Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4

Bao Wang, Luzhang Ji, Qian Bian

Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China. · pubmed

Paper

Abstract

Precise three-dimensional (3D) genome organization is crucial for regulating gene expression during development, yet its role in age-related transcriptional changes and physiological decline remains elusive. Here, we show that aging reshapes chromatin architecture and gene regulation in murine naive CD4

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Research summary

Aging-associated deficiency of the chromatin organizer SATB1 drives the remodeling of 3D genome architecture and transcriptional programs in naive CD4+ T cells. This paper is relevant because it identifies a specific molecular mechanism (SATB1 loss) underlying age-related changes in immune cell gene regulation, contributing to the understanding of the fundamental biological processes of aging rather than just treating symptoms.

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