Concordance between changes in epigenetic clocks and changes in clinical outcomes in geroscience intervention trials: A systematic review.

Mingyang Yi, Minghao Li, Haixia Li, Yinzhe Gui, Zhiwan Wang

Department of Respiratory Medicine, Henan Province Hospital of Traditional Chinese Medicine (the Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou, 450003, China.Department of Respiratory Medicine, Henan Province Hospital of Traditional Chinese Medicine (the Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou, 450003, China. · pubmed

Paper

Abstract

To evaluate whether intervention-induced changes in epigenetic clocks correspond to changes in clinical outcomes in human geroscience intervention studies.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper tests the claim that changes in epigenetic clock age are concordant with changes in clinical health outcomes in human geroscience intervention trials. This is relevant because it evaluates the validity of epigenetic clocks as surrogate biomarkers for interventions aimed at slowing or reversing the biological aging process, which is a core objective of longevity research.

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