Granzyme K is a driver of age-related tissue remodeling and functional decline independently of age-associated immune dysfunction.

Dulakara Kannangara, Jessica Runting, April L Raftery, Ekaterina Salimova, Xavier Y X Sng, Ali Zaid, Samantha J Emery-Corbin, David Chisanga, Hui Xu, Angela Nguyen, Tania Camilleri, Joel A Eliades, Zijian Huang, Iona S Schuster, Ralf B Schittenhelm, Phillip I Bird, Laura Mackay, Kim L Good-Jacobson, Adam J Rose, Nicholas D Huntington, Mariapia Degli-Esposti, Christopher T Turner, Daniel Thiele, Nicole L La Gruta

Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. · pubmed

Paper

Abstract

Aging is characterized by progressive tissue and organ decline, with chronic low-grade inflammation (inflammaging) implicated as a central driver. Granzyme K (GzmK), a serine protease that is markedly upregulated in aged memory CD8

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Research summary

Granzyme K drives age-related tissue remodeling and functional decline independently of age-associated immune dysfunction. This paper identifies a specific molecular mechanism (GzmK) contributing to the physiological decline of aging, moving beyond general inflammation to pinpoint a driver of tissue damage, which is relevant to understanding the root causes of aging.

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