Longevity Papers

Current Week (May 26 - May 30, 2025)
and Previous Week (May 23 - May 25, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), May 29 episode:
Thursday, May 29, 2025
Kevin O Murray, Sophia A Mahoney, Katelyn R Ludwig ... · Aging cell · Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA. · pubmed
Excess cellular senescence contributes to age-related increases in frailty and reductions in skeletal muscle strength. In the present study, we determined the efficacy of oral intermittent treatment (1 week on-2 weeks off-1 week on) with the natural flavonoid senolytic fisetin to...
Mingtong, G., Alfatah, M. · genetics · Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117544, Singapore · biorxiv
Aging involves cellular decline and reduced stress resilience. We investigated geroprotective interventions using the yeast chronological aging model and identified methyl nicotinate (MN) as a potent lifespan-extending compound. MN enhanced cellular lifespan and stress resistance...
Lisonia Gkioni, Tobias Nespital, Maarouf Baghdadi ... · Nature aging · Department Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany. · pubmed
Suppression of the insulin-IGF-mTORC1-Ras network ameliorates aging in animals. Many drugs have targets in the network because of its roles in cancer and metabolic disease and are candidates for repurposing as geroprotectors. Rapamycin, an established geroprotective drug, blocks ...
Panek, J., Sun, C., Kataura, T. ... · cell biology · Newcastle University · biorxiv
Autophagy is a critical mechanism of cellular quality control, orchestrated by selective autophagy receptor (SAR) proteins. Pharmacologically enhancing the cargo-targeting capacity of SARs presents an attractive but underexplored strategy for the precise therapeutic activation of...
Inés Fernández Maestre, Alexander S Harris, Corina Amor · Genes & development · Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. · pubmed
The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involve...
Xu Wang, Dan Guo, Chengmei He ... · Mesenchymal Stem Cells · Clinical Biobank, Department Medical Research Central, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. · pubmed
Aging leads to a gradual decline in immune function, termed immunosenescence, which significantly elevates the susceptibility to infections, cancers, and other aging-related diseases. Recent advancements have shed light on the molecular underpinnings of immune aging and pioneered...
Xu, P., Zhang, H., Zhu, S. ... · genomics · Center of Clinical Laboratory Medicine, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Southeast University · biorxiv
Cellular senescence represents a stable cell cycle arrest state that plays critical roles in tissue aging and age-related pathologies. While single-cell RNA sequencing (scRNA-seq) has enabled comprehensive profiling of millions of cells in aged tissues, reliable identification of...
Flora, Y., Shastri, D., Bohnert, K. A. · cell biology · Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana USA 70803 · biorxiv
Peroxisomes execute essential functions in cells, including detoxification and lipid oxidation. Despite their centrality to cell biology, the relevance of peroxisomes to aging remains understudied. We recently reported that peroxisomes are degraded en masse via pexophagy during e...
Carina Kern, Joseph V Bonventre, Alexander W Justin ... · Oncogene · LinkGevity, Babraham Research Campus, Cambridge, UK. [email protected]. · pubmed
Necrosis is uncontrolled cell death that marks the irreversible threshold of biological degeneration. Rooted in the Greek nekros (death), it is a pivotal mechanism underlying numerous diseases, including cancer, as well as renal, cardiac, neuronal, and hepatic disorders, and more...
Marc Daniel Opfermann, Maria Bøgelund Søndergård, Louise Vase Bech ... · Nature chemical biology · Department of Forensic Medicine, Aarhus University, Aarhus, Denmark. · pubmed
Methylglyoxal (MG) is a reactive metabolite involved in diabetes and aging through the formation of protein adducts. Less is known about the extent that MG and its metabolic product S-D-lactoylglutathione (LGSH) form adducts with cell metabolites. Using a 'symmetric' isotope-labe...
Mingyu Xia, Feng Zhang, Jiaoyao Ma ... · Cell reports · ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China. · pubmed
Degeneration of the auditory and vestibular hair cells (HCs) leads to dysfunction of two essential senses: hearing loss and decompensated balance perception. However, the cellular and molecular mechanisms governing inner ear aging and its link to dysfunctions of sensory HCs remai...
Chen, F., Nam, Q., Wang, L. D. ... · molecular biology · Nanyang Technological University · biorxiv
Lipofuscin, a protein-lipid complex that progressively accumulates in senescent cells, was commonly observed in the liver biopsies from patients with liver fibrosis or cirrhosis regardless of the etiological insults. However, whether and how lipofuscin contributes to the developm...
Wednesday, May 28, 2025
Gupta, R., Durham, T. J., Chau, G. ... · genetics · Harvard Medical School · biorxiv
One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, abundance, and heteroplasmic variation in human blood using whole genome sequences...
Zhenguo Wang, Zhe Li, Hongyu Liu ... · Nature aging · CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. · pubmed
Mitochondria rapidly accumulate mutations throughout a lifetime, potentially acting as a molecular clock for aging and disease. We profiled mitochondrial RNA across 47 human tissues from 838 individuals, revealing rapid development of clonal mosaicism with two distinct tissue-spe...
Shiyi Zhou, Katherine E Novak, Rachel Kaletsky ... · Nature aging · Department of Molecular Biology, Princeton University, Princeton, NJ, USA. · pubmed
While memory regulation is predominantly understood as autonomous to neurons, factors outside the brain can also affect neuronal function. In Caenorhabditis elegans, the insulin/IGF-1-like signaling (IIS) pathway regulates longevity, metabolism and memory: long-lived daf-2 insuli...
Dandan Zong, Baihui Sun, Qiting Ye ... · Aging cell · Department of Endocrinology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. · pubmed
As global aging accelerates, the incidence of thyroid diseases, particularly hypothyroidism, is rising in the elderly. The thyroid-stimulating hormone (TSH) levels increase in healthy elderly populations. However, whether the thyroid undergoes cellular senescence and how this rel...
Pushkal Sharma, Colin Y Kim, Heather R Keys ... · Polyamines · Whitehead Institute for Biomedical Research, Cambridge, MA, USA. · pubmed
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutical...
Anna Calabrò, Anna Aiello, Paula Silva ... · GeroScience · Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90134, Palermo, Italy. · pubmed
Geroprotectors are compounds that target the underlying mechanisms of ageing to delay the onset of age-related diseases and extend both lifespan and health span. As ageing is driven by the accumulation of cellular damage, DNA instability, epigenetic changes, mitochondrial dysfunc...
Xinying Wang, Limin Song, Jingwen Zhao ... · Journal of materials chemistry. B · National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, P. R. China. [email protected]. · pubmed
During tissue repair, stress-induced cellular senescence represents a critical factor that impedes the regenerative potential of tissues. While the regulatory effects of matrix viscoelasticity on cellular behavior have been documented, their role and correlated mechanisms underly...
Graham, Z. A., Bubak, M. P., Raymond-Pope, C. J. ... · geriatric medicine · Florida Institute for Human and Machine Cognition · medrxiv
Age-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments compromising intrinsic capacity, healthspan and quality-of-life. Exercise is a multipotent treatment with promise to mitigate mos...
Koitz, F. A., Miller, C. P., Gordon, K. L. · developmental biology · The University of North Carolina at Chapel Hill · biorxiv
Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improve. We discovered dramatic differences in gonad size and germ cell number among d...
Yao Zhang, Peng Ma, Saifei Wang ... · Autophagy · Yangzhi Rehabilitation Hospital, Sunshine Rehabilitation Center, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 20092, China. · pubmed
Breakdown of calcium network is closely associated with cellular aging. Previously, we found that cytosolic calcium (CytoCa
Klara Kohoutova, Pavel Srb, Veronika Obsilova ... · Tumor Suppressor Protein p53 · Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic. · pubmed
The transcription factors FOXO4 and p53 regulate aging, and their deregulation has been linked to several diseases, including cancer. Under stress conditions, cellular senescence is promoted by p53 sequestration and senescence-associated protein p21 transcriptional upregulation i...
Tuesday, May 27, 2025
Matias Fuentealba, Dobri Kiprov, Kevin Schneider ... · Aging cell · Buck Institute for Research on Aging, Novato, California, USA. · pubmed
We conducted a randomized, placebo-controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE) regimens in healthy adults over 50. Participants received bi-weekly TPE with or without intravenous immunoglobulin (IVIG), monthly...
Allavena, G., Rossiello, F., Idilli, A. I. ... · pathology · Institute for Research on Cancer and Aging of Nice (IRCAN) · biorxiv
Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and cellular senescence or apoptosis. We previously reported that telomere dysfunction...
Vivas, O., Baudot, M., Choi, S. ... · biophysics · University of Washington · biorxiv
Every heartbeat is initiated by a spontaneous electrical signal generated inside the cardiac pacemaker. The generation of this electrical signal depends on the coordinated opening and closing of different ion channels, where voltage-gated L-type calcium channels play a central ro...
Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin ... · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. · pubmed
Human aging is intrinsically associated with the onset and the progression of several disease states causing significant disability and poor quality of life. Although such association was traditionally considered immutable, recent advances have led to a better understanding of se...
Woldhuis, R. R., Bekker, N. J., Nijnatten, J. L. L. ... · pathology · Department of Pathology and Medical Biology, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Gronin · biorxiv
Rationale: Higher levels of senescence have been demonstrated in COPD patients, including severe early onset (SEO)-COPD. Recently we demonstrated a link between senescence and extracellular matrix (ECM) dysregulation in lung fibroblasts. Whether this in vitro observation also tra...
Jung Min Hwang, Soo Hyun Lee, Eun Jae Baek ... · Skin Aging · Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. · pubmed
Skin ageing is a complex and multifaceted biological process that involves the accumulation of senescent dermal fibroblasts. While fractional microneedle radiofrequency (MNRF) is widely used for skin rejuvenation, the underlying molecular mechanisms are unknown. This study aimed ...
Shu, J., Guo, Y., Chirinos, J. ... · genetic and genomic medicine · University of Pennsylvania · medrxiv
Organ-specific aging clocks have shown promise as predictors of disease risk and aging trajectories; however, the underlying biological mechanisms they reflect remain largely unexplored. Here, we use large-scale proteomic and imaging data to investigate the relationships among or...
Yan Pan, Hongxia Cai, Fang Ye ... · Aging cell · Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
Despite the growing interest in developing anti-aging drugs, high costs and low success rates of traditional drug discovery methods pose significant challenges. Aging is a complex biological process associated with numerous diseases, making the identification of compounds that ca...
Sibin Nambidi, Sneha Pallatt, Antara Banerjee ... · Neoplasms · Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, India. · pubmed
Klotho, named after the youngest of the three Fates in Greek mythology daughters of Zeus and Nyx, who together spin the thread of life, allot destiny, and determine the time of passing for both mortals and immortals, is an important regulatory factor in aging and cancer dynamics....
Noureen, N., Kang, M. H. · bioinformatics · Texas Tech University Health Sciences Center · biorxiv
Telomerase activity plays a critical role in tumor growth and is quantified based on its level of expression. However, how these levels are associated with different pathways across various cancer types remains elusive due to the lack of a classification schema. Here, we defined ...
Yu Zhang, Xiaojie Liu, Hairong Lian ... · Aging cell · College of Marine Science and Engineering, Nanjing Normal University, Nanjing, Jiangsu, People's Republic of China. · pubmed
Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties. Although the metabolic and cellular pathways behind its longevity effects have been widely studied, few studies have explored the epigenetic regulatory effects ...
Filippos Anagnostakis, Sarah Ko, Mehrshad Saadatinia ... · Metabolome · Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. · pubmed
Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 pl...
Abhishek Vats, Yibo Xi, Amanda S Wolf-Johnston ... · Guanine · Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. · pubmed
Vision decline in the elderly, often due to retinal aging, predisposes individuals to pathologies like age-related macular degeneration. Currently, there are few effective oral treatments for this condition. Our study introduces an oral agent, 8-aminoguanine (8-AG), which targets...
Arun Balachandran, Heming Pei, Yifan Shi ... · Nature aging · Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. · pubmed
As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy do not distinguish differences caused by early-life factors, like prenatal care and nut...
Monday, May 26, 2025
Nicholas Riccardi, Alex Teghipco, Sarah Newman-Norlund ... · Aging · Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA. [email protected]. · pubmed
'Brain age' is a biological clock typically used to describe brain health with one number, but its relationship with established gradients of cortical organization remains unclear. We address this gap by leveraging a data-driven, region-specific brain age approach in 335 neurolog...
Schurman, C. A., Bons, J., Kumaar, P. V. ... · cell biology · Buck Institute for Research on Aging · biorxiv
Mass spectrometry imaging (MSI) is a rapidly advancing technology that provides mapping of the spatial molecular landscape of tissues for a variety of analytes. Matrix-assisted laser desorption/ionization (MALDI)-MSI is commonly employed, however, confident in situ identification...
Aitor Picos, Nuria Seoane, Manuel Campos-Toimil ... · Aging · Physiology and Pharmacology of Chronic Diseases (FIFAEC), Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. [email protected]. · pubmed
The aging vasculature is characterized by endothelial dysfunction, arterial stiffness, and increased susceptibility to vascular pathologies. Central to these changes is the process of cellular senescence, where endothelial and vascular smooth muscle cells lose their replicative a...
Saswat Kumar Mohanty, Vikas Kumar Sahu, Bhanu Pratap Singh ... · Renal Insufficiency, Chronic · Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India. [email protected]. · pubmed
Chronic kidney disease (CKD) is a global health challenge marked by progressive renal decline and increased mortality. The interplay between CKD and hypothyroidism, particularly nonthyroidal low-triiodothyronine (T3) syndrome, exacerbates disease progression, driven by HPT axis d...
Ghazal Darfarin, Janice Pluth · Environmental and molecular mutagenesis · Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, Nevada, USA. · pubmed
The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress-rel...
Sunday, May 25, 2025
Lee, B., Ciciurkaite, G., Peng, S. ... · epidemiology · New York University · medrxiv
Negative social ties, or "difficult ties," are pervasive yet understudied components of social networks that may accelerate biological aging and morbidity. Using ego-centric network data and DNA methylation-based biological aging clocks from a state representative probability sam...
Toga, K., Oka, K., Tanaka, H. ... · genomics · Hiroshima University · biorxiv
The naked mole rat (NMR, Heterocephalus glaber) is a eusocial rodent that is native to northeastern Africa. NMRs exhibit extraordinary traits such as longevity, resistance to age-related decline, and remarkable hypoxia tolerance. Although the reference genome of this species has ...
Saturday, May 24, 2025
Daozheng Yang, Natalia Skinder, Yun-Ruei Kao ... · Nature aging · European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. · pubmed
During aging, hematopoietic stem cell (HSC) function progressively declines which can lead to reduced blood cell production and regeneration. This work uncovered that cell surface presentation of P-selectin (CD62P, encoded by Selp) increases in a large fraction of aging HSCs driv...
Bianca Aparecida Martin, Juliana Viegas, Luciana Facco Dalmolin ... · ACS biomaterials science & engineering · School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n°, 14040-903 Ribeirão Preto, São Paulo, Brazil. · pubmed
The skin is a complex organ composed of multiple layers and diverse cell types, including keratinocytes, fibroblasts, adipocytes, and sensory neurons, which maintain its structural and functional integrity together. Conventional in vitro and ex vivo models help investigate drug p...
Yidong Zhu, Juan Zhao, Zihua Li ... · Mammalian genome : official journal of the International Mammalian Genome Society · Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. · pubmed
Osteoporosis, characterized by decreased bone mineral density, is a common skeletal disorder in the aging population. Cellular senescence is a key factor in the pathophysiology of osteoporosis. This study aimed to identify senescence-related biomarkers and evaluate the functional...
Lorène Rousseau, Karina L Hajdu, Ping-Chih Ho · Epigenesis, Genetic · Department of Fundamental Oncology, University of Lausanne, 155 Ch. Des Boveresses, 1066, Epalinges, Switzerland. · pubmed
Epigenetic regulation, including DNA methylation and histone modifications, play a pivotal role in shaping T cell functionality throughout life. With aging, these epigenetic changes profoundly affect gene expression, altering T cell plasticity, activation, and differentiation. Th...
Dantong Zhu, Judy Z Wu, Patrick T Griffin ... · npj aging · Institute for Systems Biology, Seattle, WA, USA. · pubmed
Frailty is an age-related geriatric syndrome. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured frailty index and derived metabolomics data from plasma. We identify age-related differentially abundant metabolites, determine fra...
Fiorenza Gianì, Benjamin B Roos, Patrick A Link ... · American journal of physiology. Cell physiology · Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota. · pubmed
Idiopathic pulmonary fibrosis (IPF) is a fatal aging-related disease characterized by aberrant lung remodeling and progressive scarring, leading to organ failure and death. Current FDA approved anti-fibrotic treatments are unable to reverse established disease, highlighting the n...
Friday, May 23, 2025
Foley, E. E., Thomas, C. L., Kyriacou, C. ... · genetics · University of Leicester · biorxiv
Epigenetic clocks based on DNA methylation provide robust biomarkers of biological age, yet the mechanistic basis and functional significance of slowing these clocks remain unclear. Progress has been limited by the lack of short-lived, genetically tractable model organisms with f...
Zhang, Q., Dang, W., Wang, M. C. · genetics · HHMI Janelia Research Campus · biorxiv
Epigenome is sensitive to metabolic inputs and crucial for aging. Lysosomes emerge as a signaling hub to sense metabolic cues and regulate longevity. We unveil that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in Caenorhabditis...
Piskova, T., Kozyrina, A. N., Astrauskaite, G. ... · cell biology · Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Germany · biorxiv
Mechanical homeostasis in healthy tissues relies on a dynamic balance of mechanical properties essential for maintaining tissue integrity and function. Over the lifetime, this integrity decays due to structural reorganisation from extracellular remodelling or an imbalance of cell...
Jung, M., Reisert, M., Rieder, H. ... · radiology and imaging · Medical Center - University of Freiburg · medrxiv
Body composition (adiposity and muscle depots) is strongly associated with cardiometabolic risk. However, using body composition measures for future disease risk prediction is difficult as they may reflect total body size or typical aging rather than poor health. We used data fro...
Khajuria, P., Kour, D., Sharma, K. ... · pharmacology and toxicology · CSIR-Indian Institute of Integrative Medicine, Jammu 180016, India · biorxiv
AD pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and help ameliorate AD pathology. We discovered that Bisdemethoxycurcumin (BDMC), a n...
Naikawadi, R. P., Bazarov, A., Wax, M. ... · cell biology · University of California, San Francisco · biorxiv
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, age-associated, lung disease characterized by short telomeres in alveolar type 2 (AT2) cells, epithelial remodeling, and fibrosis. Objectives: This study investigated how telomere dysfunction in AT2 cells lacking Te...
Gregory R Keele, Yue Dou, Seth P Kodikara ... · Aging · GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA. · pubmed
Aging results in a progressive decline in physiological function due to the deterioration of essential biological processes. While proteomics offers insights into aging mechanisms, prior studies are limited in proteome coverage and lifespan range. To address this, we integrate th...
Rafal Gulej, Roland Patai, Anna Ungvari ... · GeroScience · Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. · pubmed
Aging is a complex biological process that detrimentally affects the brain and cerebrovascular system, contributing to the pathogenesis of age-related diseases like vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). While cell-autonomous mechanisms th...
Zixuan Dong, Xiaobing Liu, Shichun Li ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, P. R. China. · pubmed
The aberrant cellular senescence in chronic wounds presents a significant barrier to healing. Mitochondrial dysfunction is critical in initiating and maintaining cellular senescence, underscoring therapeutic potential in restoring mitochondrial function by delivering healthy mito...
Yu Li, Lu Qian, Fei Liu ... · Nano letters · Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing, 211198, Jiangsu Province, China. · pubmed
Small extracellular vesicles (sEV) derived from mesenchymal stem cells hold promise for anti-skin aging, yet their clinical application is hindered by poor transdermal permeability. Herein, we report an innovative light-controlled sEV-based spherical nucleic acid nanomotor (NM-ES...
Guillaume Le Cosquer, Melissa Pannier, Elodie Meunier ... · Biofilms · Institute of Digestive Health Research (IRSD), INSERM, Toulouse University, INRAe, ENVT, University Toulouse III Paul Sabatier (UPS), Toulouse, France. · pubmed
Pathophysiological mechanisms of unhealthy aging, particularly the transition from robustness to frailty, remain poorly understood. Despite extensive microbiome research on taxonomy, the behavior of early prefrail gut bacteria in their natural community-host mucosal tissue contex...
Fabio Bento, Matteo Longaretti, Vanessa Borges Pires ... · EMBO reports · Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg Universität, 55128, Mainz, Germany. · pubmed
Telomere repeat-containing RNA (TERRA) is transcribed at telomeres and forms RNA-DNA hybrids. In budding yeast, the presence of RNA-DNA hybrids at short telomeres promotes homology-directed repair (HDR) and prevents accelerated replicative senescence. RNA-DNA hybrids at telomeres...
Wang, X., Nishida, M., Yoshioka, A. ... · cell biology · Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University · biorxiv
Xeroderma pigmentosum (XP) is an inherited photoaging syndrome caused by mutations in genes involved in the nucleotide excision repair (NER) pathway. XP patients exhibit hypersensitivity to ultraviolet (UV) radiation, leading to accelerated skin aging and requiring lifelong sun a...
Kosakamoto, H., Okada, R., Barker, C. ... · physiology · RIKEN Center for Biosystems and Dynamics Research · biorxiv
Dietary restriction (DR), whether applied during adulthood or juvenile stages, extends lifespan across diverse species. However, the mechanisms by which early-life dietary interventions influence adult physiology and longevity remain poorly understood. Here, using Drosophila as a...
Fei Cong, Hongcun Bao, Xianfeng Wang ... · The EMBO journal · Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA, USA. · pubmed
Paraneoplastic syndrome represents severe and complex systemic clinical symptoms manifesting in multiple organs of cancer patients, but its cause and cellular underpinnings remain little explored. In this study, establishing a Drosophila model of paraneoplastic syndrome triggered...
Mandal, R., Xie, N., Alterovitz, G. · genomics · Biomedical Cybernetics Laboratory, Harvard Medical School, 75 Francis Street, Boston, MA 02115 USA. · biorxiv
This research investigates the complex biochemical mechanisms underlying aging by analyzing primary human fibroblasts using a longitudinal multi-omics dataset. This dataset includes cytology, DNA methylation and epigenetic clocks, bioenergetics, mitochondrial DNA sequencing, RNA ...