Mechanisms and interventions of epigenetic aging.
Abstract
Increasing evidence suggests that epigenetic dysregulation is both a hallmark and a potential driving force of aging. As a multifactorial, non-linear, and systemic biological process, aging likely results from a progressive imbalance in a complex epigenetic network involving DNA, histones, RNA, and non-coding sequences. These interconnected alterations collectively lead to core aging features such as genomic instability, heightened inflammation, and loss of cellular identity. In this review, we highlight the central role of epigenetic mechanisms across different dimensions in cellular, tissue, and organismal aging. Furthermore, we discuss potential intervention strategies designed to counteract these epigenetic alterations, indicating both their promise and the associated challenges.
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Research summary
This review proposes that epigenetic dysregulation is a primary driver of aging and discusses potential interventions to reverse these changes. The paper is relevant because it addresses the root causes of aging through epigenetic mechanisms rather than treating specific age-related symptoms, but as a general review without novel experimental data or transformative new theories, its scientific impact is limited to summarizing existing knowledge.
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