Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.

Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia

State Key Laboratory For Innovation and Transformation of Luobing Theory Shijiazhuang China.State Key Laboratory For Innovation and Transformation of Luobing Theory Shijiazhuang China. · pubmed

Paper

Abstract

Chronic stress potentially accelerates aging and increases age-related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12-month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significantly exacerbates systemic inflammation, causing widespread tissue damage and lifespan shortening. Integrated single-cell RNA sequencing analysis of multiple tissues suggests a common feature of lymphocyte reduction and myeloid cell expansion. The lungs and kidneys exhibited pronounced stress responses, including epigenetic dysregulation and mitochondrial dysfunction. Both β-nicotinamide mononucleotide (NMN) and compound medicine Bazi Bushen (BZBS) effectively alleviate the UCMS-induced aging phenotypes. BZBS restores immune system homeostasis and reduces stress/inflammation levels in various tissues. Bioactive compounds from BZBS constituents

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Research summary

Bazi Bushen Formula reverses chronic stress-induced inflammaging and extends lifespan by activating the AMPK-Sirtuins axis and resetting myeloid cells. The paper is relevant because it investigates the mechanistic pathways (AMPK/Sirtuins) underlying stress-accelerated aging and demonstrates that a specific intervention can reverse these aging phenotypes and extend lifespan in a chronic stress model, addressing the root causes of accelerated aging rather than just treating symptoms.

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