P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice.

Chong Yang, Tong Wang, Yue Chai, Lisha Wang, Yixuan Wang, Weili Wang, Fang Dong, Toshio Suda

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. · pubmed

Paper

Abstract

Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategies. Here, we identify P-selectin (Selp) as a surface marker that stratifies HSCs into conserved functional and transcriptional states during organismal aging in humans and mice. P-selectin expression increases early during aging and remains elevated in old HSCs. Selp

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Research summary

The study identifies P-selectin as a conserved surface marker that stratifies hematopoietic stem cells into functional states associated with aging, providing a tool for monitoring but offering no direct mechanism for rejuvenation or lifespan extension. This work represents an incremental observational advance in characterizing stem cell heterogeneity rather than solving the root causes of aging or bypassing them.

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