Mitochondrial quality control in human ageing and longevity.
Abstract
Mitochondria play central roles in cellular metabolism and in key processes such as inflammation, stress response, cell death and signalling. Mitochondrial quality control (MQC) mechanisms continuously monitor organelle integrity and function, and repair or eliminate damaged mitochondria to replace them with newly formed, healthy organelles. MQC is particularly important under metabolic or environmental stress conditions. Failure of MQC paves the way to chronic diseases, such as diabetes, metabolic syndromes and immunosenescence. This Review summarizes our current understanding of MQC biology in the context of healthy human longevity. We explore the regulation of MQC in physiological conditions and explain how the dysregulation of MQC in ageing negatively impacts systemic metabolism and immune function. We discuss emerging therapeutic strategies-such as NAD
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
This review summarizes existing knowledge on mitochondrial quality control mechanisms and their dysregulation in aging, rather than presenting new experimental data or a novel therapeutic breakthrough. The paper is relevant because it addresses a fundamental biological process (mitochondrial integrity) linked to the root causes of aging and age-related metabolic decline, but as a summary of current understanding, its incremental scientific impact is low.
Author of this paper? Send a correction.