Longevity Papers

Current Week (August 04 - August 07, 2025)
and Previous Week (July 31 - August 03, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), August 04 episode:
Thursday, August 07, 2025
Valentin Flietner, Bernd Heidergott, Frank den Hollander ... · Aging · PwC, Bernhard-Wicki-Strasse 8, 80636, Munich, Germany. · pubmed
In this paper, we advance the network theory of aging and mortality by developing a causal mathematical model for the mortality rate. First, we show that in large networks, where health deficits accumulate at nodes representing health indicators, the modelling of network evolutio...
Marin Truchi, Marine Gautier-Isola, Grégoire Savary ... · Endothelial Cells · Université Côte d'Azur, UMR CNRS 7275 Inserm U1323, IPMC, Valbonne, France. · pubmed
Aging increases the risk of developing fibrotic diseases by hampering tissue regeneration after injury. Using longitudinal single-cell RNA-seq and spatial transcriptomics, here we compare the transcriptome of bleomycin (BLM) -induced fibrotic lungs of young and aged male mice, at...
Yichu Fu, Binhan Wang, Aqu Alu ... · Signal Transduction · College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. · pubmed
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of proinflammatory cytokines in aged immun...
Nazma Malik, Reuben J Shaw · Annual review of cell and developmental biology · 1Metabolism in Immunity, Cancer & Aging Group, MRC Laboratory of Medical Sciences, Imperial College London, London, United Kingdom; email: [email protected]. · pubmed
Cells must constantly adapt their metabolism to the availability of nutrients and signals from their environment. Under conditions of limited nutrients, cells need to reprogram their metabolism to rely on internal stores of glucose and lipid metabolites. From the emergence of euk...
Wednesday, August 06, 2025
Amin Haghani, Ake T Lu, Qi Yan ... · GeroScience · Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. [email protected]. · pubmed
Several widely used epigenetic clocks have been developed for mice and other species, but a persistent challenge remains: different mouse clocks often yield inconsistent results. To address this limitation in robustness, we present EnsembleAge, a suite of ensemble-based epigeneti...
Mishra, M., Kim, H.-H., Youm, Y.-H. ... · physiology · Yale School of Medicine · biorxiv
Caloric restriction (CR) extends lifespan, yet the convergent immunometabolic mechanism of healthspan remains unclear. Using longitudinal plasma proteomics analyses in humans achieving 14% CR for 2 years, we identified that inhibition of the complement pathway is linked to lower ...
Peng Li, Yi Yang, Xiang Qin ... · Research (Washington, D.C.) · Department of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
This perspective critically examines the paradigm-shifting findings regarding cellular senescence's dual role in tissue biology, particularly focusing on its unexpected regenerative potential in hair growth. While cellular senescence has traditionally been viewed as a detrimental...
Shanshan Yao, Megan M Marron, Samaneh Farsijani ... · Aging cell · University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · pubmed
Unintentional weight loss (UWL) is related to mortality and mobility limitation. Here, we aimed to develop a metabolite-based score for UWL and evaluate its prediction performance and explanation value for UWL-related health outcomes. Participants from the Health, Aging and Body ...
Barbara Arbeithuber, Kate Anthony, Bonnie Higgins ... · Oocytes · Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Experimental Gynaecology and Obstetrics, Johannes Kepler University Linz, Linz 4040, Austria. · pubmed
Mitochondria, cellular powerhouses, harbor DNA [mitochondrial DNA (mtDNA)] inherited from the mothers. mtDNA mutations can cause diseases, yet whether they increase with age in human oocytes remains understudied. Here, using highly accurate duplex sequencing, we detected de novo ...
Offringa, R., Chouaref, J., Luden, T. · plant biology · Leiden University, Institute of Biology · biorxiv
Members of the AT-HOOK MOTIF NUCLEAR LOCALIZED (AHL) gene family have been shown to play important roles in plant development. In Arabidopsis thaliana, one member of this family, AHL15, induces somatic embryogenesis and extends plant longevity when overexpressed - the latter thro...
Diana C Hilpert, Muhammad Abdul Haseeb, Sharon E Bickel · Molecular biology of the cell · Department of Biological Sciences, Dartmouth College, 78 College St. Hanover, NH 03755. · pubmed
Meiotic segregation errors in human oocytes are the leading cause of miscarriages and trisomic pregnancies and their frequency increases exponentially for women in their thirties. One factor that contributes to increased segregation errors in aging oocytes is premature loss of si...
Britton Scheuermann, Kathryn Nichol, Cathy Levenson ... · The Journal of physiology · Department of Kinesiology, Kansas State University, Manhattan, KS, USA. · pubmed
The ageing global population is experiencing an increased prevalence of cerebrovascular diseases, such as stroke and dementia. This highlights a need for understanding the pathophysiological mechanisms of age-related cerebrovascular alterations, alongside benefits of intervention...
Yohei Arai, Nicholas W Chavkin, Yuka Arai ... · Cellular Senescence · Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22903, USA. · pubmed
The accumulation of senescent cells contributes to morbidity and mortality; however, common mechanisms underpinning this age-associated phenomenon remain elusive. Hematopoietic loss of the Y chromosome (LOY) is the most frequently acquired somatic mutation in males, and this cond...
Fei Jiang, Takeshi Tohgasaki, Mayuko Kami ... · Elastin · Department of Mechanical Engineering, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube, Yamaguchi, 755-8611, Japan. [email protected]. · pubmed
Skin firmness and elasticity are largely determined by the dermal extracellular matrix, particularly the elastin fiber network. Age-related degradation of elastin alters its architecture, contributing to diminished skin resilience. However, the quantitative relationship between e...
Shiqi Hu, Zhenhua Li, Dashuai Zhu ... · Advanced materials (Deerfield Beach, Fla.) · Department of Biomedical Engineering, Columbia University, 3960 Broadway, New York, NY, 10032, USA. · pubmed
Circulating extracellular vesicles (EVs) play a crucial role in mediating communication between different cell populations and organs, significantly influencing inflammation and vascular diseases. To evaluate the role of EVs in regulating senescence, small EVs isolated from umbil...
Mamoru Oyabu, Tomoki Sato, Runa Kawaguchi ... · Cell reports · Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan. · pubmed
Muscle wasting leads to reduced activities of daily living, an increased number of care-dependent individuals, and increased mortality. However, the metabolomic adaptations underlying muscle wasting remain poorly understood. Here, by comparing physiological, genetically induced, ...
Deng, J., Wang, Z. · bioinformatics · City of Hope · biorxiv
Premature senescence is essential for tissue remodeling. Myocardial infarction (MI) induces pathological cardiac remodeling through fibroblast-driven extracellular matrix (ECM) production. The role of senescence in MI-induced remodeling process remains elusive. Here we identify a...
Julian, T. H., Dou, H., Duan, J. ... · ophthalmology · The University of Manchester · medrxiv
The eye is a recognised source of biomarkers for cardiovascular and neurodegenerative disease risk. Here, we characterise the breadth of these associations and identify biological axes that may mediate them. Using UK Biobank data, we developed a multi-omic analysis pipeline integ...
Jie Luo, Ling Chen, Xiaoxian Zhang ... · Cell proliferation · Cord Blood Bank Centre, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. · pubmed
Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress, inflammation and aberrant mitochondrial dynamics. However, there is currently no effective treatment. Here, we de...
Malcolm J Jackson · Experimental physiology · Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. · pubmed
Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H
Junhao Wen · Nature aging · Laboratory of AI and Biomedical Science (LABS), Department of Radiology, Columbia University, New York, NY, USA. [email protected]. · pubmed
Multi-organ biological aging clocks derived from clinical phenotypes and neuroimaging data have emerged as valuable tools for studying human aging and disease. Plasma proteomics provides an additional molecular dimension to enrich these clocks. In this study, I developed 11 multi...
Lan Zhang, Yawei Liu, Zhijuan Hua ... · Myocytes, Cardiac · Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China. · pubmed
Cardiovascular aging is a key contributor to cardiovascular diseases (CVDs). As individuals age, the frequency and severity of cardiovascular events rise, establishing CVDs as a primary cause of death in older adults. Therefore, the development and exploration of drugs or bioacti...
Yuxuan Jiang, Guo-Yang Li, Keshuai Hu ... · Blood Pressure · Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China. · pubmed
Arterial biomechanical indicators have long been recognized as fundamental contributors to the physiology and pathology of cardiovascular systems. Probing multiple biomechanical parameters of arteries simultaneously throughout the cardiac cycle is highly important but remains cha...
Chia-Heng Hsu, Yi-Jhan Li, Ting-Ni Guo ... · Autophagy · Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan. · pubmed
Autophagic decline accompanies age and causes a deterioration in proteostasis, rendering neuronal demise. Rab27 functions as a vesicle regulator for macroautophagic/autophagic degradation and exocytosis. Loss of
Tuesday, August 05, 2025
Xiaoli Li, Yuecong Chen, Zhuoyi Gao ... · Aging cell · National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China. · pubmed
Aging is a process of gradual decline in physical and cognitive function and is a major risk factor for mortality. Despite the increasing number of relevant studies, the mechanisms regulating the aging process have not been fully elucidated. Genetic factors have long been recogni...
Sanish Sathyan, Fangyu Liu, Toshiko Tanaka ... · Aging cell · Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA. · pubmed
Frailty is an age-related syndrome characterized by an increased vulnerability to adverse health outcomes in the face of stressors. By deriving a blood-based proteomic signature for frailty, the current study aimed to enhance the understanding of frailty biology and created a per...
Aaron O Gonzalez, Parveez A Abdul Azees, Jerry P Chen ... · Aging cell · Department of Comprehensive Dentistry, UT Health San Antonio, School of Dentistry, San Antonio, Texas, USA. · pubmed
Older adults are the primary population for cell-based therapies for age-related diseases, but the efficacy of administering autologous mesenchymal stem cells (MSCs) is impaired due to biological aging. In the present study, we cultured aging adipose (AD)-derived MSCs from > 65-y...
Xie Mingzheng, Weng You · Molecular and cellular biochemistry · College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, 421002, Hunan, China. · pubmed
Age-related reductions in skeletal muscle insulin responsiveness promote metabolic dysregulation and contribute to an elevated probability of type 2 diabetes onset. The malfunction of nutrient-responsive signaling routes, specifically AMP-activated protein kinase (AMPK) and mecha...
Anamika Nanda, Daniel H Aslan, M Katherine Sayre ... · GeroScience · Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. [email protected]. · pubmed
A physically active lifestyle benefits cellular aging, however the mechanisms linking physical activity (PA) with longevity remain unclear. PA is associated with longer telomere length (TL), while shorter TL has been associated with increased cellular aging. Some research suggest...
Yongwang Xue, Runting Yin, Liang Yin ... · Food & function · School of Pharmacy, Jiangsu University, No. 301, Xuefu Road, Zhenjiang, China. [email protected]. · pubmed
In recent years, the intensifying global aging trend has made anti-aging research a critical area of scientific interest, with dietary interventions playing an essential role. Among dietary components, food-derived microRNAs (miRNAs), emerging as biologically active nutrients, ha...
Amir Ajoolabady, Domenico Pratico, Suhad Bahijri ... · Cell death discovery · National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China. · pubmed
Cellular senescence, often referred to simply as "senescence", is a complex intracellular process with diverse biological, physiological, and pathological roles. Biologically, it is essential for embryogenesis and development. Physiologically, senescence acts as a safeguard again...
Rhine, K., Epstein, E., Carlson, N. M. ... · cell biology · University of California San Diego · biorxiv
Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. Cellular stress can arise from several sources, but there is significant disagreement about which stress might ...
Jiayu Ye, Anupama Melam, Sheila A Stewart · Nature reviews. Cancer · Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, USA. · pubmed
Ageing is a process characterized by a wide array of cellular and systemic changes that together increase the risk of developing cancer. While cell-autonomous mutations within incipient tumour cells are important, age-related changes in the microenvironment are critical partners ...
Isabelle F Foote, Jonny P Flint, Anna E Fürtjes ... · Nature genetics · Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA. [email protected]. · pubmed
Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread health improvements across the aging population. Frailty is currently measured using aggregate scor...
Monday, August 04, 2025
Jongsun Lee, Bora Lee, Hyein Lee ... · Ribosomes · Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 34141, South Korea. · pubmed
Ribosome-associated quality control (RQC) is a pivotal biological process that governs the fidelity of messenger RNA (mRNA) homeostasis and protein synthesis. Defects in RQC are implicated in cellular dysfunction and proteotoxicity, but their impact on aging remains elusive. Here...
Wei Wang, Xing Zhang, Lichen Zhang ... · ACS nano · Department of Orthopedics, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou 215006, P.R. China. · pubmed
Osteoporosis, which is characterized by reduced bone mass and structurally compromised bone tissue, along with aberrant levels of reactive oxygen species (ROS) and inflammation, has been a pressing clinical challenge. A large accumulation of ROS and pro-inflammatory factors can r...
Ee Phie Tan, Nora Lyang, Saam Doroodian ... · Caenorhabditis elegans · Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037. · pubmed
The degradation of cellular components through autophagy is essential for longevity and healthy aging. However, autophagy function decreases with aging, contributing to age-related diseases. In this study, we characterized a small-molecule activator of autophagy called
Xin Liu, Heng Liu, Yuan Lin ... · European heart journal · State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin 150081, China. · pubmed
Vascular ageing often accompanies inflammation, contributing to the onset of local or systemic vascular diseases. Nevertheless, limited research focuses on pivotal factors triggering chronic vascular inflammation and associated pathological changes. This study aimed to investigat...
Eunseok Kang, Rosa Haque, Hanseul Lee ... · BMB reports · Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea. · pubmed
RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence indicates that RNA modification is crucial for various physiological and pathological processes, including aging. This review...
Laura Boose de Mendonça, Guido Lenz, Eduardo Cremonese Filippi-Chiela · Biochemical Society transactions · Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil. · pubmed
Senescent cells (SnCs) have typical changes in multiple features, such as increased cellular and nuclear size, morphofunctional alterations in organelles, and high secretory activity. The literature generally groups cellular changes and the non-proliferative character of SnCs int...
Susanne Holtze, Defne Demirtürk, Oliver Ohlenschläger ... · Transcriptome · Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. [email protected]. · pubmed
The olm (Proteus anguinus), with a predicted maximum lifespan of more than 100 years, is the longest-lived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underlying molecular signatures, we present the fi...
Sunday, August 03, 2025
R A Santana, J M McWhirt, G J Brewer · GeroScience · Department of Biomedical Engineering, University of California Irvine, Irvine, CA, 92697, USA. · pubmed
Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged organelles and proteins. Age-related ATP depletion would impact cognition dependent on ionic homeostasis, but limits on proteostasis powered by GTP are less cl...
Saturday, August 02, 2025
Bene, M. R., Chung, T., Fountain, W. A. ... · physiology · Division of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA · biorxiv
Sarcopenia, the age-related loss of muscle strength and mass, contributes to adverse health outcomes in older adults. While exercise mitigates sarcopenia by transiently activating calcium (Ca2+)- and reactive oxygen species (ROS)-dependent signaling pathways that enhance muscle p...
Xiu Fan, Qili Qian, Wenran Li ... · Genome research · China National Center for Bioinformation, Beijing Institute of Genomics. · pubmed
Epigenetic drift refers to the gradual and stochastic accumulation of epigenetic changes, such as DNA methylation variability, with advancing age. Although increasingly recognized for its potential role in aging biology, its extent, biological significance, and population specifi...
Leng, H., jiang, j., Gassner, K. ... · cell biology · Institute for Research in Biomedicine (IRB Barcelona) · biorxiv
Mitochondrial heteroplasmy, the co-existence of different mitochondrial genomes within a cell, is linked to aging and disease. Patients with heteroplasmy due to mitochondrial mutations experience multiple organ complications, particularly poor bone health and bone structure defec...
Rajesh, A., Havas, A. P., Arnold, R. ... · cell biology · Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA · biorxiv
Cellular senescence contributes to aging and age-related diseases by driving chronic inflammation through the Senescence Associated Secretory Phenotype (SASP) and interferon-stimulated genes (ISGs). Cyclin D1 (CCND1), a key cell cycle regulator, is paradoxically upregulated in th...
Shinsuke Nirengi, Benjamin Buck, Devleena Das ... · Calcium-Calmodulin-Dependent Protein Kinase Type 2 · Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. · pubmed
Aging poses significant challenges to cardiovascular health necessitating novel therapeutic approaches. This study investigates the potential of the brown adipose tissue (BAT) derived lipokine 12,13-diHOME to mitigate age-induced impairments in cardiovascular function. Analysis o...
Ansa E Cobham, Alexander Kenzior, Pedro Morales-Sosa ... · npj metabolic health and disease · Stowers Institute for Medical Research, Kansas City, MO, 64110, USA. [email protected]. · pubmed
All animals age, but the rate of aging across species varies widely. The environmental pressures and molecular factors underlying this remarkable diversity in aging across species remains largely enigmatic. The Mexican tetra, Astyanax mexicanus, provides an intriguing new model t...
Wang, Y., Ding, Y., He, C. ... · cell biology · Shanghaitech University · biorxiv
Ensuring the identity and optimal aging state of cell products is critical for the efficacy and safety of cell therapies. Despite rapid iterations, there remains an urgent need for robust and easy-to-implement tests to characterize cell products. Here, we present CIAdex (Cell Ide...
Connolly, M. G., Fliflet, A. M., Ravi, P. ... · neuroscience · University of Alberta, Canada · biorxiv
Aerobic exercise enhances cognition in part by increasing adult hippocampal neurogenesis, angiogenesis, and astrogliogenesis. Since hippocampal atrophy is a hallmark of several neurological and psychiatric conditions- including depression, PTSD, Alzheimers disease, and aging- und...
Liming Gui, Jiajia Sun, Qin Zhong ... · Mitophagy · Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China. [email protected]. · pubmed
Ovarian aging profoundly impacts reproductive health and accelerates the overall aging process, yet the development of effective therapeutic strategies remains a formidable challenge. In this study, we report the rejuvenating effects of HEP14, a natural activator of protein kinas...
Pantelis, P., Tremoulis, D. C., Evangelou, K. ... · immunology · Medical School, National Kapodistrian University of Athens · biorxiv
Background: Immunotherapy has significantly improved cancer treatment. However, it is not effective in all cancer patients, rendering the need to further delineate the differences among responders and non-responders at the molecular and cellular level. Unresponsiveness to immunot...
Marcu, D., Sannino, D., Dornan, A. ... · genetics · University of Glasgow · biorxiv
Gut microbiota exert an evolutionarily conserved influence on ageing, from invertebrates to humans. How do microbes that are physically confined to the gut lumen affect the systemic physiological process of ageing? In female Drosophila, we show that microbiota increase expression...
Friday, August 01, 2025
AlOkda, A., Yadav, S., Pacis, A. ... · developmental biology · McGill University · biorxiv
As aging is the primary risk factor for many chronic diseases, geroscience aims to target aging to delay age-related decline. Here, we identify Cyrene (dihydrolevoglucosenone), a sustainable, biocompatible solvent, as a novel geroprotective compound. Cyrene extends lifespan and h...
Yucel, D., Trembley, M., Ke, Q. ... · molecular biology · Boston Children\'s Hospital · biorxiv
Aging is a major risk factor for cardiovascular diseases, yet the underlying molecular mechanisms remain poorly understood. In this study, we integrated physiological characterization of cardiomyocyte (CM) aging with concurrent single-nucleus RNA-seq and ATAC-seq, and reduced rep...
Ting Dong, Nianyu Li, Huirui Wang ... · Nature aging · Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, China. [email protected]. · pubmed
Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified deleterious mutations and decreased expres...
Wenbo Wu, Genshiro A Sunagawa, Hong Chen · Nature metabolism · Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. · pubmed
Torpor is a naturally occurring state of metabolic suppression that enables animals to adapt and survive extreme environmental conditions. Inspired by this adaptation, researchers have pursued synthetic torpor-an artificially induced, reversible hypometabolic state with transform...
Abbas Mohammadi, Daniel Thomas Jones, Somayeh Mohammadi ... · Cardiology in review · From the Department of Medicine, Valley Health System, Las Vegas, NV. · pubmed
Telomere attrition stands as a fundamental hallmark of cardiovascular aging, driving cellular senescence and dysfunction across endothelial, cardiomyocyte, and vascular smooth muscle compartments. This review systematically examines: (1) molecular mechanisms linking telomere shor...
Jodi Protasiewicz, Sarah Snider, Mousumee Khan ... · Longevity · Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. · pubmed
Prolonged inactivity due to medical conditions can cause chronic muscle disuse and lead to physical incapacity and poor quality of life. Here, we developed a Drosophila model of confinement inactivity (CI) to observe its effects on lifespan and muscle function. We found that, sim...
Power, L. N., Zawrotna, N., Dinda, M. ... · molecular biology · University of Virginia School of Medicine · biorxiv
Genomic instability and loss of proteostasis are two of the primary Hallmarks of Aging. Although these hallmarks are well-defined in the literature, the mechanisms that drive genomic instability and loss of proteostasis as cells age are still largely unknown. Using budding yeast ...
Hu, D., Wen, W., Li, H. ... · neuroscience · The University of Iowa · biorxiv
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic protein localized in the endoplasmic reticulum (ER) and pivotally involved in maintaining ER homeostasis. MANF plays an important role in mitigating neurodegenerative processes. Aging, the primary risk f...
Yanggang Hong · European archives of psychiatry and clinical neuroscience · The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. [email protected]. · pubmed
Aging is a complex process influenced by genetic, environmental, and psychiatric factors. Recent evidence suggests that epigenetic age acceleration (EAA), a biomarker of biological aging, may be linked to psychiatric disorders, yet the causal direction remains unclear. This study...
Manuel M Gómez de Las Heras, Elisa Carrasco, Mario Pérez-Manrique ... · Inflammation · Tissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. · pubmed
Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut...
Zhi Yu, Pin-Shi Ni, Zhuang-Zhi Wang ... · Cell biochemistry and biophysics · Nanjing Normal University, Nanjing, Jiangsu, China. · pubmed
Understanding the impact of different exercise types on skeletal muscle atrophy in older adults is crucial for designing effective strategies to combat age-related muscle loss. This study explores the molecular mechanisms through which resistance exercise (RES) and endurance exer...
Pitaksin Chitta, Timothy M Barrow, Busadee Pratumvinit ... · Scientific reports · Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. · pubmed
Epigenetic age provides a reliable biomarker for biological aging, reflecting the cumulative impact on health over time. Frailty is common among elderly individuals and is further compounded by hypertension, which increases the risk associated with aging. Therefore, we examined t...
bin Kashem, M. S., Varnum, S., Lazorik, O. ... · biophysics · Washington University in St. Louis · biorxiv
Mitochondria are multifunctional organelles that convert the potential energy stored in nutrients and intermediary metabolites into both heat and an electro- chemical proton-motive force. However, how these outputs are synchronized in cells remains an enduring question. In this w...
Yu Wu, Yuru Deng, Borislav Angelov ... · FASEB bioAdvances · Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay Orsay France. · pubmed
Plasmalogens are natural glycerophospholipids that account for approximately 15%-20% (mol%) of human tissues' cellular membrane phospholipid composition. They play an important role in lipid membrane organization and function, including acting as endogenous antioxidants. Plasmalo...
Bruno César Feltes · Brain · Institute of Biosciences, Department of Biophysics, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil. [email protected]. · pubmed
The disposable soma theory (DST) posits that organisms prioritize reproductive success over long-term somatic maintenance, resulting in an inevitable decline after reproduction. However, such a basis does not fully explain the human brain's capacity to preserve metabolically cost...
Enikő Kutasi, Adina Chis, Mihaela Adela Vintan ... · Molecular neurobiology · Department of Molecular Sciences, Medical Genetics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. [email protected]. · pubmed
Telomeres play a crucial role in safeguarding DNA integrity. With each cell division, these protective structures undergo shortening, limiting the number of divisions to prevent improper genetic material distribution in aging cells. Senescent cells accumulate in tissues and contr...
Thursday, July 31, 2025
Domenico Di Fraia, Antonio Marino, Jae Ho Lee ... · Aging · Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany. · pubmed
Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the transcriptome, translatome, and proteome in the brain of short-lived killifish....
Yaqing Wang, Pengyu Sun, Fuqiang Yang ... · Aging cell · State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. · pubmed
cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER-to-Golgi trafficking, and secretion. However, whether cTAGE5/MEA6 is involved in other cellular functions remains unclear. Here, we show that conditional cTAGE5 knockout results in embryonic lethality during developme...
Zhou, Z., Lamanna, A., Halder, R. ... · microbiology · Luxembourg Centre for Systems Biomedicine, University of Luxembourg · biorxiv
The gut microbiota both adapts to, and shapes, the metabolic state of individuals. This bidirectional relationship is mediated via circulating metabolites and gene regulatory networks and interacts with many organs, including by the gut-brain axis. Here, we have processed the cec...
Sugai, A., Moridono, H., Bilgic, M. ... · neuroscience · Institute for Quantitative Biosciences, The University of Tokyo · biorxiv
Microglial senescence contributes to inflammation and various neurodegenerative diseases. Recent single-cell transcriptome data have revealed age-associated microglial substates (AAMs) and their potential roles in the development of neurodegenerative diseases. However, the charac...
Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang ... · Aging cell · Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas, USA. · pubmed
Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens d...
Matlack, J. K., Miner, R. E., Lokhandwala, J. ... · biochemistry · Moffitt Cancer Center · biorxiv
Protein glycation is a detrimental byproduct of living cells\' reliance on carbohydrate metabolism, and nearly all organisms encode kinases that facilitate the removal of early glycation products. In humans, these repair functions are performed by Fructosamine-3 kinase (FN3K) and...
Jacob-Dolan, J. W., Sterling, A. C., Brutus, M. E. ... · biochemistry · Tufts University · biorxiv
Glycation crosslinks account for more than 40% of all known advanced glycation end products (AGEs) and are correlated with many age-related diseases. Despite much interest, crosslinking AGEs (xl-AGEs) remain poorly understood, as they have been challenging to discover, prepare, a...
Jin, X., Tang, W., Zheng, Z. ... · neuroscience · Institute of Psychology, Chinese Academy of Sciences · biorxiv
Non-pharmacological interventions (NPIs) in aging neuroscience have largely focused on intervention-specific regional effects, with limited understanding of generalizable network-level mechanisms. Here, adopting a previously unexplored gradient-based perspective of functional bra...
Cong Chen, Tong-Yao Gao, Hua-Wei Yi ... · Proteasome Endopeptidase Complex · Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China. · pubmed
Ubiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson's disease, but the mechanistic lin...
Ebenebe, O. V., Kabir, R., Booher, A. ... · physiology · Johns Hopkins University · biorxiv
S-nitrosoglutathione reductase (GSNOR), a regulator of protein S-nitrosylation (SNO), has been proposed as a longevity protein. GSNOR signaling has been implicated in both the alleviation and exacerbation of aging. In the context of ischemia reperfusion injury, we previously show...
Cécile Marcourt, Claudio Rivera, Jürgen Tuvikene ... · GeroScience · Aix Marseille Univ, INSERM, INMED, Marseille, France. · pubmed
Aging is associated with metabolic decline in the brain, increasing susceptibility to neurodegenerative diseases. While exercise is a well-established strategy to counteract these changes, no study has directly compared the effects of moderate-intensity continuous training (MICT)...
Battaglia, M. C., Bhalla, M., Marzullo, B. ... · immunology · Department of Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo NY · biorxiv
Aging drives increased susceptibility to respiratory infections by Streptococcus pneumoniae (pneumococci). Polymorphonuclear leukocytes (PMNs) are among the first responders in the lung following pneumococcal infection and are required for bacterial clearance. However, PMN antimi...
Sturgis, J., Jiang, K., Hagstrom, S. ... · cell biology · Cleveland Clinic Foundation · biorxiv
Retinal degenerative diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, and glaucoma, have been linked to mitochondrial dysfunction. However, the impact of mitochondrial DNA (mtDNA) mutation accumulation in the context of these retinopathies has yet t...
Xiao Lu, Jiao Wu, Ewud Agborbesong ... · Cell death discovery · Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA. · pubmed
Diabetic kidney disease (DKD) is characterized by kidney damage and abnormal renal energy metabolism, but the molecular mechanism of DKD is still unclear. In this study, we show that p16- positive senescent cells are an important regulator in the progression of DKD. The expressio...
Donghoon Kang, Yeji Lim, Dabin Ahn ... · Journal of medicinal chemistry · Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. · pubmed
Cellular senescence, marked by irreversible cell cycle arrest and senescence-associated secretory phenotype, contributes to aging and cancer recurrence. While chemotherapy can induce senescence in cancer cells, these therapy-induced senescent cells often resist apoptosis and prom...
Joruiz, S. M., Lissa, D., von Muhlinen, N. ... · cell biology · Center for Cancer Research, National Cancer Institute, National Institutes of Health · biorxiv
Background: Patients with Hutchinson-Gilford progeria syndrome (HGPS) show accelerated aging phenotypes and have shortened lifespan, with implications in physiological aging processes as well. While therapeutic approaches targeting the disease-causing abnormal protein, progerin, ...
Shigeru Chiba · International journal of hematology · Division of Stem Cell Therapy, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. [email protected]. · pubmed
Clonal hematopoiesis (CH) has emerged as a common age-related phenomenon and a central concept linking somatic mutations in hematopoietic stem cells to both malignant and non-malignant diseases. While initially recognized in the context of hematologic neoplasms, CH is now known t...
Nehar-Belaid, D., Thibodeau, A., Eroglu, A. ... · immunology · The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA · biorxiv
The human immune system undergoes continuous remodeling from infancy through old age, yet the timing and trajectory of these changes across the lifespan remain poorly defined. To address this, we profiled peripheral blood mononuclear cells from 95 healthy individuals (ages 2 mont...
Ali, M., Li, F., Katari, M. S. · bioinformatics · New York University · biorxiv
Identifying the set of genes that regulate baseline healthy aging - aging that is not confounded by illness - is critical to understating aging biology. Machine learning-based age-estimators (such as epigenetic clocks) offer a robust method for capturing biomarkers that strongly ...
Olivier Dionne, Benoit Laurent · Aging · Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. · pubmed
Ribosome stalling drives aging in the killifish brain.