Sea buckthorn flavonoid IGRh and its metabolites delay Caenorhabditis elegans aging via SIR-2.1/DAF-16-mediated IIS and autophagy-lysosomal pathways.

Jinmei Zhao, Wenxia Dong, Juan Wei, Yumei Jiang, Zeqiang Deng, Yury A Zubarev, Yang Bi

College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730000, China; College of Life Sciences and Engineering, Hexi University, Zhangye 734000, China.College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730000, China; College of Life Sciences and Engineering, Hexi University, Zhangye 734000, China. · pubmed

Paper

Abstract

Isorhamnetin-3-O-glucoside-7-O-rhamnoside (IGRh) is a characteristic flavonoid in sea buckthorn leaves, yet its anti-aging potential and underlying mechanisms remain largely unexplored.

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Research summary

The paper claims that the sea buckthorn flavonoid IGRh extends the lifespan of C. elegans by modulating the SIR-2.1/DAF-16-mediated insulin/IGF-1 signaling (IIS) and autophagy-lysosomal pathways. This is a standard incremental study in the field of natural product gerontology, demonstrating that a specific dietary compound extends worm lifespan via well-characterized conserved pathways (IIS and autophagy) without offering novel mechanistic insights or surprising biological discoveries.

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