Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity.

Naibedya Dutta, Daniel Hicks, Edgar Esparza, Anna Entin, Priyadharshini Vijayakumar, Caitlin M Lange, Tripti Nair, Elijah A Roditi, Athena Alcala, Maxim Averbukh, Matthew Vega, Rebecca Aviles Barahona, Caitlin McTygue, Veronica Kuo, Juri Kim, Herbert Anson, Aeowynn J Coakley, George Wang, Steven E Pilley, Max A Thorwald, Whitaker Cohn, Sean P Curran, Nicolas Brouilly, Caroline Kumsta, Rachel N Arey, Peter J Mullen, Gilberto Garcia, Ryo Higuchi-Sanabria

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA. · pubmed

Paper

Abstract

Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that neuronal expression of bromodomain proteins regulates systemic protein homeostasis and longevity. This represents a minor, incremental advance in understanding tissue-specific chromatin regulation of aging, lacking the surprising or transformative nature required for higher impact scores.

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