Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.

Jun Wang, Zixin Cai, Jiaojiao Gu, Shiqi Xiong, Jianhan Yi, Meng Yang, Kexin Chang, Xinrui Ning, Yilin Wen, Yan Yan, Jiongming Lu, Yirong Wang, Zongzhao Zhai

Hunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China.Hunan Research Center of the Basic Discipline for Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, China. · pubmed

Paper

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes that are crucial for physiological homeostasis and ageing

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Lsp2 acts as a critical mediator linking mTORC1 signaling to the translation of TOP mRNA, thereby regulating lifespan in Drosophila. This paper is relevant because it elucidates a specific molecular mechanism within the mTOR pathway, a central regulator of aging, that directly influences organismal longevity.

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