CHCHD2 mitigates age-associated proteostatic collapse by maintaining homeostasis of the mitochondria-lysosome axis.

Teresa R Kee, Brianna M Masters, Khoi D Tran, Hanna Jeon, Ma Long, Grace Xu, Sophia A Khan, Edwin Vázquez-Rosa, Preethy S Sridharan, Yeojung Koh, Hisashi Fujioka, Dale Chaput, Xinming Wang, Xingyu Zhao, Andrew A Pieper, David E Kang, Jung-A A Woo

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. · pubmed

Paper

Abstract

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), including the Parkinson's disease (PD)-linked CHCHD2

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Research summary

CHCHD2 mutations cause age-associated proteostatic collapse by disrupting the mitochondria-lysosome axis, and maintaining this homeostasis mitigates the resulting cellular dysfunction. This paper is relevant because it identifies a specific molecular mechanism (the mitochondria-lysosome axis) underlying proteostatic failure, a core hallmark of aging, and links it to a known genetic risk factor for neurodegeneration, offering a potential target for interventions aimed at preserving cellular health during aging.

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