Atp12 regulates mitochondrial fusion and chronological aging through Fzo1 in

Zecheng Liu, Guoxing Zhu, Yuhan Zeng, Beibei Deng, Yingjie Su, Xueting Zheng, Rui Yao

Center for Environment and Health in Water Source Area of South-to-North Water Diversion, School of Public Health, Hubei University of Medicine, Shiyan, Hubei, China.Center for Environment and Health in Water Source Area of South-to-North Water Diversion, School of Public Health, Hubei University of Medicine, Shiyan, Hubei, China. · pubmed

Paper

Abstract

Atp12 is known as a chaperone for mitochondrial ATP synthase assembly, yet its functions and mechanisms in regulating mitochondrial and cellular aging remain elusive. In this study, we demonstrate that Atp12 plays a critical role in regulating mitochondrial dynamics and chronological lifespan (CLS) in the fission yeast

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Research summary

Atp12 regulates mitochondrial fusion and chronological lifespan in fission yeast through the interaction with Fzo1. This paper is relevant because it identifies a specific molecular mechanism (Atp12/Fzo1 interaction) governing mitochondrial dynamics that directly influences chronological lifespan, a fundamental model for studying cellular aging and the root causes of senescence.

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