Deciphering senescence-associated mechanisms through cell painting & transcriptomics.
Abstract
Senescence is a key pathomechanism across chronic diseases but also highly heterogeneous. In this study, we demonstrate that high-content imaging and transcriptomics can jointly shed light on senescence in vitro, distinguishing replicative and chemically induced senescence, differentiating from quiescence and characterizing the senolytic response.
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Research summary
The paper demonstrates that high-content imaging and transcriptomics can jointly distinguish replicative and chemically induced senescence from quiescence and characterize senolytic responses. This is relevant because cellular senescence is a core mechanism of aging, and developing precise methods to identify and characterize senescent cells is a prerequisite for effective senolytic therapies aimed at extending healthspan.
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