Integrated analysis of hematopoietic changes following heterochronic bone marrow transplantation between young and aged mice.

José Antonio Bejarano-García, Melanie Nufer, Rocío Caracuel, Teresa Caballero-Velázquez, Alfonso Rodríguez Gil, Alicia Jordano, Raquel Muñoz, José Ignacio Piruat, José Antonio Pérez-Simón

Instituto de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío / Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Sevilla; Campus Universitario Virgen del Rocío, Av. Manuel Siurot s/n; 41013, Sevilla, Spain. Electronic address: [email protected] de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío / Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Sevilla; Campus Universitario Virgen del Rocío, Av. Manuel Siurot s/n; 41013, Sevilla, Spain. Electronic address: [email protected]. · pubmed

Paper

Abstract

aging is a multifactorial process characterized by progressive loss of tissue homeostasis and regenerative capacity, with haematopoiesis being profoundly affected. Age-associated changes in hematopoietic stem cells (HSCs) include increased frequency but reduced function, impaired self-renewal, and myeloid bias, driven by both intrinsic defects and extrinsic cues from the bone marrow (BM) niche. While heterochronic BM transplantation (hBMT) has been used to distinguish donor- versus niche-driven mechanisms, most studies have focused on isolated readouts under simplified conditions.

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Research summary

The paper investigates the specific contributions of intrinsic hematopoietic stem cell defects versus extrinsic bone marrow niche changes to age-associated hematopoiesis by analyzing heterochronic bone marrow transplantation in mice. This is relevant to longevity research because it seeks to distinguish between cell-intrinsic aging mechanisms and environmental niche factors, which is a fundamental step in understanding the root causes of regenerative decline and identifying potential targets for rejuvenation therapies.

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