A hormonal message for a longer life.
Abstract
The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.
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Research summary
Dafachronic acid acts as a systemic signal that transmits the effects of reduced mTOR activity to coordinate metabolism and extend lifespan. This paper is relevant because it identifies a specific hormonal mechanism that mediates the systemic benefits of mTOR inhibition, a well-established pathway for longevity, thereby advancing the understanding of how tissue-specific interventions can be coordinated to extend healthspan.
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