NAD+ replenishment reduces cardiomyocyte senescence and improves diastolic function in the aged male heart.

Qingxia Huang, Yongjie Wang, Karina Farias, Xinliu Zeng, Qiuying Chen, Huiyong Cheng, Vijaya B Baki, Steven S Gross, Jacob Geri, Anthony A Sauve, Yue Yang

Department of Pharmacology, Weill Cornell Medicine, New York, NY 10021.Department of Pharmacology, Weill Cornell Medicine, New York, NY 10021. · pubmed

Paper

Abstract

Cardiomyocyte senescence is a hallmark of cardiac aging and closely associated with diastolic dysfunction and heart failure in older adults. Strategies to effectively delay or reverse cardiomyocyte senescence in the aged heart remain limited. We investigated whether NAD+ replenishment regulates cardiomyocyte senescence and cardiac function in aging.

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Research summary

NAD+ replenishment reduces cardiomyocyte senescence and improves diastolic function in the aged male heart. This study addresses a fundamental mechanism of aging (NAD+ decline and cellular senescence) rather than merely treating symptoms, demonstrating that restoring metabolic precursors can mitigate specific age-related cardiac dysfunction.

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