An NAD

Na Liang, Jia He, Xiangji Guo, Jiaqi Yan, Xiaoqian Zhang, Xiaozhong Peng, Jun Li

State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China. · pubmed

Paper

Abstract

Loss of skeletal muscle mass is a major driver of frailty and disability, yet how systemic metabolic cues protect muscle integrity remains unclear. We identify Serpina3n, an adipose-derived adipokine, as a key mediator of the protective effects of nicotinamide adenine dinucleotide (NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Serpina3n is an adipose-derived adipokine that mediates the protective effects of NAD+ supplementation on skeletal muscle integrity. This paper is relevant because it identifies a specific systemic metabolic mechanism (an adipokine) through which NAD+ precursors, a major class of longevity interventions, prevent age-related muscle loss (sarcopenia), thereby addressing a root cause of frailty rather than just treating symptoms.

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