selp) increases in a large fraction of aging HSCs driv...
Bianca Aparecida Martin, Juliana Viegas, Luciana Facco Dalmolin ... · ACS biomaterials science & engineering · School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n°, 14040-903 Ribeirão Preto, São Paulo, Brazil. · pubmed
The skin is a complex organ composed of multiple layers and diverse cell types, including keratinocytes, fibroblasts, adipocytes, and sensory neurons, which maintain its structural and functional integrity together. Conventional in vitro and ex vivo models help investigate drug p...
Yidong Zhu, Juan Zhao, Zihua Li ... · Mammalian genome : official journal of the International Mammalian Genome Society · Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. · pubmed
Osteoporosis, characterized by decreased bone mineral density, is a common skeletal disorder in the aging population. Cellular senescence is a key factor in the pathophysiology of osteoporosis. This study aimed to identify senescence-related biomarkers and evaluate the functional...
Lorène Rousseau, Karina L Hajdu, Ping-Chih Ho · Epigenesis, Genetic · Department of Fundamental Oncology, University of Lausanne, 155 Ch. Des Boveresses, 1066, Epalinges, Switzerland. · pubmed
Epigenetic regulation, including DNA methylation and histone modifications, play a pivotal role in shaping T cell functionality throughout life. With aging, these epigenetic changes profoundly affect gene expression, altering T cell plasticity, activation, and differentiation. Th...
Dantong Zhu, Judy Z Wu, Patrick T Griffin ... · npj aging · Institute for Systems Biology, Seattle, WA, USA. · pubmed
Frailty is an age-related geriatric syndrome. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured frailty index and derived metabolomics data from plasma. We identify age-related differentially abundant metabolites, determine fra...
Fiorenza Gianì, Benjamin B Roos, Patrick A Link ... · American journal of physiology. Cell physiology · Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota. · pubmed
Idiopathic pulmonary fibrosis (IPF) is a fatal aging-related disease characterized by aberrant lung remodeling and progressive scarring, leading to organ failure and death. Current FDA approved anti-fibrotic treatments are unable to reverse established disease, highlighting the n...