ROS-Responsive H

Lili Luo, Huijie Ma, Linxiang Zhou, Yi Zhu, Min Ma, Yuxuan Ding, Lixin Ma, Xuli Feng, Libing Liu

Key Laboratory of Precision Nutrition and Food Quality, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.Key Laboratory of Precision Nutrition and Food Quality, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. · pubmed

Paper

Abstract

Cellular senescence is a durable state of cell-cycle arrest, and the progressive accumulation of senescent cells compromises tissue repair and promotes age-related functional decline. ROS drive oxidative stress when excessively produced or inadequately cleared, thereby inducing mitochondrial dysfunction that accelerates senescence. In this work, ROS-responsive branched reductive compound HS-N has been designed and synthesized, which serves as a dual-functional donor: effectively scavenges ROS and simultaneously releases H

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Research summary

The study demonstrates that a synthesized ROS-responsive compound (HS-N) effectively scavenges reactive oxygen species and releases hydrogen to mitigate oxidative stress and delay cellular senescence in vitro. This represents an incremental advance in the development of senolytic or senomorphic agents targeting oxidative stress, a known hallmark of aging, though it currently lacks in vivo lifespan extension data.

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