A probiotic

Zhao-Qing Shen, Tran Thi Dieu Thuy, Chung-Kuang Lu, Thanh-Sang Nguyen, Chien-Yi Tung, Cheng-Yen Kao, Ting-Fen Tsai

Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. · pubmed

Paper

Abstract

Dietary flavonoids often require microbial metabolism to generate bioactive metabolites that influence host physiology. Hesperidin, a citrus flavanone glycoside, exhibits limited intestinal absorption and depends on gut microbial biotransformation to yield its active aglycone, hesperetin. Hesperetin activates CDGSH iron-sulfur domain 2 (CISD2), a pro-longevity gene whose expression declines with age, and its pharmacological activation has emerged as a strategy to promote healthy aging. Here, we identified a probiotic strain,

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Research summary

The paper identifies a specific probiotic strain capable of metabolizing hesperidin into hesperetin, which activates the pro-longevity gene CISD2. This is relevant because it proposes a microbiome-based mechanism to upregulate a gene associated with healthy aging, addressing the root cause of age-related decline rather than just treating symptoms, though the impact is limited to a specific dietary intervention pathway.

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