microRNA-Loaded Extracellular Vesicles: Mechanisms and Therapeutic Potential in Senescence and Ageing.

Justin T Millares-Cangiani, Juan D Rayo Parra, Zachary Grand, Jonathan Brutti, Gabriel A Gonzalez, Ukesh Karki, Dipendra Pandeya, Prem Chapagain

Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8(th) Street AHC2, Miami, FL 33199, USA.Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8(th) Street AHC2, Miami, FL 33199, USA. · pubmed

Paper

Abstract

Cellular senescence is a biological process characterized by stable cell cycle arrest that contributes to tumor suppression and tissue remodeling but can also promote aging-associated dysfunction when senescent cells persist and accumulate. Senescent cells influence neighboring and distant tissues through the senescence-associated secretory phenotype (SASP), of which extracellular vesicles (EVs) are an increasingly recognized component. This review examines how microRNAs (miRNAs) carried by EVs regulate senescence and ageing. miRNAs are key post-transcriptional regulators of senescence, particularly within the p53/p21

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Research summary

The paper reviews how microRNA-loaded extracellular vesicles mediate the senescence-associated secretory phenotype (SASP) to propagate aging signals. This is relevant because it addresses the mechanism of senescent cell accumulation and its systemic effects, which are considered root causes of aging, though as a review article it provides a synthesis of existing knowledge rather than a novel breakthrough.

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