The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Maria Jose Perez J, Alicia Lam, Christin Weissleder, Federico Bertoli, Hariam Raji, Mariella Bosch, Ivan Nemazanyy, Stefanie Kalb, Mohammed Kehili, Insa Hirschberg, Dario Brunetti, Indra Heckenbach, Morten Scheibye-Knudsen, Michela Deleidi

Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. [email protected] and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. [email protected]. · pubmed

Paper

Abstract

Mitochondria have evolved a specialized mitochondrial unfolded protein response (UPR

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Mitochondrial stress in microglia triggers neuronal-glial communication failure and cellular senescence, suggesting that targeting the mitochondrial unfolded protein response could mitigate age-related neurodegeneration. This work is relevant because it identifies a specific mechanistic root cause of brain aging (mitochondrial dysfunction in glia) rather than merely describing symptoms, although the findings represent a solid incremental advance in understanding glial contributions to aging rather than a transformative breakthrough.

Author of this paper? Send a correction.