Effects of nutritional interventions on biomarkers of cellular senescence in humans: a systematic review.

Yao Lin, Abdullah Altulea, Marco Demaria

European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), 9713AV Groningen, the Netherlands. · pubmed

Paper

Abstract

Cellular senescence is a fundamental mechanism of ageing, characterised by stable cell cycle arrest and the acquisition of a pro-inflammatory secretory phenotype. Nutritional interventions are widely proposed to modulate ageing biology, but their effects on cellular senescence in humans remain unclear. We systematically synthesised evidence from interventional human studies assessing the impact of nutritional strategies on biomarkers of cellular senescence.

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Research summary

This systematic review synthesizes existing evidence on how nutritional interventions affect cellular senescence biomarkers in humans. The paper is relevant because it directly addresses a fundamental mechanism of aging (cellular senescence) rather than just treating downstream symptoms, although as a review of existing data, its primary contribution is consolidating knowledge rather than presenting a novel breakthrough.

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