Dioscin extends lifespan and ameliorates aging associated phenotypes in association with the endoplasmic reticulum unfolded protein response.

Yi Luo, Nian Jiang, Xiaocong Li, Yi Xiao

Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, China; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Guizhou, 563000, China.Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, China; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Guizhou, 563000, China. · pubmed

Paper

Abstract

Dioscin, a naturally occurring steroidal saponin isolated from various kinds of herbs with pleiotropic pharmacological properties, remains mechanistically undefined regarding its mammalian aging modulation. This study discovered that dioscin extended the lifespan of Caenorhabditis elegans. Concurrently, dioscin improved the motor function of C. elegans and reduced age pigment accumulation, while having no effect on the reproductive performance of the C. elegans. By pathway screening, we identified that dioscin extends healthspan via the endoplasmic reticulum unfolded protein response (UPR

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Research summary

Dioscin extends lifespan and improves healthspan in C. elegans by modulating the endoplasmic reticulum unfolded protein response. This study represents a minor incremental advance in the field of geroscience, as it identifies a natural compound with modest effects in a single invertebrate model without demonstrating efficacy in more complex organisms or providing definitive mechanistic proof that the observed benefits are directly causative of extended longevity rather than general health improvements.

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