Multi-omic profiling of cardiomyocyte ageing and functional decline.

Dogacan Yucel, Michael A Trembley, Qingen Ke, Zexuan Wu, Durgesh Bonde, Peter Kang, William T Pu

Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. · pubmed

Paper

Abstract

Ageing is the strongest risk factor for heart failure, yet the molecular mechanisms underlying cardiomyocyte (CM) ageing remain unclear. We aimed to map the transcriptomic and epigenomic landscape of CM ageing and to test whether DNA hypermethylation is a causal driver of diastolic dysfunction.

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Research summary

The study maps transcriptomic and epigenomic changes in cardiomyocytes during ageing and tests the causal role of DNA hypermethylation in diastolic dysfunction. This research is relevant because it investigates fundamental molecular mechanisms of cellular ageing (epigenetic drift) in a key cell type associated with age-related organ failure, potentially identifying upstream drivers of functional decline rather than just downstream symptoms.

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