The Circulating Senosome: Blood as the Therapeutic Interface of Aging.
Abstract
Aging is commonly framed as a progressive accumulation of cellular and tissue-level damage. However, the aged organism does not decline as a collection of isolated organs. Aging is communicated systemically through blood-borne signals that connect senescent cells, immune remodeling, vascular dysfunction, metabolic stress, dysbiosis, and chronic inflammation. I propose the concept of the circulating senosome to describe the composite network of age-associated circulating mediators, including senescence-associated secretory phenotype proteins, extracellular vesicles, inflammatory cytokines, lipids, metabolites, complement and coagulation mediators, autoantibodies, cell-free nucleic acids, and microbiome-derived products. This framework positions blood as both a biomarker compartment and a therapeutic interface in aging biology. The circulating senosome does not replace established hallmarks of aging; rather, it provides a systemic layer through which multiple hallmarks interact. Defining, measuring, and therapeutically remodeling this circulating network may create new opportunities for translational geroscience.
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Research summary
The paper proposes a conceptual framework defining the "circulating senosome" as a systemic network of blood-borne mediators that integrates various hallmarks of aging, suggesting that targeting this network offers a new therapeutic interface for aging biology. This is a relevant theoretical synthesis that reframes blood not just as a biomarker source but as a causal therapeutic target, although it currently lacks experimental validation or novel mechanistic data.
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