Extension of host lifespan by polyamines derived from gut bacteria.

Hiromi Shimokawa, Emil Salim, Aki Hori, Tsuyoshi Fujita, Hayato Takihara, Hibiki Kadoguchi, Yuki Kontani, Rika Hirano, Mitsuharu Matsumoto, Shujiro Okuda, Takayuki Kuraishi, Shin Kurihara

Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Suematsu, Nonoichi, Ishikawa, Japan.Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Suematsu, Nonoichi, Ishikawa, Japan. · pubmed

Paper

Abstract

Metabolites produced by gut bacteria are taken up by the host and have a direct impact on its health. However, to our knowledge, no studies have investigated the effects of gut bacterial metabolites on the lifespan of the host using gnotobiotic animals colonized with gut bacteria deficient in biosynthetic genes involved in the production of specific metabolites. Polyamines, such as putrescine and spermidine, are among the most important metabolites of gut bacteria. Previous studies have shown that increasing polyamines in the colon of mice extends their lifespan and biological functions. In this study, we produced gnotobiotic flies colonized with

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Research summary

The paper demonstrates that gut bacteria-derived polyamines extend host lifespan in gnotobiotic flies. This is relevant because it identifies a specific microbial metabolite pathway that directly influences longevity, offering a potential mechanism for lifespan extension through microbiome modulation rather than just treating age-related symptoms.

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