Ferro-aging: iron-lipid axis in systemic decline.

Lixiao Liu, Jing Qu, Guang-Hui Liu, Weiqi Zhang

Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. · pubmed

Paper

Abstract

Ferro-aging links age-associated iron dyshomeostasis to chronic lipid peroxidation and progressive functional decline across human and nonhuman primate tissues. Vitamin C extends beyond its antioxidant activity by directly inhibiting ACSL4, limiting polyunsaturated fatty acid incorporation into membrane phospholipids and thereby reducing lipid peroxidation and ferro-aging-associated phenotypes.

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Research summary

Vitamin C extends its longevity benefits by directly inhibiting ACSL4 to limit polyunsaturated fatty acid incorporation into membranes, thereby reducing lipid peroxidation and ferro-aging phenotypes. This paper is relevant because it proposes a specific molecular mechanism (ACSL4 inhibition) by which a common nutrient mitigates a fundamental driver of aging (iron-dependent lipid peroxidation), offering a potential pathway for lifespan extension rather than just symptom management.

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