Evaluation of the anti-ageing potential of manganese ion in human dermal fibroblasts.

Delfina Aranda, Carlos Manuel Fajardo Videla, Eyke de Beláustegui, Carina Shayo, Luciano Vellón, Luis Alberto Haro Durand

Laboratory of Pathology and Molecular Pharmacology, Institute of Biology and Experimental Medicine (IBYME-CONICET), Vuelta de Obligado 2490, Buenos Aires C1428, Argentina.Laboratory of Pathology and Molecular Pharmacology, Institute of Biology and Experimental Medicine (IBYME-CONICET), Vuelta de Obligado 2490, Buenos Aires C1428, Argentina. · pubmed

Paper

Abstract

During skin ageing, fibroblasts' proliferation declines, leading to reduced collagen turnover, increased in expression of senescence markers, and secretion of pro-inflammatory molecules associated with the Senescence-Associated Secretory Phenotype (SASP). The SASP generates a chronic pro-inflammatory state that causes tissue damage and impairs repair mechanisms. Among the molecular pathways implicated in ageing, the PI3K/AKT/mTOR signalling axis is now recognised as a central regulator of cellular metabolism, growth, and survival, and its attenuation has been identified as one of the main anti-ageing interventions. In this context, the present study aimed to evaluate the anti-ageing potential of the manganese ion (Mn

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Research summary

The study tests whether manganese ions can mitigate cellular senescence and inflammation in human dermal fibroblasts by modulating the PI3K/AKT/mTOR pathway. This is a minor, incremental in vitro investigation into a specific molecular mechanism of skin aging, lacking evidence of systemic lifespan extension or significant clinical breakthrough.

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