Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.
Abstract
Hematopoietic stem cell (HSCs) aging is a complex biological process driven by both cell-intrinsic alterations and extrinsic cues from the bone marrow niche. Understanding these mechanisms is critical for developing therapies against aging-related hematopoietic disorders. This review synthesizes recent advances in the molecular mechanisms underlying HSCs aging, including microenvironmental aging, genomic instability, epigenetic dysregulation, mitochondrial dysfunction, and aberrant nuclear mechanotransduction. We summarize that the functional decline of HSCs during aging drives a compensatory expansion of the phenotypically defined stem cell pool, leading to an aberrant increase in cell number. We also highlight aging-associated HSCs heterogeneity, including CD150
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
This review synthesizes known mechanisms of hematopoietic stem cell aging, such as genomic instability and epigenetic dysregulation, to contextualize emerging rejuvenation strategies. The paper is relevant because it addresses the root causes of stem cell decline associated with aging, but it is rated low impact as it is a descriptive review of established concepts rather than presenting novel, transformative experimental data or a surprising breakthrough.
Author of this paper? Send a correction.