Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging.

Yuting Jessy Tan, Travis E Conley, Fuwen Yao, Fernando J García-Marqués, Damilola E Akinyemi, Van Vuong Dinh, Qian Wang, Abel Bermudez, Jieun Kim, Julia A Belk, Oliver Soehnlein, Sharon J Pitteri, Katrin I Andreasson

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. · pubmed

Paper

Abstract

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescent neutrophils, a process regulated by the immunomodulatory prostaglandin E2 (PGE

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Research summary

Restoring the clearance of senescent neutrophils by tissue-resident macrophages mitigates organ aging, suggesting that enhancing this specific physiological cleanup mechanism is a viable strategy to address root causes of age-related decline. This work is relevant because it targets a fundamental hallmark of aging (accumulation of damaged cells) rather than merely treating downstream symptoms, although the incremental nature of identifying a specific cell-cell interaction limits its transformative impact.

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