Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming.

Jiang Chenhao, Han Lu, Liu Yasong, Zhang Jianhao, Chen Huaxin, Wen Xinyun, Chi Xianda, Fan Linda, Li Tianyi, Shi Shaojun, Chen Sunrui, Xiao Jiaqi, Lv Xing, Zhang Jiebin, Zhao Xuegang, Zhang Yujun, Liu Jianrong, Zhang Xu, Lv Guo, Qiu Yuan, Yao Jia, Zeng Kaining, Li Haibo, Lu Tongyu, Ye Linsen, Fu Binsheng, Li Hua, Yi Shuhong, Liu Wei, Zhang Qi, Chen Guihua, Cai Jianye, Xiang Andy Peng, Zhang Yingcai, Sui Xin, Yang Yang

Department of Hepatic Surgery and Liver Transplantation Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Guangdong Engineering Laboratory for Transplantation, China; Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.Department of Hepatic Surgery and Liver Transplantation Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Guangdong Engineering Laboratory for Transplantation, China; Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China. · pubmed

Paper

Abstract

The regenerative capacity of the liver decreases with age, limiting surgical options for elderly patients. While youthful systemic factors can reverse liver aging, the underlying mediators remain unclear. This study aimed to investigate the systemic factors and cellular mechanisms that promote aged liver regeneration.

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Research summary

The paper claims that youthful systemic factors restore aged liver regeneration by driving hepatocyte reprogramming via the LTβ pathway. This is relevant because it identifies a specific molecular mechanism (LTβ-driven reprogramming) by which systemic rejuvenation factors can reverse age-related functional decline in a major organ, offering a potential target for interventions aimed at restoring regenerative capacity in the elderly.

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