Cold activates a BH2 metabolic network promoting longevity and proteostasis.

Hyun Ju Lee, Cansu Doğan, Seda Koyuncu, Markus Wehrmann, Murat Artan, Dunja Petrovic, Rute Loureiro, Amit Kumar Sahu, Joana Schnubel, Pavel Grobushkin, Dimitrios Prymidis, Theodoros Georgomanolis, Agnieszka Sokol, Ming Yang, Thorsten Hoppe, Christian Frezza, David Vilchez

Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. [email protected] for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. [email protected]. · pubmed

Paper

Abstract

Moderately cold temperatures extend lifespan and promote health across species

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Research summary

The paper claims that exposure to moderate cold activates a specific BH2 metabolic network that directly promotes longevity and proteostasis. This is highly relevant because it identifies a novel, specific molecular mechanism (the BH2 network) underlying the well-established phenomenon of cold-induced lifespan extension, offering a potential target for interventions aimed at extending healthspan and lifespan.

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