β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells.

Jing Mi, Chenxin Wang, Hongfei Gu, Mengxuan Wang, Weihua Zhang, Qiangqiang Zhou, Yuejiao Zhang, Jie Pan, Liming Yu

Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China, fudan.edu.cn.Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China, fudan.edu.cn. · pubmed

Paper

Abstract

β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD

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Research summary

The paper claims that β-Nicotinamide mononucleotide (NMN) inhibits cellular senescence in mouse C2C12 skeletal muscle cells. This is relevant to longevity research as it investigates a direct precursor to NAD+, a key molecule in metabolic aging pathways, and demonstrates a mechanism for mitigating cellular senescence, a fundamental hallmark of aging, in a muscle cell model.

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