Longevity Papers

Current Week (September 01 - September 04, 2025)
and Previous Week (August 28 - August 31, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), September 02 episode:
Thursday, September 04, 2025
Seda Koyuncu, Yaiza Dominguez-Canterla, Rafael Alis ... · Nature aging · Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. [email protected]. · pubmed
Aging is a major risk factor for neurodegenerative diseases associated with protein aggregation, including Huntington's disease and amyotrophic lateral sclerosis (ALS). Although these diseases involve different aggregation-prone proteins, their common late onset suggests a link t...
Qifeng Song, Shi Sun, Yuxiu Song ... · Neural regeneration research · Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. · pubmed
Ferroptosis is a newly recognized form of programmed cell death characterized by iron overload-dependent lipid peroxidation. These pathological phenomena are often observed in neurodegenerative diseases. Aging is an irreversible process characterized by the deterioration of tissu...
A Ibáñez de Opakua, R Conde, A de Diego ... · npj metabolic health and disease · ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain. · pubmed
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-th...
Ailsa M Jeffries, Tianxiong Yu, Jennifer S Ziegenfuss ... · Nature · Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA. · pubmed
Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process
Jiaxin Shi, Jason M Fletcher · Population studies · The Hong Kong University of Science and Technology. · pubmed
Research indicates a significant slowdown in life expectancy growth in the United States (US) post 2010, marking a departure from the consistent progress in longevity throughout the twentieth century. We extend this understanding, tracing the deceleration of US life expectancy ba...
Wednesday, September 03, 2025
Bnaya Gross, Joseph Ehlert, Vadim N. Gladyshev ... · q-bio.MN · Not available · arxiv
Despite the thousands of genes implicated in age-related phenotypes, effective interventions for aging remain elusive, a lack of advance rooted in the multifactorial nature of longevity and the functional interconnectedness of the molecular components implicated in aging. Here, w...
Xie, G. · bioinformatics · Nantong University · biorxiv
Aging Clock models have emerged as a crucial tool for measuring biological age, with significant implications for anti-aging interventions and disease risk assessment. However, human aging clock models that offer single-cell resolution and account for cell and tissue heterogeneit...
Fuentes-Ramos, M., Alaiz-Noya, M., Miozzo, F. ... · neuroscience · Instituto de Neurociencias (UMH-CSIC) · biorxiv
While aging impairs memory precision, its effects on engram dynamics and gene expression remain poorly understood. To address this, we used TRAP2 activity-reporter mice, nuclear tagging, and FOS-based activity mapping to track neurons activated during contextual fear memory encod...
Juan Long, Meng Ma, Yuting Chen ... · eLife · Department of Health Management and Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
The regulation of cellular metabolism and growth in response to nutrient availability is crucial for cell survival and can significantly impact on lifespan. Central to this regulation is a class of transporters that sense and transport specific nutrients and transduce the signal ...
Foley, J., McPherson, J., Roger, M. ... · evolutionary biology · University of Bristol · biorxiv
Evolution has given rise to lifespans in extant species ranging from days to centuries. Given that mechanisms of ageing are highly conserved, studying long-lived lineages across the animal kingdom could yield insights relevant for healthy ageing in humans. However, typical models...
Luciano, A., Robinson, L., Schott, W. H. ... · genetics · The Jackson Laboratory · biorxiv
Research methods for the investigation of the biology of aging have often implicitly generalized strain-specific results. Dietary interventions, such as caloric restriction and periodic fasting, have been shown to enhance metabolic health and extend lifespan in preclinical models...
Kun Zhang, Yehua Li, Yi Ren ... · Aging cell · Department of Histology and Developmental Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. · pubmed
Osteoporosis (OP) is a metabolic bone disease, characterized by loss of bone mass and destruction of bone microstructure, which has a high incidence of disability. Identification of the key factors of pathogenesis is essential for diagnosis and therapy. In this study, we have ide...
Jiale Cai, Deng Wu, Dahua Xu ... · Cancer science · College of Biomedical Information and Engineering, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China. · pubmed
Cancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the comparative features of normal aging, cellular s...
Gutierrez, I., Edgar, C., Tyler, J. K. · cell biology · Weill Cornell Medicine · biorxiv
Overexpression of the mRNA binding protein Ssd1 extends the yeast replicative lifespan. Using microfluidics to trap and image single cells throughout their lifespans, we find that lifespan extension by Ssd1 overexpression is accompanied by formation of cytoplasmic Ssd1 foci. The ...
Ziyou Yuan, Eugenie Nepovimova, Qinghua Wu ... · Biogerontology · College of Life Science, Yangtze University, Jingzhou, 434025, China. · pubmed
The circadian rhythm is a key biological mechanism that aligns organisms' physiological processes with Earth's 24-h light-dark cycle, crucial for cellular and tissue homeostasis. Disruption of this system is linked to accelerated aging and age-related diseases. Central to circadi...
Vijayraghavan Seshadri, Charmaine Chng, Joel Tyler ... · Aging cell · Monash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Victoria, Australia. · pubmed
Cellular senescence is a state of irreversible cell cycle arrest accompanied by a distinctive inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP). While various biomarkers, such as senescence-associated beta-galactosidase (SA-βgal), EdU in...
Chin, R., Zhang, X.-H., Anderson, K. M. ... · neuroscience · Yale University · biorxiv
The microstructural architecture of white matter supporting information flow across local circuits and large-scale networks changes throughout the lifespan. However, the genetic and cellular factors underlying age-related variations in white matter microstructure have yet to be e...
Zhouwei Wu, Shu Yang, Zhichen Jiang ... · Autophagy · Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. · pubmed
Chaperone-mediated autophagy (CMA), a lysosome-dependent protein degradation pathway, plays a pivotal yet poorly understood role in cellular senescence-related degenerative diseases. Our study sheds light on a novel mechanism whereby UCHL1 plays a crucial role in mitigating nucle...
Tuesday, September 02, 2025
Kim, Y. L., Jo, Y.-W., Yoo, T. ... · developmental biology · Seoul National University · biorxiv
Muscle stem cells (MuSCs) are parenchymal cells in skeletal muscle regeneration and maintenance. With aging, MuSCs experience a decline in their regenerative function and reduction in their number. However, recent evidence points to substantial heterogeneity within the aged MuSC ...
Shaokai Tang, Yuanwen Geng, Qinqin Lin · Lipids in health and disease · College of Sports Science, Jishou University, Jishou, 416000, China. · pubmed
Aging is widely regarded as an irreversible arrest of cellular growth and proliferation, often accompanied by systemic metabolic organ abnormalities, ultimately reducing quality of life and increasing mortality in the elderly. Multi-organ transcriptomic analyses suggest that adip...
Lauren M Hablitz, Maiken Nedergaard · The Journal of clinical investigation · Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA. · pubmed
Cerebrospinal fluid dynamics play an important role in maintaining brain health and clearing metabolic waste from the brain. In this issue of the JCI, Gursky et al. investigate how CSF distribution is affected when its primary efflux pathway - the deep cervical lymph nodes - is d...
Andrew Patton, Jörn Davidsen · PLoS computational biology · Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada. · pubmed
Although the brain's structural and functional alterations with age are individually well documented, how differences in cognitive abilities emerge from variations in the underlying spatio-temporal patterns of regional brain activity is largely unknown. Patterns of increased sync...
Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes ... · NLR Family, Pyrin Domain-Containing 3 Protein · BioAge Labs , Emeryville, CA, USA. · pubmed
The NLRP3 inflammasome is an intracellular protein complex that causes inflammation via the release of IL-1β and pyroptosis. NLRP3 activation is associated with many age-related inflammatory diseases, and NLRP3 inhibition is a promising therapeutic strategy. We previously perform...
Emma B Hasselholm, Jesper Just, Simon Chang ... · Klinefelter Syndrome · Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. [email protected]. · pubmed
The sex chromosome aneuploidies Turner syndrome (45,X; TS) and Klinefelter syndrome (47,XXY; KS) are associated with aging-related comorbidities, reduced life expectancy and genome-wide DNA methylation changes. This indicates that biological aging, reflecting physiological functi...
Levy, T., Anselmi, C., Ishizuka, K. J. ... · cell biology · Stanford University · biorxiv
Germline stem cells (GSCs), the source of gametes, are the only stem cells capable of passing genes to future generations and are therefore considered units of natural selection. Yet, the factors that influence GSC fitness, and thus govern GSC competition, which exist in both pro...
Wei-Li Wang, Yu-Tsung Shih, Shu-Yi Wei ... · Atherosclerosis · Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan. · pubmed
Aging is the foremost risk factor for metabolic syndrome and atherosclerosis, which is a principal cause of cardiovascular diseases (CVDs). Vascular endothelial cells (ECs), which line the vascular intima, play a central role in maintaining vascular homeostasis. Their dysfunction...
Elsie Gonzalez-Hurtado, Claire Leveau, Keyi Li ... · Nature aging · Department of Pathology, Yale School of Medicine, New Haven, CT, USA. · pubmed
Age-related inflammation or 'inflammaging' increases disease burden and controls lifespan. Adipose tissue macrophages (ATMs) are critical regulators of inflammaging; however, the mechanisms involved are not well understood in part because the molecular identities of niche-specifi...
Xiao-Ting Yu, Nan Zhao, Yu-Tao Ma ... · Acta pharmacologica Sinica · Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100069, China. · pubmed
Progressive loss of vascular smooth muscle cells (VSMCs) is the pathophysiological basis for aortic aneurysm and dissection (AAD), a life-threatening disease, but the underlying mechanisms are largely unknown. Sirtuin 6 (SIRT6), a class III histone deacetylase, is critical for ma...
Stefania Lucia, Silvia Fornaro, Massimo Federici ... · Acta diabetologica · Neuroscience Area, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy. [email protected]. · pubmed
The growing prevalence of type 2 diabetes (T2D) among older adults represents a major public health concern, given its association with accelerated cognitive decline and increased risk of neurodegenerative diseases. Several diabetes-related mechanisms, including chronic hyperglyc...
Fernandes, S. A., Pan, J., Terziyska, D. S. ... · cell biology · Max Planck Institute for Biology of Ageing (MPI-AGE) · biorxiv
Proper control of mTOR (mechanistic/mammalian target of rapamycin) signaling is relevant for health, disease and ageing. Information from intra- and extra-cellular signaling cues is transmitted to mTOR through an intricate signaling network that impinges on the Rag and Rheb GTPas...
Lopez-Pernas, G., Murga, M., Ahmed, W. ... · cancer biology · CNIO · biorxiv
The one-two-punch approach refers to the sequential administration of two different chemotherapies, the second of which targets cancer cells that resisted the initial treatment. To find such a second punch, we performed a chemical screen to find drugs that are preferentially toxi...
Mingzhuang Hou, Yifan Ma, Yaoge Deng ... · Proceedings of the National Academy of Sciences of the United States of America · Department of Orthopaedics, First Affiliated Hospital of Soochow University, Suzhou 215006, China. · pubmed
Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondr...
Monday, September 01, 2025
Herzog, C. M. S., Vavourakis, C. D., Redl, E. ... · systems biology · Universitaet Innsbruck · biorxiv
Extending human healthspan requires understanding how lifestyle interventions impact molecular systems across tissues and time. Here, we present the TirolGESUND Lifestyle Atlas (ClinicalTrials.gov: NCT05678426), a longitudinal, multi-modal resource profiling 156 healthy women (ag...
Thalida Em Arpawong, Belinda Hernandez, Claire Potter ... · GeroScience · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. [email protected]. · pubmed
The complexity of epigenetic changes that accompany aging has been distilled into a number of molecular timepieces-termed epigenetic clocks-that characterize the pace of biological aging to differing degrees. Here, we develop and validate a DNA methylation-based Physiological hea...
Lu, Y. R., Cameron, J. C., Hu, Y. ... · genetics · Whitehead Institute for Biomedical Research · biorxiv
Oct4, Sox2, and Klf4 (OSK) Yamanaka factors induce pluripotency and reverse age-related epigenetic changes, yet the mechanisms by which they promote rejuvenation remain poorly explored. Oxidative stress contributes to CNS aging and retinal pigmented epithelium (RPE) degeneration ...
Maria Grazia Perino, Miguel Calvo-Rubio Barrera, Daniel R Riordon ... · GeroScience · Laboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA. [email protected]. · pubmed
Dysregulated proteostasis is a hallmark of aging. We investigated how efficiently proteostatic adaptations to chronic cardiac cyclic-adenosine-monophosphate (cAMP)-dependent stress change with aging in mice harboring marked cardiac-specific over-expression of adenylyl cyclase VII...
Hiebert, L. S., Soesbe, A., Cui, Q. ... · evolutionary biology · University of California Santa Barbara · biorxiv
While most knowledge of animal DNA methylation comes from vertebrates, this epigenetic mark remains poorly understood in invertebrates, which comprise the majority of animal diversity. For instance, how promoter and gene body methylation contribute to gene regulation, and how met...
Calvo-Asensio, I., Tarcevski, A., Dhalla, F. ... · immunology · Institute of Medical Sciences, University of Aberdeen · biorxiv
The thymus is a primary lymphoid organ which provides essential structural and functional support for the development of naive T cells. Thymic epithelial cells (TECs), key components of the thymic stroma, are classified into cortical (cTEC) and medullary (mTEC) lineages based on ...
Rebecca C S Ong, Alexander D Tang · Aging cell · Experimental and Regenerative Neurosciences, The University of Western Australia, Perth, Australia. · pubmed
Repetitive transcranial magnetic stimulation (rTMS) is an attractive tool to promote healthy brain ageing in older adults and treat age-related neurological conditions. Despite its popularity, the neurological processes and plasticity mechanisms altered by rTMS in the aged brain,...
Sunday, August 31, 2025
Dimitris-Foivos Thanos, Orestis A Ntintas, Emmanouil I Athanasiadis ... · Cellular Senescence · Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. · pubmed
Chromatin, the spatial organizer of genomic DNA, is hierarchically folded into higher-order structures to facilitate DNA compaction, enabling genome surveillance. Understanding the organization and function of the three-dimensional (3D) genome is critical to profile chromatin acc...
Thi Quynh Trang Nguyen, Kyung A Cho · Experimental & molecular medicine · Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Republic of Korea. · pubmed
Here we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various factors that lead to immu...
Saturday, August 30, 2025
Yajie Hu, Xueqi Xue, Tian Han ... · Cellular Senescence · Discovery Biology Unit, WuXi Biology, WuXi AppTec Ltd., Shanghai, China. · pubmed
Study of cellular senescence is critical in aging research and anti-senescence therapy drug development. Current methods for the evaluation of the widely accepted cellular senescence marker senescence-associated beta galactosidase (SA-β-gal) activity assay rely on bright-field im...
Jiayu Huang, Lu Sun, Yuehan Yin ... · Cell reports · Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China. · pubmed
Aging is closely related to the decline of male reproductive endocrine function, which is manifested as insufficient testosterone production. It is well known that stem cell pool stability is crucial for maintaining tissue function. However, the relationship between aging and the...
Haiyue Tang, Wenjie Ma, Guoyou Zhang ... · Molecular diversity · Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China. · pubmed
SIRT6, a pivotal member of the NAD
Bopp, V., LeeBae, J., Oeckl, P. ... · neuroscience · German Center for Neurodegenerative Diseases (DZNE) · biorxiv
Aging as well as the presence of a-synuclein (a-syn) oligomers in the brain are indisputably linked to Parkinsons disease (PD). A central concept of geroscience is that the biological processes of aging drive the onset of aging-associated diseases. The extent to which the biologi...
Tripathi, U., Suda, M., Kulshreshtha, V. ... · cell biology · Center for Advanced Gerotherapeutics, Division of Endocrinology and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA · biorxiv
The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30-70% of SCs, act by transiently disabling the senescent cell anti-apoptotic pathways (SCAPs), which defend those SCs that ar...
Friday, August 29, 2025
Chandramouli Muralidharan, Enikő Zakar-Polyák, Anita Adami ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, 221 84, Sweden. · pubmed
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, human cell-type-specific transcriptomic aging clocks are developed using high-quality single-nucleus RNA sequencing data fr...
Masato Horino, Kenji Ikeda, Rei Okazaki ... · Reactive Oxygen Species · Department of Molecular Endocrinology and Metabolism, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, 113-8510, Tokyo, Japan. · pubmed
The induction of beige adipocytes is significantly reduced in aged mice due to the senescence of adipocyte progenitor cells (APCs). Recent studies have revealed the existence of beige adipocyte subtypes, suggesting that APCs comprise a heterogeneous population. Therefore, in this...
Manmeet Bhalla, Shaunna R Simmons, Alexsandra Lenhard ... · mSphere · Department of Microbiology and Immunology, University at Buffalo School of Medicine, , Buffalo, New York, USA. · pubmed
In response to damage triggered by various stimuli including infections, ATP is released from damaged cells and converted to adenosine in the extracellular space by the ectonucleotidases CD39 and CD73. Extracellular adenosine is an immune modulatory molecule that signals via four...
Thursday, August 28, 2025
Aisin, S. I., Lidskii, B. V., Lidsky, P. V. · evolutionary biology · Department of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Tat Chee Ave, Kowloon, Hong Kong SAR · biorxiv
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus on reversing aging in older individuals, or on pausing its progression at earlier ages? We ad...
Ge, Y., Zhang, F., Liu, Y. ... · bioinformatics · Nanyang Technological University · biorxiv
Extracting coherent, biologically meaningful insights from vast, complex multi-omics data remains challenging. Currently, pathway enrichment analysis serves as a cornerstone for the functional interpretation of such data. However, conventional approaches often suffer from extensi...
Daniel L Vera, Patrick T Griffin, David Leigh ... · The journals of gerontology. Series A, Biological sciences and medical sciences · VoLo Foundation, Palm Beach, FL 33410 USA. · pubmed
Biological age refers to a person's overall health in aging, as distinct from their chronological age. Diverse measures of biological age, referred to as "clocks", have been developed in recent years and enable risk assessments, and an estimation of the efficacy of longevity inte...
Homann, J., Korologou-Linden, R., Viallon, V. ... · neurology · Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany; Ageing and Epidemiology Unit (AGE), School of Public Health, Imperial · medrxiv
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a largely unknown duration and pathophysiology of the pre-diagnostic phase, especially for the common non-monogenic form. Methods: We leveraged the European Prospective Investigation into C...
Matthew A McLoughlin, Sruthi Cheloor Kovilakam, William G Dunn ... · Nature genetics · Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. · pubmed
The mechanisms through which mutations in splicing factor genes drive clonal hematopoiesis (CH) and myeloid malignancies, and their close association with advanced age, remain poorly understood. Here we show that telomere maintenance plays an important role in this phenomenon. Fi...
Cheyenne Rechsteiner, Francesco Morandini, Sei Joong Kim ... · Nature aging · Department of Biology, University of Rochester, Rochester, NY, USA. · pubmed
The comparative biology of aging leverages the remarkable diversity in aging rates and lifespans across species to uncover naturally evolved adaptations that promote longevity, disease resistance and injury resilience. The beauty of comparative biology is that it discovers adapta...
Pyne, S., Ray, D., Ray, M. S. · bioinformatics · Health Analytics Network, LLC · biorxiv
With a general increase in human lifespan, the need for technological advances to develop strategies for healthy aging has assumed great importance. In the present study, our goal is to predict the progression of selected aging phenotypes in a given healthy individual as one cont...
Samrat Chakraborty, Raz Ben-David, Shenhav Shemer · The FEBS journal · Faculty of Biology, Technion Institute of Technology, Haifa, Israel. · pubmed
Skeletal muscle is essential for life as it enables physical movement, maintains posture, is crucial for breathing, and serves as a major site for energy and carbohydrate metabolism. Pathological conditions that reduce skeletal muscle mass and function-such as muscular dystrophie...
Wencong Lyu, Haochen Wang, Zhehao Du ... · Enalapril · The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China. · pubmed
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, using IMR90 cells and age...
Hongkun Li, Nuo Xu, Shuaichen Li ... · Stem cell research & therapy · Department of Stomatology, the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. · pubmed
The age-related functional decline of bone marrow mesenchymal stem cells significantly impairs bone regeneration capacity. Exosomes derived from umbilical cord mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic agents in regenerative medicine and anti-aging res...
Chengcheng Li, Jiaze Tang, Junshuan Cui ... · Brain · Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, People's Republic of China. · pubmed
The relationship between the brain and aging remains unclear. Our objective is to explore the causal connections between brain structure,gene expression, and traits associated with aging. Mendelian randomization(MR) analysis was conducted to explore the associations between brain...
Luke Spray, Gavin Richardson, Laura K Booth ... · Cardiovascular research · Translational and Clinical Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle Upon Tyne NE1 3BZ, UK. · pubmed
Most acquired cardiovascular diseases are more common in older people, and the biological mechanisms and manifestations of aging provide insight into cardiovascular pathophysiology. Measuring aging within the cardiovascular system may help to better understand risk profiles for s...
Otu-Boakye, S., Natarajan, D., Plakkot, B. ... · neuroscience · Oklahoma State University, Stillwater, OK, USA · biorxiv
Dysregulation in lipid metabolism is increasingly recognized as a key contributor to age-related diseases, including neurodegeneration and cerebrovascular dysfunction. While prior studies have largely focused on glial cells, the impact of lipid dysregulation on brain endothelial ...
Grahek, I., Leng, X., Fengler, A. ... · animal behavior and cognition · University of California, Berkeley · biorxiv
Older adulthood is associated with declines across a wide range of cognitive functions, limiting the ability to perform tasks necessary for independent living. Changes in cognitive flexibility are a promising candidate mechanism underlying age-related changes in cognition, but th...
Liao, G. Y., Klug, J., Dai, S. ... · pharmacology and toxicology · University of Washington · biorxiv
The house cricket (Acheta domesticus) is a promising preclinical geroscience model due to its short lifespan, low maintenance, age-associated functional decline, and responsiveness to geroprotective drugs. Continuous dosing with rapamycin, acarbose, and phenylbutyrate extends lif...
Emma A Rodrigues, Abdoul Jalil Djiberou Mahamadou, Sylvain Moreno · Life Style · School of Interactive Arts and Technology, Simon Fraser University, Surrey, BC, Canada. · pubmed
Cognitive aging is a complex process influenced by diverse life experiences and environmental factors. However, some traditional studies have oversimplified this process by assuming that cognitive aging trajectories follow a uniform process and that all individuals will experienc...
Chen Liang, Yi Yi, Jia Li ... · Stem cell research & therapy · Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei Province, China. · pubmed
Skin ageing is a multifactorial process influenced by both intrinsic (genetic and metabolic) and extrinsic (environmental) factors, leading to noticeable changes such as wrinkles, loss of elasticity, and pigmentation disorders. Recent advancements in regenerative medicine have hi...