T Cell Engraftment, survival, and the effect on large artery stiffness.
Abstract
Low-grade inflammation is persistent with advancing age in healthy people and mice. Endothelial cells and large arteries increasingly express pro-inflammatory cytokines, coinciding with increased T cell infiltration into the aorta. Arterial stiffness is an independent risk factor for cardiovascular diseases, and stiffness increases with age. T cells particularly affect vascular dysfunction, and we have shown that T cell depletion in old mice prevented elevations in stiffness. We sought to understand how the aged phenotype of T cells affects arterial stiffness and arterial T cell infiltration. T cells were isolated from young or old C57BL/6 mice and adoptively transferred into young or old RAG1
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Research summary
The paper tests the claim that the aged phenotype of T cells drives age-associated arterial stiffness and infiltration. This is relevant to longevity research because it identifies a specific immunological mechanism (T cell aging) contributing to a major age-related physiological change (vascular stiffness), offering a potential target for interventions aimed at delaying vascular aging rather than just treating symptoms.
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