ADORA2B/ador-1 is required for multi-system transcriptional adaptation to mild hypoxia and healthspan extension in C. elegans.

Xavier Capó, Margalida Torrens-Mas, Guillermo Calvo-Navarrete, Frederique Gill, Adelaide Raimundo, Christopher Saunter, Aitor Carretero, Cayetano Navas-Enamorado, Ana Molina de la Llave, Andrés Sánchez-Polo, Luis Masmiquel, David Weinkove, Marta Gonzalez-Freire

Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, 07122 Palma, Spain; Translational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Mallorca, Spain. · pubmed

Paper

Abstract

Mild intermittent hypoxia is emerging as a promising strategy to enhance healthspan, but the molecular mechanisms remain poorly defined. ADORA2B, a hypoxia-inducible adenosine receptor, is known to regulate metabolism and stress responses, yet its role in functional aging is unclear.

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Research summary

The study identifies ADORA2B as a necessary mediator for the healthspan benefits of mild intermittent hypoxia in C. elegans. This is a relevant mechanistic study linking a specific gene to aging outcomes, but it represents a standard incremental finding in a model organism without evidence of broader transformative potential or surprising paradigm shifts.

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