Ziyu glycoside I suppresses senescence and ameliorates age-related functional decline by stabilizing LDHA and restoring lactate output.

Shi-Ying Li, Qi Peng, Hui Cai, Jiang-Min Zhou, An-Guo Wu, Xiang Li, Yong-Ping Wen, Ning Wu, Long Wang, Lu Yu, Fei-Hong Huang, Jian-Ming Wu, Xiao-Gang Zhou

Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Key Laboratory of Medical Electrophysiology of Ministry of Education School of Pharmacy Southwest Medical University, Luzhou, Sichuan 646000, China.Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Key Laboratory of Medical Electrophysiology of Ministry of Education School of Pharmacy Southwest Medical University, Luzhou, Sichuan 646000, China. · pubmed

Paper

Abstract

Cellular senescence contributes to age-related tissue dysfunction and is closely linked to metabolic remodeling and mitochondrial redox imbalance. However, senotherapeutic strategies with defined molecular targets and functionally validated downstream mechanisms remain limited.

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Research summary

Ziyu glycoside I suppresses cellular senescence and ameliorates age-related functional decline by stabilizing LDHA and restoring lactate output. This paper is relevant because it identifies a specific molecular mechanism (LDHA stabilization) and a potential senotherapeutic agent that targets the root cause of aging (cellular senescence) rather than just treating downstream symptoms.

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