Ergothioneine attenuates age-related declines in circadian rhythmicity.

Kippei Wakita, Kazuto Watanabe, Takahiro J Nakamura

Laboratory of Animal Physiology, School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.Laboratory of Animal Physiology, School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan. · pubmed

Paper

Abstract

Aging is accompanied by the progressive deterioration of circadian clock function, characterized by reduced amplitude, increased period variability, and impaired metabolic coupling. Declining intracellular nicotinamide adenine dinucleotide (NAD

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Research summary

Ergothioneine supplementation attenuates age-related declines in circadian rhythmicity by restoring intracellular NAD+ levels. This is relevant because it addresses a fundamental physiological mechanism of aging (circadian disruption and metabolic coupling) rather than just treating a specific age-related disease symptom, offering a potential intervention to slow functional decline.

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