ASAP3 deficiency alleviates hepatic senescence and correlates with extended healthspan in mice.

Zhen Tian, Yuhua Song, Xinyue Ao, Changhao Sun

National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, P. R. China 150081; Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Heilongjiang, China 150081; NHC Specialty Laboratory Coperation Unit of Food Safety Risk Assessment and Standard Development, Heilongjiang, China 150081. Electronic address: [email protected] Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, P. R. China 150081; Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Heilongjiang, China 150081; NHC Specialty Laboratory Coperation Unit of Food Safety Risk Assessment and Standard Development, Heilongjiang, China 150081. Electronic address: [email protected]. · pubmed

Paper

Abstract

The aging liver not only declines in function but also accelerates systemic aging and shortens lifespan. Identifying key molecular targets to delay liver aging is important for promoting health and longevity. ASAP3 is involved in cytoskeletal remodeling, but its role in aging remains unexplored. Here, we found that ASAP3 expression was upregulated in aged mouse livers and H

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Research summary

ASAP3 deficiency reduces hepatic senescence and extends healthspan in mice, suggesting a potential molecular target for delaying liver aging. The study identifies a specific protein linked to age-related liver decline and demonstrates functional benefits in a mouse model, contributing incremental evidence to the field of geroscience.

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