Engineering ATP import in yeast uncovers a synthetic route to extend cellular lifespan.

Naci Oz, Hetian Su, Vedat Sari, Paraveen Patnaik, Rohil Hameed, Jong Hee Song, Derek C Prosser, Vyacheslav M Labunskyy, Vadim N Gladyshev, Nan Hao, Alaattin Kaya

School of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, United States. · pubmed

Paper

Abstract

Mitochondrial dysfunction and declining ATP production are common features of aging, yet whether ATP availability itself directly regulates cellular lifespan is unclear. However, the causal relationship between cellular ATP homeostasis and aging has not been established. Here, we developed a synthetic system to manipulate intracellular ATP independently of endogenous energy production by expressing a plasma membrane-targeted nucleotide transporter,

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Research summary

The paper claims that artificially increasing intracellular ATP levels via a synthetic plasma membrane transporter can extend cellular lifespan in yeast. This is relevant because it directly investigates the causal link between mitochondrial energy homeostasis and aging, testing whether ATP availability is a fundamental regulator of longevity rather than just a symptom of decline.

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