FUBL-3/FUBP1 mediates mitochondrial stress-induced chromatin remodeling and longevity.
Abstract
Mitochondrial stress activates nuclear transcriptional programs to restore homeostasis and promote longevity; yet, the nuclear effector that directly reshapes chromatin during stress remains unclear. Through a forward genetic screen in
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Research summary
The study identifies FUBL-3/FUBP1 as a nuclear effector that mediates mitochondrial stress-induced chromatin remodeling to promote longevity. This work is relevant because it elucidates a specific molecular mechanism linking mitochondrial-nuclear communication to lifespan extension, addressing a fundamental root cause of aging rather than just treating symptoms.
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