Extracellular Vesicles From Young Human Myogenic Progenitor Cells Rejuvenate Aged Cells.

Lorenzo Marramiero, Ester Sara Di Filippo, Federica Di Marco, Piero Del Boccio, Cristian Celia, Luisa Di Marzio, Nicola d'Avanzo, Tiziana Pietrangelo, Stefania Fulle, Rosa Mancinelli

Dept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it. · pubmed

Paper

Abstract

The physiological age-related decline in skeletal muscle mass, power, and function is challenging for humans. Skeletal muscle has been recently recognized as a secretory organ, with human myogenic progenitor cells (hMPCs) releasing extracellular vesicles (EVs). Here, we investigate the role of hMPC-derived EVs as mediators in skeletal muscle aging. This heterologous approach enables the analysis of age-related variations in EV burden and their impact on human muscle stem cell function. Therefore, we isolated EVs from hMPCs obtained from

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Research summary

Extracellular vesicles derived from young human myogenic progenitor cells can reverse age-related functional decline in aged cells. This study represents an incremental mechanistic exploration of a specific cell-secreted factor in muscle aging, lacking the broad transformative potential or definitive proof of lifespan extension required for higher impact scores.

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