A metabolomic clock of population ageing: cross-cohort validation and associations with frailty and cognitive function.

Chung-Ho E Lau, Elena Chekmeneva, Rui Pinto, Aisling M O'Halloran, Daniel K H Chu, Abbas Dehghan, Ioanna Tzoulaki, Paul Elliott, Rose Anne Kenny, Cathal McCrory, Oliver Robinson

Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. · pubmed

Paper

Abstract

Understanding the links between metabolism, ageing, and age-related phenotypes may clarify the role of ageing in disease onset and improve risk prediction. We conducted a cross-cohort assessment of biological age using broad-spectrum LC-MS metabolomics of 3,686 plasma samples in 2,295 participants, aged 20-89, from the UK Airwave study (N = 960) and the Irish Longitudinal Study of Ageing (N = 1,335). The nucleoside N

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Research summary

The study develops and validates a metabolomic biomarker for biological age and demonstrates its association with frailty and cognitive function. This represents an incremental advance in biomarker development rather than a breakthrough in understanding or intervening in the root causes of aging.

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