Resveratrol exerts stage- and sex-specific anti-aging and multigenerational effects via epigenetic and metabolic pathways in Drosophila.

Quanyong Wu, Boya Ouyang, Wanning Ma, Yuxuan Zhao, Jingyimei Liang, Yi Yuan, Hui Cao, Jesus Simal-Gandara, Shaoping Nie, Jianbo Xiao

Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecoloxía e Alimentación (IAA), 32004, Ourense, Spain. Electronic address: [email protected] de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecoloxía e Alimentación (IAA), 32004, Ourense, Spain. Electronic address: [email protected]. · pubmed

Paper

Abstract

Resveratrol is a polyphenolic compound with reported anti-aging properties that exhibit complex and context-dependent biological effects, while its potential multigenerational influence remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Resveratrol extends lifespan and exerts multigenerational effects in Drosophila through stage- and sex-specific epigenetic and metabolic mechanisms. This study provides mechanistic insight into how a known geroprotector influences aging trajectories and transgenerational inheritance in a model organism, contributing to the understanding of dietary interventions on longevity.

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