Sirtuin signaling as therapeutic targets of immunosenescence.

Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Damiano Galimberti, Chiara Puleo, Rosa Zarcone, Giuseppina Candore

Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy. · pubmed

Paper

Abstract

Aging is characterized by immunosenescence, encompassing, immune aging and inflammaging. Because immune competence is a critical determinant of lifespan and healthspan, targeting immunosenescence has become a major objective of geroscience. In this context, sirtuins have emerged as compelling therapeutic candidates.

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Research summary

Sirtuins act as critical regulators of the inflammatory and metabolic pathways driving immunosenescence, making them viable targets to mitigate age-related immune decline. This paper is relevant because it addresses the mechanistic drivers of inflammaging and immune aging, which are core components of the geroscience framework for extending healthspan, rather than merely treating downstream symptoms.

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