Lsp2 links early-life diet to adult translation and lifespan in Drosophila.

Hina Kosakamoto, Rina Okada, Clive S Barker, Ayako Isomura-Matoba, Jun Seita, Naoshi Dohmae, Koshi Imami, Fumiaki Obata

Laboratory for Nutritional Biology, RIKEN Center for Biosystems and Dynamics Research, Kobe, Japan. · pubmed

Abstract

Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia

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Research summary

The paper claims that the protein Lsp2 mediates the effect of early-life dietary restriction on adult translational activity and lifespan in Drosophila. This is relevant because it identifies a specific molecular mechanism linking early-life nutritional status to long-term aging outcomes, contributing to the understanding of how developmental diet influences the rate of aging and lifespan extension.

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