Age-related IGF-1 decline permits a redox-sensitive transcriptional shift that directs hematopoiesis toward a CCR2

Zhengyi Chen, Xidan Fu, Chao Liu, Wenkang Jiang, Jiurong Liu, Miao Hao, Ling Fu, Wei Huang, Xiujuan Lang, Xijun Liu, Yumei Liu, Hulun Li, Rui Li, Bo Sun

Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, PR China. · pubmed

Paper

Abstract

Aging reshapes hematopoiesis toward myelopoiesis, particularly increased output of classical monocytes, contributing to immunosenescence. However, the underlying mechanisms remain unclear. Here, we identify that aging drives hematopoietic stem cells (HSCs) to progressively commit to a CCR2

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Research summary

Aging-induced decline in IGF-1 triggers a redox-sensitive transcriptional shift that drives hematopoietic stem cells toward CCR2+ monocyte production. This paper is relevant because it identifies a specific upstream molecular mechanism (IGF-1/redox signaling) driving a fundamental age-related physiological change (myelopoiesis bias), offering a potential target for intervening in the root causes of immunosenescence rather than just treating downstream symptoms.

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