NNMT Safeguards Vascular Aging by Modulating an Endothelial LMNA-HSP Stress-Response Axis.

Jun Guo, Huilin Tu, Jiameng Yin, Shang Gao, Deping Liu, Mingjun Wang, Yajun Lin, Xin Zhang, Lingbing Meng, Jingyu Sun, Di Wang, Yongjun Li, Miao Wang, Jian Li

Department of Basic Innovation Research, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Beijing Key Laboratory of Aging Mechanism and Intervention Research on Aging-Related Diseases; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China (J.G., H.T., J.Y., Mingjun Wang, Y. Lin, X.Z., J.S., D.W., J.L.). · pubmed

Paper

Abstract

NNMT (nicotinamide N-methyltransferase) is a pivotal metabolic-epigenetic integrator that regulates cellular methylation balance. Although its expression and function exhibit profound, context-dependent heterogeneity in metabolic diseases and cancer, its role within the vascular system, particularly in aging endothelial cells, remains elusive.

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Research summary

NNMT safeguards vascular aging by modulating an endothelial LMNA-HSP stress-response axis. This paper is relevant because it identifies a specific metabolic-epigenetic mechanism (NNMT) that protects against cellular senescence and stress in endothelial cells, addressing a fundamental driver of vascular aging rather than merely treating downstream symptoms.

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