Longevity Papers

Week of July 14 - July 20, 2025


Weekly AI-generated podcast (YT) (Apple) (feed), June 26 episode:
Sunday, July 20, 2025
Douglas M Ruden · Epigenomics · C. S. Mott Center for Human Growth and Development, Institute for Environmental Health Sciences, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. · pubmed
Aging is a complex biological process involving coordinated changes across multiple molecular systems. Traditional reductionist approaches, while valuable, are insufficient to capture the full scope of aging's systemic nature. Multiomics - integrating data from genomics, transcri...
Saturday, July 19, 2025
Korcari, A., Tauc, H., Duggan, J. ... · immunology · Genentech · biorxiv
Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake ...
Nusrat Jan, Shazia Sofi, Aijaz Ahmad Mir ... · Molecular and cellular biochemistry · Cancer Biology Laboratory, Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, 190006, India. · pubmed
Aging and cancer are interconnected processes resulting from irreversible dysfunctions, primarily caused by stress-induced DNA and cellular damage. While aging is characterized by the accumulation of senescent cells (SnCs), cancer development is linked to a progressive decline in...
Dieu-Huong Hoang, Jessica Bouvière, Johanna Galvis ... · EMBO reports · Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, Université Claude Bernard Lyon 1, Inserm U1315, CNRS 5261, Lyon, France. · pubmed
Muscle regeneration is impaired with aging, due to both intrinsic defects of muscle stem cells (MuSCs) and alterations of their niche. Here, we monitor the cells constituting the MuSC niche over time in young and old regenerating mouse muscle. Aging alters the expansion of all ni...
Lihuan Guan, Lei Feng, Anderson Li Yang Khoo ... · European journal of epidemiology · Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · pubmed
The global population is ageing rapidly. While genetics, lifestyle, and environment are known contributors to healthspan, most insights are drawn from Western cohorts, leaving Asian populations underrepresented despite unique biological, lifestyle, and cultural factors. The SG90 ...
Friday, July 18, 2025
Li, M., Song, Z., Reed, E. ... · molecular biology · Boston University · biorxiv
Background. Age is one of the major risk factors for a wide range of diseases. Nevertheless, some individuals can better cope with these changes and become centenarians. We hypothesize that their blood transcriptome may provide insights into the mechanisms contributing to healthy...
Sadoughi, B., Petersen, R., Patterson, S. K. ... · genomics · Vanderbilt University · biorxiv
Age and early life adversity (ELA) are both key determinants of health, but whether they target similar physiological mechanisms across the body is unknown due to limited multi-tissue datasets from well-characterized cohorts. We generated DNA methylation (DNAm) profiles across 14...
Jantrapirom, S., Sangphukieo, A., U-on, N. ... · neuroscience · Faculty of Medicine, ChiangMai University · biorxiv
Targeting Endoplasmic Reticulum Oxidoreductase 1 Alpha (ERO1A) offers therapeutic potential for ER stress-related conditions, including motor neurone diseases and congenital muscle disorders. However, selective ERO1A inhibitors remain unavailable. Here, we developed a multi-modal...
Wanting Jiang, Xing Wang, Lijuan Mao · Journal of Alzheimer's disease : JAD · School of Athletic Performance, Shanghai University of Sport, Shanghai, China. · pubmed
Cognitive decline is age-specific or related to dementia and Alzheimer's disease (AD), which poses great concern to older adults. Exercise contributes to cognitive gains, with aerobic exercise (AE) being the most commonly studied type. However, other types, such as resistance exe...
Bahr, L., Amrit, F. R., Silvia, P. E. ... · genetics · University of Pittsburgh School of Medicine · biorxiv
Reproduction and immunity are fundamental, energy intensive processes that often compete for resources, leading to trade-offs observed across diverse species. Lipid metabolism plays a crucial role in integrating these processes, particularly during stressful conditions such as pa...
Guoqing Pan, Yi Zhang, Ju-Jiao Kang ... · npj aging · Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. · pubmed
Given the growing global elderly population and the accelerating decrease in grey matter volume (GMV) with age, understanding healthy brain aging is increasingly important. This study investigates whether variations in modifiable traits can account for differences in GMV and whet...
Pei Lin Li, Jie Tang, Xiao Tong Li ... · Osteoarthritis · Department of Stem Cells and Regenerative Medicine, Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing 100850, P.R. China. · pubmed
Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenit...
Huang, Q., Wang, Y., Farias, K. ... · pharmacology and toxicology · Weill Cornell Medicine · biorxiv
Cardiomyocyte senescence, characterized by elevated cell cycle inhibitor expression, persistent DNA damage response, and mitochondrial dysfunction, contributes to myocardial stiffness and the progression of heart failure with preserved ejection fraction (HFpEF), the most common f...
Pablo-Reina Gonzalez, Muhammet Ay, Monica Langley ... · Toxicological sciences : an official journal of the Society of Toxicology · Dept of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA. · pubmed
Astrocytes, the most abundant glial cells in the central nervous system, play essential roles in maintaining neuronal homeostasis, synaptic regulation, and blood-brain barrier integrity. However, these cells can undergo senescence, a cellular state characterized by irreversible g...
Gopal, S., Chaturbedi, A., Ramachandrula, T. V. ... · developmental biology · Cornell University · biorxiv
The nuclear hormone receptor NHR-49, a homolog of mammalian PPAR and HNF4, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here we uncovered a new function of NHR-49 in reproduction - controlling oocyte activation and o...
Gotz, M., Hayman, D. J., Adams, G. ... · physiology · University of Sheffield · biorxiv
Stress response pathways are emerging as conserved modulators of lifespan. The prevailing hypothesis is that activation of stress responsive pathways, including the amino acid deprivation arm of the integrated stress response (ISR; the GCN2-ATF4 pathway) is pro-longevity. Activat...
Thursday, July 17, 2025
Onder Albayram, Natalia Oleinik, Besim Ogretmen · Aging cell · Department of Pathology and Laboratory Medicine, ER-AL Neurovascular Protection Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA. · pubmed
The misclassification of functional genomic loci as pseudogenes has long obscured critical regulators of cellular homeostasis, particularly in aging-related pathways. One such locus, originally annotated as RPL29P31, encodes a 17-kDa protein now redefined as PERMIT (Protein that ...
Shchukina, I., Rodriguez-Hernandez, C., Ruiz, H. S. ... · immunology · Washington University in St. Louis · biorxiv
Aging profoundly reshapes the immune cell landscape, with particularly strong effects on CD8+ T cells, including a marked decline in naive cells and the emergence of age-associated GZMK+ CD8+ T cells (TAA cells). Although TAA cells make up a significant fraction of the aged CD8+ ...
Mekulu, K., Aqlan, F., Yang, H. · health informatics · Pennsylvania State University · medrxiv
Early detection of cognitive impairment in assisted living is hindered by time intensive tools like MMSE and MoCA. We present a 60-second voice based screening model that analyzes picture descriptions to estimate dementia risk. Using transcripts from the DementiaBank corpus, our ...
Bravo, J. I., Tewelde, E., King, C. D. ... · genomics · University of Southern California · biorxiv
During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though Alu elements are often studied for thei...
Alan Kavšek, Jérôme Salignon, Lluís Millan-Ariño ... · Caenorhabditis elegans · Integrated Cardio Metabolic Centre (ICMC) and Division of Biosciences and Nutrition, Department of Medicine, Karolinska Institute, Huddinge, Sweden. · pubmed
The nuclear chromatin landscape changes with age. Here, we investigate whether chromatin alterations distinguish also animals with unusual aging rates, focusing on Caenorhabditis elegans with reduced insulin/IGF-like signaling (IIS), i.e., daf-2 mutants. In these animals, enhance...
Brittany Intzandt, Safa Sanami, Julia Huck ... · The journals of gerontology. Series A, Biological sciences and medical sciences · BrainLab, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto Canada. · pubmed
Cerebral blood flow (CBF) declines consistently in aging and this decline is a critical component of several late life diseases. Understanding why this occurs in normal aging, prior to pathological changes, is crucial. Physical activity (PA) is a powerful preventative tool to imp...
Shoma Ishikawa, Björn Schumacher · Annual review of genetics · 1Institute for Genome Stability in Aging and Disease and Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne and University Hospital of Cologne, Cologne, Germany; email: [email protected], [email protected]. · pubmed
The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current understanding of heredity; it proposed that genetic inheritance is exclusively ...
Wednesday, July 16, 2025
Yidan Liu, Xiuxing Liu, Jianjie Lv ... · Receptors, Adiponectin · State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510060, China. · pubmed
Aging induces substantial structural and functional decline in the retina, yet the molecular drivers of this process remain elusive. In this study, we used heterochronic parabiosis (HP) combined with single-cell RNA sequencing to generate comprehensive transcriptomic profiles of ...
Valentin J A Barthet, Scott W Lowe · Genes & development · Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. · pubmed
Cellular senescence plays a dual role in tissue biology by promoting tumor suppression and wound healing when transient but driving inflammation, fibrosis, and age-related disease when persistent. The growing recognition that senescent cell clearance can reverse these pathologies...
Enzo Scifo, Sarah Morsy, Ting Liu ... · The EMBO journal · Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany. · pubmed
Aging is associated with the accumulation of molecular damage, functional decline, increasing disease prevalence, and ultimately mortality. Although our system-wide understanding of aging has significantly progressed at the genomic and transcriptomic levels, the availability of l...
Ryan G Walker, Tomohiro Kato, Laura Ben Driss ... · Growth Differentiation Factors · Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. · pubmed
Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 after prodomain activation. In 11,609 pat...
Ki Yun Park, Abraham Z Snyder, Manu S Goyal ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, 63110, USA. · pubmed
Cerebral glucose metabolism (CMRGlc) systematically decreases with advancing age. We sought to identify correlates of decreased CMRGlc in the spectral properties of fMRI signals imaged in the task-free state. Lifespan resting-state fMRI data acquired in 455 healthy adults (ages 1...
Amelia Farinas, Jarod Rutledge, Veronica Augustina Bot ... · Nature medicine · Graduate Program in Neuroscience, Stanford University, Stanford, CA, USA. · pubmed
The brain barrier system, including the choroid plexus, meninges and brain vasculature, regulates substrate transport and maintains differential protein concentrations between blood and cerebrospinal fluid (CSF). Aging and neurodegeneration disrupt brain barrier function, but pro...
Willian R Gomes, Shan Hama, Giorgio Napolitani ... · Blood advances · University of Sao Paulo, Brazil. · pubmed
Pathogenic germline variants causing excessive telomere shortening may result in bone marrow failure, hematopoietic malignancy, and extramedullary complications, such as pulmonary fibrosis, liver cirrhosis, and solid tumors. Patients with short telomeres also develop immunodefici...
Tan Ma, Lulin Tan, Chenghao Shen ... · Environmental science & technology · Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China. · pubmed
Dibutyl phthalate (DBP), a common plastic additive, is employed extensively to enhance the flexibility of various polymeric materials despite its known toxicity to multiple organ systems. Our previous study found that maternal DBP exposure caused early puberty in male offspring, ...
Jose Alberto Santiago-de-la-Cruz, Nadia Alejandra Rivero-Segura, Juan Carlos Gomez-Verjan · Journal of cheminformatics · Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City, 10200, México. · pubmed
Age-related diseases and syndromes result in poor quality of life and adverse outcomes, representing a challenge to healthcare systems worldwide. Several pharmacological interventions have been proposed to target the aging process to slow its adverse effects. The so-called geropr...
Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga ... · Cellular Senescence · Department of Orthopaedics, Emory University School of Medicine, Atlanta, United States. · pubmed
Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. While previous studies have highlighted that platelet-derived growth factor (PDGF) mitigated IVD degeneration through a...
Tuesday, July 15, 2025
Guillem Santamaria, Cristina Iglesias, Sascha Jung ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6 Avenue du Swing, Esch-Belval Esch-sur-Alzette, 4367, Luxembourg. · pubmed
The increase in life expectancy has caused a rise in age-related brain disorders. Although brain rejuvenation is a promising strategy to counteract brain functional decline, systematic discovery methods for efficient interventions are lacking. A computational platform based on a ...
Feng, B., Yang, R., Wang, G. R. ... · genetic and genomic medicine · St. Jude Children\'s Research Hospital · medrxiv
Objective: To assess the causal effects of leukocyte telomere length (TL) and epigenetic age acceleration (EAA) on healthspan. Methods: We performed two-sample Mendelian randomization (MR) analyses in accordance with STROBE-MR guidelines. Genetic instrumental variables (IVs) for ...
Sujan Chatterjee, Sayan Ghosh, Zachary Sin ... · Aging cell · Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Nevada, USA. · pubmed
Age-related macular degeneration (AMD), a leading cause of vision loss affecting retinal pigment epithelial (RPE) cells, remains largely unexplained by current genome-wide association studies (GWAS) risk variants. Our research on Cryba1, encoding βA3/A1-crystallin protein, reveal...
Mavrommatis, C., Belsky, D., Ying, K. ... · epidemiology · University of Edinburgh · medrxiv
Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present the first large-scale (n=18,849), unbiased c...
Caini Yu, Yanling Peng, Tong Yu ... · Advanced healthcare materials · College of Pharmaceutical Science, Zhejiang University, Hangzhou, 310058, China. · pubmed
Senile osteoporosis (SOP) primarily arises from an imbalance between bone formation and bone resorption. The tightly regulated coupling between osteoblasts and osteoclasts limits the therapeutic efficacy of conventional anti-resorptive agents and anabolic agents. Anti-aging thera...
Yiming Hao, Beibei Yu, Mingze Qin ... · Nature aging · Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. · pubmed
Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candi...
Glebov, O. O., Du, F., Wan, Q. · neuroscience · Qingdao University · biorxiv
Physiological impact of fever in the brain remains poorly understood. Here, we demonstrate that induction of fever by yeast injection in rats (N=9) and by whole-body hyperthermia in mice (N=7) triggers structural synaptic enhancement in the prefrontal cortex involving AMPA-type g...
Kanglun Yu, Sagar Vyavahare, Dima W Alhamad ... · JCI insight · Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, United States of America. · pubmed
The aryl hydrocarbon receptor (AhR) is proposed to mediate the frailty-promoting effects of the tryptophan metabolite kynurenine (Kyn), which increases with age in mice and humans. The goal of the current study was to test whether administration of pharmacological AhR inhibitors,...
Lei Zhang, Bernhard Ross, Yi Du ... · Music · State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. · pubmed
During cognitive tasks, older adults often show increased frontoparietal neural activity and functional connectivity. Cognitive reserve accrued from positive life choices like long-term musical training can provide additional neural resources to help cope with the effect of aging...
Bowen Xu, Alexander Hull, Olivia N M Hill ... · Longevity · Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, United Kingdom. · pubmed
Attenuating protein synthesis promotes longevity in multiple species. However, numerous studies indicate that aging drives a decrease in protein synthetic capacity. These observations hint at potential, unexplored benefits of stimulating protein synthesis in old age. In this work...
Siyu Li, Songming Tang, Haocheng Ma ... · DNA Methylation · School of Mathematical Sciences and LPMC, Nankai University, Tianjin, 300071, China. · pubmed
Accurately quantifying biological age is crucial for understanding the mechanisms of aging and developing effective interventions. Molecular aging clocks, particularly epigenetic clocks that use DNA methylation data to estimate biological age, have become essential tools in this ...
Luciele Guerra Minuzzi, Helena Batatinha, Christopher Weyh ... · Killer Cells, Natural · Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, São Paulo State University (UNESP), 305 Roberto Simonsen, Presidente Prudente, 19060-900, Brazil. [email protected]. · pubmed
Aging is associated with immune dysfunction, but long-term endurance training may confer protective effects on immune cell function. This study investigates how natural killer (NK) cell phenotypes, functional markers, and metabolism differ between endurance-trained and untrained ...
de Witte, A., Matthijs, A., Parrell, B. ... · neuroscience · KU Leuven · biorxiv
Aging is frequently perceived negatively due to its association with the decline of various brain and bodily functions. While it is evident that motor abilities deteriorate with age, it is incorrect to assume that all aspects of movement execution are equally affected. The cerebe...
Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis, Bennett G Childs ... · Nature aging · Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. · pubmed
Growing evidence suggests that the induction of cellular senescence in vascular cells is causally linked to the etiology of cardiovascular diseases. To investigate systematically the heterogeneity of senescent vascular cells in atherosclerosis, we used a high-fat diet and PCSK9 o...
Dan Wu, Chen Yan, Linhui Han ... · Journal of nanobiotechnology · Department of Orthopedic Surgery, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China. · pubmed
Intervertebral disc degeneration (IVDD) is a significant contributor to chronic low back pain and disability worldwide, yet effective treatment options remain limited. Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncov...
Hernan Hernandez, Hernando Santamaria-Garcia, Sebastian Moguilner ... · Nature medicine · Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. · pubmed
Protective and risk factors can drive healthy or accelerated aging, with distinct environments modulating their effects. The impact of the exposome-the combined physical and social exposures experienced throughout life-on accelerated aging remains unknown. We assessed delayed and...
Haijun He, Ruixue Ai, Evandro Fei Fang ... · npj aging · Department of Physiology, Medical School, National and Kapodistrian University of Athens, 157 27, Athens, Greece. · pubmed
The Rab3 protein family is composed of a series of small GTP-binding proteins, including Rab3a, Rab3b, Rab3c, and Rab3d, termed Rab3s. They play crucial roles in health, including in brain function, such as through the regulation of synaptic transmission and neuronal activities. ...
Monday, July 14, 2025
Motwani, S., Bhandari, S., Chitkara, S. ... · cell biology · Molecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India · biorxiv
Adaptive modulation of physiological traits in response to environmental variability, particularly dietary fluctuations, is essential for organismal fitness. Such adaptability is governed by complex gene-diet interactions, yet the molecular circuits integrating microbe-derived me...
Corley, M. J., Dwaraka, V., Pang, A. P. ... · hiv aids · Weill Cornell Medicine · medrxiv
Semaglutide is a once-weekly GLP-1 receptor agonist that has been proposed as a gerotherapeutic, yet no data exist on its effects on epigenetic aging. We therefore conducted a post-hoc epigenetic analysis of a 32-week, double-blind, placebo-controlled phase 2b trial in adults wit...
Vendrov, A. E., Chamon, J., Levin, J. ... · physiology · University of Michigan · biorxiv
Background: Aging and male sex are major risk factors for abdominal aortic aneurysm (AAA), a disease characterized by vascular cell phenotypic switching and aortic wall remodeling. Mitochondrial oxidative stress (mtOS) has been implicated in these changes. We previously demonstra...
Sejung Park, Yan Liu, Suji Lim ... · iScience · Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea. · pubmed
Cells experience a progressive decline in function and lifespan, accompanied by epigenetic changes. Here, we show that intracellular BCAA (icBCAA) homeostasis is regulated by histone H3K4 and H3K121 in budding yeast. Using a comprehensive H3/H4 mutant library, we identified resid...
Tieshi Zhu, Yong He, Yixi Wang ... · Aging · Department of Medical Affairs, Agricultural Reclamation Central Hospital of Guangdong, Zhanjiang, Guangdong, China. · pubmed
Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality. However, the comparative predictive value of AAs derived from different epigenetic clocks for mortali...
Patel, R., Kalailingam, P., Ngan, S. C. ... · neuroscience · Brock University · biorxiv
Brain aging is characterized by progressive breakdown of the blood-brain barrier (BBB), which correlates with neuroinflammation and cognitive decline. Emerging evidence implicates degenerative modifications of the vascular proteins as a key driver of BBB dysfunction. In particula...
Flor, S., Dost, T., Haase, M. ... · systems biology · Christian Albrechts University of Kiel, University Hospital Schleswig-Holstein · biorxiv
Aging-related cognitive decline is associated with changes across different tissues and the gut microbiome, including dysfunction of the gut-brain axis. However, only few studies have linked multi-organ alterations to cognitive decline during aging. Here we report a multi-omics a...
Sanne van der Rijt, Marte Molenaars, Rashmi Kamble ... · iScience · Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. · pubmed
Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, ...
Saffet Ozturk · Journal of assisted reproduction and genetics · Department of Histology and Embryology, Akdeniz University School of Medicine, Campus, 07070, Antalya, Türkiye. [email protected]. · pubmed
Oocyt e development from non-growing to metaphase II (MII) stages is largely dependent on timely and correctly controlling gene expression. During the process of biological or postovulatory aging, the epigenetic mechanisms, particularly DNA methylation, histone methylation, and a...
Yang, W., Zhang, X., Xu, R. ... · cell biology · Southern University of Science and Technology · biorxiv
Ovarian aging is closely associated with a decline in fertility and an increase in reproductive dysfunction. Ovarian granulosa cells (GCs) support oocyte homeostasis and development, yet insight into GC dysfunction during aging is limited. Here, we show that aged GCs of humans an...