NAT10-mediated RNA N4-acetylation promotes intestinal fibroblast senescence via DHRS2.

Jing Zhong, Jianing Zhu, Meng Xue, Jingyu Chen

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. · pubmed

Paper

Abstract

Intestinal fibroblast senescence contributes to gut aging and the development of related diseases, yet the regulatory mechanisms governing this process remain largely elusive. In this study, we identify the RNA N4-acetylcytidine (ac

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Research summary

NAT10-mediated RNA N4-acetylation promotes intestinal fibroblast senescence via DHRS2. The study identifies a specific molecular mechanism linking RNA modification to cellular senescence in the gut, a hallmark of aging, but represents an incremental mechanistic detail rather than a transformative breakthrough or direct lifespan extension intervention.

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