Small extracellular vesicles as mediators of paracrine senescence in cellular models of aging.

Aina M Llabrés-Mas, Antonio Merino-Navarro, Marta Menéndez-García, Ana O'Loghlen

Epigenetics and Cellular Senescence Group, Spanish National Research Council (CSIC), Biological Research Centre (CIB), Madrid 28040, Spain.Epigenetics and Cellular Senescence Group, Spanish National Research Council (CSIC), Biological Research Centre (CIB), Madrid 28040, Spain. · pubmed

Paper

Abstract

Senescent cells accumulate during both physiological and pathological processes, including aging. They are characterized by the expression of the cell cycle inhibitor p16

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Research summary

Small extracellular vesicles mediate the paracrine effects of senescent cells in aging models. This paper is relevant because it investigates the mechanisms of cellular senescence, a fundamental driver of biological aging, rather than merely treating downstream symptoms of age-related diseases.

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