Longevity Papers

Current Week (June 09 - June 13, 2025)
and Previous Week (June 06 - June 08, 2025)


Weekly AI-generated podcast (YT) (Apple) (feed), June 05 episode:
Friday, June 13, 2025
Jianda Kong, Yingao Xie, Rao Fan ... · Aging · College of Basic Medicine, Qilu Medical University, Zibo, China. · pubmed
Aging is a systemic process marked by progressive multi-organ dysfunction, metabolic dysregulation, and chronic low-grade inflammation ("inflammaging"), which collectively drive neurodegenerative diseases such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). Emerging evi...
Arturo Bujarrabal-Dueso, George A Garinis, Paul D Robbins ... · Nature reviews. Drug discovery · Institute for Genome Stability in Aging and Disease, University and University Hospital of Cologne, Cologne, Germany. · pubmed
Ageing is the most important risk factor for many common human diseases, including cancer, diabetes, neurodegeneration and cardiovascular disease. Consequently, combating ageing itself has emerged as a rational strategy for addressing age-related multimorbidity. Over the past thr...
Limor Zwi-Dantsis, Vignesh Jayarajan, George M Church ... · Advanced healthcare materials · Department of Mechanical Engineering, Roberts Building, University College London, London, WC1E 6BT, United Kingdom. · pubmed
Aging is a complex process and the main risk factor for many common human diseases. Traditional aging research using short-lived animal models and two-dimensional cell cultures has led to key discoveries, but their relevance to human aging remains debatable. Microfluidics, a rapi...
Zhangrong Cheng, Haiyang Gao, Pengzhi Shi ... · Intervertebral Disc Degeneration · Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. · pubmed
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been associated with inflammat...
Xichi Ma, Yun Ma, Xilin Ma ... · Food science & nutrition · Bayi Orthopaedic Hospital Chengdu China. · pubmed
Osteoporosis, characterized by reduced bone mineral density (BMD) and impaired bone microarchitecture, imposes a significant global health and economic burden, particularly on postmenopausal women. This study investigated the efficacy of a novel supplement that combines pilose an...
Avery Rui Sun, Md Faris H Ramli, Xingyu Shen ... · Nature materials · Mechanobiology Institute (MBI), National University of Singapore, Singapore, Singapore. · pubmed
Extracellular matrix remodelling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodelling is multifaceted including changes to the biochemical composition, architecture and mechanics, clouding our understanding of how and whic...
Xin Sun, Xiang Xu, Xue Zhao ... · ACS nano · Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China. · pubmed
Age-related bone defects cause disability and mortality in older individuals. During bone repair in older individuals, high oxidative stress and excessive inflammation in the senescent microenvironment (SME) lead to bone marrow mesenchymal stem cell (BMSC) senescence, thereby aff...
Thursday, June 12, 2025
Behnam Sabayan, Bernadette Boden-Albala, Natalia S Rost · Neurologists · Hennepin Healthcare Research Institute, Department of Neurology, Hennepin County Medical Center, Minneapolis, MN. · pubmed
The global burden of neurologic disorders is rising, driven by aging populations and improved survival following acute neurologic events. As a result, more individuals are living with long-term disabilities from conditions such as stroke, dementia, and other neurodegenerative dis...
Kalailingam, P., Ngan, S. C., Gallart-Palau, X. ... · pharmacology and toxicology · NTU · biorxiv
Background: Degenerative protein modifications (DPMs) accumulate with aging and can alter biomolecule structure and function, including via spontaneous conversion of Asn-Gly-Arg (NGR) to isoAsp-Gly-Arg (isoDGR) motifs that can bind integrins and drive chronic inflammation. Since ...
Anglas, U., Tamez Gonzalez, A. A., Promi, M. M. ... · genetics · McGill University · biorxiv
The reactive oxygen species superoxide is generated by mitochondria during the process of producing energy. While superoxide can cause oxidative damage to the cell, we and others have shown that a mild increase in mitochondrial superoxide extends longevity in multiple model organ...
Agus Surachman, Meera N Harhay, Rose Ann DiMaria-Ghalili ... · GeroScience · Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, 3215 Market St, Rm 552, Philadelphia, PA, 19104, USA. [email protected]. · pubmed
Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioeconomic status (SES) and decrements in kid...
Ping Wu, Lieselot Vandemeulebroucke, Kevin Rey A Guiritan ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium. · pubmed
Axenic dietary restriction (ADR) represents a powerful and unique DR regimen for C. elegans as it robustly extends lifespan independently of well-known key genes associated with DR, such as those of insulin/IGF-1 signaling, skn-1, and pha-4. Here, we analyze C. elegans survival i...
Xieyang Xu, Yan Pang, Xianqun Fan · Oxidative Stress · Department of Ophthalmology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces an imbalance between oxidation and anti...
Na Zhang, Yan You, Yanhua Zhao ... · Biology of reproduction · Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, P. R. China. · pubmed
The advanced maternal age is strongly correlated with a notable decline in oocyte quality, yet definitive and effective strategies to enhance it remain incompletely identified. In this study, we reported that near-infrared light, administered in vitro, efficaciously improves the ...
Haoxian Zhou, Shu Wu, Bin Li ... · Protein & cell · Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. · pubmed
Loss of protein homeostasis is a hallmark of cellular senescence, and ribosome pausing plays a crucial role in the collapse of proteostasis. However, our understanding of ribosome pausing in senescent cells remains limited. In this study, we utilized ribosome profiling and G-quad...
Wallis, R., Hughes, B. K., Moore, M. ... · cancer biology · Blizard Institute, Queen Mary University of London · biorxiv
Background Senescence identification is rendered challenging due to a lack of universally available biomarkers. This represents a bottleneck in efforts to develop pro-senescence therapeutics - agents designed to induce the arrest of cellular proliferation associated with a senesc...
Santana, R. A., McWhirt, J., Brewer, G. J. · neuroscience · University of California Irvine · biorxiv
Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged organelles and proteins. Age-related ATP depletion would impact cognition dependent on ionic homeostasis, but limits on proteostasis powered by GTP are less cl...
Shuying Chen, Qian Chen, Xinru You ... · Nature aging · Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · pubmed
Aging is characterized by a gradual decline of cellular and physiological functions over time and an increased risk of different diseases. RNA therapeutics constitute an emerging approach to target the molecular mechanisms of aging and age-related diseases via rational design and...
Wednesday, June 11, 2025
Zhen Yu, Ruiye Chen, Peng Gui ... · NPJ digital medicine · The AIM for Health Lab, Monash University, Melbourne, VIC, Australia. · pubmed
Retinal age has emerged as a promising biomarker of aging, offering a non-invasive and accessible assessment tool. We developed a deep learning model to estimate retinal age with enhanced accuracy, leveraging retinal images from diverse populations. Our approach integrates self-s...
Sergiy Libert, Alex Chekholko, Cynthia Kenyon · Aging · Calico Life Sciences, South San Francisco, United States. · pubmed
Why people age at different rates is a fundamental, unsolved problem in biology. We created a model that predicts an individual's age from physiological traits that change with age in the large UK Biobank dataset, such as blood pressure, lung function, strength, and stimulus-reac...
Balun Li, Yanheng Ding, Miao Han ... · Aging · College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, China. · pubmed
Dogs serve as ideal research subjects for aging studies. In this study, 9 aging-related cell populations are identified through single-cell RNA sequencing of dogs of different ages. Additionally, 9 CD8+ T cell senescence-specific markers conserved across species are identified. F...
Cassandra J McGill, Amy Christensen, Wenjie Qian ... · Communications medicine · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed
The apolipoprotein ε4 allele (APOE4) is associated with decreased longevity and increased vulnerability to age-related declines and disorders across multiple systems. Interventions that promote healthspan and lifespan represent a promising strategy to attenuate the development of...
Gwladys Revêchon, Anna Witasp, Nikenza Viceconte ... · Nature aging · Department of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden. [email protected]. · pubmed
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we found progerin, the prote...
Piero Rigo, Sara Ahmed-de-Prado, Rebecca L Johnston ... · Hippocampus · Neural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK. · pubmed
Adult neural stem cells exist on a continuum from deep to shallow quiescence that changes in response to injury or aging; however, the transcription factors controlling these stepwise transitions have not been identified. Single-cell transcriptomic analyses of mice with loss of f...
Young Du Choi, Young Un Kim, HyunJoon Gi ... · BMB reports · Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22212; Program in Biomedical Science & Engineering, Inha University, Incheon 22212; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Korea. · pubmed
Skin aging is a complex biological process driven by intrinsic and extrinsic factors, leading to a progressive structural and functional decline. The balance between extracellular matrix (ECM) degradation and synthesis is critical for maintaining skin homeostasis, with collagen l...
Fangxi Xu, Yuqi Guo, Scott C Thomas ... · Dysbiosis · Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA. · pubmed
Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation. This study examines the role of succinate...
Yi-Wen Liao, Hsi-Hsien Hsieh, Jin-Wei Yeh ... · Cellular Senescence · Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan. · pubmed
The limited doubling capacity of human cells, known as replicative senescence or cellular senescence, is a major factor in cellular aging. This process is triggered by telomere erosion, which activates a p53-mediated DNA damage response (DDR) that halts cell proliferation. p53, a...
Tuesday, June 10, 2025
Naz Şerifoğlu, Giulia Allavena, Bruno Lopes-Bastos ... · The EMBO journal · Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR7284, INSERM U1081, Université Cote d'Azur, 06107, Nice, France. · pubmed
Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA-damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro, cells with short telomeres activate the cGAS-STING innate im...
Lauren Monroe, Samantha Kaonis, Natalie Calahan ... · Advanced biology · School of Biomedical Engineering, Colorado State University, 800 Meridian Ave, Fort Collins, CO, 80523, USA. · pubmed
In eukaryotic cell nuclei, chromatin exhibits a high degree of structural and functional dynamics. Recent findings suggest that chromatin has the ability to reorganize in response to changes within the cellular microenvironment. Such changes include oxidative stress found in hype...
M N Núñez-Lisboa, A H Dewolf · npj aging · Laboratory of biomechanics and Physiology of Locomotion, Institute of NeuroScience, Université catholique de Louvain, Louvain-la-Neuve, Belgium. · pubmed
Exercise induces neural and muscular adaptations, improving muscle mass and function in older adults. We investigated its impact on gait neuromuscular control in young and older adults, classified as more active (young: n = 15, 5185 ± 1471 MET-min/week; old: n = 14, 6481 ± 4846 M...
Gilbert B Ampomah, Eldon R Hard, Matthew Robert Pratt · Chembiochem : a European journal of chemical biology · University of Southern California, Chemistry, UNITED STATES OF AMERICA. · pubmed
The overall process of protein aggregation from soluble species to amyloid fibrils is toxic to neurons and can propagate along neuronal connections in ways that potentially explain the pathological progression in most neurodegenerative diseases. One of these aggregation-prone pro...
Monday, June 09, 2025
Schleh, M., Cambraia, A., Cutler, M. ... · physiology · Vanderbilt University · biorxiv
Aging is a major risk factor for insulin resistance and type 2 diabetes, driven in part by declining pancreatic beta cell function. While calorie restriction (CR) initiated early in life improves metabolic health and preserves beta cell function, its impact when initiated later i...
Arjun Jain, Yuuki Hosokawa, Kevin Joseph · Cellular reprogramming · Retro Biosciences, San Francisco, California, USA. · pubmed
Sahu et al. (2024) demonstrate that targeted partial reprogramming with Oct4, Sox2, and Klf4 (OSK) delivered via adeno-associated virus (AAV) to Cdkn2a-positive cells rejuvenates senescent cells while maintaining cellular identity. In a progeroid and naturally aged mouse model, a...
Fullerton, M. O., Phillips, L. C., Redgrave, R. E. ... · genetics · Newcastle University · biorxiv
Abstract Background and Aims The sodium-dependent multivitamin transporter, encoded by SLC5A6, mediates cellular uptake of the vitamins, biotin and pantothenic acid, both of which are essential cofactors for energy metabolism. Here, we report two families with SLC5A6 mutations pr...
Masahiro Tamura, Wakana Yamashita, Takahide Hibi ... · Schizosaccharomyces · Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan. · pubmed
Inhibition of the activity of Pma1, a widely conserved P-type proton exporting ATPase, has been shown to extend the chronological lifespan (CLS) in fission yeast Schizosaccharomyces pombe. To develop a specific inhibitor for Pma1 of S. pombe, we focused on Si01, a candidate inhib...
Shvedova, M., Thanapaul, R. J. R. S., Wang, Q. ... · cell biology · Boston University School of Medicine · biorxiv
The transient upregulation of cellular senescence within wound tissues has been demonstrated to be an important biological process facilitating efficient tissue repair. Dysregulation of this transient wound-induced senescence-like response can result in impaired healing outcomes....
Samuel D Anderson, Maria Razzoli, Brian Chen ... · GeroScience · Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed
A strong association exists between exposure to life stressors and accelerated aging in humans and animal models. However, the molecular mechanisms that underlie the adverse effect of stress on aging remain poorly characterized, and there is a paucity of prognostic predictors of ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar ... · Aging cell · Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary. · pubmed
Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorl...
Zhang, W., Lukacsovich, D., Young, J. ... · genetic and genomic medicine · University of Miami · medrxiv
Aging is the strongest risk factor for Alzheimer's disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. In this study, we performed a meta-analysis of blood DNAm samples from 475 dementia-free su...
Sunday, June 08, 2025
Rehman, A., Duffy, M., Gresova, K. ... · genomics · National Institute on Aging, NIH · biorxiv
Aging is associated with increases in risk of multiple chronic diseases and at the cellular level, with disruptions in RNA homeostasis. Single-cell transcriptomic studies have revealed RNA abundance heterogeneity across brain cell types but the more complex changes in RNA process...
Xiao, L., Sharma, P., Yang, X. ... · neuroscience · NICHD,NIH · biorxiv
Background The global aging population is increasingly inflicted with Alzheimer\'s disease (AD), but a cure is still unavailable. Neurotrophic Factor-1/carboxypeptidase E (NF-1/CPE) gene therapy has been shown to prevent and reverse memory loss and pathology AD mouse models Howev...
Kim, M., Berger, C., Wolf, A. ... · bioengineering · Institute of Biological and Medical Imaging, Bioengineering Center, Helmholtz Zentrum Muenchen · biorxiv
Adipose tissue plasticity and functional heterogeneity play a central role in maintaining energy homeostasis, and their malfunction leads to metabolic disorders such as obesity, diabetes, and cardiometabolic disease. Rapid, single-cell metabolic imaging of intact fat tissue not o...
Saturday, June 07, 2025
Otto, D. J., Arriaga-Gomez, E., Thieme, E. ... · bioinformatics · Fred Hutchinson Cancer Center · biorxiv
Kompot is a statistical framework for holistic comparison of multi-condition single-cell datasets, supporting both differential abundance and differential expression. Differential abundance captures changes in how cells populate the phenotypic manifold across conditions, while di...
Emily, M. F., Guillaud, L., De la Fuente Ruiz, S. ... · neuroscience · Okinawa Institute of Science and Technology · biorxiv
Mitochondria are trafficked along axons and provide the energy required for several intracellular mechanisms including molecular transport and local translation, which is believed to contribute to the homeostasis of the axonal compartment. Decline in mitochondria activity is one ...
Antonio Marino, Domenico Di Fraia, Diana Panfilova ... · Ubiquitination · Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany. · pubmed
Post-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse aging brain. We show that...
Dmitrii Usoltsev, Ekaterina Moguchaya, Maria Boyarinova ... · Cardiovascular Diseases · Almazov National Medical Research Centre, St. Petersburg, Russia. · pubmed
Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular ris...
Yuan Zhang, Huayu Wang, Fang Li ... · Cellular Senescence · Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · pubmed
MRG15, a chromatin remodeling protein, plays a pivotal role in cellular senescence and proliferation. However, the precise roles and mechanisms of MRG15 in aging regulation remain unclear. Our research elucidates the distinct functions of MRG15's splice variants in aging. We find...
Xing-Yi Chen, Dong-Mei Wang, Ya Zhou ... · Mitophagy · Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, 611137, Sichuan, China. · pubmed
Pulmonary fibrosis is often associated with aging, marked notably by the senescence of lung epithelial cells and the development of interstitial fibrosis. Mitophagy plays a crucial role in aging by degrading damaged mitochondria, thereby maintaining mitochondrial quality and cell...
Watowich, M., Brassington, L., Longtin, A. ... · epidemiology · Vanderbilt University · medrxiv
Declines in cardiometabolic health among older individuals are so ubiquitous in Western, high-income countries that non-communicable diseases (NCDs) like type 2 diabetes, hypertension, and cardiovascular disease have been termed "diseases of aging". In contrast, research from non...
Friday, June 06, 2025
Chia-Ling Kuo, Peiran Liu, Gabin Drouard ... · Proteomics · Department of Public Health Sciences, University of Connecticut Health Center, Farmington, CT 06032. · pubmed
The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-ba...
de Lima Camillo, L. P., Gam, R., Maskalenka, K. ... · cell biology · Shift Bioscience Ltd · biorxiv
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the Yamanaka factors (OCT4, SOX2, KLF4, with or without c-MYC: \"OSK(M)\") have been...
Sadoughi, B., Hernandez-Rojas, R., Hamou, H. ... · genomics · Arizona State University · biorxiv
Elucidating the socio-ecological factors that shape patterns of epigenetic modification in long-lived vertebrates is of broad interest to evolutionary biologists, geroscientists, and ecologists. However, aging research in wild populations is limited due to inability to measure ce...
Shemtov, S. J., McGann, E., Carrillo, L. ... · molecular biology · University of Southern California · biorxiv
Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian lifespan and protects against a range of age-related diseases. Surprisingly though, we found that reduced IGF-1 signaling fails to extend the lifespan of mitochondrial mutator mice. Accordingly, most ...
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu ... · Aging cell · Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. · pubmed
Multiple studies in mice with genetically disrupted growth hormone (GH) signaling have demonstrated that such disruption results in reduced body size, robustly increased longevity (> 50% in some cases), and improvements across multiple health parameters. However, it remains uncle...
Sturmlechner, I., Jain, A., Jiang, J. ... · immunology · Mayo Clinic · biorxiv
Older adults are susceptible to infections, in part due to waning of immune memory. To determine mechanisms that determine long-lasting versus short-term immunity, we examined varicella zoster virus (VZV) vaccination as a model system. We contrasted VZV antigen-specific T cells s...
Ming Ann Sim, Jorming Goh, Jasinda Lee ... · Sirolimus · Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [email protected]. · pubmed
The geroprotective effects of rapamycin in mitigating frailty and cognitive complications in the perioperative period remains unknown. Of 39 C57BL/6 mice tested, 19 were young (16 weeks), and 20 were old (80 weeks). The interventional group (10 old, 10 young) received daily oral ...
Jia Xie, Ze-Guang Han · BioEssays : news and reviews in molecular, cellular and developmental biology · Key Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. · pubmed
Heterochromatin, a crucial constituent of the eukaryotic nucleus with highly conserved and transcriptionally silenced characteristics, plays a pivotal role in safeguarding genome stability, regulating nuclear morphology, and mediating cell fate. Recent convincing evidence indicat...
Rychlicka-Buniowska, E., Sarkisyan, D., Horbacz, M. ... · genetic and genomic medicine · Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; 3P-Medicine Laboratory, Medical Universit · medrxiv
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events associated with multiple adverse outcomes in the elderly. While LOY has been associated with higher risk of Alzheimer disease (AD), CHIP has been suggested to perfo...
McQuade, A., Castillo, V. C., Hagan, V. ... · neuroscience · University of California, San Francisco · biorxiv
Microglia dynamically support brain homeostasis through the induction of specialized activation programs or states. One such program is the Interferon-Responsive Microglia state (IRM), which has been identified in developmental windows, aging, and disease. While the functional im...
Palomares, D., Vanparys, A., Jorgji, J. ... · neuroscience · Aging and Dementia group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium · biorxiv
Background: Although the connection between aging and neurodegenerative pathologies like Alzheimer\'s disease (AD) has long been recognized, the underlying pathological mechanisms remain largely unknown. Senescent brain cells build up in the brains of AD patients and a causal lin...
Hiroshi Kobayashi, Shogo Imanaka · DNA, Mitochondrial · Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Nara 634‑0813, Japan. · pubmed
Mitochondria and mitochondrial DNA (mtDNA) are crucial for cellular energy metabolism and the adaptive response to environmental changes. mtDNA collaborates with the nuclear genome to regulate mitochondrial function. Dysfunctional mitochondria and mutations in mtDNA are implicate...